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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic-type endopeptidase activity
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Accession:GO:0004190 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Synonyms:exact_synonym: aspartic endopeptidase activity
 narrow_synonym: aspartate protease activity;   aspartic protease activity;   aspartyl protease activity;   carboxyl protease activity
 xref: EC:3.4.23;   reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1";   reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2";   reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants";   reactome:R-HSA-373705 "Caspase cleavage of DCC";   reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3";   reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3";   reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"


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aspartic-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asprv1 aspartic peptidase, retroviral-like 1 enables ISO (PMID:16098038)
(MGI:3694389|PMID:16837463)		 RGD PMID:16098038 PMID:16837463 MGI:3694389 NCBI chr 4:119,077,415...119,078,887
Ensembl chr 4:119,077,356...119,078,379 		JBrowse link
G Bace1 beta-secretase 1 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:10531052)
GO_REF:0000043
(MGI:6316502|PMID:29325091), (PMID:25592972)		 UniProt
RGD		 PMID:10531052 PMID:25592972 PMID:29325091 GO_REF:0000024 GO_REF:0000043 MGI:6316502 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bace2 beta-secretase 2 enables ISS
ISO		 GO_REF:0000024
(PMID:10591213)		 UniProt
RGD		 PMID:10591213 GO_REF:0000024 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Casp3 caspase 3 enables ISO (PMID:15231831), (PMID:23727203) RGD PMID:15231831 PMID:23727203 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 enables ISO (MGI:7327228|PMID:35705808), (PMID:15231831) RGD PMID:15231831 PMID:35705808 MGI:7327228 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ctsd cathepsin D enables IEA
ISO
IBA		 GO_REF:0000043
(PMID:19293336)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:19293336 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctse cathepsin E enables ISO
IDA
IBA		 (PMID:7789521)
PMID:8157122
(MGI:87708|PMID:9180269)
GO_REF:0000033		 RGD
GO_Central		 PMID:7789521 PMID:9180269 PMID:8157122 GO_REF:0000033 MGI:87708, RGD:8554034 NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502 		JBrowse link
G Cym chymosin enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:194,828,739...194,839,096
Ensembl chr 2:194,828,739...194,839,096 		JBrowse link
G Ddi1 DNA-damage inducible 1 homolog 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:3,596,658...3,598,505
Ensembl chr 8:3,595,149...3,598,533 		JBrowse link
G Ddi2 DNA damage inducible 1 homolog 2 enables ISO (PMID:27528193) RGD PMID:27528193 NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283 		JBrowse link
G ENSRNOG00000067229 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:83,921,470...83,930,590 JBrowse link
G ENSRNOG00000069797 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:11,438,116...11,449,855 JBrowse link
G Napsa napsin A aspartic peptidase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094 		JBrowse link
G Nrip2 nuclear receptor interacting protein 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:161,673,964...161,684,055
Ensembl chr 4:161,639,356...161,684,070 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600 		JBrowse link
G Pga5 pepsinogen A5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:207,317,021...207,327,156
Ensembl chr 1:207,317,021...207,327,156 		JBrowse link
G Pgc progastricsin enables ISO
IBA		 (PMID:12759353)
GO_REF:0000033		 RGD
GO_Central		 PMID:12759353 GO_REF:0000033 NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682 		JBrowse link
G Pip prolactin induced protein enables ISO
IBA		 (PMID:10713110)
GO_REF:0000033		 RGD
GO_Central		 PMID:10713110 GO_REF:0000033 NCBI chr 4:70,787,627...70,791,921
Ensembl chr 4:70,787,627...70,791,921 		JBrowse link
G Psen1 presenilin 1 enables ISO MGI:1930934 (PMID:12684521) RGD PMID:12684521 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Ren renin enables IEA
IBA
ISO		 GO_REF:0000043
GO_REF:0000033
(PMID:20927107), (PMID:4289389), (PMID:4322712), (PMID:4330891), (PMID:4360430)
(PMID:12045255)		 UniProt
GO_Central
RGD		 PMID:4289389 PMID:4322712 PMID:4330891 PMID:4360430 PMID:12045255 More... GO_REF:0000033 GO_REF:0000043 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-CE15 RT1 class I, locus CE15 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:3,275,575...3,279,074
Ensembl chr20:3,264,172...3,279,563
Ensembl chr20:3,264,172...3,279,563 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables ISO (PMID:30733280) RGD PMID:30733280 NCBI chr10:89,095,279...89,097,487
Ensembl chr10:89,095,261...89,098,580 		JBrowse link
G Sval1 seminal vesicle antigen-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,845,228...70,856,192
Ensembl chr 4:70,845,228...70,856,192 		JBrowse link
G Sval2 seminal vesicle antigen-like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,809,366...70,813,330
Ensembl chr 4:70,809,366...70,813,340 		JBrowse link
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 enables ISO
IBA		 (PMID:16873890), (PMID:25239945)
GO_REF:0000033		 RGD
GO_Central		 PMID:16873890 PMID:25239945 GO_REF:0000033 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Ncstn nicastrin contributes_to ISO MGI:1202717|MGI:3522097 (PMID:16371134) RGD PMID:16371134 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:17428795), (PMID:26280335)
GO_REF:0000033
MGI:1891700|MGI:3522097 (PMID:16371134)
MGI:109284 (PMID:21206757)		 UniProt
RGD
GO_Central		 PMID:16371134 PMID:17428795 PMID:21206757 PMID:26280335 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 enables IBA
ISO		 GO_REF:0000033
MGI:1202717|MGI:1930939 (PMID:12684521), (PMID:21206757)		 GO_Central
RGD		 PMID:12684521 PMID:21206757 GO_REF:0000033 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Sppl2a signal peptide peptidase-like 2A enables ISO
IBA		 (PMID:2313285)
GO_REF:0000033		 RGD
GO_Central		 PMID:2313285 GO_REF:0000033 NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264 		JBrowse link
G Sppl2b signal peptide peptidase-like 2B NOT|enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:16873890)
(PMID:19114711), (PMID:22194595), (PMID:2313285)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:2313285 PMID:16873890 PMID:19114711 PMID:22194595 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,843,918...8,856,642
Ensembl chr 7:8,843,918...8,856,608 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables ISO
IBA		 (MGI:6281843|PMID:30733280), (MGI:7332329|PMID:35960805), (MGI:7387163|PMID:30733281)
GO_REF:0000033		 RGD
GO_Central		 PMID:30733280 PMID:30733281 PMID:35960805 GO_REF:0000033 MGI:6281843 MGI:7332329 MGI:7387163 NCBI chr10:89,095,279...89,097,487
Ensembl chr10:89,095,261...89,098,580 		JBrowse link
G Sppl3 signal peptide peptidase like 3 enables ISO
IBA		 (PMID:16873890), (PMID:2313285)
GO_REF:0000033		 RGD
GO_Central		 PMID:2313285 PMID:16873890 GO_REF:0000033 NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      hydrolase activity 2592
        peptidase activity 689
          endopeptidase activity 458
            aspartic-type endopeptidase activity 30
              aspartic endopeptidase activity, intramembrane cleaving 8
              aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0
paths to the root