Gene: Plce1 (phospholipase C, epsilon 1)
Rattus norvegicus
Symbol:
Plce1
Name:
phospholipase C, epsilon 1
Description:
ENCODES a protein that exhibits phosphatidylinositol phospholipase C activity; Ras GTPase binding; enzyme binding (ortholog); INVOLVED IN G-protein coupled receptor signaling pathway; Ras protein signal transduction; activation of MAPK activity (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; ASSOCIATED WITH NEPHROTIC SYNDROME, TYPE 3 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C epsilon; phospholipase C epsilon 1; phospholipase C, epsilon; phospholipase C, epsilon 1; phospholipase C-epsilon-1; PLC-epsilon-1; Plce
Orthologs:
Homo sapiens : PLCE1
(phospholipase C, epsilon 1)
HGNC
Plce1
(phospholipase C, epsilon 1)
MGI
Allele / Splice:
Plce1Tn(sb-T2/Bart3)2.146Mcwi
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 1 q53 NCBI RGSC Genome Assembly v5.0 1 264,652,842 - 264,956,664 + NCBI RGSC Genome Assembly v3.4 1 242,794,858 - 243,103,437 + NCBI Rat Celera Assembly 1 233,337,820 - 233,642,815 + NCBI Genome Assembly 3.1 1 242,891,416 - 243,199,995 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate increases expression ISO RGD:1606000 6480464 epigallocatechin gallate results in increased expression of PLCE1 mRNA CTD PMID:22079256 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1606000 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLCE1 mRNA CTD PMID:22079256 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735564 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLCE1 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1606000 6480464 Tetrachlorodibenzodioxin affects the expression of PLCE1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PLCE1 mRNA CTD PMID:22298810 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of PLCE1 mRNA CTD PMID:21346803 aflatoxin B1 increases expression ISO RGD:735564 6480464 Aflatoxin B1 results in increased expression of PLCE1 mRNA CTD PMID:19770486 all-trans-retinoic acid multiple interactions ISO RGD:735564 6480464 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of PLCE1 mRNA] CTD PMID:16505366 all-trans-retinoic acid increases expression ISO RGD:1606000 6480464 Tretinoin results in increased expression of PLCE1 mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression ISO RGD:735564 6480464 Tretinoin results in increased expression of PLCE1 mRNA CTD PMID:16505366 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PLCE1 mRNA CTD PMID:16483693 asbestos decreases expression ISO RGD:1606000 6480464 Asbestos results in decreased expression of PLCE1 mRNA CTD PMID:22398240 benzo[a]pyrene decreases expression ISO RGD:1606000 6480464 Benzo(a)pyrene results in decreased expression of PLCE1 mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:735564 6480464 Benzo(a)pyrene results in increased expression of PLCE1 mRNA CTD PMID:22610609 benzo[a]pyrene multiple interactions ISO RGD:735564 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PLCE1 mRNA CTD PMID:21715664 capecitabine increases response to substance ISO RGD:1606000 6480464 PLCE1 protein results in increased susceptibility to capecitabine CTD PMID:16734730 choline multiple interactions ISO RGD:735564 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA CTD PMID:20938992 crocidolite asbestos affects expression ISO RGD:1606000 6480464 Asbestos, Crocidolite affects the expression of PLCE1 mRNA CTD PMID:17331233 cyclosporin A decreases expression ISO RGD:735564 6480464 Cyclosporine results in decreased expression of PLCE1 mRNA CTD PMID:19770486 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of PLCE1 mRNA CTD PMID:20655511 folic acid multiple interactions ISO RGD:735564 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA CTD PMID:20938992 L-methionine multiple interactions ISO RGD:735564 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA CTD PMID:20938992 lead diacetate increases expression ISO RGD:735564 6480464 lead acetate results in increased expression of PLCE1 mRNA CTD PMID:20542052 maneb multiple interactions ISO RGD:735564 6480464 [Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA CTD PMID:22563483 manganese atom increases expression ISO RGD:1606000 6480464 Manganese results in increased expression of PLCE1 mRNA CTD PMID:17175027 manganese(0) increases expression ISO RGD:1606000 6480464 Manganese results in increased expression of PLCE1 mRNA CTD PMID:17175027 manganese(II) chloride increases expression ISO RGD:1606000 6480464 manganese chloride results in increased expression of PLCE1 mRNA CTD PMID:17175027 menadione affects expression ISO RGD:1606000 6480464 Vitamin K 3 affects the expression of PLCE1 mRNA CTD PMID:20044591 paclitaxel decreases response to substance ISO RGD:1606000 6480464 PLCE1 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 paracetamol affects expression ISO RGD:735564 6480464 Acetaminophen affects the expression of PLCE1 mRNA CTD PMID:17562736 paraquat increases expression ISO RGD:735564 6480464 Paraquat results in increased expression of PLCE1 mRNA CTD PMID:22563483 paraquat multiple interactions ISO RGD:735564 6480464 [Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA CTD PMID:22563483 phenobarbital affects expression ISO RGD:735564 6480464 Phenobarbital affects the expression of PLCE1 mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:735564 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCE1 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:735564 6480464 pirinixic acid results in increased expression of PLCE1 mRNA CTD PMID:18301758 pyridaben increases expression ISO RGD:735564 6480464 pyridaben results in increased expression of PLCE1 mRNA CTD PMID:22563483 tert-butyl hydroperoxide decreases expression ISO RGD:1606000 6480464 tert-Butylhydroperoxide results in decreased expression of PLCE1 mRNA CTD PMID:15336504
1600363 Hc6 Hypercalciuria QTL 6 2.7 Renal function calcium excretion 1 112148733 250430505 Rat 2302378 Insul11 Insulin level QTL 11 3.25 Insulin level 1 146971846 247322277 Rat 724531 Uae5 Urinary albumin excretion QTL 5 4 Renal function urine albumin level 1 153578442 259173490 Rat 1354610 Bw34 Body weight QTL 34 4.1 Body weight 1 154074905 263699089 Rat 1354646 Kidm18 Kidney mass QTL 18 5.7 Kidney mass right kidney mass adjusted for body weight 1 154074905 263699089 Rat 1354661 Bw33 Body weight QTL 33 5.2 Body weight 1 154074905 263699089 Rat 1549837 Hcar15 Hepatocarcinoma resistance QTL 15 .05 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 156124624 247322277 Rat 1354580 Scort1 Serum corticosterone level QTL 1 3.4 Hormone level corticosterone 1 159782445 263699089 Rat 2292220 Bp306 Blood pressure QTL 306 3.47 .00087 Blood pressure systolic 1 167931220 250119874 Rat 70163 Bw20 Body weight QTL 20 5.1 Body weight 1 178054386 247322277 Rat 738032 Hcas5 Hepatocarcinoma susceptibility QTL 5 3.12 Liver tumor susceptibility nodule number 1 180678929 265343617 Rat 1354624 Cm35 Cardiac mass QTL35 5.7 Cardiac mass left ventricle adjusted for body weight 1 181524849 263699089 Rat 1354652 Kidm20 Kidney mass QTL 20 4.3 Kidney mass left kidney mass adjusted for body weight 1 181524849 263699089 Rat 634321 Hc1 Hypercalciuria QTL 1 2.91 Renal function calcium excretion 1 183163129 248833756 Rat 1578759 Uae30 Urinary albumin excretion QTL 30 3.3 .003 Renal function urine albumin level 1 183946692 267910886 Rat 1578763 Kidm29 Kidney mass QTL 29 3.3 .0001 Kidney mass 1 183946692 267910886 Rat 1358898 Bp255 Blood pressure QTL 255 3.6 Blood pressure post nitric oxide system block 1 195927908 252497797 Rat 1358191 Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 3.8 Gland mass pituitary 1 197770157 250119666 Rat 61455 Niddm7 Non-insulin dependent diabetes mellitus QTL 7 5.5 Glucose level 1 198139596 243139596 Rat 1600388 Niddm67 Non-insulin dependent diabetes mellitus QTL 67 5.84 .000004 Glucose level 1 200882874 264367394 Rat 1600395 Niddm69 Non-insulin dependent diabetes mellitus QTL 69 4.14 .0002 Insulin level 1 200882874 264367394 Rat 1600396 Niddm68 Non-insulin dependent diabetes mellitus QTL 68 4.97 .0003 Glucose level 1 200882874 264367394 Rat 631658 Cm7 Cardiac mass QTL 7 5.32 .0001 Cardiac mass aorta 1 201920676 246920676 Rat 1358292 Cm37 Cardiac mass QTL 37 6.2 .00000081 Cardiac mass cardiac mass index 1 201920676 246920676 Rat 61345 Rf1 Renal disease susceptibility QTL 1 8.9 Renal function urine protein excretion rate 1 202322277 247322277 Rat 1600374 Mcs17 Mammary carcinoma susceptibility QTL 17 3 Mammary tumor susceptibility 1 202763018 247763018 Rat 2302375 Bw83 Body weight QTL 83 4.87 .0002 Body weight 1 202790380 247322277 Rat 1641926 Teswt2 Testicular weight QTL 2 2.82 Testicular weight 1 202790380 247790380 Rat 61376 Bp42 Blood pressure QTL 42 23.4 Blood pressure 1 202906624 247322277 Rat 1357335 Bw39 Body weight QTL 39 3.3 Body weight 1 202906624 247322277 Rat 1298084 Thym4 Thymus enlargement QTL 4 10.68 Gland mass thymus 1 202906624 247906624 Rat 634313 Niddm43 Non-insulin dependent diabetes mellitus QTL 43 Glucose level 1 204280278 267111153 Rat 2293655 Bss36 Bone structure and strength QTL 36 10.66 .0001 Bone strength 1 207376933 252376933 Rat 2293674 Bss39 Bone structure and strength QTL 39 7.1 .0001 Bone strength 1 207376933 252376933 Rat 2293694 Bss38 Bone structure and strength QTL 38 7.05 .0001 Bone strength 1 207376933 252376933 Rat 2300175 Bmd40 Bone mineral density QTL 40 15.4 .0001 Bone mineral density 1 207376933 252376933 Rat 1357399 Bw45 Body weight QTL 45 3.05 Body weight body mass index 1 212121314 247322277 Rat 1357404 Bw42 Body weight QTL 42 4.49 .0001 Body weight 1 212121314 247322277 Rat 1358916 Kidm22 Kidney mass QTL 22 3.32 Kidney mass 1 216662939 247322277 Rat 1358890 Bp259 Blood pressure QTL 259 3.06 Blood pressure mean arterial 1 216662939 247322277 Rat 2292216 Bw80 Body weight QTL 80 3.23 .0019 Body weight 1 219629755 250119874 Rat 724538 Kidm1 Kidney mass QTL 1 3.2 Kidney mass 1 219804771 259173490 Rat 1600397 Edcs4 Endometrial carcinoma susceptibility QTL 4 2.2 Endometrial tumor susceptibility 1 221868279 247322277 Rat 1598821 Rf55 Renal function QTL 55 6.3 Renal function renal blood flow 1 224420592 265343617 Rat 61400 Niddm1 Non-insulin dependent diabetes mellitus QTL 1 11 Glucose level postprandial 1 224426266 252340527 Rat 724533 Rf51 Renal function QTL 51 5.3 .0002 Renal function renal blood flow 1 224426393 263698966 Rat 634343 Hcar6 Hepatocarcinoma resistance QTL 6 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 224822211 267910886 Rat 1549911 Stresp9 Stress response QTL 9 6.13 .0035 Stress response defensive burying - approach 1 225366432 267910886 Rat 2303579 Insul12 Insulin level QTL 12 4 Insulin level 1 225366432 267910886 Rat 2303581 Bw85 Body weight QTL 85 4 Body weight 1 225366432 267910886 Rat 2303576 Gluco45 Glucose level QTL 45 4 Glucose level post-restraint 1 225366432 267910886 Rat 2303592 Gluco51 Glucose level QTL 51 3 Glucose level post-prandial 1 225366432 267910886 Rat 631835 Scl67 Serum cholesterol level QTL 67 4.27 .0000116 Lipid level cholesterol 1 226083572 267910886 Rat 731175 Uae20 Urinary albumin excretion QTL 20 3.5 .0018 Renal function urine albumin level 1 227005311 267111153 Rat 1600392 Bw123 Body weight QTL 123 .001 Body weight 1 229633779 267910886 Rat 2293700 Bmd27 Bone mineral density QTL 27 6.6 .0001 Bone mineral density 1 229876870 249951685 Rat 2293701 Bmd34 Bone mineral density QTL 34 8.3 .0001 Bone mineral density Femoral neck ultimate force 1 229876870 249951685 Rat 631843 Bw116 Body weight QTL 116 4.1 .016 Body fat amount 1 229876870 267593558 Rat 734767 Niddm57 Non-insulin dependent diabetes mellitus QTL 57 Body weight 1 229876870 267593558 Rat 734769 Niddm58 Non-insulin dependent diabetes mellitus QTL 58 Body weight 1 230411091 267593558 Rat 631215 Stl8 Serum triglyceride level QTL 8 9.27 .0001 Lipid level triglyceride 1 230963695 267910886 Rat 1300108 Rf8 Renal function QTL 8 3.75 Renal function salt-loaded renal vascular resistance 1 234595190 267111153 Rat 2316896 Gluco57 Glucose level QTL 57 7.2 Glucose level postprandial 1 235098616 252340527 Rat 1578778 Pur4 Proteinuria QTL 4 3.3 .003 Renal function urine protein level 1 236673382 267910886 Rat 1581544 Rf52 Renal function QTL 52 .05 Renal function urine protein level 1 238613503 267111153 Rat 61327 Eae7 Experimental allergic encephalomyelitis QTL 7 5.6 Brain/spinal cord inflammation change in body weight 1 240980142 247322277 Rat 71112 Bw115 Body weight QTL 115 6 .0001 Body weight 1 240980321 267110921 Rat 631536 Lnnr2 Liver neoplastic nodule remodeling QTL 2 2.9 .0005 Liver neoplastic nodule remodeling frequency 1 241199027 267910886 Rat
Gene-Chemical Interaction Annotations
