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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:RIG-I signaling pathway
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Accession:GO:0039529 term browser browse the term
Definition:The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
Synonyms:exact_synonym: DDX58 signaling pathway;   RIG-I signalling pathway;   RIG-I-like receptor (RLR) signaling pathway;   RIG-like helicase signaling pathway;   RIG-like receptor signaling pathway;   RLH signaling pathway;   RLR signaling pathway;   retinoic acid inducible gene I signaling pathway


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RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLPB ClpB family mitochondrial disaggregase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:6,836,367...7,089,896
Ensembl chr 9:6,836,390...6,981,892 		JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chr 6:43,847,882...43,901,697
Ensembl chr 6:43,847,732...43,903,587 		JBrowse link
G MAVS mitochondrial antiviral signaling protein acts_upstream_of_or_within ISO (PMID:22745163) MGI PMID:22745163 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,900...31,869,188 		JBrowse link
G PHB1 prohibitin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:25,596,520...25,609,693
Ensembl chr12:25,596,523...25,609,706 		JBrowse link
G PHB2 prohibitin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:63,751,566...63,756,480
Ensembl chr 5:63,751,558...63,756,478 		JBrowse link
G RIGI RNA sensor RIG-I involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:33,891,720...33,976,151
Ensembl chr10:33,891,763...33,933,455 		JBrowse link
G RNF135 ring finger protein 135 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,793,755...42,808,937
Ensembl chr12:42,795,409...42,808,897 		JBrowse link
G TRIM25 tripartite motif containing 25 NOT|involved_in ISO (PMID:31006531) UniProt PMID:31006531 NCBI chr12:33,184,039...33,212,440
Ensembl chr12:33,184,049...33,212,398 		JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,548,361...51,553,076
Ensembl chr12:51,548,415...51,555,689 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:20,647,698...20,656,691
Ensembl chr12:20,647,699...20,656,683 		JBrowse link
G GPATCH3 G-patch domain containing 3 involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:84,200,727...84,218,710
Ensembl chr 6:84,209,809...84,218,701 		JBrowse link
G NLRX1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21703540) Ensembl
MGI		 PMID:21703540 GO_REF:0000107 NCBI chr 9:46,384,373...46,400,752
Ensembl chr 9:46,384,948...46,400,983 		JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,251,377...1,285,668
Ensembl chr12:1,251,053...1,285,666 		JBrowse link
G RNF125 ring finger protein 125 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:115,857,697...115,905,550
Ensembl chr 6:115,857,721...115,903,677 		JBrowse link
G SEC14L1 SEC14 like lipid binding 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:4,439,045...4,489,078
Ensembl chr12:4,441,114...4,489,081 		JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:51,113,858...51,132,820
Ensembl chr14:51,113,713...51,133,072 		JBrowse link
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:69,360,641...69,531,418
Ensembl chr 8:69,360,649...69,531,286 		JBrowse link
G DDX60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:21,077,491...21,163,563
Ensembl chr14:21,083,350...21,163,561 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:20,647,698...20,656,691
Ensembl chr12:20,647,699...20,656,683 		JBrowse link
G OASL 2'-5'-oligoadenylate synthetase like involved_in ISO (PMID:25925578) ARUK-UCL PMID:25925578 NCBI chr14:40,900,050...40,917,189
Ensembl chr14:40,899,856...40,917,266 		JBrowse link
G PUM1 pumilio RNA binding family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:87,546,388...87,687,483
Ensembl chr 6:87,547,320...87,687,442 		JBrowse link
G PUM2 pumilio RNA binding family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:117,857,930...117,965,564
Ensembl chr 3:117,883,673...117,965,293 		JBrowse link
G TRIM15 tripartite motif containing 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:22,730,372...22,742,941
Ensembl chr 7:22,731,274...22,743,146 		JBrowse link
G USP15 ubiquitin specific peptidase 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,964,380...27,082,549
Ensembl chr 5:26,964,553...27,097,444 		JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 involved_in ISO (PMID:21102435) UniProt PMID:21102435 NCBI chr18:10,529,805...10,588,913
Ensembl chr18:10,531,897...10,588,832 		JBrowse link
G ZCCHC3 zinc finger CCHC-type containing 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:34,882,812...34,885,632
Ensembl chr17:34,882,816...34,885,505 		JBrowse link
regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOP53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:53,443,453...53,451,707
Ensembl chr 6:53,443,385...53,452,017 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    cellular process 16826
      signal transduction 6963
        intracellular receptor signaling pathway 372
          cytoplasmic pattern recognition receptor signaling pathway 167
            RIG-I signaling pathway 26
              negative regulation of RIG-I signaling pathway 8
              positive regulation of RIG-I signaling pathway 10
              regulation of RIG-I signaling pathway + 18
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to biotic stimulus 1716
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  regulation of innate immune response 425
                    positive regulation of innate immune response 351
                      activation of innate immune response 287
                        innate immune response-activating signaling pathway 266
                          pattern recognition receptor signaling pathway 256
                            cytoplasmic pattern recognition receptor signaling pathway 167
                              RIG-I signaling pathway 26
                                negative regulation of RIG-I signaling pathway 8
                                positive regulation of RIG-I signaling pathway 10
                                regulation of RIG-I signaling pathway + 18
paths to the root