IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon) - Rat Genome Database

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Gene: IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon) Sus scrofa
Analyze
Symbol: IKBKE
Name: inhibitor of nuclear factor kappa B kinase subunit epsilon
RGD ID: 14175992
Description: ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN cellular response to virus (inferred); gene expression (inferred); immune response (inferred); ASSOCIATED WITH autistic disorder (ortholog); familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (inferred); mitochondrial membrane (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,123,265 - 67,147,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,367,929 - 73,388,131 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
mitochondrial membrane  (IEA)
nucleus  (IEA)
PML body  (IEA)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IKBKE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,123,265 - 67,147,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,367,929 - 73,388,131 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,470,476 - 206,496,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,470,476 - 206,496,889 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,643,819 - 206,670,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,710,419 - 204,736,845 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,032,190 - 203,058,617NCBI
Celera1179,895,028 - 179,921,668 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,341,834 - 177,368,529 (+)NCBIHuRef
CHM1_11207,915,782 - 207,942,429 (+)NCBICHM1_1
T2T-CHM13v2.01205,734,655 - 205,761,052 (+)NCBIT2T-CHM13v2.0
Ikbke
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,182,337 - 131,207,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,182,080 - 131,207,344 (-)EnsemblGRCm39 Ensembl
GRCm381131,254,600 - 131,279,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,254,343 - 131,279,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,151,179 - 133,176,140 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,082,148 - 133,107,109 (-)NCBIMGSCv36mm8
Celera1133,876,834 - 133,902,322 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.93NCBI
Ikbke
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,264,404 - 45,290,737 (-)NCBIGRCr8
mRatBN7.21342,712,154 - 42,738,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,712,159 - 42,737,143 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,320,191 - 45,345,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,608,323 - 46,633,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,872,035 - 43,897,029 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,031,325 - 48,056,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,031,410 - 48,056,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,107,093 - 53,132,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,197,625 - 44,222,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,211,668 - 44,233,796 (-)NCBI
Celera1343,057,856 - 43,082,833 (-)NCBICelera
Cytogenetic Map13q13NCBI
Ikbke
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,056,014 - 42,077,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,056,014 - 42,077,701 (+)NCBIChiLan1.0ChiLan1.0
IKBKE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,881,624 - 42,909,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,847,151 - 42,873,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,070,565 - 182,096,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,351,807 - 186,377,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,351,807 - 186,377,971 (+)Ensemblpanpan1.1panPan2
IKBKE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,747,303 - 2,772,574 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,747,297 - 2,772,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,839,619 - 2,864,841 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,744,869 - 2,770,037 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,744,859 - 2,770,035 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,738,094 - 2,763,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,131,469 - 3,156,703 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,331,693 - 3,356,866 (+)NCBIUU_Cfam_GSD_1.0
Ikbke
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,825,925 - 68,851,246 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365576,066,207 - 6,090,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,865,720 - 22,892,346 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,865,734 - 22,891,920 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,564,077 - 23,591,390 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbke
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,913,742 - 4,933,267 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,913,734 - 4,934,096 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IKBKE
627 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 4 1 1
Low 7 3 1 23 2 2
Below cutoff 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030765   ⟹   ENSSSCP00000019776
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl967,123,265 - 67,147,989 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034975   ⟹   ENSSSCP00000030728
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl967,123,272 - 67,147,989 (+)Ensembl
RefSeq Acc Id: XM_021063307   ⟹   XP_020918966
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,057 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063308   ⟹   XP_020918967
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,056 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063309   ⟹   XP_020918968
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,056 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063310   ⟹   XP_020918969
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,057 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063311   ⟹   XP_020918970
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063312   ⟹   XP_020918971
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063313   ⟹   XP_020918972
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,055 - 67,142,547 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002335790
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020918970   ⟸   XM_021063311
- Peptide Label: isoform X3
- UniProtKB: A0A4X1USU0 (UniProtKB/TrEMBL),   A0A8D0W6P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918971   ⟸   XM_021063312
- Peptide Label: isoform X4
- UniProtKB: A0A8D0YHD0 (UniProtKB/TrEMBL),   A0A8D2BP08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918972   ⟸   XM_021063313
- Peptide Label: isoform X5
- UniProtKB: A0A8D0PZL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918967   ⟸   XM_021063308
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UMW1 (UniProtKB/TrEMBL),   M9MMN5 (UniProtKB/TrEMBL),   A0A0B8RTL1 (UniProtKB/TrEMBL),   A0A8D0W8A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918968   ⟸   XM_021063309
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UMW1 (UniProtKB/TrEMBL),   M9MMN5 (UniProtKB/TrEMBL),   A0A0B8RTL1 (UniProtKB/TrEMBL),   A0A8D0W8A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918966   ⟸   XM_021063307
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UMW1 (UniProtKB/TrEMBL),   M9MMN5 (UniProtKB/TrEMBL),   A0A0B8RTL1 (UniProtKB/TrEMBL),   A0A8D0W8A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918969   ⟸   XM_021063310
- Peptide Label: isoform X2
- UniProtKB: A0A8D0HX70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019776   ⟸   ENSSSCT00000030765
RefSeq Acc Id: ENSSSCP00000030728   ⟸   ENSSSCT00000034975
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005005730 UniProtKB/TrEMBL
  ENSSSCG00015074383 UniProtKB/TrEMBL
  ENSSSCG00025065077 UniProtKB/TrEMBL
  ENSSSCG00030025332 UniProtKB/TrEMBL
  ENSSSCG00035001057 UniProtKB/TrEMBL
  ENSSSCG00045001192 UniProtKB/TrEMBL
  ENSSSCG00055017223 UniProtKB/TrEMBL
  ENSSSCG00060055728 UniProtKB/TrEMBL
  ENSSSCG00070018986 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030765 ENTREZGENE
  ENSSSCT00000030765.4 UniProtKB/TrEMBL
  ENSSSCT00005009510.1 UniProtKB/TrEMBL
  ENSSSCT00015100174.1 UniProtKB/TrEMBL
  ENSSSCT00015100352.1 UniProtKB/TrEMBL
  ENSSSCT00025089343.1 UniProtKB/TrEMBL
  ENSSSCT00025089684.1 UniProtKB/TrEMBL
  ENSSSCT00030035370.1 UniProtKB/TrEMBL
  ENSSSCT00030035382.1 UniProtKB/TrEMBL
  ENSSSCT00035001290.1 UniProtKB/TrEMBL
  ENSSSCT00035001293.1 UniProtKB/TrEMBL
  ENSSSCT00045001859.1 UniProtKB/TrEMBL
  ENSSSCT00045001884.1 UniProtKB/TrEMBL
  ENSSSCT00055033953.1 UniProtKB/TrEMBL
  ENSSSCT00055034143.1 UniProtKB/TrEMBL
  ENSSSCT00060075931.1 UniProtKB/TrEMBL
  ENSSSCT00060075939.1 UniProtKB/TrEMBL
  ENSSSCT00070037499.1 UniProtKB/TrEMBL
  ENSSSCT00070037510.1 UniProtKB/TrEMBL
  ENSSSCT00070037530.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.420 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
NCBI Gene IKBKE ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0B8RTL1 ENTREZGENE
  A0A4X1UMW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1USU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0HX70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0I5X9_PIG UniProtKB/TrEMBL
  A0A8D0PZL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W6P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W8A2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YHD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BP08 ENTREZGENE, UniProtKB/TrEMBL
  M9MMN5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89071 ENTREZGENE