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ONTOLOGY REPORT - ANNOTATIONS

Term:metalloendopeptidase activity
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Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"


show annotations for term's descendants           Sort by:
metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme enables IEA Ensembl GO_REF:0000107 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:10423016 GO_REF:0000002 GO_REF:0000107 RGD:631800 NCBI chr15:37,562,930...37,717,175
Ensembl chr15:55,873,606...56,027,188 		JBrowse link
G ADAM11 ADAM metallopeptidase domain 11 enables IEA InterPro GO_REF:0000002 NCBI chr17:12,541,921...12,564,625
Ensembl chr17:12,716,159...12,736,786 		JBrowse link
G ADAM12 ADAM metallopeptidase domain 12 enables IEA InterPro GO_REF:0000002 NCBI chr10:122,583,989...122,958,895
Ensembl chr10:126,852,441...127,165,048 		JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 enables IEA InterPro GO_REF:0000002 NCBI chr 1:130,398,961...130,410,860
Ensembl chr 1:134,008,959...134,020,467 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G ADAM18 ADAM metallopeptidase domain 18 enables IEA InterPro GO_REF:0000002 Ensembl chr 8:36,283,808...36,435,537 JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:152,839,326...152,972,741
Ensembl chr 5:159,494,786...159,593,171 		JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 enables IEA InterPro GO_REF:0000002 NCBI chr 8:38,939,413...39,034,142
Ensembl chr 8:36,448,201...36,542,784 		JBrowse link
G ADAM21 ADAM metallopeptidase domain 21 enables IEA InterPro GO_REF:0000002 NCBI chr14:51,009,420...51,051,012
Ensembl chr14:69,918,713...69,920,880 		JBrowse link
G ADAM22 ADAM metallopeptidase domain 22 enables IEA InterPro GO_REF:0000002 NCBI chr 7:79,930,613...80,197,498
Ensembl chr 7:93,579,306...93,840,484 		JBrowse link
G ADAM23 ADAM metallopeptidase domain 23 enables IEA InterPro GO_REF:0000002 NCBI chr2B:93,677,971...93,855,647
Ensembl chr2B:211,806,871...211,980,399 		JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 enables IEA InterPro GO_REF:0000002 NCBI chr 8:23,549,892...23,623,859
Ensembl chr 8:20,474,029...20,540,692 		JBrowse link
G ADAM29 ADAM metallopeptidase domain 29 enables IEA InterPro GO_REF:0000002 NCBI chr 4:167,133,174...167,194,160
Ensembl chr 4:179,426,082...179,428,753 		JBrowse link
G ADAM30 ADAM metallopeptidase domain 30 enables IEA InterPro GO_REF:0000002 NCBI chr 1:82,630,734...82,633,448
Ensembl chr 1:117,628,573...117,631,026 		JBrowse link
G ADAM32 ADAM metallopeptidase domain 32 enables IEA InterPro GO_REF:0000002 NCBI chr 8:38,408,648...38,592,282
Ensembl chr 8:35,583,724...35,766,318 		JBrowse link
G ADAM33 ADAM metallopeptidase domain 33 enables IEA InterPro GO_REF:0000002 NCBI chr20:3,750,158...3,764,262
Ensembl chr20:3,508,620...3,521,628 		JBrowse link
G ADAM7 ADAM metallopeptidase domain 7 enables IEA InterPro GO_REF:0000002 NCBI chr 8:23,710,208...23,778,026
Ensembl chr 8:20,627,325...20,713,165 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 enables IEA InterPro GO_REF:0000002 Ensembl chr10:134,172,724...134,186,227 JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 8:38,298,194...38,406,706
Ensembl chr 8:35,473,278...35,581,192 		JBrowse link
G ADAMDEC1 ADAM like decysin 1 enables IEA InterPro GO_REF:0000002 NCBI chr 8:23,653,257...23,674,893
Ensembl chr 8:20,570,606...20,591,383 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr21:13,270,668...13,279,217
Ensembl chr21:26,656,370...26,665,485 		JBrowse link
G ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr19:7,861,870...7,892,442
Ensembl chr19:8,708,164...8,737,556 		JBrowse link
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:76,442,053...76,818,726
Ensembl chr 5:81,827,560...82,199,840 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:104,541,051...104,582,574
Ensembl chr 9:133,156,761...133,193,707 		JBrowse link
G ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr10:67,145,400...67,232,934
Ensembl chr10:69,671,222...69,758,229 		JBrowse link
G ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:125,264,129...125,291,655
Ensembl chr11:129,154,895...129,182,326 		JBrowse link
G ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:5,470,841...5,651,360
Ensembl chr 5:5,150,365...5,329,556 		JBrowse link
G ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr15:78,703,728...79,076,861
Ensembl chr15:97,999,448...98,366,893 		JBrowse link
G ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr16:57,857,112...58,011,181
Ensembl chr16:77,291,148...77,445,664 		JBrowse link
G ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif 19 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:124,873,078...125,153,730
Ensembl chr 5:130,635,937...130,893,174 		JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:174,264,811...174,502,817
Ensembl chr 5:181,557,928...181,786,175 		JBrowse link
G ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:45,178,058...45,369,042
Ensembl chr12:46,046,555...46,236,676 		JBrowse link
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 4:51,648,293...51,941,329
Ensembl chr 4:57,966,197...58,259,404 		JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:136,602,140...136,611,469
Ensembl chr 1:140,514,247...140,523,623 		JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr21:13,352,222...13,402,165
Ensembl chr21:26,744,807...26,788,736 		JBrowse link
G ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:48,517,814...48,854,545
Ensembl chr 5:50,181,529...50,502,433 		JBrowse link
G ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 enables ISO (PMID:18485748) BHF-UCL PMID:18485748 NCBI chr15:61,291,451...61,295,148 JBrowse link
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:125,220,258...125,244,841
Ensembl chr11:129,112,176...129,136,928 		JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 3:64,415,621...64,590,984
Ensembl chr 3:65,792,223...65,967,631 		JBrowse link
G ADAMTSL2 ADAMTS like 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:104,658,540...104,698,854
Ensembl chr 9:133,269,369...133,309,602 		JBrowse link
G ADAMTSL4 ADAMTS like 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:125,893,739...125,905,337
Ensembl chr 1:129,541,795...129,553,376 		JBrowse link
G ADAMTSL5 ADAMTS like 5 enables IEA TreeGrafter GO_REF:0000118
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr18:1,951,279...1,999,313
Ensembl chr18:17,062,250...17,109,400 		JBrowse link
G ASTL astacin like metalloendopeptidase enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr2A:103,176,662...103,192,542
Ensembl chr2A:97,049,184...97,063,747 		JBrowse link
G ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA InterPro GO_REF:0000002 NCBI chr12:30,969,266...30,985,043
Ensembl chr12:31,231,287...31,247,020 		JBrowse link
G BMP1 bone morphogenetic protein 1 enables IEA UniProt
TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:21,410,139...21,457,144
Ensembl chr 8:18,349,836...18,396,796 		JBrowse link
G CIROP ciliated left-right organizer metallopeptidase enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr14:3,919,246...3,926,039
Ensembl chr14:22,015,750...22,021,372 		JBrowse link
G ECE1 endothelin converting enzyme 1 enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909 		JBrowse link
G ECE2 endothelin converting enzyme 2 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:181,310,554...181,327,602
Ensembl chr 3:189,766,786...189,811,206 		JBrowse link
G IDE insulin degrading enzyme enables ISO
IEA		 atrial natriuretic peptide cleaved at the Ser25-Phe26 bond RGD
TreeGrafter
InterPro
Ensembl		 PMID:15494400 PMID:15749695 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:1626705 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353 		JBrowse link
G LMLN leishmanolysin like peptidase enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:195,396,514...195,477,580
Ensembl chr 3:205,268,896...205,348,412 		JBrowse link
G LOC100968595 disintegrin and metalloproteinase domain-containing protein 1-like enables IEA InterPro GO_REF:0000002 NCBI chr12:109,473,137...109,476,766 JBrowse link
G LOC100972888 cytochrome b-c1 complex subunit 2, mitochondrial enables IEA InterPro GO_REF:0000002 NCBI chr16:16,750,102...16,780,867
Ensembl chr16:22,263,433...22,294,137 		JBrowse link
G LOC100976854 A disintegrin and metalloproteinase with thrombospondin motifs 7 enables IEA TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:63,951,548...63,979,068
Ensembl chr15:76,692,416...76,735,344 		JBrowse link
G LOC100988948 disintegrin and metalloproteinase domain-containing protein 20-like enables IEA InterPro GO_REF:0000002 NCBI chr14:51,059,727...51,063,204 JBrowse link
G LOC100989288 disintegrin and metalloproteinase domain-containing protein 20 enables IEA InterPro GO_REF:0000002 NCBI chr14:51,112,799...51,143,333
Ensembl chr14:69,983,295...69,985,625 		JBrowse link
G LOC100989368 Kell metallo-endopeptidase (Kell blood group) enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:134,897,567...135,237,214
Ensembl chr 7:147,423,103...147,443,895
Ensembl chr 7:147,423,103...147,443,895 		JBrowse link
G LOC100993088 endothelin-converting enzyme-like 1 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:119,711,355...119,719,378
Ensembl chr2B:238,630,731...238,637,233 		JBrowse link
G LOC106634355 disintegrin and metalloproteinase domain-containing protein 21-like enables IEA InterPro GO_REF:0000002
G MBTPS2 membrane bound transcription factor peptidase, site 2 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:14,470,268...14,529,854
Ensembl chr  X:21,825,780...21,883,550 		JBrowse link
G MEP1A meprin A subunit alpha enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 6:46,382,105...46,425,300
Ensembl chr 6:47,647,721...47,691,070 		JBrowse link
G MEP1B meprin A subunit beta enables ISO
IEA		 RGD
TreeGrafter
InterPro
UniProt		 PMID:12437103 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:633322 NCBI chr18:25,396,288...25,427,530
Ensembl chr18:28,991,439...29,021,928 		JBrowse link
G MIPEP mitochondrial intermediate peptidase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr13:5,040,237...5,207,674
Ensembl chr13:23,334,267...23,500,582 		JBrowse link
G MME membrane metalloendopeptidase enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119 		JBrowse link
G MMEL1 membrane metalloendopeptidase like 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:11964170 GO_REF:0000002 GO_REF:0000118 RGD:2314417 NCBI chr 1:1,323,914...1,362,178
Ensembl chr 1:2,462,621...2,504,213 		JBrowse link
G MMP1 matrix metallopeptidase 1 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104 		JBrowse link
G MMP10 matrix metallopeptidase 10 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:97,710,819...97,721,263
Ensembl chr11:101,201,665...101,212,103 		JBrowse link
G MMP11 matrix metallopeptidase 11 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr22:4,528,639...4,540,118
Ensembl chr22:22,615,969...22,624,567 		JBrowse link
G MMP12 matrix metallopeptidase 12 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762 		JBrowse link
G MMP13 matrix metallopeptidase 13 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:8910479 PMID:17941091 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2296055 RGD:2298541 NCBI chr11:97,890,811...97,902,778
Ensembl chr11:101,377,001...101,387,679 		JBrowse link
G MMP14 matrix metallopeptidase 14 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058 		JBrowse link
G MMP15 matrix metallopeptidase 15 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr16:38,304,856...38,326,193
Ensembl chr16:57,433,813...57,457,122 		JBrowse link
G MMP16 matrix metallopeptidase 16 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:84,736,752...85,026,711
Ensembl chr 8:86,701,882...86,982,518 		JBrowse link
G MMP17 matrix metallopeptidase 17 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr12:129,481,501...129,505,696
Ensembl chr12:133,922,882...133,936,152 		JBrowse link
G MMP19 matrix metallopeptidase 19 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr12:33,068,282...33,075,324
Ensembl chr12:33,794,249...33,801,658 		JBrowse link
G MMP2 matrix metallopeptidase 2 enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP20 matrix metallopeptidase 20 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:97,518,573...97,566,881
Ensembl chr11:101,011,084...101,059,322 		JBrowse link
G MMP21 matrix metallopeptidase 21 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr10:122,325,909...122,338,047
Ensembl chr10:126,591,824...126,601,001 		JBrowse link
G MMP23B matrix metallopeptidase 23B enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:396,629...399,103
Ensembl chr 1:1,554,922...1,557,325 		JBrowse link
G MMP24 matrix metallopeptidase 24 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:31,554,770...31,606,348
Ensembl chr20:32,686,887...32,729,403 		JBrowse link
G MMP26 matrix metallopeptidase 26 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:5,154,066...5,158,891
Ensembl chr11:4,823,666...4,828,035 		JBrowse link
G MMP27 matrix metallopeptidase 27 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:97,630,268...97,644,959
Ensembl chr11:101,123,253...101,137,315 		JBrowse link
G MMP28 matrix metallopeptidase 28 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr17:20,999,658...21,039,476
Ensembl chr17:21,293,767...21,323,691 		JBrowse link
G MMP3 matrix metallopeptidase 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354 		JBrowse link
G MMP7 matrix metallopeptidase 7 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099 		JBrowse link
G MMP8 matrix metallopeptidase 8 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736 		JBrowse link
G MMP9 matrix metallopeptidase 9 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G NLN neurolysin enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:7836437 GO_REF:0000002 GO_REF:0000118 RGD:9831155 NCBI chr 5:48,180,768...48,283,281
Ensembl chr 5:49,840,482...49,938,192 		JBrowse link
G NRDC nardilysin convertase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:51,038,711...51,130,404
Ensembl chr 1:52,535,603...52,625,998 		JBrowse link
G OMA1 OMA1 zinc metallopeptidase enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:57,549,404...57,811,246
Ensembl chr 1:59,448,436...59,516,170 		JBrowse link
G PAPLN papilin, proteoglycan like sulfated glycoprotein enables IEA TreeGrafter GO_REF:0000118 NCBI chr14:53,816,437...53,853,704
Ensembl chr14:72,679,910...72,712,009 		JBrowse link
G PAPPA pappalysin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435 		JBrowse link
G PAPPA2 pappalysin 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:151,727,598...152,369,670
Ensembl chr 1:155,769,395...156,063,989 		JBrowse link
G PHEX phosphate regulating endopeptidase X-linked enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:14,663,847...14,859,294
Ensembl chr  X:22,017,681...22,232,501 		JBrowse link
G PITRM1 pitrilysin metallopeptidase 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:3,135,895...3,171,235
Ensembl chr10:3,148,758...3,184,120 		JBrowse link
G PMPCA peptidase, mitochondrial processing subunit alpha enables IEA InterPro GO_REF:0000002 NCBI chr 9:107,483,608...107,499,176
Ensembl chr 9:136,464,070...136,477,569 		JBrowse link
G PMPCB peptidase, mitochondrial processing subunit beta enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:95,288,747...95,320,294
Ensembl chr 7:108,033,235...108,050,302 		JBrowse link
G RCE1 Ras converting CAAX endopeptidase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:62,101,228...62,203,793
Ensembl chr11:65,427,937...65,522,087
Ensembl chr11:65,427,937...65,522,087 		JBrowse link
G SPG7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr16:70,258,902...70,309,438
Ensembl chr16:89,866,884...89,917,867 		JBrowse link
G SPRTN SprT-like N-terminal domain enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:206,889,897...206,906,047
Ensembl chr 1:211,914,082...211,931,093 		JBrowse link
G THOP1 thimet oligopeptidase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr19:1,810,316...1,839,523
Ensembl chr19:2,765,550...2,793,235 		JBrowse link
G THSD4 thrombospondin type 1 domain containing 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:50,067,560...50,732,761
Ensembl chr15:68,859,819...69,491,696 		JBrowse link
G TLL1 tolloid like 1 enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 4:158,068,424...158,300,856
Ensembl chr 4:170,157,417...170,384,260 		JBrowse link
G TLL2 tolloid like 2 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr10:92,978,334...93,129,098
Ensembl chr10:96,483,401...96,633,281 		JBrowse link
G TRABD2A TraB domain containing 2A enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:84,875,464...84,979,886
Ensembl chr2A:86,433,980...86,493,762 		JBrowse link
G TRABD2B TraB domain containing 2B enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:47,055,618...47,292,055
Ensembl chr 1:48,571,772...48,799,960 		JBrowse link
G YBEY ybeY metalloendoribonuclease enables IEA InterPro GO_REF:0000002 NCBI chr21:32,628,599...32,638,914
Ensembl chr21:45,879,824...45,888,717 		JBrowse link
G YME1L1 YME1 like 1 ATPase enables IEA InterPro GO_REF:0000002 NCBI chr10:27,220,951...27,263,841
Ensembl chr10:27,584,099...27,626,453 		JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:39,545,264...39,589,721
Ensembl chr 1:40,869,076...40,912,747 		JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:37,562,930...37,717,175
Ensembl chr15:55,873,606...56,027,188 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA Ensembl GO_REF:0000107 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:152,839,326...152,972,741
Ensembl chr 5:159,494,786...159,593,171 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chr 8:38,298,194...38,406,706
Ensembl chr 8:35,473,278...35,581,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17494
    catalytic activity 5388
      hydrolase activity 2314
        peptidase activity 580
          endopeptidase activity 386
            metalloendopeptidase activity 110
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root