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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:perinatal necrotizing enterocolitis
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Accession:DOID:8677 term browser browse the term
Definition:ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.
Synonyms:exact_synonym: NEC;   necrotizing enterocolitis;   necrotizing enterocolitis in fetus or newborn;   perinatal necrotising enterocolitis;   pseudomembranous enterocolitis in newborn
 primary_id: MESH:D020345
 xref: EFO:0003928;   ICD10CM:K55.3;   ICD10CM:K55.30
For additional species annotation, visit the Alliance of Genome Resources.


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perinatal necrotizing enterocolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A susceptibility IMP RGD PMID:21788941 RGD:8657143 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Becn1 beclin 1, autophagy related ISO protein:increased expression:intestine RGD PMID:20539009 RGD:6483081 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 ISO protein:increased expression:ileum RGD PMID:16002567 RGD:11561971 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cd14 CD14 antigen disease_progression ISO protein:increased expression:small intestine RGD PMID:19824106 PMID:19824106 RGD:4144091, RGD:4144091 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd40 CD40 antigen ISO protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand ISO protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cryl1 crystallin, lambda 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr14:57,512,491...57,635,940
Ensembl chr14:57,512,450...57,635,986 		JBrowse link
G Egf epidermal growth factor treatment ISO RGD PMID:19390485 PMID:18607263 RGD:2317627, RGD:10395236 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16567187 PMID:18607263 RGD:10395236 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Hspa9 heat shock protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma treatment ISO RGD PMID:17426653 RGD:12791281 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Il10 interleukin 10 treatment ISO
IMP		 RGD PMID:23783008 PMID:22450025 RGD:7365018, RGD:11049491 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il10rb interleukin 10 receptor, beta ISO protein:increased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr16:91,203,166...91,222,718
Ensembl chr16:91,203,052...91,222,722 		JBrowse link
G Il18 interleukin 18 IMP
ISO		 protein:increased expression:ileum
protein:increased expression:liver		 RGD PMID:17947451 PMID:21240009 PMID:12529262 PMID:12032269 RGD:4889475, RGD:5490305, RGD:4889473, RGD:729222 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23158403 RGD:7175550 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:20501441 RGD:2324672 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lgals2 lectin, galactose-binding, soluble 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr15:78,735,060...78,739,729
Ensembl chr15:78,735,060...78,739,729 		JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16640825 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased expression:intestine: RGD PMID:20716917 RGD:10412640 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Muc2 mucin 2 ISO mRNA:decreased expression:ileum RGD PMID:20501441 RGD:2324672 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IMP RGD PMID:20580721 RGD:8547529 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:17923197 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell ISO CTD Direct Evidence: marker/mechanism CTD PMID:23650378 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Oat ornithine aminotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 severity ISO protein:increased expression:intestinal mucosa RGD PMID:21399558 PMID:21399558 RGD:10413911, RGD:10413911 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:1304722 RGD:6483787 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393 		JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:17515866 RGD:9999208 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Snai3 snail family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 8:123,180,943...123,187,546
Ensembl chr 8:123,180,947...123,187,472 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sord sorbitol dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 2:122,065,320...122,095,818
Ensembl chr 2:122,065,230...122,095,821 		JBrowse link
G Tjp1 tight junction protein 1 ISO protein:increased expression:liver RGD PMID:19390485 RGD:2317627 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tlr1 toll-like receptor 1 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr 5:65,082,023...65,090,945
Ensembl chr 5:65,082,022...65,090,906 		JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr3 toll-like receptor 3 ISO mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA:increased expression:ileum
CTD Direct Evidence: marker/mechanism
protein:increased expression:ileum		 CTD
RGD		 PMID:23650378 PMID:19608731 PMID:21240009 RGD:5128779, RGD:5490305 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr5 toll-like receptor 5 ISO mRNA:decreased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010 		JBrowse link
G Tlr6 toll-like receptor 6 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440 		JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum (rat); protein:increased expression:intestine (human)
mRNA:increased expression:ileum (rat)		 RGD PMID:19824106 PMID:20501441 PMID:16269520 RGD:4144091, RGD:2324672, RGD:1580205 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tubb5 tubulin, beta 5 class I EXP CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16107
    disease of anatomical entity 15663
      gastrointestinal system disease 6787
        gastroenteritis 538
          Enterocolitis 61
            perinatal necrotizing enterocolitis 46
Path 2
Term Annotations click to browse term
  disease 16107
    disease of anatomical entity 15663
      Immune & Inflammatory Diseases 5179
        Inflammation 2529
          gastroenteritis 538
            Enterocolitis 61
              perinatal necrotizing enterocolitis 46
paths to the root