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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | RGD:735299 | 6480464 | Nicotine results in decreased expression of CXCR2 mRNA | CTD | PMID:18247414 | (S)-nicotine | increases expression | ISO | RGD:735299 | 6480464 | Nicotine results in increased expression of CXCR2 mRNA | CTD | PMID:20457658 | 17beta-estradiol | affects expression | ISO | RGD:735299 | 6480464 | Estradiol affects the expression of CXCR2 mRNA; more ... | CTD | PMID:19401270 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | Estradiol inhibits the reaction [Cholesterol, Dietary results in increased expression of CXCR2 mRNA]; more ... | CTD | PMID:12852833 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:735300 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of CXCR2 mRNA | CTD | PMID:15973123 | 2-naphthylamine | decreases expression | ISO | RGD:735299 | 6480464 | 2-Naphthylamine results in decreased expression of CXCR2 mRNA | CTD | PMID:18247414 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:735300 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CXCR2 mRNA | CTD | PMID:20188158 | aflatoxin B1 | increases expression | ISO | RGD:735299 | 6480464 | Aflatoxin B1 results in increased expression of CXCR2 mRNA | CTD | PMID:18316174 | aflatoxin B1 | decreases expression | ISO | RGD:735299 | 6480464 | Aflatoxin B1 results in decreased expression of CXCR2 mRNA | CTD | PMID:18316174 | aminoguanidine | multiple interactions | ISO | RGD:735300 | 6480464 | [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein | CTD | PMID:17138957 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CXCR2 mRNA | CTD | PMID:16483693 | atrazine | multiple interactions | ISO | RGD:735299 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of CXCR2 mRNA | CTD | PMID:18585445 | benzo[a]pyrene | decreases expression | ISO | RGD:735299 | 6480464 | Benzo(a)pyrene results in decreased expression of CXCR2 mRNA | CTD | PMID:18247414 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:735300 | 6480464 | Mustard Gas results in increased expression of CXCR2 mRNA | CTD | PMID:15674843 | calcium atom | affects transport | ISO | RGD:735299 | 6480464 | CXCR2 protein affects the transport of Calcium | CTD | PMID:15618463 | calcium atom | multiple interactions | ISO | RGD:735299 | 6480464 | [IL8 protein binds to and results in increased activity of CXCR2 protein] which results in increased abundance of and results in increased activity of Calcium | CTD | PMID:11298490 | calcium atom | multiple interactions | ISO | RGD:735300 | 6480464 | Excitatory Amino Acid Agonists inhibits the reaction [CXCR2 protein affects the localization of Calcium] | CTD | PMID:15914698 | calcium(0) | affects transport | ISO | RGD:735299 | 6480464 | CXCR2 protein affects the transport of Calcium | CTD | PMID:15618463 | calcium(0) | multiple interactions | ISO | RGD:735299 | 6480464 | [IL8 protein binds to and results in increased activity of CXCR2 protein] which results in increased abundance of and results in increased activity of Calcium | CTD | PMID:11298490 | calcium(0) | multiple interactions | ISO | RGD:735300 | 6480464 | Excitatory Amino Acid Agonists inhibits the reaction [CXCR2 protein affects the localization of Calcium] | CTD | PMID:15914698 | celecoxib | decreases expression | ISO | RGD:735300 | 6480464 | celecoxib results in decreased expression of CXCR2 mRNA | CTD | PMID:12902868 | curcumin | increases expression | ISO | RGD:735299 | 6480464 | Curcumin results in increased expression of CXCR2 protein | CTD | PMID:12216086 | cytochalasin D | multiple interactions | ISO | RGD:735299 | 6480464 | Cytochalasin D promotes the reaction [IL8 protein results in decreased expression of CXCR2 protein] | CTD | PMID:11145710 | diarsenic trioxide | increases expression | ISO | RGD:735299 | 6480464 | arsenic trioxide results in increased expression of CXCR2 mRNA | CTD | PMID:15761015 | diazoxide | increases activity | ISO | RGD:735300 | 6480464 | Isoproterenol results in increased activity of CXCR2 protein | CTD | PMID:15477226 | dichloroacetate | increases expression | ISO | RGD:735299 | 6480464 | Dichloroacetate results in increased expression of CXCR2 mRNA | CTD | PMID:20426967 | dichloroacetic acid | increases expression | ISO | RGD:735299 | 6480464 | Dichloroacetic Acid results in increased expression of CXCR2 mRNA | CTD | PMID:20426967 | dichloromethane | increases expression | EXP | | 6480464 | Methylene Chloride results in increased expression of CXCR2 mRNA | CTD | PMID:20955722 | ethylbenzene | increases expression | EXP | | 6480464 | ethylbenzene results in increased expression of CXCR2 mRNA | CTD | PMID:20955722 | isoprenaline | increases activity | ISO | RGD:735300 | 6480464 | Isoproterenol results in increased activity of CXCR2 protein | CTD | PMID:15477226 | mechlorethamine | affects response to substance | ISO | RGD:735300 | 6480464 | CXCR2 protein affects the susceptibility to Mechlorethamine | CTD | PMID:12753603 | mycophenolic acid | increases expression | ISO | RGD:735300 | 6480464 | Mycophenolic Acid results in increased expression of CXCR2 mRNA | CTD | PMID:19818335 | ozone | multiple interactions | ISO | RGD:735300 | 6480464 | Ozone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride] | CTD | PMID:15361358 | paracetamol | affects expression | ISO | RGD:735300 | 6480464 | Acetaminophen affects the expression of CXCR2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:735300 | 6480464 | [Acetaminophen results in increased expression of CXCL10 protein] which results in increased expression of CXCR2 protein | CTD | PMID:11739529 | paracetamol | multiple interactions | ISO | RGD:735300 | 6480464 | CXCR2 protein affects the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; more ... | CTD | PMID:16552707 | paracetamol | affects response to substance | ISO | RGD:735300 | 6480464 | CXCR2 protein affects the susceptibility to Acetaminophen | CTD | PMID:16552707 | phenobarbital | decreases expression | ISO | RGD:735300 | 6480464 | Phenobarbital results in decreased expression of CXCR2 mRNA | CTD | PMID:19270015 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:735299 | 6480464 | [Ionophores co-treated with Tetradecanoylphorbol Acetate] results in decreased localization of CXCR2 protein | CTD | PMID:15265017 | prednisolone | decreases expression | ISO | RGD:735299 | 6480464 | Prednisolone results in decreased expression of CXCR2 protein | CTD | PMID:15804745 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of CXCR2 mRNA | CTD | PMID:21602193 | silicon dioxide | decreases expression | ISO | RGD:735299 | 6480464 | Silicon Dioxide results in decreased expression of CXCR2 mRNA | CTD | PMID:19428942 | simvastatin | decreases expression | EXP | | 6480464 | Simvastatin results in decreased expression of CXCR2 mRNA | CTD | PMID:16414398 | thalidomide | decreases expression | ISO | RGD:735299 | 6480464 | Thalidomide results in decreased expression of CXCR2 protein | CTD | PMID:16344495 | titanium dioxide | increases expression | ISO | RGD:735300 | 6480464 | titanium dioxide results in increased expression of CXCR2 mRNA | CTD | PMID:23409001 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CXCR2 mRNA | CTD | PMID:20955722 | wortmannin | multiple interactions | ISO | RGD:735299 | 6480464 | wortmannin inhibits the reaction [IL8 protein results in increased activity of CXCR2 protein] | CTD | PMID:12975484 | | 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Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events (PID:200167) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events (PID:200167) |
References - curated| 1. |
Dunstan CA, etal., J Biol Chem 1996 Dec 20;271(51):32770-6. |
| 2. |
Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Gobl AE, etal., Biochim Biophys Acta 1997 Jun 12;1326(2):171-7. |
| 5. |
Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9. |
| 6. |
Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5. |
| 7. |
MGD data from the GO Consortium |
| 8. |
Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28. |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11. |
| 11. |
RGD automated data pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122. |
| 14. |
Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3. |
| 15. |
Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73. |
| 16. |
Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24. |
| 17. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncurated| PubMed | 10558890 |
| 12829448 | |
| 15516486 | |
| 16472549 | |
| 17891165 | |
| 18391506 | |
| 18462836 | |
| 19155217 | |
| 19255141 | |
| 20420568 | |
| 20877331 | |
| 21670971 | |
| 22361324 |
RGD Disease Portals| Cxcr2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cxcr2 (Rattus norvegicus) |
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| CXCR2 (Homo sapiens) |
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| Cxcr2 (Mus musculus) |
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Position Markers| L23637 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017183 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06061085 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01060846 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474004 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D63584 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U70988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X77797 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017183 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058879 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058879 | (Get FASTA) |
| GenBank Protein | AAC52961 | (Get FASTA) |
| BAA09797 | (Get FASTA) | |
| CAA54824 | (Get FASTA) | |
| EDL75335 | (Get FASTA) | |
| P35407 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014269 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000019109 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000019109 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29385 | ENTREZGENE |
| Germonline | ENSRNOG00000014269 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 10439 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Chemokine_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IL8_rcpt | UniProtKB/Swiss-Prot | |
| IL8B_rcpt | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29385 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR24227 | UniProtKB/Swiss-Prot |
| PTHR24227:SF39 | UniProtKB/Swiss-Prot | |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | GPCRRHODOPSN | UniProtKB/Swiss-Prot |
| INTRLEUKIN8R | UniProtKB/Swiss-Prot | |
| INTRLEUKN8BR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| TIGR | TC207804 | |
| UniGene | Rn.90347 | ENTREZGENE |
| UniProt | CXCR2_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-07-06 | Cxcr2 | chemokine (C-X-C motif) receptor 2 | Il8rb | interleukin 8 receptor, beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Il8rb | interleukin 8 receptor, beta | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in spleen, heart, lung, liver, skeletal muscle and kidney but not found in brain and testis | 729076 |
| gene_product | members of the rhodopsin G-protein coupled receptor (GCR) superfamily | 69860 |
| More on Cxcr2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2906 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




