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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl salicylate
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Accession:CHEBI:31832 term browser browse the term
Definition:A benzoate ester that is the methyl ester of salicylic acid.
Synonyms:related_synonym: 2-(Methoxycarbonyl)phenol;   2-Carbomethoxyphenol;   2-Hydroxybenzoic acid methyl ester;   Betula oil;   Formula=C8H8O3;   Gaultheria oil;   InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3;   InChIKey=OSWPMRLSEDHDFF-UHFFFAOYSA-N;   Methyl 2-hydroxybenzoate;   Methyl o-hydroxybenzoate;   Natural wintergreen oil;   Oil of wintergreen;   SMILES=COC(=O)c1ccccc1O;   Spicewood Oil;   Sweet birch oil;   Teaberry oil
 xref: CAS:119-36-8;   Drug_Central:4245;   KEGG:C12305;   KEGG:D01087;   KNApSAcK:C00030767
 xref_mesh: MESH:C033069
 xref: PMID:21249432;   PMID:21287406;   PMID:21327960;   PMID:21404848;   PMID:21609308;   PMID:21790190;   PMID:21936953;   Reaxys:971516;   Wikipedia:Methyl_salicylate


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methyl salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 affects expression ISO methyl salicylate affects the expression of ACOD1 mRNA CTD PMID:22302311 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO methyl salicylate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO methyl salicylate results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO methyl salicylate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO methyl salicylate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO methyl salicylate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] CTD PMID:36416909 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO methyl salicylate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:36416909 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO methyl salicylate affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO methyl salicylate affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO methyl salicylate affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO methyl salicylate affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
increases expression		 ISO methyl salicylate results in decreased expression of CXCL2 protein
methyl salicylate results in increased expression of CXCL2 protein		 CTD PMID:23178550 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Emd emerin affects expression ISO methyl salicylate affects the expression of EMD mRNA CTD PMID:19527780 NCBI chr  X:152,038,990...152,042,190
Ensembl chr  X:152,038,998...152,045,807 		JBrowse link
G Esr1 estrogen receptor 1 affects expression ISO methyl salicylate affects the expression of ESR1 mRNA CTD PMID:19527780 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Fech ferrochelatase increases expression ISO methyl salicylate results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO methyl salicylate results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO methyl salicylate results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 affects expression ISO methyl salicylate affects the expression of GAL3ST1 mRNA CTD PMID:19527780 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO methyl salicylate results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO methyl salicylate results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methyl salicylate results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO methyl salicylate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A decreases expression ISO methyl salicylate results in decreased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO methyl salicylate results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il4 interleukin 4 affects expression ISO methyl salicylate affects the expression of IL4 mRNA CTD PMID:22302311 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases secretion ISO methyl salicylate results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgav integrin subunit alpha V affects expression ISO methyl salicylate affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Lgals7 galectin 7 affects expression ISO methyl salicylate affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO methyl salicylate results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO methyl salicylate results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO methyl salicylate affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO methyl salicylate results in decreased expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Npr3 natriuretic peptide receptor 3 affects expression ISO methyl salicylate affects the expression of NPR3 mRNA CTD PMID:19527780 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO methyl salicylate results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO methyl salicylate results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO methyl salicylate results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO methyl salicylate results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO methyl salicylate affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO methyl salicylate affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623 		JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions		 ISO methyl salicylate affects the expression of TNF mRNA
methyl salicylate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]		 CTD PMID:20385217 PMID:36416909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO methyl salicylate results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of methyl salicylate CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing		 EXP UGT1A6 protein results in increased metabolism of methyl salicylate
UGT1A6 gene polymorphism affects the metabolism of methyl salicylate		 CTD PMID:9429234 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
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  CHEBI ontology 19838
    role 19814
      biological role 19812
        insect attractant 84
          methyl salicylate 46
Path 2
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  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      aromatic carboxylic acid 12617
                                        benzoic acids 12594
                                          benzoic acid 5331
                                            hydroxybenzoic acid 4798
                                              monohydroxybenzoic acid 2613
                                                salicylic acid 1544
                                                  methyl salicylate 46
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