PMPCA (peptidase, mitochondrial processing subunit alpha)

Gene: PMPCA (peptidase, mitochondrial processing subunit alpha) Pan paniscus

Analyze

Symbol:

PMPCA

Name:

peptidase, mitochondrial processing subunit alpha

RGD ID:

11719292

Description:

ENCODES a protein that exhibits endopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN protein processing (ortholog); PARTICIPATES IN presequence pathway of mitochondrial protein import; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mitochondrial-processing peptidase subunit alpha; peptidase, mitochondrial processing alpha subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,960,393 - 2,975,426 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,962,728 - 2,977,761 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,483,608 - 107,499,176 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,464,070 - 136,477,569 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,464,070 - 136,477,569 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

autosomal recessive spinocerebellar ataxia 2 (ISO)

cerebellar ataxia (ISO)

developmental and epileptic encephalopathy 14 (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

genetic disease (ISO)

Immunodeficiency 103 (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

normal pressure hydrocephalus (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

tuberous sclerosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein processing (ISO)

protein processing involved in protein targeting to mitochondrion (IEA)

proteolysis (IEA)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrion (IEA)

Molecular Function

endopeptidase activity (ISO)

metal ion binding (IEA)

metalloendopeptidase activity (IEA)

metallopeptidase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

presequence pathway of mitochondrial protein import (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PMPCA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,960,393 - 2,975,426 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,962,728 - 2,977,761 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,483,608 - 107,499,176 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,464,070 - 136,477,569 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,464,070 - 136,477,569 (+)	Ensembl	panpan1.1		panPan2

PMPCA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,410,658 - 136,423,761 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,410,630 - 136,427,992 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,305,110 - 139,318,213 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,424,937 - 138,438,034 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	136,580,952 - 136,594,049	NCBI
Celera	9	109,819,961 - 109,833,058 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	108,764,482 - 108,777,579 (+)	NCBI		HuRef
CHM1_1	9	139,453,320 - 139,466,417 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	148,639,988 - 148,653,102 (+)	NCBI		T2T-CHM13v2.0

Pmpca
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	26,275,554 - 26,287,134 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	26,279,351 - 26,287,134 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	26,389,348 - 26,397,121 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	26,389,339 - 26,397,122 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	26,244,868 - 26,252,641 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	26,211,357 - 26,219,130 (+)	NCBI		MGSCv36	mm8
Celera	2	26,107,024 - 26,114,797 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	18.88	NCBI

Pmpca
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	29,605,823 - 29,614,936 (+)	NCBI		GRCr8
mRatBN7.2	3	9,207,731 - 9,216,846 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	9,207,717 - 9,216,844 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	12,261,246 - 12,269,510 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,844,476 - 20,852,740 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	19,099,813 - 19,108,077 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	3,834,262 - 3,842,061 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	3,834,078 - 3,842,078 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	9,195,490 - 9,203,287 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	4,560,961 - 4,568,758 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	4,560,966 - 4,568,716 (+)	NCBI
Celera	3	4,027,067 - 4,034,864 (+)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Pmpca
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,315,159 - 4,322,609 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,315,159 - 4,322,609 (-)	NCBI	ChiLan1.0	ChiLan1.0

PMPCA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	49,073,124 - 49,083,302 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	49,073,108 - 49,224,961 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	48,323,798 - 48,334,000 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,949,879 - 49,960,083 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,947,786 - 49,960,010 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,730,499 - 48,740,634 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	49,024,590 - 49,034,785 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	49,072,094 - 49,082,307 (-)	NCBI		UU_Cfam_GSD_1.0

Pmpca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	201,979,349 - 201,994,196 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	1,386,817 - 1,395,597 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	1,385,010 - 1,395,715 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PMPCA
(Sus scrofa - pig)

No map positions available.

PMPCA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,778,376 - 1,791,878 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,776,983 - 1,791,787 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,424,477 - 3,437,983 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pmpca
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	1,568,710 - 1,575,867 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	1,568,655 - 1,576,273 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003816960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008970073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000052387 ⟹ ENSPPAP00000029538

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	136,464,070 - 136,477,569 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000052395 ⟹ ENSPPAP00000029545

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	136,464,165 - 136,477,074 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000052397 ⟹ ENSPPAP00000029547

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	136,466,008 - 136,477,074 (+)	Ensembl

RefSeq Acc Id:

XM_003816960 ⟹ XP_003817008

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	2,960,393 - 2,975,426 (-)	NCBI
NHGRI_mPanPan1	9	2,962,728 - 2,977,761 (-)	NCBI
Mhudiblu_PPA_v0	9	107,483,608 - 107,499,176 (+)	NCBI
PanPan1.1	9	136,464,070 - 136,477,569 (+)	NCBI

Sequence:

show sequence

AAGCGCGTGCCTGAACGCCTTGGGCCGTCGGCGAGGGGGAGGGGAAGCCGTGGGCGGAAGCGGA
AGTGACGACTGAAGCGGGGCGGAGACGCAAGATGGCGGCTGTGGTGCTGGCGGCGACGCGGTTG
CTGCGGGGCTCGGGTTCTTGGGGCTGTTCGCGGCTGAGGTTTGGACCTCCTGCGTACAGACGGT
TTAGTAGTGGGGGTGCCTATCCCAACATCCCCCTCTCTTCTCCCTTACCTGGAGTACCCAAGCC
TGTTTTTGCTACAGTTGATGGACAGGAAAAGTTTGAAACCAAAGTAACCACATTGGATAATGGG
CTTCGCGTGGCATCTCAGAATAAGTTTGGACAGTTTTGTACAGTAGGAATTCTTATCAATTCAG
GATCGAGATATGAAGCGAAATACCTTAGTGGAATTGCTCACTTTTTGGAAAAATTGGCATTTTC
GTCTACTGCTCGATTTGACAGCAAAGATGAAATTCTGCTTACGTTGGAAAAGCATGGGGGTATC
TGTGACTGCCAGACATCAAGAGACACCACCATGTATGCTGTGTCTGCTGATAGCAAAGGCTTGG
ACACGGTGGTTGGCTTACTGGCCGATGTGGTTCTGCAGCCCCGGCTAACAGATGAAGAAGTCGA
GATGACGCGGATGGCGGTCCAGTTTGAGCTGGAGGACCTGAACCTGCGGCCTGACCCAGAGCCA
CTTCTCACCGAGATGATTCATGAAGCGGCTTACAGGGAGAACACAGTTGGCCTCCACCGTTTCT
GCCCCACAGAAAACATAGCAAAGATCAACCGAGAGGTGCTGCATTCGTACCTGAGGAACTACTA
CACTCCCGACCGCATGGTGCTGGCTGGCGTGGGCGTGGAGCACGAGCATCTGGTGGACTGTGCC
CGGAAGTACCTCCTGGGGGTCCAGCCGGCCTGGGGGAGCGCAGAGGCCGTGGATATTGACAGAT
CTGTGGCCCAGTACACTGGGGGGATTGCCAAGCTAGAAAGAGACATGTCCAATGTCAGCCTGGG
CCCGACCCCCATCCCCGAGCTCACGCACATCATGGTTGGACTGGAGAGCTGCTCCTTCCTGGAG
GAGGACTTCATCCCCTTTGCAGTGTTGAACATGATGATGGGCGGAGGTGGCTCCTTCTCGGCTG
GTGGGCCCGGCAAGGGCATGTTCTCCAGGCTCTACCTCAACGTGCTCAACAGGCACCACTGGAT
GTATAACGCGACCTCCTACCACCACAGCTACGAGGACACTGGCCTCCTTTGCATCCATGCCAGT
GCCGACCCAAGACAGGTTCGAGAAATGGTAGAAATCATCACAAAGGAGTTTATTTTAATGGGCG
GAACCGTGGACGCGGTGGAGCTGGAACGAGCCAAGACGCAGCTGACGTCAATGCTCATGATGAA
CCTGGAATCCAGGCCTGTGATCTTCGAGGATGTGGGGAGGCAGGTGCTGGCCACTCGCTCCAGA
AAGCTGCCGCACGAGCTGTGCACGCTCATCCGCAACGTGAAGCCGGAAGATGTGAAGAGAGTCG
CTTCTAAGATGCTCCGAGGGAAGCCGGCAGTGGCCGCCCTGGGTGACCTGACTGACCTGCCCAC
GTATGAACACATCCAGACCGCCCTGTCGAGTAAGGACGGGCGCCTGCCCAGGACGTACCGGCTC
TTCCGGTAGAACTGCTCCCCGGCCTGACAGACCCAGGAGCTGCAGCTGGAGCCTGTTCCCATGC
GTGTTAGTTTGGACACGAATTTAGTCTAAAAAGCTGTCTGGTTGTATAAACGGTGCAAACAATG
TCGCCACAGCACCCACGCGGTTTGCATTCTTTCGGAACTCAATGTGCCGATCAGTGGAGTCAGT
ATCGAGCCTGACCACCGCAAGCCAGGAAGCAGGTGAAGTGCCCAGCGCTGGAGTGCAGCGTGCC
ACGAGGAGGGCGGTCAGTGCTTCCCTCCTCGGGCTGTGGGCACATGGGGCCCCGCAGGTTCCTT
GGAGGAGCCCTGAGCTGGGAGGCAGCAAAGACCGACCTATCAGAGCCTCCCAGAGGCCACCGTG
TTGGGTACCAGGACTCACCTCTGACAAACAGGACAAGGCAAGGGCCCAGTCAGCTCCGAGGAGC
GCGGCCACGCGTGTGCACACAGCTTCCCTGGTAATAAAGAGCTGGCATCTTTCTTA

hide sequence

RefSeq Acc Id:

XM_008970073 ⟹ XP_008968321

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	2,960,393 - 2,973,529 (-)	NCBI
NHGRI_mPanPan1	9	2,962,728 - 2,975,864 (-)	NCBI
Mhudiblu_PPA_v0	9	107,485,530 - 107,499,176 (+)	NCBI
PanPan1.1	9	136,466,008 - 136,477,569 (+)	NCBI

Sequence:

show sequence

ATGAAGCGAAATACCTTAGTGGAATTGCTCACTTTTTGGAAAAATTGGCATTTTCGTCTACTGC
TCGATTTGACAGCAAAGATGAAATTCTGCTTACGTTGGAAAAGCATGGGGGTATCTGTGACTGC
CAGACATCAAGACACCACCATGTATGCTGTGTCTGCTGATAGCAAAGGCTTGGACACGGTGGTT
GGCTTACTGGCCGATGTGGTTCTGCAGCCCCGGCTAACAGATGAAGAAGTCGAGATGACGCGGA
TGGCGGTCCAGTTTGAGCTGGAGGACCTGAACCTGCGGCCTGACCCAGAGCCACTTCTCACCGA
GATGATTCATGAAGCGGCTTACAGGGAGAACACAGTTGGCCTCCACCGTTTCTGCCCCACAGAA
AACATAGCAAAGATCAACCGAGAGGTGCTGCATTCGTACCTGAGGAACTACTACACTCCCGACC
GCATGGTGCTGGCTGGCGTGGGCGTGGAGCACGAGCATCTGGTGGACTGTGCCCGGAAGTACCT
CCTGGGGGTCCAGCCGGCCTGGGGGAGCGCAGAGGCCGTGGATATTGACAGATCTGTGGCCCAG
TACACTGGGGGGATTGCCAAGCTAGAAAGAGACATGTCCAATGTCAGCCTGGGCCCGACCCCCA
TCCCCGAGCTCACGCACATCATGGTTGGACTGGAGAGCTGCTCCTTCCTGGAGGAGGACTTCAT
CCCCTTTGCAGTGTTGAACATGATGATGGGCGGAGGTGGCTCCTTCTCGGCTGGTGGGCCCGGC
AAGGGCATGTTCTCCAGGCTCTACCTCAACGTGCTCAACAGGCACCACTGGATGTATAACGCGA
CCTCCTACCACCACAGCTACGAGGACACTGGCCTCCTTTGCATCCATGCCAGTGCCGACCCAAG
ACAGGTTCGAGAAATGGTAGAAATCATCACAAAGGAGTTTATTTTAATGGGCGGAACCGTGGAC
GCGGTGGAGCTGGAACGAGCCAAGACGCAGCTGACGTCAATGCTCATGATGAACCTGGAATCCA
GGCCTGTGATCTTCGAGGATGTGGGGAGGCAGGTGCTGGCCACTCGCTCCAGAAAGCTGCCGCA
CGAGCTGTGCACGCTCATCCGCAACGTGAAGCCGGAAGATGTGAAGAGAGTCGCTTCTAAGATG
CTCCGAGGGAAGCCGGCAGTGGCCGCCCTGGGTGACCTGACTGACCTGCCCACGTATGAACACA
TCCAGACCGCCCTGTCGAGTAAGGACGGGCGCCTGCCCAGGACGTACCGGCTCTTCCGGTAGAA
CTGCTCCCCGGCCTGACAGACCCAGGAGCTGCAGCTGGAGCCTGTTCCCATGCGTGTTAGTTTG
GACACGAATTTAGTCTAAAAAGCTGTCTGGTTGTATAAACGGTGCAAACAATGTCGCCACAGCA
CCCACGCGGTTTGCATTCTTTCGGAACTCAATGTGCCGATCAGTGGAGTCAGTATCGAGCCTGA
CCACCGCAAGCCAGGAAGCAGGTGAAGTGCCCAGCGCTGGAGTGCAGCGTGCCACGAGGAGGGC
GGTCAGTGCTTCCCTCCTCGGGCTGTGGGCACATGGGGCCCCGCAGGTTCCTTGGAGGAGCCCT
GAGCTGGGAGGCAGCAAAGACCGACCTATCAGAGCCTCCCAGAGGCCACCGTGTTGGGTACCAG
GACTCACCTCTGACAAACAGGACAAGGCAAGGGCCCAGTCAGCTCCGAGGAGCGCGGCCACGCG
TGTGCACACAGCTTCCCTGGTAATAAAGAGCTGGCATCTTTCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003817008	(Get FASTA)	NCBI Sequence Viewer
	XP_008968321	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000029538
	ENSPPAP00000029538.1
	ENSPPAP00000029545.1
	ENSPPAP00000029547
	ENSPPAP00000029547.1

RefSeq Acc Id:	XP_003817008 ⟸ XM_003816960
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BJK8 (UniProtKB/TrEMBL), A0A2R9BIQ1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAVVLAATRLLRGSGSWGCSRLRFGPPAYRRFSSGGAYPNIPLSSPLPGVPKPVFATVDGQEK FETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSKDE ILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVGLLADVVLQPRLTDEEVEMTRMAVQFEL EDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTENIAKINREVLHSYLRNYYTPDRMVLAGV GVEHEHLVDCARKYLLGVQPAWGSAEAVDIDRSVAQYTGGIAKLERDMSNVSLGPTPIPELTHI MVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSY EDTGLLCIHASADPRQVREMVEIITKEFILMGGTVDAVELERAKTQLTSMLMMNLESRPVIFED VGRQVLATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKPAVAALGDLTDLPTYEHIQTALSS KDGRLPRTYRLFR hide sequence

RefSeq Acc Id:	XP_008968321 ⟸ XM_008970073
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9BMA7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRNTLVELLTFWKNWHFRLLLDLTAKMKFCLRWKSMGVSVTARHQDTTMYAVSADSKGLDTVV GLLADVVLQPRLTDEEVEMTRMAVQFELEDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTE NIAKINREVLHSYLRNYYTPDRMVLAGVGVEHEHLVDCARKYLLGVQPAWGSAEAVDIDRSVAQ YTGGIAKLERDMSNVSLGPTPIPELTHIMVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPG KGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGGTVD AVELERAKTQLTSMLMMNLESRPVIFEDVGRQVLATRSRKLPHELCTLIRNVKPEDVKRVASKM LRGKPAVAALGDLTDLPTYEHIQTALSSKDGRLPRTYRLFR hide sequence

RefSeq Acc Id:

ENSPPAP00000029538 ⟸ ENSPPAT00000052387

RefSeq Acc Id:

ENSPPAP00000029547 ⟸ ENSPPAT00000052397

RefSeq Acc Id:

ENSPPAP00000029545 ⟸ ENSPPAT00000052395

Protein Domains

Peptidase M16 C-terminal Peptidase M16 N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037773	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000052387.1	UniProtKB/TrEMBL
	ENSPPAT00000052395.1	UniProtKB/TrEMBL
	ENSPPAT00000052397.1	UniProtKB/TrEMBL
Gene3D-CATH	Metalloenzyme, LuxS/M16 peptidase-like	UniProtKB/TrEMBL
InterPro	Metalloenz_LuxS/M16	UniProtKB/TrEMBL
	Pept_M16_N	UniProtKB/TrEMBL
	Pept_M16_Zn_BS	UniProtKB/TrEMBL
	Peptidase_M16_C	UniProtKB/TrEMBL
KEGG Report	pps:100975657	UniProtKB/TrEMBL
NCBI Gene	PMPCA	ENTREZGENE
PANTHER	METALLOPROTEASE	UniProtKB/TrEMBL
	PTHR11851:SF192	UniProtKB/TrEMBL
Pfam	Peptidase_M16	UniProtKB/TrEMBL
	Peptidase_M16_C	UniProtKB/TrEMBL
PROSITE	INSULINASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63411	UniProtKB/TrEMBL
UniProt	A0A2R9BIQ1	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BJK8	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BMA7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-07-01	PMPCA	peptidase, mitochondrial processing subunit alpha	PMPCA	peptidase, mitochondrial processing alpha subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations