RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Viral Hemorrhagic Fevers
Accession: DOID:9007401
browse the term
Definition: A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Synonyms: exact_synonym: Viral Hemorrhagic Fever
narrow_synonym: mosquito-borne hemorragic fever
primary_id: MESH:D006482
xref: EFO:0009575
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Ifna1
interferon, alpha 1
susceptibility
ISO
DNA:SNP:promoter: -1823G>A (rs1332190)(human)
RGD
PMID:26694082
RGD:36174029
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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Cd209d
CD209d molecule
susceptibility severity
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Dengue fever, protection against | ClinVar Annotator: match by term: Dengue virus, susceptibility to DNA:SNP:promoter: -336G>A (human)
CTD OMIM ClinVar RGD
PMID:15564514 PMID:15838506 PMID:16379498 PMID:25741868 PMID:16274635
RGD:39939064
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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Cxcr2
C-X-C motif chemokine receptor 2
treatment
ISO
RGD
PMID:30098206
RGD:39938828
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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F2
coagulation factor II, thrombin
ISO
RGD
PMID:22138554
RGD:40818430
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fcgr2a
Fc gamma receptor 2A
severity
ISO
DNA:polymorphism:cds:p.H131R(human)
RGD
PMID:26240159
RGD:13463456
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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Gc
GC, vitamin D binding protein
ISO
protein:increased expression:plasma
RGD
PMID:19845402
RGD:5509870
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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Ido1
indoleamine 2,3-dioxygenase 1
treatment
ISO
RGD
PMID:31821895
RGD:39939074
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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Ifnl1
interferon, lambda 1
ameliorates
ISO
protein:increased expression:blood serum (human)
RGD
PMID:28238051
RGD:126848771
NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
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Il1rl1
interleukin 1 receptor-like 1
treatment
ISO
RGD
PMID:30098206
RGD:39938828
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il33
interleukin 33
severity
ISO
RGD
PMID:30098206
RGD:39938828
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Mapk8
mitogen-activated protein kinase 8
ISO
protein:increased phosphorylation:liver (mouse)
RGD
PMID:28188818
RGD:150340680
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mir146a
microRNA 146a
ISO
RNA:decreased expression:serum:
RGD
PMID:26941580
RGD:41404658
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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Mir21
microRNA 21
ISO
RNA:increased expression:serum:
RGD
PMID:26941580
RGD:41404658
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Stat2
signal transducer and activator of transcription 2
susceptibility
ISO
RGD
PMID:21075352 PMID:21379341
RGD:41789625 , RGD:41789629
NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
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Cd1d1
CD1d1 molecule
disease_progression
ISO
protein:increased expression:cd14-positive monocyte (human)
RGD
PMID:24945350
RGD:127345113
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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Cd209d
CD209d molecule
severity susceptibility
ISO
DNA:SNPs:introns, promoter:multiple (human) DNA:SNP:promoter: -336 A>G (rs4804803) (human)
RGD
PMID:15838506 PMID:21245921
RGD:39938993 , RGD:41410809
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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Clec5a
C-type lectin domain containing 5A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18496526
NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
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Fcgr2a
Fc gamma receptor 2A
susceptibility
ISO
DNA:polymorphism:cds:p.H131R(human)
RGD
PMID:22817980
RGD:11040906
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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Ifnl1
interferon, lambda 1
ameliorates
ISO
DNA:SNP:enhancer:-1043C>T (rs7247086) (human)
RGD
PMID:31981768
RGD:126848742
NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
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Il21
interleukin 21
severity
ISO
protein:increased expression:blood serum (human)
RGD
PMID:24858204
RGD:127285368
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Micb
MHC class I polypeptide-related sequence B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22001756
NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827
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Osbp
oxysterol binding protein
ISO
mRNA:increased expression:peripheral blood mononuclear cell
RGD
PMID:28241052
RGD:41404654
NCBI chr 1:208,888,697...208,918,511
Ensembl chr 1:208,887,895...208,918,506
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Plce1
phospholipase C, epsilon 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22001756
NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
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Slc6a4
solute carrier family 6 member 4
severity
ISO
DNA;polymorphism:5'utr: (rs25531) (human)
RGD
PMID:30452889
RGD:38676265
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Tap2
transporter 2, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:SNPs: :
RGD
PMID:18071882
RGD:6482261
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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Cd163
CD163 molecule
exacerbates
ISO
protein:increased expression:blood plasma (human)
RGD
PMID:30666927
RGD:149735528
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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Il3
interleukin 3
ISO
protein: reduced expression: plasma
RGD
PMID:20957152
RGD:5686879
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Alb
albumin
severity
ISO
RGD
PMID:14555823
RGD:11035280
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Apoc3
apolipoprotein C3
disease_progression
ISO
RGD
PMID:20797315
RGD:7207210
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Cd163
CD163 molecule
exacerbates
ISO
protein:increased expression:blood plasma (human) protein:increased expression:CD14-positive, CD16-positive monocyte, blood plasma (human) protein:increased expression:CD14-positive monocyte (human)
RGD
PMID:25789628 PMID:25392926 PMID:29857122
RGD:127285679 , RGD:127345131 , RGD:127285683
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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Ifng
interferon gamma
severity
ISO
protein:increased expression:serum
RGD
PMID:22613426
RGD:6893374
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1rl1
interleukin 1 receptor-like 1
severity
ISO
RGD
PMID:25658420
RGD:40400702
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il2ra
interleukin 2 receptor subunit alpha
ISO
protein:increased expression:T cell
RGD
PMID:21436245
RGD:5147436
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il33
interleukin 33
severity
ISO
RGD
PMID:25658420
RGD:40400702
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Itgb3
integrin subunit beta 3
severity
ISO
protein:increased expression:platelet
RGD
PMID:18419255
RGD:6907404
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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RT1-Db1
RT1 class II, locus Db1
susceptibility
ISO
DNA:polymorphism:cds:HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202 and HLA-DRB1*1305 (human)
RGD
PMID:25169964
RGD:40818303
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Foxp3
forkhead box P3
IEP
mRNA:increased expression:lung
RGD
PMID:17878294
RGD:2325989
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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Il2ra
interleukin 2 receptor subunit alpha
treatment
IMP
RGD
PMID:17878294
RGD:2325989
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Dag1
dystroglycan 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17287727
NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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Stat2
signal transducer and activator of transcription 2
susceptibility
ISO
RGD
PMID:31043530
RGD:41789622
NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
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