ZBP1 (Z-DNA binding protein 1) - Rat Genome Database

Name: ZBP1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ZBP1 (Z-DNA binding protein 1) Sus scrofa

Analyze

Symbol:

ZBP1

Name:

Z-DNA binding protein 1

RGD ID:

14050649

Description:

ENCODES a protein that exhibits double-stranded RNA binding (ortholog); identical protein binding (ortholog); left-handed Z-DNA binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); defense response to fungus (ortholog); positive regulation of apoptotic process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DAI; DNA-dependent activator of IFN-regulatory factor; Z-DNA-binding protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZBP1 (Z-DNA binding protein 1)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Zbp1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Zbp1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Zbp1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZBP1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZBP1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Zbp1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZBP1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Zbp1 (Z-DNA binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	57,973,096 - 57,986,136 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	57,975,982 - 57,986,117 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	65,133,675 - 65,147,101 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

antiviral innate immune response (IEA)

defense response to fungus (ISO)

defense response to virus (IEA)

positive regulation of apoptotic process (ISO)

positive regulation of inflammatory response (ISO)

positive regulation of necroptotic process (IEA)

positive regulation of type I interferon-mediated signaling pathway (IBA,IEA,ISO)

pyroptotic inflammatory response (ISO)

regulation of inflammatory response (ISO)

regulation of interleukin-1-mediated signaling pathway (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

nucleus (IBA,IEA)

Molecular Function

DNA binding (IBA,IEA)

double-stranded RNA adenosine deaminase activity (IEA)

double-stranded RNA binding (ISO)

identical protein binding (ISO)

left-handed Z-DNA binding (ISO)

protein binding (ISO)

RNA binding (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:19850075	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ZBP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	57,973,096 - 57,986,136 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	57,975,982 - 57,986,117 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	65,133,675 - 65,147,101 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	57,603,852 - 57,620,426 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	57,603,846 - 57,620,576 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	56,178,908 - 56,195,482 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	55,612,308 - 55,628,935 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	55,612,309 - 55,628,935	NCBI
Celera	20	52,919,278 - 52,936,016 (-)	NCBI		Celera
Cytogenetic Map	20	q13.31	NCBI
HuRef	20	52,960,880 - 52,977,617 (-)	NCBI		HuRef
CHM1_1	20	56,079,953 - 56,096,848 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	59,381,747 - 59,398,460 (-)	NCBI		T2T-CHM13v2.0

Zbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	173,048,405 - 173,060,715 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	173,048,405 - 173,060,716 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	173,206,612 - 173,218,959 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	173,206,612 - 173,218,923 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	173,032,113 - 173,044,423 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	172,849,551 - 172,861,829 (-)	NCBI		MGSCv36	mm8
Celera	2	179,174,441 - 179,186,462 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	95.83	NCBI

Zbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	182,411,665 - 182,427,604 (-)	NCBI		GRCr8
mRatBN7.2	3	161,993,351 - 162,009,297 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	161,993,351 - 162,003,870 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	165,792,609 - 165,802,971 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	174,296,563 - 174,306,915 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	172,033,385 - 172,043,749 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	171,276,062 - 171,292,062 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	171,276,062 - 171,286,537 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	177,340,450 - 177,356,357 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	164,078,444 - 164,088,795 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	163,984,480 - 163,994,831 (-)	NCBI
Celera	3	161,180,812 - 161,191,132 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Zbp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	1,866,376 - 1,881,948 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	1,867,436 - 1,878,132 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZBP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	63,355,078 - 63,372,627 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	63,348,196 - 63,365,298 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	53,944,224 - 53,961,362 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	55,222,405 - 55,239,136 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	55,222,405 - 55,239,130 (-)	Ensembl	panpan1.1		panPan2

ZBP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	42,583,674 - 42,589,857 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	42,584,083 - 42,589,753 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	41,824,727 - 41,836,590 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	43,442,817 - 43,454,678 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	24	42,527,583 - 42,539,421 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	42,667,206 - 42,679,124 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	43,325,535 - 43,337,462 (-)	NCBI		UU_Cfam_GSD_1.0

Zbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	182,896,282 - 182,907,707 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936530	398,980 - 408,798 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZBP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	6,494,410 - 6,510,928 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	54,552,351 - 54,568,525 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zbp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624741	24,022,433 - 24,033,090 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ZBP1
417 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	6	1		3				1
Low	4	3	3	2	2	21	2	2	3
Below cutoff						1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001123216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK239309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK350043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR956367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ455510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01102871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000008223 ⟹ ENSSSCP00000008004

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	57,973,096 - 57,986,136 (-)	Ensembl

RefSeq Acc Id:

NM_001123216 ⟹ NP_001116688

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	57,975,982 - 57,986,117 (-)	NCBI

Sequence:

show sequence

CACAGCTGCCAGCAGCCCCAGGCTGGGTCACAAAACGACACTCAGCCTCGGCCGGACCCACCTT
CTCAAGGCCATGGAGTCGGAGCAGGCCACTGTCCCCAAGGCTCCCAGGCTCCCAGCGGCTGCTG
CCGACGTGGCCGAGACCCCTGCCGACCCAGAGGATGCAGAGCTTGAGCGGAGGATCCTGCAGGT
GCTGAGGGATGCCAGCTCCCCCGTGAGGACTGCCCAGCTGGTCATCAAATGCCAGGTGCCCAAG
AAGAAACTCAACCAAGTCCTCCACCGGATGAAGAAGGAGTCCAGGGGAGGGCTCACCCTCGTGG
GCCCTGCGACGTGGTGCCTGGGCGATGCTGGGACCGACGGGACCAGAGAAGTGGTGCTGGCAGA
GCAGGCAGAGAGGCCCCGGCAAGAGGCAGTTGCGATTCCAAGGACGCCTGGCCCAAGGACGCCT
GGCCCTGAGCTCAGCGAGCGGCAGATGGAGATCTACGGGCTTCTGAAAGCCCAGGGGCCCCACA
AGGCCCTGCACATCGCCCGGGCCCTGGGGCTGAAGACGGCGAAGGAAGTCAACCGCGACCTGTA
TGCCATGAGGAATATGCACCTCCTGACCCTGGACCAGAAGTCAAACGCCTGGGGGGTTTACCAG
CCAGAAGATTCTAGAAATCAGTCCACCCCGGTTATTTACCAGCAAAATCCAATCAACATGATCT
GTCAGAAGGGACTGAACAACTGCATTTCCATTGAGAACTCTGAAAACATCCAGATTGGACATGG
CAATGTCATCATGAGACACGAGTCCTCTGGGGAAAGCGGCTCCATGGCTGCCTTCTACCTCCCT
CCGACGGTACCTGCCGACTCCTCAGCCCAGGGTCCCCTGGCTGGATCCTGGGGGCCCCAGGACA
TCTGCATGGAGAAGTCTGTGCTCAGACGGGTACAGATGGGCCATGGCAACGAGATGAGACTTCA
CAGCTTCCCGGCTGAGGGCCCTGCCCATAGCGCTTGTGGCAGCCCCCCAGGCTCTGTCTCAGCT
ACGAGTCCAGAGGCTTCCATTGATATTCAGATCCCCGAGCCAGGACCTCACGCCGAAGGGGTCA
TGGCCCAGAAGGTCCGAATTCGCTCGTGCTTCCTGGAGGACACGACCGTGGGCAACAGCAACAG
GATGAGCGTCAGCCCGGGGACGGCTGGTCCCGGGGGAGTCTCGGGGCCTGAGGAGGGCAGGGCG
GACCCCGGGGAGCCAGGAGAGGACCCAGACTCTCTCTCTGGAGCTGCTGGACGCAGCAGCCAAG
TCCCTCCCGACGGCGGTCAGGCTGCCCCCAGCGACGCTGAGATGCTCACCTCCCAGCTGGAAGC
TCTGACTCTCAGAAGCAGGGGTCCCAGAACCACAGAAGATGGCCACTGAGGGGACAGAACAGCC
GA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001116688	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACJ70709	(Get FASTA)	NCBI Sequence Viewer
	CAN13344	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000008004
	ENSSSCP00000008004.3
	ENSSSCP00015002524.1
	ENSSSCP00070031221.1
	ENSSSCP00070031234.1

RefSeq Acc Id:

NP_001116688 ⟸ NM_001123216

- UniProtKB:

A5GFP5 (UniProtKB/TrEMBL), F1RJT0 (UniProtKB/TrEMBL), A0A8D0MEV6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESEQATVPKAPRLPAAAADVAETPADPEDAELERRILQVLRDASSPVRTAQLVIKCQVPKKKL
NQVLHRMKKESRGGLTLVGPATWCLGDAGTDGTREVVLAEQAERPRQEAVAIPRTPGPRTPGPE
LSERQMEIYGLLKAQGPHKALHIARALGLKTAKEVNRDLYAMRNMHLLTLDQKSNAWGVYQPED
SRNQSTPVIYQQNPINMICQKGLNNCISIENSENIQIGHGNVIMRHESSGESGSMAAFYLPPTV
PADSSAQGPLAGSWGPQDICMEKSVLRRVQMGHGNEMRLHSFPAEGPAHSACGSPPGSVSATSP
EASIDIQIPEPGPHAEGVMAQKVRIRSCFLEDTTVGNSNRMSVSPGTAGPGGVSGPEEGRADPG
EPGEDPDSLSGAAGRSSQVPPDGGQAAPSDAEMLTSQLEALTLRSRGPRTTEDGH

hide sequence

RefSeq Acc Id:

ENSSSCP00000008004 ⟸ ENSSSCT00000008223

Protein Domains

Z-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000007508	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015004604	UniProtKB/TrEMBL
	ENSSSCG00070018931	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000008223	ENTREZGENE
	ENSSSCT00000008223.4	UniProtKB/TrEMBL
	ENSSSCT00015006179.1	UniProtKB/TrEMBL
	ENSSSCT00070037346.1	UniProtKB/TrEMBL
	ENSSSCT00070037359.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
	Zalpha_dom	UniProtKB/TrEMBL
	ZBP1	UniProtKB/TrEMBL
KEGG Report	ssc:100144524	UniProtKB/TrEMBL
NCBI Gene	ZBP1	ENTREZGENE
PANTHER	PTHR14966	UniProtKB/TrEMBL
	Z-DNA-BINDING PROTEIN 1	UniProtKB/TrEMBL
PROSITE	Z_BINDING	UniProtKB/TrEMBL
SMART	Zalpha	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A288CFW7_PIG	UniProtKB/TrEMBL
	A0A4X1UMC9_PIG	UniProtKB/TrEMBL
	A0A4X1USI9_PIG	UniProtKB/TrEMBL
	A0A8D0MEV6	ENTREZGENE, UniProtKB/TrEMBL
	A5GFP5	ENTREZGENE, UniProtKB/TrEMBL
	F1RJT0	ENTREZGENE
UniProt Secondary	F1RJT0	UniProtKB/TrEMBL
VGNC ID	VGNC:95770	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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