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ONTOLOGY REPORT - ANNOTATIONS

Term:protein kinase activator activity
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Accession:GO:0030295 term browser browse the term
Definition:Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.


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protein kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 enables ISO
IEA
IDA		 (PMID:14761976) RGD
Ensembl
MGI		 PMID:11136977 PMID:14761976 GO_REF:0000107 RGD:632423 NCBI chr12:57,723,761...57,742,161
Ensembl chr12:57,723,761...57,742,157 		JBrowse link
G AJUBA ajuba LIM protein enables IEA Ensembl GO_REF:0000107 NCBI chr14:22,971,177...22,982,551
Ensembl chr14:22,971,177...22,982,551 		JBrowse link
G CAB39 calcium binding protein 39 enables IDA (PMID:19892943) UniProt PMID:19892943 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075 		JBrowse link
G CCNQ cyclin Q enables ISO (PMID:24218572) MGI PMID:24218572 NCBI chr  X:153,587,925...153,599,139
Ensembl chr  X:153,587,925...153,600,045 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 enables TAS (PMID:8090221) GO_Central PMID:8090221 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G DAXX death domain associated protein enables IGI (PMID:15983381) ParkinsonsUK-UCL PMID:15983381 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016 		JBrowse link
G DBF4B DBF4B-CDC7 kinase regulatory subunit enables IDA (PMID:12065429), (PMID:15668232) UniProt PMID:12065429 PMID:15668232 NCBI chr17:44,708,665...44,752,264
Ensembl chr17:44,708,608...44,752,264 		JBrowse link
G DUSP19 dual specificity phosphatase 19 enables ISS BHF-UCL GO_REF:0000024 NCBI chr 2:183,078,747...183,100,008
Ensembl chr 2:183,078,559...183,100,008 		JBrowse link
G EPO erythropoietin enables IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr12:12,891,562...12,917,937
Ensembl chr12:12,890,782...12,917,937 		JBrowse link
G GPRC5B G protein-coupled receptor class C group 5 member B enables IDA
IEA
IBA		 (PMID:23169819) MGI
TreeGrafter
GO_Central		 PMID:23169819 GO_REF:0000033 GO_REF:0000118 NCBI chr16:19,856,691...19,885,634
Ensembl chr16:19,856,691...19,886,167 		JBrowse link
G GPRC5C G protein-coupled receptor class C group 5 member C enables IBA GO_Central GO_REF:0000033 NCBI chr17:74,432,088...74,451,658
Ensembl chr17:74,424,851...74,451,653 		JBrowse link
G GPRC5D G protein-coupled receptor class C group 5 member D enables IBA GO_Central GO_REF:0000033 NCBI chr12:12,940,575...12,952,170
Ensembl chr12:12,940,575...12,952,170 		JBrowse link
G HMGB1 high mobility group box 1 enables ISO (PMID:7741753) MGI PMID:7741753 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G MADD MAP kinase activating death domain enables TAS (PMID:9115275) UniProt PMID:9115275 NCBI chr11:47,269,188...47,330,031
Ensembl chr11:47,269,161...47,330,031 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 enables IDA (PMID:10644344) GO_Central PMID:10644344 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 enables IDA (PMID:32610081) UniProt PMID:32610081 NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015 		JBrowse link
G MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 enables IDA
IGI		 (PMID:12244047) MGI PMID:12244047 NCBI chr22:50,600,793...50,613,978
Ensembl chr22:50,600,793...50,613,981 		JBrowse link
G MARK2 microtubule affinity regulating kinase 2 enables TAS (PMID:24522549) ParkinsonsUK-UCL PMID:24522549 NCBI chr11:63,839,110...63,911,020
Ensembl chr11:63,838,928...63,911,020 		JBrowse link
G MOB1A MOB kinase activator 1A enables IBA GO_Central GO_REF:0000033 NCBI chr 2:74,152,528...74,178,879
Ensembl chr 2:74,152,528...74,178,898 		JBrowse link
G MOB1B MOB kinase activator 1B enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:70,901,851...70,988,168
Ensembl chr 4:70,902,326...71,022,449 		JBrowse link
G MOB2 MOB kinase activator 2 enables IBA GO_Central GO_REF:0000033 NCBI chr11:1,469,448...1,486,779
Ensembl chr11:1,469,457...1,501,247 		JBrowse link
G MOB3A MOB kinase activator 3A enables IBA GO_Central GO_REF:0000033 NCBI chr19:2,071,036...2,096,515
Ensembl chr19:2,071,036...2,096,673 		JBrowse link
G MOB3B MOB kinase activator 3B enables IBA GO_Central GO_REF:0000033 NCBI chr 9:27,325,209...27,529,814
Ensembl chr 9:27,325,209...27,529,814 		JBrowse link
G MOB3C MOB kinase activator 3C enables IBA GO_Central GO_REF:0000033 NCBI chr 1:46,607,719...46,616,811
Ensembl chr 1:46,607,719...46,616,811 		JBrowse link
G MT3 metallothionein 3 enables IDA (PMID:18295594) UniProt PMID:18295594 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088 		JBrowse link
G NCKAP1L NCK associated protein 1 like enables IMP (PMID:16417406) UniProt PMID:16417406 NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243 		JBrowse link
G NEK9 NIMA related kinase 9 enables IDA (PMID:12840024) UniProt PMID:12840024 NCBI chr14:75,079,353...75,127,202
Ensembl chr14:75,079,353...75,127,344 		JBrowse link
G PDE8A phosphodiesterase 8A enables IMP (PMID:23509299) UniProt PMID:23509299 NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha enables IEA Ensembl GO_REF:0000107 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 enables IMP (PMID:15877279) BHF-UCL PMID:15877279 NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214 		JBrowse link
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 enables IDA (PMID:29170442) UniProt PMID:29170442 NCBI chr 2:178,431,414...178,451,175
Ensembl chr 2:178,431,292...178,451,512 		JBrowse link
G RGCC regulator of cell cycle enables IDA
IBA		 (PMID:11687586) BHF-UCL
GO_Central		 PMID:11687586 GO_REF:0000033 NCBI chr13:41,457,550...41,470,871
Ensembl chr13:41,457,550...41,470,871 		JBrowse link
G RHEB Ras homolog, mTORC1 binding enables IDA (PMID:29236692), (PMID:33157014) UniProt PMID:29236692 PMID:33157014 NCBI chr 7:151,466,012...151,519,895
Ensembl chr 7:151,466,012...151,520,120 		JBrowse link
G RPLP1 ribosomal protein lateral stalk subunit P1 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:69,452,818...69,456,205
Ensembl chr15:69,452,814...69,456,205 		JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 enables IDA (PMID:12150926) WB PMID:12150926 NCBI chr17:80,544,838...80,966,368
Ensembl chr17:80,544,819...80,966,371 		JBrowse link
G SPDYA speedy/RINGO cell cycle regulator family member A enables IDA
IEA		 (PMID:28666995) UniProt
Ensembl		 PMID:28666995 GO_REF:0000107 NCBI chr 2:28,810,834...28,850,610
Ensembl chr 2:28,782,517...28,850,611 		JBrowse link
G STK11 serine/threonine kinase 11 enables IDA
IEA		 (PMID:19892943) UniProt
InterPro
Ensembl		 PMID:19892943 GO_REF:0000002 GO_REF:0000107 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G STRADA STE20 related adaptor alpha enables IDA (PMID:19892943) UniProt PMID:19892943 NCBI chr17:63,702,832...63,741,986
Ensembl chr17:63,682,336...63,741,986 		JBrowse link
G TAOK1 TAO kinase 1 ISO RGD PMID:9786855 RGD:1299457 NCBI chr17:29,390,363...29,551,903
Ensembl chr17:29,390,363...29,551,903 		JBrowse link
G TOM1L1 target of myb1 like 1 membrane trafficking protein enables IEA Ensembl GO_REF:0000107 NCBI chr17:54,900,852...54,961,956
Ensembl chr17:54,899,387...54,961,956 		JBrowse link
G TPX2 TPX2 microtubule nucleation factor enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:31,739,290...31,801,800
Ensembl chr20:31,739,271...31,801,805 		JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 enables IMP (PMID:16669787) ParkinsonsUK-UCL PMID:16669787 NCBI chr12:752,579...911,452
Ensembl chr12:752,579...911,452 		JBrowse link
G WNT11 Wnt family member 11 enables IMP (PMID:20103596), (PMID:20219091) UniProt PMID:20103596 PMID:20219091 NCBI chr11:76,186,325...76,210,761
Ensembl chr11:76,186,325...76,210,736 		JBrowse link
cyclin-dependent protein kinase activating kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK20 cyclin dependent kinase 20 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:87,966,441...87,974,533
Ensembl chr 9:87,966,441...87,974,753 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A enables IDA (PMID:9106657) UniProt PMID:9106657 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
cyclin-dependent protein serine/threonine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNB1 cyclin B1 enables IDA (PMID:24746669) CAFA PMID:24746669 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 enables TAS
IDA		 (PMID:33854239)
(PMID:19237565)		 UniProt PMID:19237565 PMID:33854239 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND2 cyclin D2 enables IDA
TAS		 (PMID:18827403)
(PMID:33854239)		 UniProt PMID:18827403 PMID:33854239 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353 		JBrowse link
G CCND3 cyclin D3 enables TAS
IDA		 (PMID:33854239)
(PMID:8114739)		 UniProt PMID:8114739 PMID:33854239 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CCNK cyclin K enables IBA GO_Central GO_REF:0000033 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044 		JBrowse link
G CCNT1 cyclin T1 enables IDA
IEA
IBA		 (PMID:29849146), (PMID:35393539) UniProt
TreeGrafter
GO_Central		 PMID:29849146 PMID:35393539 GO_REF:0000033 GO_REF:0000118 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998 		JBrowse link
G CCNT2 cyclin T2 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:134,918,822...134,959,342
Ensembl chr 2:134,918,235...134,959,342 		JBrowse link
G CCNY cyclin Y enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:35,247,025...35,572,667
Ensembl chr10:35,247,025...35,572,669 		JBrowse link
G CCNYL1 cyclin Y like 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 2:207,711,640...207,756,174
Ensembl chr 2:207,711,540...207,761,839 		JBrowse link
G CCNYL2 cyclin Y like 2 (pseudogene) enables IBA GO_Central GO_REF:0000033 NCBI chr10:42,408,174...42,472,240
Ensembl chr10:42,409,727...42,454,385
Ensembl chr10:42,409,727...42,454,385 		JBrowse link
G CCNYL3 cyclin Y like 3 (pseudogene) enables IBA GO_Central GO_REF:0000033 NCBI chr16:35,030,349...35,060,328
Ensembl chr16:35,040,164...35,084,313 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 enables ISO
IEA
TAS
IBA
IGI		 (PMID:17491008)
(PMID:17517623)		 RGD
Ensembl
ARUK-UCL
InterPro
GO_Central
TreeGrafter		 PMID:8662984 PMID:17491008 PMID:17517623 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:632374 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CDK5R2 cyclin dependent kinase 5 regulatory subunit 2 enables TAS
ISS
IEA
IBA		 (PMID:17491008) ARUK-UCL
InterPro
Ensembl
GO_Central
TreeGrafter		 PMID:17491008 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:218,959,666...218,962,155
Ensembl chr 2:218,959,666...218,962,155 		JBrowse link
G CKS1B CDC28 protein kinase regulatory subunit 1B enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:154,974,681...154,979,251
Ensembl chr 1:154,974,653...154,979,251 		JBrowse link
G CKS2 CDC28 protein kinase regulatory subunit 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703 		JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase enables IEA InterPro GO_REF:0000002 NCBI chr14:60,734,761...60,969,965
Ensembl chr14:60,734,742...60,969,965 		JBrowse link
protein serine/threonine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL1 acyl-CoA synthetase long chain family member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing enables IEA Ensembl GO_REF:0000107 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ALS2 alsin Rho guanine nucleotide exchange factor ALS2 enables IDA (PMID:16049005) UniProt PMID:16049005 NCBI chr 2:201,700,267...201,780,933
Ensembl chr 2:201,700,267...201,782,112 		JBrowse link
G ATG13 autophagy related 13 enables IDA (PMID:19225151) UniProt PMID:19225151 NCBI chr11:46,617,553...46,674,518
Ensembl chr11:46,617,527...46,674,818 		JBrowse link
G BMP2 bone morphogenetic protein 2 enables IEA
IDA		 (PMID:22227436) Ensembl
UniProt		 PMID:22227436 GO_REF:0000107 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G CAB39 calcium binding protein 39 enables IDA
IBA
IEA		 (PMID:19892943), (PMID:24393035) ParkinsonsUK-UCL
GO_Central
TreeGrafter		 PMID:19892943 PMID:24393035 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075 		JBrowse link
G CAB39L calcium binding protein 39 like enables IBA GO_Central GO_REF:0000033 NCBI chr13:49,308,650...49,444,064
Ensembl chr13:49,308,650...49,444,064 		JBrowse link
G CALM1 calmodulin 1 enables TAS
IDA		 (PMID:20668654)
(PMID:14722083), (PMID:35568036)		 BHF-UCL
UniProt		 PMID:14722083 PMID:20668654 PMID:35568036 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268 		JBrowse link
G CALM2 calmodulin 2 enables TAS
IDA		 (PMID:20668654)
(PMID:14722083), (PMID:35568036)		 BHF-UCL
UniProt		 PMID:14722083 PMID:20668654 PMID:35568036 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921 		JBrowse link
G CALM3 calmodulin 3 enables TAS
IDA		 (PMID:20668654)
(PMID:14722083), (PMID:35568036)		 BHF-UCL
UniProt		 PMID:14722083 PMID:20668654 PMID:35568036 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782 		JBrowse link
G CCDC88A coiled-coil domain containing 88A enables ISS UniProt GO_REF:0000024 NCBI chr 2:55,287,842...55,419,856
Ensembl chr 2:55,287,842...55,419,895 		JBrowse link
G CD40LG CD40 ligand enables IDA (PMID:15067037) UniProt PMID:15067037 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 enables ISO
ISS
IDA
IEA		 (PMID:12832520) RGD
UniProt
Ensembl		 PMID:8662984 PMID:12832520 GO_REF:0000024 GO_REF:0000107 RGD:632374 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G DAB2IP DAB2 interacting protein enables IDA (PMID:19903888) GO_Central PMID:19903888 NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530 		JBrowse link
G DAZAP2 DAZ associated protein 2 enables IEA Ensembl GO_REF:0000107 NCBI chr12:51,238,826...51,246,717
Ensembl chr12:51,238,724...51,271,362 		JBrowse link
G DBF4 DBF4-CDC7 kinase regulatory subunit enables IBA GO_Central GO_REF:0000033 NCBI chr 7:87,876,493...87,909,553
Ensembl chr 7:87,876,216...87,909,553 		JBrowse link
G DBF4B DBF4B-CDC7 kinase regulatory subunit enables IBA GO_Central GO_REF:0000033 NCBI chr17:44,708,665...44,752,264
Ensembl chr17:44,708,608...44,752,264 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked enables IDA (PMID:23413191) UniProt PMID:23413191 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472 		JBrowse link
G DELE1 DAP3 binding cell death enhancer 1 enables IDA (PMID:32132706), (PMID:32132707), (PMID:37327776), (PMID:37550454), (PMID:37832546), (PMID:38340717) UniProt PMID:32132706 PMID:32132707 PMID:37327776 PMID:37550454 PMID:37832546 More... NCBI chr 5:141,923,871...141,942,047
Ensembl chr 5:141,923,855...141,942,047 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase enables IDA
IBA		 (PMID:27723717), (PMID:27723720), (PMID:30139873) UniProt
GO_Central		 PMID:27723717 PMID:27723720 PMID:30139873 GO_REF:0000033 NCBI chr 2:67,397,333...67,412,089
Ensembl chr 2:67,397,322...67,412,089 		JBrowse link
G FAM20A FAM20A golgi associated secretory pathway pseudokinase enables IDA
IBA
IEA		 (PMID:25789606) UniProt
GO_Central
TreeGrafter		 PMID:25789606 GO_REF:0000033 GO_REF:0000118 NCBI chr17:68,535,116...68,601,367
Ensembl chr17:68,535,113...68,601,367 		JBrowse link
G GCN1 GCN1 activator of EIF2AK4 enables ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:120,127,202...120,194,715
Ensembl chr12:120,127,202...120,194,715 		JBrowse link
G GDF2 growth differentiation factor 2 enables IDA (PMID:7664647) UniProt PMID:7664647 NCBI chr10:47,322,454...47,327,588
Ensembl chr10:47,322,454...47,327,588 		JBrowse link
G IGF1 insulin like growth factor 1 enables ISO PMID:17023532 BHF-UCL PMID:17023532 RGD:1600072 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF2 insulin like growth factor 2 enables IEA
IBA
ISS		 Ensembl
TreeGrafter
GO_Central
BHF-UCL		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 enables IDA (PMID:17563371) BHF-UCL PMID:17563371 NCBI chr15:90,388,242...90,502,239
Ensembl chr15:90,388,242...90,502,239 		JBrowse link
G IRGM immunity related GTPase M enables IMP
IDA		 (PMID:28389568)
(PMID:25891078)		 UniProt PMID:25891078 PMID:28389568 NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,521...150,900,736 		JBrowse link
G LGALS9 galectin 9 enables ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
G LTF lactotransferrin enables IDA (PMID:20345905) UniProt PMID:20345905 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 enables IDA (PMID:8388392) UniProt PMID:8388392 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 enables IDA (PMID:8388392) UniProt PMID:8388392 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAP3K12 mitogen-activated protein kinase kinase kinase 12 enables IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:53,479,669...53,501,539
Ensembl chr12:53,479,669...53,500,063 		JBrowse link
G MAP3K13 mitogen-activated protein kinase kinase kinase 13 enables ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:185,282,961...185,489,094
Ensembl chr 3:185,282,941...185,489,094 		JBrowse link
G MLST8 MTOR associated protein, LST8 homolog enables IDA (PMID:12718876) WB PMID:12718876 NCBI chr16:2,205,454...2,209,453
Ensembl chr16:2,204,248...2,209,453 		JBrowse link
G MOB1A MOB kinase activator 1A enables IDA (PMID:18328708) UniProt PMID:18328708 NCBI chr 2:74,152,528...74,178,879
Ensembl chr 2:74,152,528...74,178,898 		JBrowse link
G MOB1B MOB kinase activator 1B enables IDA (PMID:18328708) UniProt PMID:18328708 NCBI chr 4:70,901,851...70,988,168
Ensembl chr 4:70,902,326...71,022,449 		JBrowse link
G MTCP1 mature T cell proliferation 1 enables IEA
IBA
IDA		 (PMID:10983986) InterPro
GO_Central
UniProt		 PMID:10983986 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:155,064,034...155,071,136
Ensembl chr  X:155,064,034...155,147,937 		JBrowse link
G NBN nibrin enables IDA (PMID:16622404) UniProt PMID:16622404 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228 		JBrowse link
G P2RX7 purinergic receptor P2X 7 ISO Akt (protein kinase B); Ser473, Thr308 RGD PMID:15023862 RGD:1642719 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 enables IMP
IBA		 (PMID:23103912) UniProt
GO_Central		 PMID:23103912 GO_REF:0000033 NCBI chr15:65,230,917...65,286,883
Ensembl chr15:65,234,460...65,300,618 		JBrowse link
G PARP6 poly(ADP-ribose) polymerase family member 6 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:72,241,181...72,272,554
Ensembl chr15:72,241,181...72,272,999 		JBrowse link
G PARP8 poly(ADP-ribose) polymerase family member 8 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:50,665,931...50,846,519
Ensembl chr 5:50,665,899...50,846,519 		JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase enables IMP (PMID:16186805) UniProt PMID:16186805 NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428 		JBrowse link
G RAD50 RAD50 double strand break repair protein enables IDA (PMID:16622404) UniProt PMID:16622404 NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349 		JBrowse link
G RHEB Ras homolog, mTORC1 binding enables IDA (PMID:15854902), (PMID:29236692) UniProt PMID:15854902 PMID:29236692 NCBI chr 7:151,466,012...151,519,895
Ensembl chr 7:151,466,012...151,520,120 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 enables IDA
IEA
IBA		 (PMID:16221682) UniProt
TreeGrafter
GO_Central		 PMID:16221682 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:38,937,920...39,074,399
Ensembl chr 5:38,937,920...39,074,402 		JBrowse link
G SAV1 salvador family WW domain containing protein 1 enables IDA (PMID:29063833), (PMID:35429439) UniProt PMID:29063833 PMID:35429439 NCBI chr14:50,633,580...50,668,306
Ensembl chr14:50,632,058...50,668,306 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr19:17,468,767...17,506,168
Ensembl chr19:17,468,769...17,506,168 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 enables IMP (PMID:18070883) UniProt PMID:18070883 NCBI chr13:80,335,976...80,341,126
Ensembl chr13:80,335,976...80,341,126 		JBrowse link
G STK3 serine/threonine kinase 3 enables TAS (PMID:20412773) BHF-UCL PMID:20412773 NCBI chr 8:98,343,975...98,942,610
Ensembl chr 8:98,371,228...98,942,827 		JBrowse link
G STK4 serine/threonine kinase 4 enables TAS (PMID:20412773) BHF-UCL PMID:20412773 NCBI chr20:44,966,512...45,080,021
Ensembl chr20:44,966,494...45,080,021 		JBrowse link
G STRADA STE20 related adaptor alpha enables IDA
IBA
IEA		 (PMID:12805220), (PMID:19892943) BHF-UCL
GO_Central
InterPro		 PMID:12805220 PMID:19892943 GO_REF:0000002 GO_REF:0000033 NCBI chr17:63,702,832...63,741,986
Ensembl chr17:63,682,336...63,741,986 		JBrowse link
G STRADB STE20 related adaptor beta enables IEA
IBA		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:201,451,740...201,480,846
Ensembl chr 2:201,387,858...201,480,846 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 enables IDA (PMID:37832545) UniProt PMID:37832545 NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060 		JBrowse link
G TAOK1 TAO kinase 1 enables TAS
ISS		 (PMID:22683681) ARUK-UCL PMID:22683681 GO_REF:0000024 NCBI chr17:29,390,363...29,551,903
Ensembl chr17:29,390,363...29,551,903 		JBrowse link
G TAOK2 TAO kinase 2 enables TAS (PMID:22683681) ARUK-UCL PMID:22683681 NCBI chr16:29,973,868...29,992,261
Ensembl chr16:29,973,868...29,992,261 		JBrowse link
G TCL1A TCL1 family AKT coactivator A enables IMP
IBA
IDA
IEA		 (PMID:10983986) UniProt
GO_Central
InterPro		 PMID:10983986 GO_REF:0000002 GO_REF:0000033 NCBI chr14:95,709,947...95,714,125
Ensembl chr14:95,709,947...95,714,196 		JBrowse link
G TCL1B TCL1 family AKT coactivator B enables IEA
IBA
IDA		 (PMID:10983986) InterPro
GO_Central
UniProt		 PMID:10983986 GO_REF:0000002 GO_REF:0000033 NCBI chr14:95,686,426...95,692,628
Ensembl chr14:95,686,426...95,692,628 		JBrowse link
G TGFB1 transforming growth factor beta 1 enables IEA Ensembl GO_REF:0000107 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 enables IDA (PMID:21777809) UniProt PMID:21777809 NCBI chr 3:133,600,238...133,661,941
Ensembl chr 3:133,598,175...133,662,380 		JBrowse link
protein tyrosine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI1 abl interactor 1 enables ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:26,746,596...26,860,958
Ensembl chr10:26,746,593...26,861,087 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 enables IDA (PMID:17412687) HGNC-UCL PMID:17412687 NCBI chr10:114,280,725...114,405,175
Ensembl chr10:114,294,824...114,404,756 		JBrowse link
G CD24 CD24 molecule enables IDA
IBA		 (PMID:11313396) UniProt
GO_Central		 PMID:11313396 GO_REF:0000033 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627 		JBrowse link
G EGFR epidermal growth factor receptor enables IDA (PMID:11336639), (PMID:2176151) MGI PMID:2176151 PMID:11336639 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 enables IDA (PMID:7556068) BHF-UCL PMID:7556068 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor enables IDA (PMID:17626041) MGI PMID:17626041 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide enables IMP (PMID:15350694) UniProt PMID:15350694 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 enables IDA (PMID:24012003) ARUK-UCL PMID:24012003 NCBI chr11:88,504,642...89,065,982
Ensembl chr11:88,504,576...89,065,982 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A enables IEA Ensembl GO_REF:0000107 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer enables IDA (PMID:12829785), (PMID:19915009) UniProt PMID:12829785 PMID:19915009 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G NRG1 neuregulin 1 enables IDA
IEA
IBA		 (PMID:19632177), (PMID:7556068), (PMID:8702723) BHF-UCL
TreeGrafter
GO_Central		 PMID:7556068 PMID:8702723 PMID:19632177 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 enables IDA (PMID:11121037) BHF-UCL PMID:11121037 NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647 		JBrowse link
G STAP1 signal transducing adaptor family member 1 enables IDA (PMID:10518561) BHF-UCL PMID:10518561 NCBI chr 4:67,558,727...67,607,337
Ensembl chr 4:67,558,727...67,607,337 		JBrowse link
receptor signaling protein tyrosine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALK ALK receptor tyrosine kinase enables IDA (PMID:30061385), (PMID:34646012) UniProt PMID:30061385 PMID:34646012 NCBI chr 2:29,192,774...29,921,586
Ensembl chr 2:29,192,774...29,921,586 		JBrowse link
G ALKAL1 ALK and LTK ligand 1 enables IEA
IBA
IDA		 (PMID:26418745), (PMID:34646012), (PMID:34819673) InterPro
GO_Central
UniProt		 PMID:26418745 PMID:34646012 PMID:34819673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr 8:52,534,037...52,565,430
Ensembl chr 8:52,534,037...52,565,430 		JBrowse link
G ALKAL2 ALK and LTK ligand 2 enables IEA
IBA
IDA		 (PMID:26418745), (PMID:30061385), (PMID:34646012), (PMID:34819673) InterPro
GO_Central
UniProt		 PMID:26418745 PMID:30061385 PMID:34646012 PMID:34819673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr 2:279,558...288,091
Ensembl chr 2:279,558...288,851 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 enables IDA (PMID:10488085) BHF-UCL PMID:10488085 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G LTK leukocyte receptor tyrosine kinase enables IDA (PMID:30061385) UniProt PMID:30061385 NCBI chr15:41,503,637...41,513,827
Ensembl chr15:41,503,637...41,513,887 		JBrowse link
transmembrane receptor protein tyrosine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKAL1 ALK and LTK ligand 1 enables IDA (PMID:34646012), (PMID:34819673) UniProt PMID:34646012 PMID:34819673 NCBI chr 8:52,534,037...52,565,430
Ensembl chr 8:52,534,037...52,565,430 		JBrowse link
G ALKAL2 ALK and LTK ligand 2 enables IDA (PMID:30061385), (PMID:34646012), (PMID:34819673) UniProt PMID:30061385 PMID:34646012 PMID:34819673 NCBI chr 2:279,558...288,091
Ensembl chr 2:279,558...288,851 		JBrowse link
G ANGPT4 angiopoietin 4 enables IDA (PMID:10051567), (PMID:15851516) UniProt PMID:10051567 PMID:15851516 NCBI chr20:869,900...916,334
Ensembl chr20:869,900...916,334 		JBrowse link
G AREG amphiregulin enables IDA
IEA		 (PMID:8702723) MGI
Ensembl		 PMID:8702723 GO_REF:0000107 NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005 		JBrowse link
G BTC betacellulin enables IDA
IEA		 (PMID:12399441), (PMID:9168114) MGI
Ensembl		 PMID:9168114 PMID:12399441 GO_REF:0000107 NCBI chr 4:74,744,759...74,794,523
Ensembl chr 4:74,744,759...74,794,523 		JBrowse link
G DGKQ diacylglycerol kinase theta enables IGI (PMID:22732145) ParkinsonsUK-UCL PMID:22732145 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895 		JBrowse link
G EFNA5 ephrin A5 enables NAS (PMID:19036963) BHF-UCL PMID:19036963 NCBI chr 5:107,376,894...107,670,937
Ensembl chr 5:107,376,894...107,670,937 		JBrowse link
G EGF epidermal growth factor enables TAS
IEA
IDA		 (PMID:9712850)
(PMID:11336639)		 UniProt
Ensembl
MGI		 PMID:9712850 PMID:11336639 GO_REF:0000107 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor enables IEA Ensembl GO_REF:0000107 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EPGN epithelial mitogen enables IEA Ensembl GO_REF:0000107 NCBI chr 4:74,308,470...74,316,789
Ensembl chr 4:74,308,470...74,316,789 		JBrowse link
G EREG epiregulin enables IDA
IEA		 (PMID:28783046), (PMID:9556621) MGI
Ensembl		 PMID:9556621 PMID:28783046 GO_REF:0000107 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749 		JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist enables ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:32,718,004...32,745,106
Ensembl chr15:32,718,004...32,745,106 		JBrowse link
G HBEGF heparin binding EGF like growth factor enables IDA
IEA		 (PMID:8702723) MGI
Ensembl		 PMID:8702723 GO_REF:0000107 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603 		JBrowse link
G IGF1 insulin like growth factor 1 enables ISO (PMID:32697974)
(PMID:35647546)		 MGI PMID:32697974 PMID:35647546 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF2 insulin like growth factor 2 enables IEA Ensembl GO_REF:0000107 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G NGF nerve growth factor enables ISO (MGI:5426777|PMID:19036963), (PMID:27655914) MGI PMID:19036963 PMID:27655914 MGI:5426777 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NRG1 neuregulin 1 enables IC
NAS		 (PMID:9553078)
(PMID:1348215), (PMID:1350381)		 BHF-UCL
UniProt		 PMID:1348215 PMID:1350381 PMID:9553078 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666 		JBrowse link
G NRG3 neuregulin 3 enables NAS (PMID:9275162) UniProt PMID:9275162 NCBI chr10:81,875,194...82,987,179
Ensembl chr10:81,875,194...82,987,179 		JBrowse link
G TGFA transforming growth factor alpha enables IEA Ensembl GO_REF:0000107 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G VEGFA vascular endothelial growth factor A enables IDA (PMID:20497126) BHF-UCL PMID:20497126 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19489
    molecular function regulator activity 2264
      enzyme regulator activity 1401
        enzyme activator activity 647
          kinase activator activity 153
            protein kinase activator activity 144
              cyclin-dependent protein kinase activating kinase activity 2
              protein serine/threonine kinase activator activity + 75
              protein tyrosine kinase activator activity + 34
paths to the root