ADAM28 (ADAM metallopeptidase domain 28) - Rat Genome Database

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Gene: ADAM28 (ADAM metallopeptidase domain 28) Pan paniscus
Analyze
Symbol: ADAM28
Name: ADAM metallopeptidase domain 28
RGD ID: 11982327
Description: ENCODES a protein that exhibits immunoglobulin receptor binding (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH asbestos-related lung carcinoma (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 28
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,796,292 - 42,863,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,523,249 - 18,602,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,549,892 - 23,623,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,474,820 - 20,540,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,474,029 - 20,540,692 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,796,292 - 42,863,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,523,249 - 18,602,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,549,892 - 23,623,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,474,820 - 20,540,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,474,029 - 20,540,692 (+)Ensemblpanpan1.1panPan2
ADAM28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,294,069 - 24,359,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,294,069 - 24,359,014 (+)EnsemblGRCh38hg38GRCh38
GRCh37824,151,582 - 24,216,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,207,525 - 24,268,671 (+)NCBINCBI36Build 36hg18NCBI36
Celera823,115,137 - 23,176,304 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,696,187 - 22,757,353 (+)NCBIHuRef
CHM1_1824,353,747 - 24,414,881 (+)NCBICHM1_1
T2T-CHM13v2.0824,569,171 - 24,634,154 (+)NCBIT2T-CHM13v2.0
Adam28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,842,447 - 68,893,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,843,476 - 68,893,291 (-)EnsemblGRCm39 Ensembl
GRCm381468,604,998 - 68,655,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,606,027 - 68,655,842 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,224,084 - 69,273,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,560,209 - 67,609,172 (-)NCBIMGSCv36mm8
Celera1466,379,012 - 66,429,923 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
Adam28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81550,184,286 - 50,250,605 (-)NCBIGRCr8
mRatBN7.21543,774,463 - 43,840,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,944,467 - 43,840,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1547,893,627 - 47,958,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,005,105 - 49,070,113 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01545,864,488 - 45,929,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01550,356,745 - 50,425,911 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1550,358,192 - 50,425,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01554,088,439 - 54,158,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,020,423 - 49,085,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11549,036,202 - 49,100,982 (-)NCBI
Celera1543,474,975 - 43,539,804 (-)NCBICelera
Cytogenetic Map15p11NCBI
Adam28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540347,319,382 - 47,409,380 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540347,304,711 - 47,409,369 (+)NCBIChiLan1.0ChiLan1.0
ADAM28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12533,092,645 - 33,147,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2533,092,628 - 33,264,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,677,242 - 33,732,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02533,298,789 - 33,353,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,299,274 - 33,470,021 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,246,937 - 33,302,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02533,103,486 - 33,158,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,261,650 - 33,316,886 (-)NCBIUU_Cfam_GSD_1.0
Adam28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,905,896 - 10,954,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,617,822 - 7,664,215 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,615,639 - 7,660,776 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,375,212 - 8,438,615 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,375,169 - 8,438,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,418,095 - 9,481,491 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,424,260 - 22,483,878 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,430,579 - 22,488,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,696,502 - 19,763,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,432,817 - 19,497,686 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475819,427,871 - 19,499,510 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008977210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034965854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055116369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055116370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055116371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008626360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000047205   ⟹   ENSPPAP00000024381
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl820,474,029 - 20,540,692 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047213   ⟹   ENSPPAP00000024388
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl820,474,029 - 20,540,477 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047227   ⟹   ENSPPAP00000024402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl820,479,018 - 20,539,925 (+)Ensembl
RefSeq Acc Id: XM_008977210   ⟹   XP_008975458
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,301 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,410 - 18,602,127 (+)NCBI
Mhudiblu_PPA_v0823,549,960 - 23,623,859 (+)NCBI
PanPan1.1820,474,820 - 20,540,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034965846   ⟹   XP_034821737
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,299 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,408 - 18,602,127 (+)NCBI
Mhudiblu_PPA_v0823,549,952 - 23,623,859 (+)NCBI
RefSeq Acc Id: XM_034965847   ⟹   XP_034821738
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,292 - 42,860,556 (+)NCBI
NHGRI_mPanPan1818,523,249 - 18,594,667 (+)NCBI
Mhudiblu_PPA_v0823,549,892 - 23,620,802 (+)NCBI
RefSeq Acc Id: XM_034965848   ⟹   XP_034821739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,298 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,407 - 18,602,127 (+)NCBI
Mhudiblu_PPA_v0823,549,951 - 23,623,859 (+)NCBI
RefSeq Acc Id: XM_034965849   ⟹   XP_034821740
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,293 - 42,860,555 (+)NCBI
NHGRI_mPanPan1818,523,252 - 18,594,666 (+)NCBI
Mhudiblu_PPA_v0823,549,937 - 23,620,801 (+)NCBI
RefSeq Acc Id: XM_034965850   ⟹   XP_034821741
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,802,391 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,529,503 - 18,602,127 (+)NCBI
Mhudiblu_PPA_v0823,556,143 - 23,623,859 (+)NCBI
RefSeq Acc Id: XM_034965851   ⟹   XP_034821742
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,301 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,410 - 18,602,127 (+)NCBI
Mhudiblu_PPA_v0823,549,957 - 23,623,859 (+)NCBI
RefSeq Acc Id: XM_055116369   ⟹   XP_054972344
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,299 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,407 - 18,602,127 (+)NCBI
RefSeq Acc Id: XM_055116370   ⟹   XP_054972345
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,297 - 42,863,608 (+)NCBI
NHGRI_mPanPan1818,523,406 - 18,602,127 (+)NCBI
RefSeq Acc Id: XM_055116371   ⟹   XP_054972346
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,295 - 42,860,554 (+)NCBI
NHGRI_mPanPan1818,523,402 - 18,594,665 (+)NCBI
RefSeq Acc Id: XR_004672839
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,294 - 42,862,445 (+)NCBI
NHGRI_mPanPan1818,523,257 - 18,596,557 (+)NCBI
Mhudiblu_PPA_v0823,549,937 - 23,622,696 (+)NCBI
RefSeq Acc Id: XR_004672840
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,296 - 42,862,445 (+)NCBI
NHGRI_mPanPan1818,523,405 - 18,596,557 (+)NCBI
Mhudiblu_PPA_v0823,549,945 - 23,622,696 (+)NCBI
RefSeq Acc Id: XR_004672841
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,293 - 42,862,445 (+)NCBI
NHGRI_mPanPan1818,523,253 - 18,596,557 (+)NCBI
Mhudiblu_PPA_v0823,549,938 - 23,622,696 (+)NCBI
RefSeq Acc Id: XR_008626360
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2742,796,293 - 42,862,445 (+)NCBI
NHGRI_mPanPan1818,523,251 - 18,596,557 (+)NCBI
RefSeq Acc Id: XP_008975458   ⟸   XM_008977210
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034821738   ⟸   XM_034965847
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034821740   ⟸   XM_034965849
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034821739   ⟸   XM_034965848
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034821737   ⟸   XM_034965846
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034821742   ⟸   XM_034965851
- Peptide Label: isoform X8
RefSeq Acc Id: XP_034821741   ⟸   XM_034965850
- Peptide Label: isoform X8
RefSeq Acc Id: ENSPPAP00000024381   ⟸   ENSPPAT00000047205
RefSeq Acc Id: ENSPPAP00000024388   ⟸   ENSPPAT00000047213
RefSeq Acc Id: ENSPPAP00000024402   ⟸   ENSPPAT00000047227
RefSeq Acc Id: XP_054972346   ⟸   XM_055116371
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054972345   ⟸   XM_055116370
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054972344   ⟸   XM_055116369
- Peptide Label: isoform X1
Protein Domains
Disintegrin   EGF-like   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035327 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047205.1 UniProtKB/TrEMBL
  ENSPPAT00000047213.1 UniProtKB/TrEMBL
  ENSPPAT00000047227.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report pps:100995681 UniProtKB/TrEMBL
NCBI Gene ADAM28 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A2R9B481_PANPA UniProtKB/TrEMBL
  A0A2R9B490_PANPA UniProtKB/TrEMBL
  A0A2R9B5R7_PANPA UniProtKB/TrEMBL