YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) - Rat Genome Database

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Gene: YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) Sus scrofa
Analyze
Symbol: YTHDF2
Name: YTH N6-methyladenosine RNA binding protein F2
RGD ID: 14294858
Description: ENCODES a protein that exhibits C5-methylcytidine-containing RNA reader activity (inferred); mRNA binding (inferred); N6-methyladenosine-containing RNA reader activity (inferred); INVOLVED IN positive regulation of translational initiation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN centriolar satellite (inferred); cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: YTH domain family, member 2; YTH domain-containing family protein 2; YTH N6-methyladenosine RNA binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,716,983 - 85,726,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,717,147 - 85,756,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,553,445 - 79,583,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202   PMID:30787270  


Genomics

Comparative Map Data
YTHDF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,716,983 - 85,726,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,717,147 - 85,756,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,553,445 - 79,583,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YTHDF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,736,624 - 28,769,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,736,621 - 28,769,775 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,063,136 - 29,096,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,935,723 - 28,968,874 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,884,098 - 28,916,902NCBI
Celera127,459,395 - 27,492,550 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,315,797 - 27,348,923 (+)NCBIHuRef
CHM1_1129,178,454 - 29,211,612 (+)NCBICHM1_1
T2T-CHM13v2.0128,578,615 - 28,611,771 (+)NCBIT2T-CHM13v2.0
Ythdf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,912,227 - 131,939,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,912,223 - 131,939,614 (-)EnsemblGRCm39 Ensembl
GRCm384132,184,916 - 132,212,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,184,912 - 132,212,303 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,740,831 - 131,768,171 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,458,133 - 131,484,332 (-)NCBIMGSCv36mm8
Celera4130,346,178 - 130,373,501 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.92NCBI
Ythdf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,665,467 - 149,693,127 (-)NCBIGRCr8
mRatBN7.25144,381,426 - 144,407,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,381,431 - 144,408,144 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,080,642 - 147,105,456 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,850,486 - 148,875,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,839,793 - 148,864,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,364,490 - 150,390,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,365,101 - 150,390,099 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,037,607 - 154,063,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,063,958 - 151,089,250 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,073,989 - 151,099,406 (-)NCBI
Celera5142,815,747 - 142,839,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ythdf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554527,783,398 - 7,815,468 (+)NCBIChiLan1.0ChiLan1.0
YTHDF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,072,609 - 198,107,749 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,191,694 - 197,225,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,007,592 - 28,041,179 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,038,751 - 29,070,533 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,038,831 - 29,070,533 (+)Ensemblpanpan1.1panPan2
YTHDF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,760,232 - 71,791,420 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,760,312 - 71,792,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,336,008 - 68,368,586 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,319,158 - 72,351,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,319,154 - 72,351,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,147,969 - 69,180,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,155,530 - 70,188,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,153,556 - 71,186,141 (-)NCBIUU_Cfam_GSD_1.0
Ythdf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,966,462 - 47,003,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,791,073 - 12,827,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,791,121 - 12,827,122 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YTHDF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,041,657 - 104,078,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,040,679 - 104,078,484 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603312,443,353 - 12,479,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ythdf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,533,257 - 12,567,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,533,317 - 12,567,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in YTHDF2
758 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 1 1 1
Low 10 3 3 2 2 22 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027438   ⟹   ENSSSCP00000019298
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl685,718,029 - 85,751,583 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048590   ⟹   ENSSSCP00000041740
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl685,716,983 - 85,724,049 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000086790   ⟹   ENSSSCP00000061310
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl685,720,979 - 85,726,473 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000090867   ⟹   ENSSSCP00000065604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl685,716,931 - 85,726,473 (+)Ensembl
RefSeq Acc Id: XM_005665152   ⟹   XP_005665209
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1685,717,147 - 85,756,750 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005665209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000041740.3
  ENSSSCP00000061310.1
  ENSSSCP00005023871.1
Reference Protein Sequences
RefSeq Acc Id: XP_005665209   ⟸   XM_005665152
- Sequence:
RefSeq Acc Id: ENSSSCP00000041740   ⟸   ENSSSCT00000048590
RefSeq Acc Id: ENSSSCP00000065604   ⟸   ENSSSCT00000090867
RefSeq Acc Id: ENSSSCP00000019298   ⟸   ENSSSCT00000027438
RefSeq Acc Id: ENSSSCP00000061310   ⟸   ENSSSCT00000086790
Protein Domains
YTH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027686 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005024468 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048590.3 UniProtKB/TrEMBL
  ENSSSCT00000086790.1 UniProtKB/TrEMBL
  ENSSSCT00005038858.1 UniProtKB/TrEMBL
Gene3D-CATH ph1033 like domains UniProtKB/TrEMBL
InterPro YTH_domain UniProtKB/TrEMBL
  YTH_prot UniProtKB/TrEMBL
NCBI Gene YTHDF2 ENTREZGENE
PANTHER PTHR12357 UniProtKB/TrEMBL
  YTH DOMAIN-CONTAINING FAMILY PROTEIN 2 UniProtKB/TrEMBL
Pfam YTH UniProtKB/TrEMBL
PROSITE YTH UniProtKB/TrEMBL
UniProt A0A287AD32_PIG UniProtKB/TrEMBL
  A0A6B7KWM6_PIG UniProtKB/TrEMBL
  A0A8D0X5N6_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2QT18 UniProtKB/TrEMBL
VGNC ID VGNC:95043 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-30 YTHDF2  YTH N6-methyladenosine RNA binding protein F2  YTHDF2  YTH N6-methyladenosine RNA binding protein 2  Symbol and/or name change 19259463 PROVISIONAL