Ddi1 (DNA-damage inducible 1 homolog 1) - Rat Genome Database

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Gene: Ddi1 (DNA-damage inducible 1 homolog 1) Rattus norvegicus
Analyze
Symbol: Ddi1
Name: DNA-damage inducible 1 homolog 1
RGD ID: 1559430
Description: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1); INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); CGP 52608 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DDI1, DNA-damage inducible 1, homolog 1; DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae); DNA-damage inducible 1 homolog 1 (S. cerevisiae); LOC367012; protein DDI1 homolog 1; RGD1559430; similar to DNA-damage inducible protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8811,881,544 - 11,883,391 (-)NCBIGRCr8
mRatBN7.283,596,658 - 3,598,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl83,595,149 - 3,598,533 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx87,558,453 - 7,560,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.085,856,235 - 5,858,082 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.083,856,298 - 3,858,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.084,547,725 - 4,549,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl84,547,725 - 4,549,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.084,561,559 - 4,563,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.483,237,986 - 3,239,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera85,168,510 - 5,170,357 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
aflatoxin B1  (ISO)
bisphenol A  (EXP,ISO)
CGP 52608  (ISO)
pirinixic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22871113   PMID:29290612  


Genomics

Comparative Map Data
Ddi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8811,881,544 - 11,883,391 (-)NCBIGRCr8
mRatBN7.283,596,658 - 3,598,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl83,595,149 - 3,598,533 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx87,558,453 - 7,560,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.085,856,235 - 5,858,082 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.083,856,298 - 3,858,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.084,547,725 - 4,549,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl84,547,725 - 4,549,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.084,561,559 - 4,563,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.483,237,986 - 3,239,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera85,168,510 - 5,170,357 (-)NCBICelera
Cytogenetic Map8q11NCBI
DDI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811104,036,640 - 104,039,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11104,036,640 - 104,039,196 (+)EnsemblGRCh38hg38GRCh38
GRCh3711103,907,368 - 103,909,924 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611103,412,518 - 103,415,132 (+)NCBINCBI36Build 36hg18NCBI36
Celera11101,068,396 - 101,071,010 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef1199,836,907 - 99,839,521 (+)NCBIHuRef
CHM1_111103,790,273 - 103,792,887 (+)NCBICHM1_1
T2T-CHM13v2.011104,040,522 - 104,043,078 (+)NCBIT2T-CHM13v2.0
Ddi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3996,265,028 - 6,266,547 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl96,262,733 - 6,269,846 (-)EnsemblGRCm39 Ensembl
GRCm3896,265,028 - 6,266,547 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl96,262,733 - 6,269,846 (-)EnsemblGRCm38mm10GRCm38
MGSCv3796,265,028 - 6,266,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3696,262,733 - 6,269,846 (-)NCBIMGSCv36mm8
Celera93,670,260 - 3,671,779 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Ddi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554126,981,036 - 6,982,346 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554126,980,778 - 6,982,453 (+)NCBIChiLan1.0ChiLan1.0
DDI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29104,814,654 - 104,891,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111105,920,410 - 105,924,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,981,511 - 98,983,500 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111102,465,983 - 102,467,513 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11102,466,220 - 102,467,398 (+)Ensemblpanpan1.1panPan2
DDI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1527,976,439 - 27,977,959 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl527,965,768 - 27,977,749 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha527,915,715 - 27,917,219 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0528,023,167 - 28,024,671 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl528,023,275 - 28,024,477 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1528,056,953 - 28,058,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0527,943,554 - 27,945,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0528,117,729 - 28,119,233 (-)NCBIUU_Cfam_GSD_1.0
Ddi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494787,448,278 - 87,449,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365514,086,744 - 4,088,006 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365514,086,113 - 4,088,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl934,503,716 - 34,504,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1934,503,087 - 34,505,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2938,497,161 - 38,498,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,423,135 - 95,425,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,423,431 - 95,424,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604330,463,747 - 30,466,101 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249181,177,614 - 1,179,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249181,177,679 - 1,179,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddi1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:24
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000039868
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 4 10 2 8 8 7 8 6 8 8
Below cutoff 5 14 8 15 8 1 5 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl83,595,149 - 3,598,533 (-)Ensembl
Rnor_6.0 Ensembl84,547,729 - 4,549,573 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl84,547,725 - 4,549,573 (-)Ensembl
RefSeq Acc Id: NM_001085475   ⟹   NP_001078944
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8811,881,544 - 11,883,391 (-)NCBI
mRatBN7.283,596,658 - 3,598,505 (-)NCBI
Rnor_6.084,547,725 - 4,549,573 (-)NCBI
Rnor_5.084,561,559 - 4,563,407 (-)NCBI
RGSC_v3.483,237,986 - 3,239,833 (-)RGD
Celera85,168,510 - 5,170,357 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001078944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0JPP7 (Get FASTA)   NCBI Sequence Viewer  
  AAI27532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091127
  ENSRNOP00000091127.1
  ENSRNOP00065002653
Reference Protein Sequences
RefSeq Acc Id: NP_001078944   ⟸   NM_001085475
- UniProtKB: A0JPP7 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPP7-F1-model_v2 AlphaFold A0JPP7 1-408 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559430 AgrOrtholog
BioCyc Gene G2FUF-31803 BioCyc
Ensembl Genes ENSRNOG00000022081 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065002762 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039868 ENTREZGENE
  ENSRNOT00000039868.4 UniProtKB/Swiss-Prot
  ENSRNOT00065003775 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131649 IMAGE-MGC_LOAD
InterPro DDI1_N UniProtKB/Swiss-Prot
  Peptidase_aspartic_DDI1-type UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/Swiss-Prot
KEGG Report rno:367012 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156792 IMAGE-MGC_LOAD
NCBI Gene 367012 ENTREZGENE
PANTHER DNA DAMAGE-INDUCIBLE 1 HOMOLOG 2 UniProtKB/Swiss-Prot
  SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED UniProtKB/Swiss-Prot
Pfam Asp_protease UniProtKB/Swiss-Prot
  ubiquitin UniProtKB/Swiss-Prot
PhenoGen Ddi1 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022081 RatGTEx
  ENSRNOG00065002762 RatGTEx
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0JPP7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Ddi1  DNA-damage inducible 1 homolog 1  Ddi1  DNA-damage inducible 1 homolog 1 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ddi1  DNA-damage inducible 1 homolog 1 (S. cerevisiae)  Ddi1  DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Ddi1  DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)  RGD1559430_predicted  similar to DNA-damage inducible protein 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559430_predicted  similar to DNA-damage inducible protein 1 (predicted)  LOC367012  similar to DNA-damage inducible protein 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367012  similar to DNA-damage inducible protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL