MMP8 (matrix metallopeptidase 8) - Rat Genome Database

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Gene: MMP8 (matrix metallopeptidase 8) Pan paniscus
Analyze
Symbol: MMP8
Name: matrix metallopeptidase 8
RGD ID: 11940388
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); asphyxiating thoracic dystrophy (ortholog); ataxia telangiectasia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: matrix metallopeptidase 8 (neutrophil collagenase); neutrophil collagenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,650,408 - 97,663,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,143,372 - 101,156,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,650,408 - 97,663,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,143,372 - 101,156,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensemblpanpan1.1panPan2
MMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,711,796 - 102,724,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,711,796 - 102,727,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,582,527 - 102,595,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,088,540 - 102,100,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,088,539 - 102,100,868NCBI
Celera1199,743,725 - 99,756,878 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,509,472 - 98,522,626 (-)NCBIHuRef
CHM1_111102,465,498 - 102,478,648 (-)NCBICHM1_1
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBIT2T-CHM13v2.0
Mmp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,558,430 - 7,568,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,558,457 - 7,568,486 (+)EnsemblGRCm39 Ensembl
GRCm3897,558,429 - 7,568,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,558,456 - 7,568,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,558,429 - 7,568,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,558,460 - 7,568,485 (+)NCBIMGSCv36mm8
Celera94,948,941 - 4,958,998 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,008,873 - 13,018,729 (+)NCBIGRCr8
mRatBN7.284,724,009 - 4,733,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,683,788 - 8,692,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,981,565 - 6,990,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,983,774 - 4,992,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,928,997 - 5,939,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,928,997 - 5,939,012 (-)NCBIChiLan1.0ChiLan1.0
MMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,036,381 - 29,047,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBIUU_Cfam_GSD_1.0
Mmp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,297,496 - 86,305,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,228,950 - 5,238,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,228,950 - 5,238,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,384,033 - 33,396,947 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,384,034 - 33,397,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,330,738 - 37,343,699 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,097,620 - 94,110,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,097,896 - 94,109,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,764,839 - 31,777,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878164,171 - 175,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878124,396 - 174,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000034772   ⟹   ENSPPAP00000012110
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034773   ⟹   ENSPPAP00000012111
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11101,143,268 - 101,154,959 (-)Ensembl
RefSeq Acc Id: XM_003828379   ⟹   XP_003828427
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBI
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBI
Mhudiblu_PPA_v01197,650,486 - 97,663,731 (-)NCBI
PanPan1.111101,143,372 - 101,156,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055094783   ⟹   XP_054950758
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29103,503,214 - 103,514,513 (-)NCBI
NHGRI_mPanPan111104,591,529 - 104,602,855 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003828427 (Get FASTA)   NCBI Sequence Viewer  
  XP_054950758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012110
  ENSPPAP00000012110.1
  ENSPPAP00000012111.1
RefSeq Acc Id: XP_003828427   ⟸   XM_003828379
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A8Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000012110   ⟸   ENSPPAT00000034772
RefSeq Acc Id: ENSPPAP00000012111   ⟸   ENSPPAT00000034773
RefSeq Acc Id: XP_054950758   ⟸   XM_055094783
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A9L1 (UniProtKB/TrEMBL)
Protein Domains
Peptidase metallopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029244 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034772.1 UniProtKB/TrEMBL
  ENSPPAT00000034773.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report pps:100967517 UniProtKB/TrEMBL
NCBI Gene MMP8 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  PTHR10201:SF137 UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt A0A2R9A8Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A9L1 ENTREZGENE, UniProtKB/TrEMBL