ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5) - Rat Genome Database

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Gene: ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5) Pan paniscus
Analyze
Symbol: ADAMTS5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
RGD ID: 11857999
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); extracellular matrix binding (ortholog); heparin binding (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); defense response to bacterium (ortholog); endocardial cushion morphogenesis (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); degenerative disc disease (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22223,102,173 - 23,151,603 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12117,964,851 - 18,015,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02113,352,222 - 13,402,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12126,738,671 - 26,788,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,744,807 - 26,788,736 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAMTS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22223,102,173 - 23,151,603 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12117,964,851 - 18,015,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02113,352,222 - 13,402,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12126,738,671 - 26,788,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,744,807 - 26,788,736 (-)Ensemblpanpan1.1panPan2
ADAMTS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382126,917,922 - 26,967,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2126,917,922 - 26,967,088 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,290,241 - 28,339,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,212,112 - 27,260,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,215,656 - 27,260,703NCBI
Celera2113,473,563 - 13,522,743 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2113,695,092 - 13,744,202 (-)NCBIHuRef
CHM1_12127,852,147 - 27,901,362 (-)NCBICHM1_1
T2T-CHM13v2.02125,276,336 - 25,326,235 (-)NCBIT2T-CHM13v2.0
Adamts5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391685,655,045 - 85,698,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1685,653,061 - 85,698,716 (-)EnsemblGRCm39 Ensembl
GRCm381685,858,157 - 85,901,125 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1685,856,173 - 85,901,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv371685,858,402 - 85,901,370 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361685,751,613 - 85,789,480 (-)NCBIMGSCv36mm8
Celera1686,076,565 - 86,106,690 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1648.34NCBI
Adamts5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,486,945 - 38,533,516 (-)NCBIGRCr8
mRatBN7.21125,000,627 - 25,047,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1125,000,637 - 25,047,205 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,692,495 - 33,740,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,392,761 - 26,440,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,581,643 - 25,629,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,411,174 - 25,456,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,410,975 - 25,456,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,035,108 - 29,080,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,503,380 - 25,548,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,503,379 - 25,548,845 (-)NCBI
Celera1124,802,423 - 24,847,800 (-)NCBICelera
Cytogenetic Map11q11NCBI
Adamts5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540726,603,479 - 26,643,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540726,597,165 - 26,643,972 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13122,242,901 - 22,289,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3122,248,092 - 22,289,802 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3122,237,302 - 22,284,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03122,341,143 - 22,388,689 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3122,342,725 - 22,388,670 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13122,313,499 - 22,361,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03122,319,121 - 22,366,648 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03122,794,062 - 22,841,615 (-)NCBIUU_Cfam_GSD_1.0
Adamts5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497122,777,168 - 22,824,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936640858,322 - 898,182 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936640857,565 - 899,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13190,361,744 - 190,413,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113190,353,019 - 190,413,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213200,401,972 - 200,451,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,252,922 - 65,359,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,254,285 - 65,299,800 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660717,902,441 - 7,947,424 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474514,896,340 - 14,935,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474514,890,111 - 14,934,972 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052731   ⟹   ENSPPAP00000029879
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2126,744,807 - 26,788,736 (-)Ensembl
RefSeq Acc Id: XM_055105203   ⟹   XP_054961178
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22223,102,173 - 23,151,603 (-)NCBI
NHGRI_mPanPan12117,964,851 - 18,015,494 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054961178 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000029879.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000029879   ⟸   ENSPPAT00000052731
RefSeq Acc Id: XP_054961178   ⟸   XM_055105203
- UniProtKB: A0A2R9BJM3 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037965 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052731.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS5 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report pps:100993355 UniProtKB/TrEMBL
NCBI Gene ADAMTS5 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS ADAMTS5 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A2R9BJM3 ENTREZGENE, UniProtKB/TrEMBL