PMPCA (peptidase, mitochondrial processing subunit alpha) - Rat Genome Database

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Gene: PMPCA (peptidase, mitochondrial processing subunit alpha) Sus scrofa
Analyze
Symbol: PMPCA
Name: peptidase, mitochondrial processing subunit alpha
RGD ID: 14105406
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN protein processing (ortholog); PARTICIPATES IN presequence pathway of mitochondrial protein import; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitochondrial-processing peptidase subunit alpha; peptidase, mitochondrial processing alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PMPCA
(Sus scrofa - pig)		 No map positions available.
PMPCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,410,658 - 136,423,761 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,410,630 - 136,427,992 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,305,110 - 139,318,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,424,937 - 138,438,034 (+)NCBINCBI36Build 36hg18NCBI36
Build 349136,580,952 - 136,594,049NCBI
Celera9109,819,961 - 109,833,058 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,764,482 - 108,777,579 (+)NCBIHuRef
CHM1_19139,453,320 - 139,466,417 (+)NCBICHM1_1
T2T-CHM13v2.09148,639,988 - 148,653,102 (+)NCBIT2T-CHM13v2.0
Pmpca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,275,554 - 26,287,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,279,351 - 26,287,134 (+)EnsemblGRCm39 Ensembl
GRCm38226,389,348 - 26,397,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,389,339 - 26,397,122 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,244,868 - 26,252,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,211,357 - 26,219,130 (+)NCBIMGSCv36mm8
Celera226,107,024 - 26,114,797 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.88NCBI
Pmpca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,605,823 - 29,614,936 (+)NCBIGRCr8
mRatBN7.239,207,731 - 9,216,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,207,717 - 9,216,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,261,246 - 12,269,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,844,476 - 20,852,740 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,099,813 - 19,108,077 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,834,262 - 3,842,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,834,078 - 3,842,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,195,490 - 9,203,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,560,961 - 4,568,758 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,560,966 - 4,568,716 (+)NCBI
Celera34,027,067 - 4,034,864 (+)NCBICelera
Cytogenetic Map3p13NCBI
Pmpca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,315,159 - 4,322,609 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,315,159 - 4,322,609 (-)NCBIChiLan1.0ChiLan1.0
PMPCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,960,393 - 2,975,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,962,728 - 2,977,761 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,483,608 - 107,499,176 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,464,070 - 136,477,569 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,464,070 - 136,477,569 (+)Ensemblpanpan1.1panPan2
PMPCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,073,124 - 49,083,302 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,073,108 - 49,224,961 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,323,798 - 48,334,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,949,879 - 49,960,083 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,947,786 - 49,960,010 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,730,499 - 48,740,634 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,024,590 - 49,034,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,072,094 - 49,082,307 (-)NCBIUU_Cfam_GSD_1.0
Pmpca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,979,349 - 201,994,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,386,817 - 1,395,597 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,385,010 - 1,395,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMPCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,778,376 - 1,791,878 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,776,983 - 1,791,787 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,424,477 - 3,437,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmpca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,568,710 - 1,575,867 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,568,655 - 1,576,273 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Protein Domains
Peptidase M16 C-terminal   Peptidase M16 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031413 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025012305 UniProtKB/TrEMBL
  ENSSSCG00030025028 UniProtKB/TrEMBL
  ENSSSCG00035023100 UniProtKB/TrEMBL
  ENSSSCG00040033708 UniProtKB/TrEMBL
  ENSSSCG00050028117 UniProtKB/TrEMBL
  ENSSSCG00055013838 UniProtKB/TrEMBL
  ENSSSCG00060022496 UniProtKB/TrEMBL
  ENSSSCG00065021567 UniProtKB/TrEMBL
  ENSSSCG00070002634 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000070721 ENTREZGENE
  ENSSSCT00000070721.2 UniProtKB/TrEMBL
  ENSSSCT00000073916.2 UniProtKB/TrEMBL
  ENSSSCT00025016298.1 UniProtKB/TrEMBL
  ENSSSCT00025016388.1 UniProtKB/TrEMBL
  ENSSSCT00030034947.1 UniProtKB/TrEMBL
  ENSSSCT00030034959.1 UniProtKB/TrEMBL
  ENSSSCT00035030246.1 UniProtKB/TrEMBL
  ENSSSCT00035030255.1 UniProtKB/TrEMBL
  ENSSSCT00040045398.1 UniProtKB/TrEMBL
  ENSSSCT00040045430.1 UniProtKB/TrEMBL
  ENSSSCT00050037822.1 UniProtKB/TrEMBL
  ENSSSCT00050037854.1 UniProtKB/TrEMBL
  ENSSSCT00055027302.1 UniProtKB/TrEMBL
  ENSSSCT00055027404.1 UniProtKB/TrEMBL
  ENSSSCT00060030532.1 UniProtKB/TrEMBL
  ENSSSCT00060030552.1 UniProtKB/TrEMBL
  ENSSSCT00065028696.1 UniProtKB/TrEMBL
  ENSSSCT00065028720.1 UniProtKB/TrEMBL
  ENSSSCT00070004929.1 UniProtKB/TrEMBL
  ENSSSCT00070004936.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
NCBI Gene PMPCA ENTREZGENE
PANTHER METALLOPROTEASE UniProtKB/TrEMBL
  MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
PROSITE INSULINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/TrEMBL
UniProt A0A286ZRT5_PIG UniProtKB/TrEMBL
  A0A4X1SNU0_PIG UniProtKB/TrEMBL
  A0A4X1SPP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QB91_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2Q8L1 UniProtKB/TrEMBL
VGNC ID VGNC:91591 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 PMPCA  peptidase, mitochondrial processing subunit alpha  PMPCA  peptidase, mitochondrial processing alpha subunit  Symbol and/or name change 5135510 APPROVED