Gene: Tlr2 (toll-like receptor 2)  Mus musculus Symbol: Tlr2 Name: toll-like receptor 2 Description: ENCODES a protein that exhibits diacyl lipopeptide binding; lipoteichoic acid binding; protein heterodimerization activity; INVOLVED IN cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; PARTICIPATES IN Toll-like receptor signaling pathway; Entamoeba histolyca infection pathway; Leishmania infection pathway; ASSOCIATED WITH abnormal adipocyte glucose uptake; abnormal adipose tissue amount; abnormal adrenal cortex morphology; ASSOCIATED WITH Acute Kidney Injury; Acute Tubulointerstitial Nephritis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; FOUND IN external side of plasma membrane; plasma membrane; Toll-like receptor 2-Toll-like receptor 6 protein complex; INTERACTS WITH (+)-pilocarpine; (-)-citrinin; 1-chloro-2,4,6-trinitrobenzene Type: protein-coding RefSeq Status: VALIDATED Also known as: Ly105; toll-like receptor 2 Orthologs: Homo sapiens : TLR2 (toll-like receptor 2)  HGNC Rattus norvegicus : Tlr2 (toll-like receptor 2) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,272 - 83,841,608 - NCBI Mouse cM Map 3   - NCBI Mouse Celera Assembly 3 83,852,064 - 83,857,400 - NCBI Mouse Genome Assembly Build 37 3 83,640,194 - 83,645,530 - NCBI Mouse Genome Assembly Build 36.1 3 83,640,194 - 83,645,689 - NCBI Mouse Cytogenetic Map 3 E3   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   IPM   7207898 associated with Sepsis RGD   Acute Tubulointerstitial Nephritis   IPM   7207900   RGD   Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis   IED   7240543   RGD   Arthritis, Experimental   ISS RGD:735138 7241099   RGD   Aspergillosis   IEP   4145322 mRNA:increased expression:lung RGD   Asthma Susceptibility ISS RGD:1353654 4144228 DNA:SNP: :596T>C (human) RGD   Asthma Susceptibility ISS RGD:1353654 4144171 DNA:SNP: :rs4696480 (human) RGD   Asthma   IEP   4145343   RGD   Asthma   ISS RGD:1353654 2312679 DNA:SNP: :rs3804100 (human) RGD   Asthma   IPM   4145334   RGD   Asthma Susceptibility ISS RGD:1353654 4145352 DNA:SNP: :rs7656411 (human) RGD   Brain Injuries   ISS RGD:735138 2312713 mRNA:increased expression:brain RGD   Carotid Stenosis Treatment ISS RGD:735138 7241095   RGD   Colorectal Neoplasms   ISS RGD:1353654 7240710   OMIM   Cough   ISS RGD:1353654 7240539 protein:decreased expression:sputum, macrophage RGD   Diabetes Mellitus, Experimental   ISS RGD:735138 2312491   RGD   Diabetes Mellitus, Experimental   IAGP   2312684   RGD   Diabetes Mellitus, Type 1   ISS RGD:1353654 2312679 DNA:SNP: :rs3804100 (human) RGD   Diabetes Mellitus, Type 1   ISS RGD:1353654 2312686 DNA:SNP: :1350T>C (human) RGD   Diabetes Mellitus, Type 1   ISS RGD:1353654 2312683 protein:increased expression:monocyte RGD   Diabetes Mellitus, Type 1 No_Association ISS RGD:1353654 2312687 DNA:SNP: :1350T>C (human) RGD   Diabetes Mellitus, Type 1   IAGP   2312684   RGD   Diabetic Nephropathies   IPM   7241083 associated with Diabetes Mellitus, Experimental RGD   Dyslipidemias   ISS RGD:1551003 7241091   RGD   Encephalomyelitis, Autoimmune, Experimental   ISS RGD:735138 2312575 protein:increased expression:spinal cord RGD   Endotoxemia Treatment ISS RGD:735138 7241094   RGD   Enterocolitis, Necrotizing   ISS RGD:735138 5128779 mRNA:increased expression:ileum RGD   Fever   IPM   7241096   RGD   Gastroesophageal Reflux   ISS RGD:1353654 7240539 protein:decreased expression:sputum, macrophage RGD   Glomerulonephritis   IPM   7241071   RGD   Gram-Positive Bacterial Infections   IPM   7240560   RGD   Inflammation   IPM   7240558 associated with Ureteral Obstruction RGD   Inflammation   IED   4889537 associated with Respiratory Hypersensitivity RGD   Inflammation   ISS RGD:735138 4889539   RGD   Influenza, Human   ISS RGD:1353654 4145339 protein:increased expression:monocyte RGD   Kidney Failure, Chronic   ISS RGD:1353654 7240546   RGD   Kidney Reperfusion Injury   IPM   7240552   RGD   Kidney Reperfusion Injury Severity IPM   7207896   RGD   Kidney Reperfusion Injury Treatment IED   7207894   RGD   Kidney Reperfusion Injury Treatment ISS RGD:735138 7207892   RGD   Kidney Reperfusion Injury   IEP   7241087   RGD   Leprosy   ISS RGD:1353654 7240710   OMIM   Leptospirosis   IPM   7240557   RGD   Liver Cirrhosis, Experimental Treatment ISS RGD:735138 7241092   RGD   Lung Diseases   ISS RGD:735138 4145321 associated with Hyperoxia;mRNA, protein:increased expression:lung RGD   Lung Diseases   ISS RGD:1353654 4145340 associated with Mycobacterium avium-intracellulare Infection;DNA:polymorphism:intron (human) RGD   Lung Diseases   ISS RGD:735138 2312725 associated with Pancreatitis, Acute Necrotizing RGD   Lung Diseases   ISS RGD:735138 4145303 Acute Lung Injury;mRNA:increased expression:lung RGD   MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO   ISS RGD:1353654 7240710   OMIM   Myocardial Reperfusion Injury   ISS RGD:735138 2312688   RGD   Neuritis, Autoimmune, Experimental Severity ISS RGD:735138 2312712   RGD   Obesity   IPM   2312681   RGD   Pancreatitis   ISS RGD:735138 2312507   RGD   Pancreatitis, Acute Necrotizing   ISS RGD:735138 2312724 mRNA:increased expression:liver RGD   Pneumonia Susceptibility IPM   4145330   RGD   Pneumonia, Bacterial   IPM   4145337   RGD   Pneumonia, Bacterial   ISS RGD:735138 4889533   RGD   Pneumonia, Pneumococcal   IPM   4145321   RGD   Pneumonia, Pneumocystis   IPM   4145341   RGD   Prostatic Neoplasms   ISS RGD:1353654 7207899 DNA:deletion:promoter:−196_−174del (human) RGD   Pulmonary Emphysema   IEP   4145342 protein:increased expression:alveolar macrophage RGD   Pulmonary Fibrosis   IPM   4144177   RGD   Pulmonary Fibrosis   IPM   4145324 associated with Pneumonia RGD   Renal Fibrosis   ISS RGD:735138 7207895 associated with Ureteral Obstruction RGD   Renal Insufficiency   ISS RGD:735138 7241085   RGD   Reperfusion Injury   ISS RGD:735138 2312727 mRNA, protein:increased expression:kidney RGD   Respiratory Syncytial Virus Infections   IPM   4889534   RGD   Rhinitis No_Association ISS RGD:1353654 4145356 associated with Sinusitis;DNA:SNPs: :multiple (human) RGD   Rhinitis Susceptibility ISS RGD:1353654 4145354 DNA:SNPs: :597T>C, 1350T>C (human) RGD   Sarcoidosis, Pulmonary   ISS RGD:1353654 4145301 mRNA:decreased expression:alveolar macrophage RGD   Sepsis   ISS RGD:735138 2312732   RGD   Sepsis   ISS RGD:735138 1302750 associated with Burns;mRNA:increased expression:liver, lung, kidney RGD   Sepsis   ISS RGD:735138 2312497 associated with Liver Diseases;mRNA:increased expression:liver RGD   Streptococcal Infections Severity IPM   7240559   RGD   Transplant Rejection   IPM   7240555   RGD   Transplant Rejection   IPM   7207901   RGD   Transplant Rejection   ISS RGD:735138 7240551 kidney RGD   Transplant Rejection   ISS RGD:1353654 7240554 liver;DNA:SNP: :p.R753Q (human) RGD   Transplant Rejection   ISS RGD:1353654 7240551 kidney RGD   Tuberculosis   ISS RGD:1353654 7240710   OMIM   Tuberculosis, Pulmonary   ISS RGD:1353654 4145355 mRNA, protein:increased expression:blood, T cell RGD   Tuberculosis, Pulmonary   ISS RGD:1353654 4145320 DNA:polymorphisms: :multiple (human) RGD   Tuberculosis, Pulmonary Susceptibility ISS RGD:1353654 4145304 DNA:polymorphism:intron (human) RGD   Tuberculosis, Pulmonary Susceptibility ISS RGD:1353654 4145323 DNA:SNP: :rs1816702 (human) RGD   Urinary Bladder Neoplasms   ISS RGD:1353654 7207893 DNA:deletion:promoter:−196_−174del (human) RGD   Urinary Tract Infections Susceptibility ISS RGD:1353654 7240561 DNA:polymorphism: :p.R753Q (human) RGD   Wallerian Degeneration   IAGP   2312723   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-pilocarpine increases expression EXP   6480464 Pilocarpine results in increased expression of TLR2 mRNA CTD PMID:15193289 (-)-citrinin increases expression EXP   6480464 Citrinin results in increased expression of TLR2 mRNA CTD PMID:22771370 1-chloro-2,4,6-trinitrobenzene multiple interactions EXP   6480464 TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 17alpha-ethynylestradiol increases expression ISO RGD:735138 6480464 Ethinyl Estradiol results in increased expression of TLR2 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:1353654 6480464 [Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA CTD PMID:17404688 17beta-estradiol increases expression ISO RGD:1353654 6480464 Estradiol results in increased expression of TLR2 mRNA CTD PMID:23373633 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of TLR2 mRNA CTD PMID:21570461 adapalene decreases expression ISO RGD:1353654 6480464 adapalene results in decreased expression of TLR2 protein CTD PMID:17518990 afimoxifene increases expression ISO RGD:1353654 6480464 4-hydroxytamoxifen results in increased expression of TLR2 mRNA CTD PMID:23373633 aflatoxin B1 increases expression EXP   6480464 Aflatoxin B1 results in increased expression of TLR2 protein CTD PMID:22445859 all-trans-retinol increases expression ISO RGD:1353654 6480464 Vitamin A results in increased expression of TLR2 mRNA CTD PMID:17033190 ammonium hexachloroplatinate affects expression ISO RGD:1353654 6480464 ammonium hexachloroplatinate affects the expression of TLR2 mRNA CTD PMID:19110044 astemizole decreases expression ISO RGD:735138 6480464 Astemizole results in decreased expression of TLR2 mRNA CTD PMID:20221588 benzene increases expression ISO RGD:1353654 6480464 Benzene results in increased expression of TLR2 mRNA CTD PMID:15929907 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of TLR2 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide increases expression EXP   6480464 Mustard Gas results in increased expression of TLR2 mRNA CTD PMID:18955075 bisdemethoxycurcumin multiple interactions ISO RGD:1353654 6480464 [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA; more ... CTD PMID:22029407 bisphenol A decreases expression ISO RGD:1353654 6480464 bisphenol A results in decreased expression of TLR2 mRNA CTD PMID:20678512 cadmium dichloride decreases expression EXP   6480464 Cadmium Chloride results in decreased expression of TLR2 mRNA CTD PMID:20061341 cefaloridine increases expression ISO RGD:735138 6480464 Cephaloridine results in increased expression of TLR2 mRNA CTD PMID:18500788 cerium trichloride increases expression EXP   6480464 cerous chloride results in increased expression of TLR2 protein; more ... CTD PMID:21656643 chitosan multiple interactions ISO RGD:1353654 6480464 Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA] CTD PMID:21329777 chitosan decreases expression ISO RGD:1353654 6480464 Chitosan results in decreased expression of TLR2 mRNA CTD PMID:21329777 ciguatoxin CTX1B affects expression EXP   6480464 Ciguatoxins affects the expression of TLR2 mRNA CTD PMID:18353800 cisplatin increases expression ISO RGD:1353654 6480464 Cisplatin results in increased expression of TLR2 protein CTD PMID:16803524 cobalt atom multiple interactions ISO RGD:1353654 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA CTD PMID:18078969 cortisol increases expression ISO RGD:1353654 6480464 Hydrocortisone results in increased expression of TLR2 mRNA CTD PMID:17033190 curcumin multiple interactions ISO RGD:735138 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:22683883 cyclosporin A increases expression ISO RGD:1353654 6480464 Cyclosporine results in increased expression of TLR2 mRNA CTD PMID:20106945 D-glucose decreases expression ISO RGD:1353654 6480464 Glucose results in decreased expression of TLR2 protein CTD PMID:20200188 diarsenic trioxide decreases expression ISO RGD:1353654 6480464 arsenic trioxide results in decreased expression of TLR2 mRNA CTD PMID:20471514 diarsenic trioxide multiple interactions ISO RGD:1353654 6480464 bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA] CTD PMID:20471514 disodium selenite decreases expression EXP   6480464 Sodium Selenite results in decreased expression of TLR2 mRNA CTD PMID:23274088 dopamine increases expression ISO RGD:735138 6480464 Dopamine results in increased expression of TLR2 mRNA CTD PMID:21983523 doxorubicin multiple interactions EXP   6480464 TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of RELA protein]; more ... CTD PMID:15505089 doxorubicin decreases response to substance EXP   6480464 TLR2 gene mutant form results in decreased susceptibility to Doxorubicin CTD PMID:15505089 fenoldopam increases expression ISO RGD:735138 6480464 Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 ferulic acid multiple interactions EXP   6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:21291945 fonofos increases methylation ISO RGD:1353654 6480464 Fonofos results in increased methylation of TLR2 promoter CTD PMID:22847954 furan increases methylation ISO RGD:735138 6480464 furan results in increased methylation of TLR2 gene CTD PMID:22079235 glucose decreases expression ISO RGD:1353654 6480464 Glucose results in decreased expression of TLR2 protein CTD PMID:20200188 glutathione decreases expression ISO RGD:1353654 6480464 Glutathione results in decreased expression of TLR2 mRNA CTD PMID:22385246 hexamethylene diisocyanate affects expression ISO RGD:1353654 6480464 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 histamine multiple interactions ISO RGD:1353654 6480464 Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; more ... CTD PMID:20040740 hydroxycitronellal increases expression ISO RGD:1353654 6480464 hydroxycitronellal results in increased expression of TLR2 mRNA CTD PMID:17936526 isoeugenol increases expression ISO RGD:1353654 6480464 isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 lycopene multiple interactions ISO RGD:1353654 6480464 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; more ... CTD PMID:22429818 muramyl dipeptide increases activity ISO RGD:1353654 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein CTD PMID:15905553 muramyl dipeptide increases response to substance EXP   6480464 TLR2 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog CTD PMID:15905553 muramyl dipeptide increases activity EXP   6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein CTD PMID:15905553 N-acetyl-L-cysteine decreases expression ISO RGD:1353654 6480464 Acetylcysteine results in decreased expression of TLR2 mRNA CTD PMID:22385246 N-nitrosodiethylamine multiple interactions ISO RGD:735138 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA CTD PMID:18164116 nitroprusside multiple interactions EXP   6480464 [Nitroprusside co-treated with TNFA co-treated with IFNG] results in increased expression of TLR2 mRNA CTD PMID:15153526 ozone multiple interactions EXP   6480464 [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA CTD PMID:16864405 ozone decreases response to substance EXP   6480464 TLR2 gene mutant form results in decreased susceptibility to Ozone CTD PMID:17626835 ozone multiple interactions EXP   6480464 TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; more ... CTD PMID:17626835 ozone increases expression EXP   6480464 Ozone results in increased expression of TLR2 mRNA CTD PMID:17626835 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of TLR2 mRNA CTD PMID:17562736 parathion increases methylation ISO RGD:1353654 6480464 Parathion results in increased methylation of TLR2 promoter CTD PMID:22847954 phenobarbital affects expression ISO RGD:1353654 6480464 Phenobarbital affects the expression of TLR2 mRNA CTD PMID:19159669 pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TLR2 mRNA CTD PMID:19710929 progesterone multiple interactions ISO RGD:1353654 6480464 [Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA CTD PMID:17404688 progesterone increases expression ISO RGD:1353654 6480464 Progesterone results in increased expression of TLR2 mRNA CTD PMID:17404688 propiconazole increases expression EXP   6480464 propiconazole results in increased expression of TLR2 mRNA CTD PMID:21278054 propiconazole increases expression EXP   6480464 propiconazole results in increased expression of TLR2 mRNA CTD PMID:21278054 PMID:22334560 prostaglandin E2 multiple interactions ISO RGD:1353654 6480464 Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] CTD PMID:20040740 silicon dioxide increases expression ISO RGD:735138 6480464 Silicon Dioxide results in increased expression of TLR2 mRNA CTD PMID:21602193 simvastatin increases expression ISO RGD:1353654 6480464 Simvastatin results in increased expression of TLR2 protein CTD PMID:16387846 simvastatin multiple interactions ISO RGD:1353654 6480464 Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] CTD PMID:16443229 sodium dichromate decreases expression ISO RGD:735138 6480464 sodium bichromate results in decreased expression of TLR2 mRNA CTD PMID:22561333 sodium dodecyl sulfate increases expression ISO RGD:1353654 6480464 Sodium Dodecyl Sulfate results in increased expression of TLR2 mRNA CTD PMID:17936526 sulfasalazine multiple interactions EXP   6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 sulindac multiple interactions ISO RGD:735138 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA CTD PMID:20371263 terbufos increases methylation ISO RGD:1353654 6480464 terbufos results in increased methylation of TLR2 promoter CTD PMID:22847954 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of TLR2 mRNA; more ... CTD PMID:21291945 tetrachloromethane multiple interactions ISO RGD:735138 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:22683883 tetrachloromethane increases expression ISO RGD:735138 6480464 Carbon Tetrachloride results in increased expression of TLR2 mRNA; more ... CTD PMID:22683883 tetrachloromethane multiple interactions EXP   6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:21291945 titanium atom multiple interactions ISO RGD:735138 6480464 [Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA CTD PMID:21308757 trimellitic anhydride affects expression ISO RGD:1353654 6480464 trimellitic anhydride affects the expression of TLR2 mRNA CTD PMID:19110044 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface pattern recognition receptor signaling pathway   IMP MGI:MGI:2178675 2290270 MGI:MGI:3042099|PMID:12719478 MGI MGI:MGI:3042099 PMID:12719478 cellular response to bacterial lipopeptide   IMP MGI:MGI:2674036 2290270 MGI:MGI:3528769|PMID:15690042 MGI MGI:MGI:3528769 PMID:15690042 cellular response to bacterial lipopeptide   TAS   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 cellular response to diacyl bacterial lipopeptide   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 cellular response to lipoteichoic acid   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 cellular response to lipoteichoic acid   IMP MGI:MGI:2674036 2290270 MGI:MGI:3528769|PMID:15690042 MGI MGI:MGI:3528769 PMID:15690042 cellular response to peptidoglycan   IMP   2290270 MGI:MGI:3686795|PMID:16949315 MGI MGI:MGI:3686795 PMID:16949315 cellular response to triacyl bacterial lipopeptide   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 central nervous system myelin formation   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 chloramphenicol transport   IMP MGI:MGI:2178675 2290270 MGI:MGI:3526877|PMID:12091878 MGI MGI:MGI:3526877 PMID:12091878 defense response to bacterium   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 defense response to Gram-positive bacterium   IMP MGI:MGI:2674036 2290270 MGI:MGI:3839525|PMID:19139201 MGI MGI:MGI:3839525 PMID:19139201 defense response to Gram-positive bacterium   IMP MGI:MGI:2178675 2290270 MGI:MGI:3619313|PMID:11067888 MGI MGI:MGI:3619313 PMID:11067888 defense response to Gram-positive bacterium   IMP MGI:MGI:2674036 2290270 MGI:MGI:3528769|PMID:15690042 MGI MGI:MGI:3528769 PMID:15690042 detection of diacyl bacterial lipopeptide   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 detection of triacyl bacterial lipopeptide   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 I-kappaB phosphorylation   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 immune response   IEA InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 induction by symbiont of defense-related host nitric oxide production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 inflammatory response   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 innate immune response   TAS   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 leukotriene metabolic process   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 microglial cell activation involved in immune response   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 MyD88-dependent toll-like receptor signaling pathway   IGI MGI:MGI:108005 2290270 MGI:MGI:3042099|PMID:12719478 MGI MGI:MGI:3042099 PMID:12719478 negative regulation of cell proliferation   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of growth of symbiont in host   IMP MGI:MGI:2674036 2290270 MGI:MGI:3528769|PMID:15690042 MGI MGI:MGI:3528769 PMID:15690042 negative regulation of growth of symbiont in host   IMP MGI:MGI:2178675 2290270 MGI:MGI:3619313|PMID:11067888 MGI MGI:MGI:3619313 PMID:11067888 negative regulation of interleukin-12 production   IMP   2290270 MGI:MGI:3686795|PMID:16949315 MGI MGI:MGI:3686795 PMID:16949315 negative regulation of interleukin-17 production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 nitric oxide metabolic process   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of chemokine production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 positive regulation of chemokine production   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cytokine secretion   IGI MGI:MGI:2157947 2290270 MGI:MGI:4365650|PMID:19770268 MGI MGI:MGI:4365650 PMID:19770268 positive regulation of interferon-beta production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-10 production   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of interleukin-12 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-18 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-6 production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3619313|PMID:11067888 MGI MGI:MGI:3619313 PMID:11067888 positive regulation of interleukin-6 production   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-6 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-6 production   IMP MGI:MGI:2178675 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of interleukin-6 production   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of interleukin-8 production   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of leukocyte migration   IMP MGI:MGI:2674036 2290270 MGI:MGI:3814295|PMID:17114491 MGI MGI:MGI:3814295 PMID:17114491 positive regulation of macrophage cytokine production   IMP MGI:MGI:2178675 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of NF-kappaB import into nucleus   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of NF-kappaB transcription factor activity   ISO UniProtKB:O60603 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 positive regulation of nitric oxide biosynthetic process   IMP MGI:MGI:2178675 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of nitric oxide biosynthetic process   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 positive regulation of nitric-oxide synthase biosynthetic process   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of oligodendrocyte differentiation   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of toll-like receptor signaling pathway   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of tumor necrosis factor biosynthetic process   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 positive regulation of tumor necrosis factor production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3042099|PMID:12719478 MGI MGI:MGI:3042099 PMID:12719478 positive regulation of tumor necrosis factor production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of tumor necrosis factor production   IMP MGI:MGI:2674036 2290270 MGI:MGI:3528769|PMID:15690042 MGI MGI:MGI:3528769 PMID:15690042 positive regulation of tumor necrosis factor production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3611539|PMID:16239543 MGI MGI:MGI:3611539 PMID:16239543 positive regulation of tumor necrosis factor production   IMP MGI:MGI:2178675 2290270 MGI:MGI:3619313|PMID:11067888 MGI MGI:MGI:3619313 PMID:11067888 positive regulation of tumor necrosis factor production   IMP MGI:MGI:2178675 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of Wnt receptor signaling pathway   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 response to bacterial lipoprotein   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to bacterium   IMP MGI:MGI:2674036 2290270 MGI:MGI:3814295|PMID:17114491 MGI MGI:MGI:3814295 PMID:17114491 response to fatty acid   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to molecule of fungal origin   IMP MGI:MGI:2178675 2290270 MGI:MGI:3042099|PMID:12719478 MGI MGI:MGI:3042099 PMID:12719478 response to peptidoglycan   IMP MGI:MGI:2674036 2290270 MGI:MGI:3814295|PMID:17114491 MGI MGI:MGI:3814295 PMID:17114491 response to peptidoglycan   IMP MGI:MGI:2178675 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 signal transduction   IEA InterPro:IPR004075|InterPro:IPR000157 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 toll-like receptor signaling pathway   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell body   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cell projection   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cell surface   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cell surface   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytoplasm   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cytoplasmic vesicle   IEA UniProtKB-KW:KW-0968 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 external side of plasma membrane   IDA   2290270 MGI:MGI:3050756|PMID:15220916 MGI MGI:MGI:3050756 PMID:15220916 integral to membrane   IEA InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 integral to membrane   IEA UniProtKB-KW:KW-0812 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 intrinsic to membrane   IEA InterPro:IPR004075 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 membrane   IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 plasma membrane   IDA   2290270 MGI:MGI:3042099|PMID:12719478 MGI MGI:MGI:3042099 PMID:12719478 plasma membrane   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Toll-like receptor 1-Toll-like receptor 2 protein complex   ISO UniProtKB:O60603 2290270 MGI:MGI:4437881|PMID:17889651 MGI MGI:MGI:4437881 PMID:17889651 Toll-like receptor 2-Toll-like receptor 6 protein complex   IPI UniProtKB:Q9EPW9 2290270 MGI:MGI:4419037|PMID:19931471 MGI MGI:MGI:4419037 PMID:19931471 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) diacyl lipopeptide binding   IDA   2290270 MGI:MGI:4419037|PMID:19931471 MGI MGI:MGI:4419037 PMID:19931471 diacyl lipopeptide binding   IDA   2290270 MGI:MGI:4437881|PMID:17889651 MGI MGI:MGI:4437881 PMID:17889651 Gram-positive bacterial cell surface binding   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 lipopeptide binding   ISO NCBI:NP_942064 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 lipoteichoic acid binding   IDA   2290270 MGI:MGI:4419037|PMID:19931471 MGI MGI:MGI:4419037 PMID:19931471 pattern recognition receptor activity   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 peptidoglycan binding   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein binding   IPI UniProtKB:Q99JY1 2290270 MGI:MGI:4943396|PMID:17322885 BHF-UCL MGI:MGI:4943396 PMID:17322885 protein heterodimerization activity   IPI UniProtKB:Q9EPW9 2290270 MGI:MGI:4419037|PMID:19931471 MGI MGI:MGI:4419037 PMID:19931471 protein heterodimerization activity   ISO UniProtKB:O60603 2290270 MGI:MGI:4437881|PMID:17889651 MGI MGI:MGI:4437881 PMID:17889651 receptor activity   ISO UniProtKB:O60603 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transmembrane signaling receptor activity   IEA InterPro:IPR004075|InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 triacyl lipopeptide binding   ISO UniProtKB:O60603 2290270 MGI:MGI:4437881|PMID:17889651 MGI MGI:MGI:4437881 PMID:17889651 triacyl lipopeptide binding   IDA   2290270 MGI:MGI:4437881|PMID:17889651 MGI MGI:MGI:4437881 PMID:17889651 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Entamoeba histolyca infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05146 Leishmania infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05140 measles infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05162 Mycobacterium tuberculosis infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05152 Plasmodium infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05144 rheumatoid arthritis pathway   IEA RGD:1551003 6907045   KEGG mmu:05323 Toll-like receptor signaling pathway   ISS RGD:735138 1643119   RGD   Toll-like receptor signaling pathway   IEA RGD:1551003 6907045   KEGG mmu:04620 Toll-like receptor signaling pathway   ISS RGD:735138 5684896   RGD   Toll-like receptor signaling pathway   ISS RGD:1353654 5685014   RGD   Toxoplasma gondii infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05145 Trypanosoma cruzi infection pathway   IEA RGD:1551003 6907045   KEGG mmu:05142 External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B Herpes simplex infection Legionellosis Leishmaniasis Malaria Measles Phagosome PI3K-Akt signaling pathway Proteoglycans in cancer Rheumatoid arthritis Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal adipocyte glucose uptake   IAGP   5509061   MGI PMID:20407745 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:19841034 abnormal adrenal cortex morphology   IAGP   5509061   MGI PMID:15546996 abnormal adrenal gland morphology   IAGP   5509061   MGI PMID:15546996 abnormal adrenal gland secretion   IAGP   5509061   MGI PMID:15546996 abnormal airway responsiveness   IAGP   5509061   MGI PMID:17626835 abnormal astrocyte morphology   IAGP   5509061   MGI PMID:17704767 abnormal astrocyte physiology   IAGP   5509061   MGI PMID:17355971 abnormal cellular extravasation   IAGP   5509061   MGI PMID:20708624 abnormal cellular extravasation   IAGP   5509061   MGI PMID:18250194 abnormal chemokine level   IAGP   5509061   MGI PMID:14739339 abnormal chemokine secretion   IAGP   5509061   MGI PMID:16244651 abnormal circulating cholesterol level   IAGP   5509061   MGI PMID:19841034 abnormal circulating corticosterone level   IAGP   5509061   MGI PMID:15546996 abnormal circulating glucose level   IAGP   5509061   MGI PMID:19841034 abnormal circulating insulin level   IAGP   5509061   MGI PMID:19841034 abnormal circulating LDL cholesterol level   IAGP   5509061   MGI PMID:19841034 abnormal circulating lipid level   IAGP   5509061   MGI PMID:19841034 abnormal circulating pituitary hormone level   IAGP   5509061   MGI PMID:15546996 abnormal cytokine secretion   IAGP   5509061   MGI PMID:11431423 abnormal cytokine secretion   IAGP   5509061   MGI PMID:17118979 abnormal cytokine secretion   IAGP   5509061   MGI PMID:17353199 abnormal dendritic cell physiology   IAGP   5509061   MGI PMID:16461338 abnormal endoplasmic reticulum morphology   IAGP   5509061   MGI PMID:15546996 abnormal enterocyte morphology   IAGP   5509061   MGI PMID:17408640 abnormal fat pad morphology   IAGP   5509061   MGI PMID:20407745 abnormal glial cell physiology   IAGP   5509061   MGI PMID:17355971 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:17707128 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:19841034 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:20407745 abnormal heart morphology   IAGP   5509061   MGI PMID:14656915 abnormal heart ventricle morphology   IAGP   5509061   MGI PMID:14656915 abnormal hepatocyte morphology   IAGP   5509061   MGI PMID:16118350 abnormal innate immunity   IAGP   5509061   MGI PMID:11751980 abnormal interleukin level   IAGP   5509061   MGI PMID:16461338 abnormal interleukin secretion   IAGP   5509061   MGI PMID:15546996 abnormal intestinal epithelium morphology   IAGP   5509061   MGI PMID:20885960 abnormal large intestine crypts of Lieberkuhn morphology   IAGP   5509061   MGI PMID:20885960 abnormal leukocyte migration   IAGP   5509061   MGI PMID:21458307 abnormal locomotor behavior   IAGP   5509061   MGI PMID:17403033 abnormal long term spatial reference memory   IAGP   5509061   MGI PMID:18509040 abnormal lung interstitium morphology   IAGP   5509061   MGI PMID:16244651 abnormal macrophage physiology   IAGP   5509061   MGI PMID:10549626 abnormal macrophage physiology   IAGP   5509061   MGI PMID:17118979 abnormal macrophage physiology   IAGP   5509061   MGI PMID:17353199 abnormal macrophage physiology   IAGP   5509061   MGI PMID:17998311 abnormal macrophage physiology   IAGP   5509061   MGI PMID:16204620 abnormal macrophage physiology   IAGP   5509061   MGI PMID:11431423 abnormal macrophage physiology   IAGP   5509061   MGI PMID:15690042 abnormal macrophage physiology   IAGP   5509061   MGI PMID:11751980 abnormal macrophage physiology   IAGP   5509061   MGI PMID:12091878 abnormal microglial cell activation   IAGP   5509061   MGI PMID:17355971 abnormal mitochondrial shape   IAGP   5509061   MGI PMID:15546996 abnormal mitochondrion morphology   IAGP   5509061   MGI PMID:15546996 abnormal myelination   IAGP   5509061   MGI PMID:20534434 abnormal neuron differentiation   IAGP   5509061   MGI PMID:17704767 abnormal osteoclast physiology   IAGP   5509061   MGI PMID:17998311 abnormal pancreatic beta cell morphology   IAGP   5509061   MGI PMID:19357791 abnormal respiratory system physiology   IAGP   5509061   MGI PMID:15843573 abnormal respiratory system physiology   IAGP   5509061   MGI PMID:17626835 abnormal tumor necrosis factor level   IAGP   5509061   MGI PMID:17707128 abnormal white fat cell size   IAGP   5509061   MGI PMID:19841034 altered response to myocardial infarction   IAGP   5509061   MGI PMID:14656915 altered response to myocardial infarction   IAGP   5509061   MGI PMID:16980352 amyloid beta deposits   IAGP   5509061   MGI PMID:18509040 atherosclerotic lesions   IAGP   5509061   MGI PMID:16211093 atherosclerotic lesions   IAGP   5509061   MGI PMID:18250194 carcinoma   IAGP   5509061   MGI PMID:20885960 cardiac interstitial fibrosis   IAGP   5509061   MGI PMID:14656915 CNS ischemia   IAGP   5509061   MGI PMID:19401158 colonic necrosis   IAGP   5509061   MGI PMID:20885960 decreased angiogenesis   IAGP   5509061   MGI PMID:20708624 decreased cerebral infarction size   IAGP   5509061   MGI PMID:17854911 decreased cerebral infarction size   IAGP   5509061   MGI PMID:17548055 decreased cerebral infarction size   IAGP   5509061   MGI PMID:17693552 decreased circulating alanine transaminase level   IAGP   5509061   MGI PMID:16118350 decreased circulating cholesterol level   IAGP   5509061   MGI PMID:16211093 decreased circulating corticosterone level   IAGP   5509061   MGI PMID:15546996 decreased circulating insulin level   IAGP   5509061   MGI PMID:20407745 decreased circulating interleukin-1 beta level   IAGP   5509061   MGI PMID:16980352 decreased circulating leptin level   IAGP   5509061   MGI PMID:20407745 decreased circulating tumor necrosis factor level   IAGP   5509061   MGI PMID:20407745 decreased circulating tumor necrosis factor level   IAGP   5509061   MGI PMID:16980352 decreased circulating VLDL cholesterol level   IAGP   5509061   MGI PMID:19841034 decreased fat cell size   IAGP   5509061   MGI PMID:20407745 decreased heart left ventricle weight   IAGP   5509061   MGI PMID:14656915 decreased heart weight   IAGP   5509061   MGI PMID:14656915 decreased IgG3 level   IAGP   5509061   MGI PMID:17118979 decreased immunoglobulin level   IAGP   5509061   MGI PMID:12091878 decreased inflammatory response   IAGP   5509061   MGI PMID:17475877 decreased interleukin-1 beta secretion   IAGP   5509061   MGI PMID:16547271 decreased interleukin-1 secretion   IAGP   5509061   MGI PMID:15546996 decreased interleukin-10 secretion   IAGP   5509061   MGI PMID:11751980 decreased interleukin-12 secretion   IAGP   5509061   MGI PMID:11431423 decreased interleukin-12b secretion   IAGP   5509061   MGI PMID:16461338 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:10549626 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:16461338 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:16547271 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:11431423 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:15546996 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:11751980 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:14739339 decreased liver tumor incidence   IAGP   5509061   MGI PMID:19122641 decreased lung tumor incidence   IAGP   5509061   MGI PMID:19122641 decreased lung weight   IAGP   5509061   MGI PMID:14656915 decreased macrophage cytokine production   IAGP   5509061   MGI PMID:11751980 decreased macrophage nitric oxide production   IAGP   5509061   MGI PMID:11751980 decreased mitochondria number   IAGP   5509061   MGI PMID:15546996 decreased neuron apoptosis   IAGP   5509061   MGI PMID:17693552 decreased sensitivity to induced morbidity/mortality   IAGP   5509061   MGI PMID:17353199 decreased splenocyte proliferation   IAGP   5509061   MGI PMID:17353199 decreased susceptibility to bacterial infection induced morbidity/mortality   IAGP   5509061   MGI PMID:17475877 decreased susceptibility to bacterial infection induced morbidity/mortality   IAGP   5509061   MGI PMID:17353199 decreased susceptibility to hepatic steatosis   IAGP   5509061   MGI PMID:20407745 decreased susceptibility to kidney reperfusion injury   IAGP   5509061   MGI PMID:17475853 decreased susceptibility to kidney reperfusion injury   IAGP   5509061   MGI PMID:16167081 decreased susceptibility to parasitic infection   IAGP   5509061   MGI PMID:17135446 decreased susceptibility to viral infection   IAGP   5509061   MGI PMID:14739339 decreased susceptibility to viral infection induced morbidity/mortality   IAGP   5509061   MGI PMID:14739339 decreased thermal nociceptive threshold   IAGP   5509061   MGI PMID:17355971 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:10549626 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:16547271 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:12077222 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:11431423 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:18250194 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:15546996 enlarged adrenal glands   IAGP   5509061   MGI PMID:15546996 hepatic steatosis   IAGP   5509061   MGI PMID:19841034 hyperoxia   IAGP   5509061   MGI PMID:16244651 hyperresponsive to tactile stimuli   IAGP   5509061   MGI PMID:17355971 impaired passive avoidance behavior   IAGP   5509061   MGI PMID:18509040 improved glucose tolerance   IAGP   5509061   MGI PMID:20407745 increased apoptosis   IAGP   5509061   MGI PMID:16244651 increased B cell apoptosis   IAGP   5509061   MGI PMID:16118350 increased body weight   IAGP   5509061   MGI PMID:16211093 increased body weight   IAGP   5509061   MGI PMID:18250194 increased circulating adrenocorticotropin level   IAGP   5509061   MGI PMID:15546996 increased circulating free fatty acid level   IAGP   5509061   MGI PMID:19841034 increased colonic adenoma incidence   IAGP   5509061   MGI PMID:20885960 increased energy expenditure   IAGP   5509061   MGI PMID:20407745 increased food intake   IAGP   5509061   MGI PMID:20407745 increased gastrointestinal tumor incidence   IAGP   5509061   MGI PMID:20885960 increased insulin secretion   IAGP   5509061   MGI PMID:20407745 increased insulin sensitivity   IAGP   5509061   MGI PMID:20407745 increased physiological sensitivity to xenobiotic   IAGP   5509061   MGI PMID:16244651 increased sensitivity to induced morbidity/mortality   IAGP   5509061   MGI PMID:15690042 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:12091878 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:15690042 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:11751980 increased susceptibility to bacterial infection induced morbidity/mortality   IAGP   5509061   MGI PMID:19139201 increased susceptibility to induced colitis   IAGP   5509061   MGI PMID:20885960 increased T cell number   IAGP   5509061   MGI PMID:16461338 insulitis   IAGP   5509061   MGI PMID:17707128 no abnormal phenotype detected   IEA   5509061   MGI   premature death   IAGP   5509061   MGI PMID:20885960 premature death   IAGP   5509061   MGI PMID:17408640 rectal hemorrhage   IAGP   5509061   MGI PMID:17408640 rectal hemorrhage   IAGP   5509061   MGI PMID:20885960 small pancreatic islets   IAGP   5509061   MGI PMID:19357791 weight loss   IAGP   5509061   MGI PMID:17408640 weight loss   IAGP   5509061   MGI PMID:20885960 Disease Annotations Acute Kidney Injury  (IPM) Acute Tubulointerstitial Nephritis  (IPM) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IED) Arthritis, Experimental  (ISS) Aspergillosis  (IEP) Asthma  (IEP,IPM,ISS) Brain Injuries  (ISS) Carotid Stenosis  (ISS) Colorectal Neoplasms  (ISS) Cough  (ISS) Diabetes Mellitus, Experimental  (IAGP,ISS) Diabetes Mellitus, Type 1  (IAGP,ISS) Diabetic Nephropathies  (IPM) Dyslipidemias  (ISS) Encephalomyelitis, Autoimmune, Experimental  (ISS) Endotoxemia  (ISS) Enterocolitis, Necrotizing  (ISS) Fever  (IPM) Gastroesophageal Reflux  (ISS) Glomerulonephritis  (IPM) Gram-Positive Bacterial Infections  (IPM) Inflammation  (IED,IPM,ISS) Influenza, Human  (ISS) Kidney Failure, Chronic  (ISS) Kidney Reperfusion Injury  (IED,IEP,IPM,ISS) Leprosy  (ISS) Leptospirosis  (IPM) Liver Cirrhosis, Experimental  (ISS) Lung Diseases  (ISS) MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO  (ISS) Myocardial Reperfusion Injury  (ISS) Neuritis, Autoimmune, Experimental  (ISS) Obesity  (IPM) Pancreatitis  (ISS) Pancreatitis, Acute Necrotizing  (ISS) Pneumonia  (IPM) Pneumonia, Bacterial  (IPM,ISS) Pneumonia, Pneumococcal  (IPM) Pneumonia, Pneumocystis  (IPM) Prostatic Neoplasms  (ISS) Pulmonary Emphysema  (IEP) Pulmonary Fibrosis  (IPM) Renal Fibrosis  (ISS) Renal Insufficiency  (ISS) Reperfusion Injury  (ISS) Respiratory Syncytial Virus Infections  (IPM) Rhinitis  (ISS) Sarcoidosis, Pulmonary  (ISS) Sepsis  (ISS) Streptococcal Infections  (IPM) Transplant Rejection  (IPM,ISS) Tuberculosis  (ISS) Tuberculosis, Pulmonary  (ISS) Urinary Bladder Neoplasms  (ISS) Urinary Tract Infections  (ISS) Wallerian Degeneration  (IAGP) Gene-Chemical Interaction Annotations (+)-pilocarpine  (EXP) (-)-citrinin  (EXP) 1-chloro-2,4,6-trinitrobenzene  (EXP) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP) adapalene  (ISO) afimoxifene  (ISO) aflatoxin B1  (EXP) all-trans-retinol  (ISO) ammonium hexachloroplatinate  (ISO) astemizole  (ISO) benzene  (ISO) benzo[a]pyrene  (EXP) bis(2-chloroethyl) sulfide  (EXP) bisdemethoxycurcumin  (ISO) bisphenol A  (ISO) cadmium dichloride  (EXP) cefaloridine  (ISO) cerium trichloride  (EXP) chitosan  (ISO) ciguatoxin CTX1B  (EXP) cisplatin  (ISO) cobalt atom  (ISO) cortisol  (ISO) curcumin  (ISO) cyclosporin A  (ISO) D-glucose  (ISO) diarsenic trioxide  (ISO) disodium selenite  (EXP) dopamine  (ISO) doxorubicin  (EXP) fenoldopam  (ISO) ferulic acid  (EXP) fonofos  (ISO) furan  (ISO) glucose  (ISO) glutathione  (ISO) hexamethylene diisocyanate  (ISO) histamine  (ISO) hydroxycitronellal  (ISO) isoeugenol  (ISO) lycopene  (ISO) muramyl dipeptide  (EXP,ISO) N-acetyl-L-cysteine  (ISO) N-nitrosodiethylamine  (ISO) nitroprusside  (EXP) ozone  (EXP) paracetamol  (EXP) parathion  (ISO) phenobarbital  (ISO) pirinixic acid  (EXP) progesterone  (ISO) propiconazole  (EXP) prostaglandin E2  (ISO) silicon dioxide  (ISO) simvastatin  (ISO) sodium dichromate  (ISO) sodium dodecyl sulfate  (ISO) sulfasalazine  (EXP) sulindac  (ISO) terbufos  (ISO) tetrachloromethane  (EXP,ISO) titanium atom  (ISO) trimellitic anhydride  (ISO) Gene Ontology Annotations Biological Process cell surface pattern recognition receptor signaling pathway  (IMP) cellular response to bacterial lipopeptide  (IMP,TAS) cellular response to diacyl bacterial lipopeptide  (ISO) cellular response to lipoteichoic acid  (IMP,ISO) cellular response to peptidoglycan  (IMP) cellular response to triacyl bacterial lipopeptide  (ISO) central nervous system myelin formation  (ISO) chloramphenicol transport  (IMP) defense response to bacterium  (ISO) defense response to Gram-positive bacterium  (IMP) detection of diacyl bacterial lipopeptide  (ISO) detection of triacyl bacterial lipopeptide  (ISO) I-kappaB phosphorylation  (ISO) immune response  (IEA) induction by symbiont of defense-related host nitric oxide production  (IMP) inflammatory response  (ISO) innate immune response  (TAS) leukotriene metabolic process  (ISO) microglial cell activation involved in immune response  (ISO) MyD88-dependent toll-like receptor signaling pathway  (IGI) negative regulation of cell proliferation  (ISO) negative regulation of growth of symbiont in host  (IMP) negative regulation of interleukin-12 production  (IMP) negative regulation of interleukin-17 production  (IMP) nitric oxide metabolic process  (ISO) pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response  (ISO) positive regulation of chemokine production  (IMP,ISO) positive regulation of cytokine secretion  (IGI) positive regulation of interferon-beta production  (IDA) positive regulation of interleukin-10 production  (ISO) positive regulation of interleukin-12 production  (IDA) positive regulation of interleukin-18 production  (IDA) positive regulation of interleukin-6 production  (IDA,IMP,ISO) positive regulation of interleukin-8 production  (ISO) positive regulation of leukocyte migration  (IMP) positive regulation of macrophage cytokine production  (IMP) positive regulation of NF-kappaB import into nucleus  (ISO) positive regulation of NF-kappaB transcription factor activity  (ISO) positive regulation of nitric oxide biosynthetic process  (IMP) positive regulation of nitric-oxide synthase biosynthetic process  (IDA) positive regulation of oligodendrocyte differentiation  (ISO) positive regulation of toll-like receptor signaling pathway  (ISO) positive regulation of transcription from RNA polymerase II promoter  (IDA) positive regulation of tumor necrosis factor biosynthetic process  (IMP) positive regulation of tumor necrosis factor production  (IDA,IMP) positive regulation of Wnt receptor signaling pathway  (ISO) response to bacterial lipoprotein  (ISO) response to bacterium  (IMP) response to fatty acid  (ISO) response to molecule of fungal origin  (IMP) response to peptidoglycan  (IMP) signal transduction  (IEA) toll-like receptor signaling pathway  (ISO) Cellular Component cell body  (ISO) cell projection  (ISO) cell surface  (ISO) cytoplasm  (ISO) cytoplasmic vesicle  (IEA) external side of plasma membrane  (IDA) integral to membrane  (IEA) intrinsic to membrane  (IEA) membrane  (IEA) plasma membrane  (IDA,ISO) Toll-like receptor 1-Toll-like receptor 2 protein complex  (ISO) Toll-like receptor 2-Toll-like receptor 6 protein complex  (IPI) Molecular Function diacyl lipopeptide binding  (IDA) Gram-positive bacterial cell surface binding  (ISO) lipopeptide binding  (ISO) lipoteichoic acid binding  (IDA) pattern recognition receptor activity  (ISO) peptidoglycan binding  (ISO) protein binding  (IPI) protein heterodimerization activity  (IPI,ISO) receptor activity  (ISO) transmembrane signaling receptor activity  (IEA) triacyl lipopeptide binding  (IDA,ISO) Molecular Pathway Annotations Entamoeba histolyca infection pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Mycobacterium tuberculosis infection pathway  (IEA) Plasmodium infection pathway  (IEA) rheumatoid arthritis pathway  (IEA) Toll-like receptor signaling pathway  (IEA,ISS) Toxoplasma gondii infection pathway  (IEA) Trypanosoma cruzi infection pathway  (IEA) External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B Herpes simplex infection Legionellosis Leishmaniasis Malaria Measles Phagosome PI3K-Akt signaling pathway Proteoglycans in cancer Rheumatoid arthritis Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) Phenotype Annotations abnormal adipocyte glucose uptake  (IAGP) abnormal adipose tissue amount  (IAGP) abnormal adrenal cortex morphology  (IAGP) abnormal adrenal gland morphology  (IAGP) abnormal adrenal gland secretion  (IAGP) abnormal airway responsiveness  (IAGP) abnormal astrocyte morphology  (IAGP) abnormal astrocyte physiology  (IAGP) abnormal cellular extravasation  (IAGP) abnormal chemokine level  (IAGP) abnormal chemokine secretion  (IAGP) abnormal circulating cholesterol level  (IAGP) abnormal circulating corticosterone level  (IAGP) abnormal circulating glucose level  (IAGP) abnormal circulating insulin level  (IAGP) abnormal circulating LDL cholesterol level  (IAGP) abnormal circulating lipid level  (IAGP) abnormal circulating pituitary hormone level  (IAGP) abnormal cytokine secretion  (IAGP) abnormal dendritic cell physiology  (IAGP) abnormal endoplasmic reticulum morphology  (IAGP) abnormal enterocyte morphology  (IAGP) abnormal fat pad morphology  (IAGP) abnormal glial cell physiology  (IAGP) abnormal glucose homeostasis  (IAGP) abnormal heart morphology  (IAGP) abnormal heart ventricle morphology  (IAGP) abnormal hepatocyte morphology  (IAGP) abnormal innate immunity  (IAGP) abnormal interleukin level  (IAGP) abnormal interleukin secretion  (IAGP) abnormal intestinal epithelium morphology  (IAGP) abnormal large intestine crypts of Lieberkuhn morphology  (IAGP) abnormal leukocyte migration  (IAGP) abnormal locomotor behavior  (IAGP) abnormal long term spatial reference memory  (IAGP) abnormal lung interstitium morphology  (IAGP) abnormal macrophage physiology  (IAGP) abnormal microglial cell activation  (IAGP) abnormal mitochondrial shape  (IAGP) abnormal mitochondrion morphology  (IAGP) abnormal myelination  (IAGP) abnormal neuron differentiation  (IAGP) abnormal osteoclast physiology  (IAGP) abnormal pancreatic beta cell morphology  (IAGP) abnormal respiratory system physiology  (IAGP) abnormal tumor necrosis factor level  (IAGP) abnormal white fat cell size  (IAGP) altered response to myocardial infarction  (IAGP) amyloid beta deposits  (IAGP) atherosclerotic lesions  (IAGP) carcinoma  (IAGP) cardiac interstitial fibrosis  (IAGP) CNS ischemia  (IAGP) colonic necrosis  (IAGP) decreased angiogenesis  (IAGP) decreased cerebral infarction size  (IAGP) decreased circulating alanine transaminase level  (IAGP) decreased circulating cholesterol level  (IAGP) decreased circulating corticosterone level  (IAGP) decreased circulating insulin level  (IAGP) decreased circulating interleukin-1 beta level  (IAGP) decreased circulating leptin level  (IAGP) decreased circulating tumor necrosis factor level  (IAGP) decreased circulating VLDL cholesterol level  (IAGP) decreased fat cell size  (IAGP) decreased heart left ventricle weight  (IAGP) decreased heart weight  (IAGP) decreased IgG3 level  (IAGP) decreased immunoglobulin level  (IAGP) decreased inflammatory response  (IAGP) decreased interleukin-1 beta secretion  (IAGP) decreased interleukin-1 secretion  (IAGP) decreased interleukin-10 secretion  (IAGP) decreased interleukin-12 secretion  (IAGP) decreased interleukin-12b secretion  (IAGP) decreased interleukin-6 secretion  (IAGP) decreased liver tumor incidence  (IAGP) decreased lung tumor incidence  (IAGP) decreased lung weight  (IAGP) decreased macrophage cytokine production  (IAGP) decreased macrophage nitric oxide production  (IAGP) decreased mitochondria number  (IAGP) decreased neuron apoptosis  (IAGP) decreased sensitivity to induced morbidity/mortality  (IAGP) decreased splenocyte proliferation  (IAGP) decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP) decreased susceptibility to hepatic steatosis  (IAGP) decreased susceptibility to kidney reperfusion injury  (IAGP) decreased susceptibility to parasitic infection  (IAGP) decreased susceptibility to viral infection  (IAGP) decreased susceptibility to viral infection induced morbidity/mortality  (IAGP) decreased thermal nociceptive threshold  (IAGP) decreased tumor necrosis factor secretion  (IAGP) enlarged adrenal glands  (IAGP) hepatic steatosis  (IAGP) hyperoxia  (IAGP) hyperresponsive to tactile stimuli  (IAGP) impaired passive avoidance behavior  (IAGP) improved glucose tolerance  (IAGP) increased apoptosis  (IAGP) increased B cell apoptosis  (IAGP) increased body weight  (IAGP) increased circulating adrenocorticotropin level  (IAGP) increased circulating free fatty acid level  (IAGP) increased colonic adenoma incidence  (IAGP) increased energy expenditure  (IAGP) increased food intake  (IAGP) increased gastrointestinal tumor incidence  (IAGP) increased insulin secretion  (IAGP) increased insulin sensitivity  (IAGP) increased physiological sensitivity to xenobiotic  (IAGP) increased sensitivity to induced morbidity/mortality  (IAGP) increased susceptibility to bacterial infection  (IAGP) increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP) increased susceptibility to induced colitis  (IAGP) increased T cell number  (IAGP) insulitis  (IAGP) no abnormal phenotype detected  (IEA) premature death  (IAGP) rectal hemorrhage  (IAGP) small pancreatic islets  (IAGP) weight loss  (IAGP) References - curated 1. 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18097024   18097414   18164130   18165267   18174025   18178848   18179383   18180038   18180310   18195069   18198209   18200499   18201559   18211965   18217947   18220700   18223102   18227157   18227170   18250194   18250425   18250466   18261938   18266299   18285403   18287559   18287966   18292574   18295350   18299340   18299458   18322236   18322244   18332137   18334542   18347044   18372043   18378636   18391010   18394314   18398934   18406368   18424698   18424755   18441280   18445119   18453609   18458086   18462086   18480050   18492657   18495130   18499758   18503635   18509040   18516712   18559343   18559428   18565585   18566366   18566425   18566426   18583567   18585792   18587008   18599609   18620001   18621910   18624355   18641052   18641340   18641349   18641352   18644971   18652890   18652908   18687905   18700834   18708593   18725520   18765239   18765807   18768873   18768886   18779779   18787704   18794294   18799752   18806780   18820644   18824534   18824550   18854239   18925411   18929413   18931326   18931363   18940178   18941239   18948575   18952897   18981139   18981140   18981147   18981243   18987631   19003933   19008784   19017981   19035506   19050249   19050267   19050280   19052080   19060881   19079173   19091752   19091986   19106411   19112093   19122641   19124755   19129756   19130558   19131641   19139093   19139201   19154987   19158348   19168746   19181857   19191335   19201838   19202130   19211042   19218085   19218193   19218237   19218854   19228664   19234125   19246719   19255194   19265136   19265148   19265198   19278729   19293401   19297619   19299700   19299719   19303021   19306954   19328626   19332531   19348925   19357791   19358332   19362712   19364834   19382314   19382893   19401158   19406832   19414550   19414781   19414785   19433551   19454663   19454708   19454709   19458089   19465927   19468929   19483718   19509469   19521507   19525933   19527807   19528242   19541650   19543380   19553529   19553540   19561094   19561617   19570822   19574958   19585512   19586996   19587376   19587448   19592497   19595715   19596768   19602669   19605353   19617348   19620350   19629181   19634192   19641135   19654875   19667087   19675137   19681597   19684606   19687097   19717524   19720755   19732955   19747212   19748987   19754309   19770268   19776284   19786535   19797072   19801985   19805031   19805530   19806220   19812191   19815878   19822644   19828841   19834062   19841034   19841185   19847289   19850890   19864601   19875664   19882655   19887845   19889726   19890065   19901344   19904768   19910051   19913447   19914204   19914211   19919859   19923446   19930040   19930041   19931471   19933194   19933827   19933833   19933834   19936231   19948716   19949074   19950169   19950174   19950179   19952355   19995266   19995952   20007584   20018613   20018859   20020500   20026776   20037584   20038642   20042569   20051628   20056129   20056792   20061538   20061547   20081527   20107166   20113368   20124731   20131263   20132051   20132416   20147635   20164426   20164431   20167866   20173040   20190136   20200276   20200402   20228680   20231693   20300608   20306223   20306471   20347487   20348242   20351187   20351694   20360550   20368346   20375605   20393111   20393135   20393136   20393140   20404835   20404927   20407745   20421349   20422028   20424490   20432233   20434320   20434372   20442858   20456021   20463690   20471681   20478617   20480503   20483752   20495560   20500089   20505314   20505832   20511710   20513152   20519121   20525885   20534434   20537708   20545783   20547845   20554644   20566357   20584314   20584977   20586817   20600022   20617171   20620328   20628601   20643855   20650880   20650991   20657826   20660347   20660707   20668698   20679445   20686034   20696824   20696947   20708624   20729214   20733560   20802178   20806319   20824059   20837714   20847111   20849355   20864677   20875459   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21622562   21622869   21632710   21645538   21664694   21674065   21685327   21687712   21690093   21695078   21695198   21696980   21698237   21705332   21708993   21709150   21709223   21722182   21731762   21738466   21742967   21746857   21757189   21763266   21768278   21775438   21784973   21791597   21813774   21813778   21817814   21820318   21827211   21829592   21829705   21835472   21844233   21846723   21849499   21862586   21865055   21873606   21875662   21895526   21899704   21901759   21925592   21930764   21930915   21930967   21935459   21947769   21947775   21951975   21960132   21960563   21966468   21984337   21998452   21998707   21998742   22025508   22025550   22031762   22033934   22036947   22039448   22046231   22063738   22075930   22095710   22096480   22101787   22110384   22126586   22131343   22140255   22156342   22156592   22162948   22163046   22171256   22174456   22184724   22198949   22207132   22207622   22215738   22227568   22235111   22250086   22273981   22276114   22278939   22303020   22303480   22306056   22312111   22323544   22336013   22371907   22384161   22385341   22431652   22432012   22442665   22455839   22466646   22479357   22486596   22509021   22511319   22523073   22529298   22556332   22565313   22569257   22596260   22610280   22622111   22622619   22634181   22634614   22634720   22635254   22661093   22662179   22665377   22666391   22677551   22677561   22706912   22713870   22721450   22724018   22732279   22737215   22750073   22772452   22777843   22808176   22808181   22808254   22808256   22815909   22821982   22823162   22826298   22837383   22841961   22848581   22848741   22859216   22870312   22902233   22905218   22915067   22927048   22931089   22933629   22938101   22951952   22962064   22970242   22995462   22995520   23011593   23027540   23034650   23063683   23073832   23077245   23079657   23082204   23089394   23092428   23123736   23135279   23151845   23162016   23183169   23197261   23208603   23209321   23209417   23223142   23233677   23264656   23319736   8743579 RGD Disease Portals Tlr2 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cancer Phenotypes Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Biological Process Neurological Diseases Neurological Pathways Neurological Phenotypes Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Diseases Respiratory Pathways Respiratory Phenotypes Genomics Comparative Map Data Tlr2   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,272 - 83,841,608 - NCBI Mouse cM Map 3   - NCBI Mouse Celera Assembly 3 83,852,064 - 83,857,400 - NCBI Mouse Genome Assembly Build 37 3 83,640,194 - 83,645,530 - NCBI Mouse Genome Assembly Build 36.1 3 83,640,194 - 83,645,689 - NCBI Mouse Cytogenetic Map 3 E3   NCBI TLR2   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 154,390,697 - 154,412,500 + NCBI Human Genome Assembly HuRef 4 150,336,457 - 150,358,268 + NCBI Human Genome Assembly GRCh37 4 154,605,441 - 154,627,243 + NCBI Human Genome Assembly Build 36 4 154,824,891 - 154,846,693 + NCBI Human Cytogenetic Map 4 q32   NCBI Human Genome Assembly 4 154,966,670 - 154,984,135   NCBI Tlr2   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 2 q34   NCBI RGSC Genome Assembly v5.0 2 202,253,256 - 202,258,683 - NCBI RGSC Genome Assembly v3.4 2 175,607,990 - 175,613,992 - NCBI Rat Celera Assembly 2 163,202,040 - 163,207,399 - NCBI Genome Assembly 3.1 2 175,558,096 - 175,564,098 - NCBI Position Markers Tlr2   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,837,015 - 83,837,120   UniSTS Mouse cM Map 3     UniSTS Mouse Celera Assembly 3 83,852,807 - 83,852,912   UniSTS Mouse Genome Assembly Build 37 3 83,640,937 - 83,641,042   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS RH144365   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,599 - 83,836,791   UniSTS Mouse Celera Assembly 3 83,852,391 - 83,852,583   UniSTS Mouse Genome Assembly Build 37 3 83,640,521 - 83,640,713   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS UniSTS:234715   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,837,106 - 83,837,306   UniSTS Mouse Celera Assembly 3 83,852,898 - 83,853,098   UniSTS Mouse Genome Assembly Build 37 3 83,641,028 - 83,641,228   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS PMC128073P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,837,903 - 83,838,229   UniSTS Mouse Celera Assembly 3 83,853,695 - 83,854,021   UniSTS Mouse Genome Assembly Build 37 3 83,641,825 - 83,642,151   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS PMC128159P2   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,838,155 - 83,838,518   UniSTS Mouse Celera Assembly 3 83,853,947 - 83,854,310   UniSTS Mouse Genome Assembly Build 37 3 83,642,077 - 83,642,440   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS PMC133006P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,759 - 83,837,138   UniSTS Mouse Celera Assembly 3 83,852,551 - 83,852,930   UniSTS Mouse Genome Assembly Build 37 3 83,640,681 - 83,641,060   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS PMC213490P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,837,501 - 83,838,083   UniSTS Mouse Celera Assembly 3 83,853,293 - 83,853,875   UniSTS Mouse Genome Assembly Build 37 3 83,641,423 - 83,642,005   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS PMC98510P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,415 - 83,836,797   UniSTS Mouse Celera Assembly 3 83,852,207 - 83,852,589   UniSTS Mouse Genome Assembly Build 37 3 83,640,337 - 83,640,719   UniSTS Mouse Cytogenetic Map 3 E3   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1301442 Pltpq1_m phospholipid transfer protein activity QTL 1 (mouse) Not determined 3 52522098 86522334 Mouse 1300593 Skull4_m skull morphology 4 (mouse) Not determined 3 52522098 86522334 Mouse 1301917 Tshp4_m tooth shape 4 (mouse) Not determined 3 52522098 86522334 Mouse 1357585 Manln3_m mandible length 3 (mouse) Not determined 3 52522098 86522334 Mouse 1301398 Rapop3_m radiation-induced apoptosis 3 (mouse) Not determined 3 59902079 93902202 Mouse 4141294 Bmd24_m bone mineral density 24 (mouse) Not determined 3 61636676 95636856 Mouse 1301705 Sles3_m systemic lupus erythmatosus suppressor 3 (mouse) Not determined 3 61636676 95636856 Mouse 1558843 Ecla_m epistatic circling A C57L/J 1 (mouse) Not determined 3 65366294 99366439 Mouse 1301971 Cia5_m collagen induced arthritis QTL 5 (mouse) Not determined 3 65943273 99943410 Mouse 4141669 Vmmt18_m vertebral morphology and mechanical traits 18 (mouse) Not determined 3 68203118 102203263 Mouse 4142498 Hctq1_m hematocrit QTL 1 (mouse) Not determined 3 68985423 102985534 Mouse 1357796 Trmq5_m T cell ratio modifier QTL 5 (mouse) Not determined 3 70067069 104067190 Mouse 1301422 Sle11_m systematic lupus erythematosus susceptibility 11 (mouse) Not determined 3 70105519 104105657 Mouse 1300595 Tmevd2_m Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse) Not determined 3 75359917 109360164 Mouse 1301392 Eae3_m susceptibility to experimental allergic encephalomyelitis 3 (mouse) Not determined 3 79445337 113445444 Mouse 4142423 Prtia1_m pristane induced arthritis 1 (mouse) Not determined 3 79885628 113885768 Mouse 1357629 Ssta5_m susceptibility to Salmonella typhimurium antigens 5 (mouse) Not determined 3 79885628 113885768 Mouse 1301277 nctm1_m Nakano cataract modifier 1 (mouse) Not determined 3 80083059 114083208 Mouse 1301947 Pcfm3_m periosteal circumference and femur length 3 (mouse) Not determined 3 80981259 114981404 Mouse 1301904 Iba2_m induction of brown adipocytes 2 (mouse) Not determined 3 82043650 116043791 Mouse 1301862 Tchol1_m total cholesterol level 1 (mouse) Not determined 3 83269519 117269667 Mouse 1302181 Lvic2_m liver iron content 2 (mouse) Not determined 3 83269519 117269667 Mouse 1300752 Ap6q_m alcohol preference 6 QTL (mouse) Not determined 3 83360598 117360744 Mouse 1301388 Hdlq21_m HDL QTL 21 (mouse) Not determined 3 83360598 117360744 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_011905 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01028595 (Get FASTA) Search GEO for Microarray Profiles   AC133160 (Get FASTA) Search GEO for Microarray Profiles   AF124741 (Get FASTA) Search GEO for Microarray Profiles   AF165189 (Get FASTA) Search GEO for Microarray Profiles   AF185284 (Get FASTA) Search GEO for Microarray Profiles   AF216289 (Get FASTA) Search GEO for Microarray Profiles   AK005043 (Get FASTA) Search GEO for Microarray Profiles   AK154504 (Get FASTA) Search GEO for Microarray Profiles   AY179346 (Get FASTA) Search GEO for Microarray Profiles   BC014693 (Get FASTA) Search GEO for Microarray Profiles   BP771904 (Get FASTA) Search GEO for Microarray Profiles   BY743020 (Get FASTA) Search GEO for Microarray Profiles   CH466547 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_011905 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_036035 Peptide Label: precursor Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,272 - 83,841,608 - ENTREZGENE Mouse cM Map 3   - ENTREZGENE Mouse Celera Assembly 3 83,852,064 - 83,857,400 - RGD Mouse Genome Assembly Build 37 3 83,640,194 - 83,645,530 - RGD Protein Sequences Protein RefSeqs NP_036035 (Get FASTA) GenBank Protein AAD46481 (Get FASTA)   AAD49335 (Get FASTA)   AAF04277 (Get FASTA)   AAF28345 (Get FASTA)   AAH14693 (Get FASTA)   AAO21125 (Get FASTA)   BAB23770 (Get FASTA)   BAE32635 (Get FASTA)   EDL15415 (Get FASTA)   Q9QUN7 (Get FASTA) Promoters RGD ID: 6834542 Promoter ID: MM_KWN:34702 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung Transcripts: UC008PPN.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 3 83,645,209 - 83,645,709 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000027995 ENTREZGENE Ensembl Protein ENSMUSP00000029623 ENTREZGENE Ensembl Transcript ENSMUST00000029623 ENTREZGENE Entrez Gene 24088 ENTREZGENE Germonline ENSMUSG00000027995 HomoloGene Group ID 20695 ENTREZGENE InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot   Leu-rich_rpt UniProtKB/Swiss-Prot   Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot   TIR_dom UniProtKB/Swiss-Prot   TLR2 UniProtKB/Swiss-Prot   Toll-like_receptor UniProtKB/Swiss-Prot IPI IPI00131898 UniProtKB/Swiss-Prot KEGG Report mmu:24088 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:1346060 ENTREZGENE PANTHER PTHR24365:SF17 UniProtKB/Swiss-Prot Pfam TIR UniProtKB/Swiss-Prot PIRSF Toll-like_receptor UniProtKB/Swiss-Prot PROSITE LRR UniProtKB/Swiss-Prot   TIR UniProtKB/Swiss-Prot SMART LRR_TYP UniProtKB/Swiss-Prot   LRRCT UniProtKB/Swiss-Prot   TIR UniProtKB/Swiss-Prot Superfamily-SCOP TIR UniProtKB/Swiss-Prot UniGene Mm.87596 ENTREZGENE UniProt G3X8Y8_MOUSE UniProtKB/TrEMBL   Q811T5_MOUSE UniProtKB/TrEMBL   Q8K3D9_MOUSE UniProtKB/TrEMBL   TLR2_MOUSE UniProtKB/Swiss-Prot

More on Tlr2 Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 1551003 Created: 2005-09-30 Species: Mus musculus Last Modified: 2013-05-14 Status: ACTIVE