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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to type I interferon
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Accession:GO:0071357 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: cellular response to type I IFN


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cellular response to type I interferon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 involved_in IMP (PMID:24525126) AgBase PMID:24525126 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:101,214,730...101,225,169
Ensembl chr14:101,214,710...101,225,164 		JBrowse link
G MX1 MX dynamin like GTPase 1 involved_in IMP (PMID:24500530) AgBase PMID:24500530 NCBI chr13:204,843,049...204,868,927
Ensembl chr13:204,843,754...204,868,922 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 involved_in IMP (PMID:24525126) AgBase PMID:24525126 NCBI chr13:140,373,571...140,406,129
Ensembl chr13:140,364,075...140,406,112 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28835460) Ensembl
MGI		 PMID:28835460 GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19060901) Ensembl
MGI		 PMID:19060901 GO_REF:0000107 NCBI chr 4:95,154,230...95,197,308
Ensembl chr 4:95,154,358...95,197,304 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,049,250...75,065,990
Ensembl chr 2:75,049,261...75,065,299 		JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:4,934,379...4,950,093
Ensembl chr17:4,933,453...4,950,346 		JBrowse link
G DCST1 DC-STAMP domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,748,430...94,768,322
Ensembl chr 4:94,748,429...94,768,452 		JBrowse link
G EIF4E2 eukaryotic translation initiation factor 4E family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:133,060,054...133,092,624
Ensembl chr15:133,060,247...133,103,719 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:133,180,638...133,313,307
Ensembl chr15:133,260,113...133,311,887 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in ISO (PMID:37656786) UniProt PMID:37656786 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,900...31,869,188 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:77,661,945...77,679,459
Ensembl chr 7:77,662,058...77,695,934 		JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,093...33,483,679 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:78,747,687...78,758,821
Ensembl chr 6:78,747,650...78,758,812 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,677...19,036,820 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,851,083...38,867,427
Ensembl chr14:38,851,918...38,859,409 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,117,348...40,171,935
Ensembl chr17:40,107,462...40,171,878 		JBrowse link
G SMIM30 small integral membrane protein 30 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr18:32,645,784...32,645,963 JBrowse link
G STAT2 signal transducer and activator of transcription 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,733,030...21,748,960
Ensembl chr 5:21,733,035...21,751,354 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18724932) Ensembl
MGI		 PMID:18724932 GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:5,687,895...5,719,003
Ensembl chr 5:5,701,583...5,720,724 		JBrowse link
G USP18 ubiquitin specific peptidase 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:70,183,321...70,227,990
Ensembl chr 5:70,183,308...70,229,572 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:85,717,147...85,756,750
Ensembl chr 6:85,716,983...85,726,473 		JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein F3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:70,887,101...70,928,839
Ensembl chr 4:70,887,105...70,928,807 		JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,185,675...3,194,818 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:67,123,055...67,147,991
Ensembl chr 9:67,123,265...67,147,989 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17618271) Ensembl
MGI		 PMID:17618271 GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17618271) Ensembl
MGI		 PMID:17618271 GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378 		JBrowse link
G LIMK2 LIM domain kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:47,946,370...47,979,702
Ensembl chr14:47,951,481...47,979,699 		JBrowse link
G LOC100622028 tripartite motif-containing protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,197,922...4,204,688
Ensembl chr 9:4,196,921...4,218,415 		JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chr 6:43,847,882...43,901,697
Ensembl chr 6:43,847,732...43,903,587 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in ISO (PMID:16127453), (PMID:20451243) BHF-UCL PMID:16127453 PMID:20451243 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,900...31,869,188 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,093...33,483,679 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,677...19,036,820 		JBrowse link
G RBM47 RNA binding motif protein 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:31,508,133...31,690,757
Ensembl chr 8:31,508,148...31,690,409 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:141,359,402...141,367,222
Ensembl chr 2:141,358,993...141,367,198 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,880,205...28,929,963 		JBrowse link
G TRIM41 tripartite motif containing 41 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:57,285,401...57,295,771
Ensembl chr 2:57,285,406...57,295,771 		JBrowse link
G TRIM56 tripartite motif containing 56 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:8,834,260...8,842,524
Ensembl chr 3:8,834,274...8,839,415 		JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,887,784...30,961,685
Ensembl chr 8:30,887,830...30,963,762 		JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:43,553,454...43,557,247
Ensembl chr  X:43,555,005...43,556,321 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:17618271) InterPro
MGI
TreeGrafter
GO_Central		 PMID:17618271 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr17:57,975,982...57,986,117
Ensembl chr17:57,973,096...57,986,136 		JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16280321) MGI
Ensembl		 PMID:16280321 GO_REF:0000107 NCBI chr 2:69,202,695...69,212,909
Ensembl chr 2:69,201,579...69,225,994 		JBrowse link
type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC4 histone deacetylase 4 involved_in ISO (PMID:31127039) UniProt PMID:31127039 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G IFIH1 interferon induced with helicase C domain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28031478) Ensembl
MGI		 PMID:28031478 GO_REF:0000107 NCBI chr15:68,930,998...68,985,145
Ensembl chr15:68,928,254...68,985,083 		JBrowse link
G IFITM1 interferon-induced transmembrane protein 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:124,095...125,495 JBrowse link
G IFITM3 interferon induced transmembrane protein 3 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:128,658...129,736
Ensembl chr 2:127,152...129,835 		JBrowse link
G IFNA1 interferon, alpha 1 involved_in ISO (MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:5583923 NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 involved_in ISS
IEA
IBA		 UniProt
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IFNAR2 interferon alpha and beta receptor subunit 2 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:196,765,915...196,852,640
Ensembl chr13:196,766,087...196,852,635 		JBrowse link
G IFNB1 interferon beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378 		JBrowse link
G JAK1 Janus kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182 		JBrowse link
G LOC100519082 interferon-induced transmembrane protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:152,490...154,732 JBrowse link
G LOC100626247 interferon-induced transmembrane protein 1-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:133,896...135,271 JBrowse link
G LOC102161418 interferon-induced transmembrane protein 1-like involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:156,364...157,650 JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in ISO (PMID:28640813) ARUK-UCL PMID:28640813 NCBI chr14:38,851,083...38,867,427
Ensembl chr14:38,851,918...38,859,409 		JBrowse link
G OAS2 2'-5'-oligoadenylate synthetase 2 involved_in ISO (MGI:6094812|PMID:29117179) UniProt PMID:29117179 MGI:6094812 NCBI chr14:38,827,667...38,847,697
Ensembl chr14:38,827,660...38,860,820 		JBrowse link
G SIN3A SIN3 transcription regulator family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:58,171,821...58,246,126
Ensembl chr 7:58,176,167...58,245,971 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 involved_in IEA
IBA
ISS		 Ensembl
TreeGrafter
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:21,733,030...21,748,960
Ensembl chr 5:21,733,035...21,751,354 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28351661) Ensembl
MGI		 PMID:28351661 GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G TRIM65 tripartite motif containing 65 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28031478) Ensembl
MGI		 PMID:28031478 GO_REF:0000107 NCBI chr12:5,523,056...5,528,884
Ensembl chr12:5,523,113...5,528,878 		JBrowse link
G TYK2 tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:69,157,774...69,183,555
Ensembl chr 2:69,157,811...69,183,456 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    immune system process 2496
      immune response 1630
        innate immune response 837
          response to type I interferon 70
            cellular response to type I interferon 64
              type I interferon-mediated signaling pathway + 59
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to biotic stimulus 1716
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  response to type I interferon 70
                    cellular response to type I interferon 64
                      type I interferon-mediated signaling pathway + 59
paths to the root