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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrofuran antibiotic
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Accession:CHEBI:87230 term browser browse the term
Definition:A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties.
Synonyms:related_synonym: nitrofuran antibiotics;   nitrofuran antimicrobial agent;   nitrofuran antimicrobial agents
 xref: AGR:IND44688035;   PMID:15776153;   PMID:16999120;   PMID:17691006;   PMID:23785991;   PMID:25437357;   Wikipedia:Nitrofuran


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furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] CTD PMID:27996348 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein		 CTD PMID:23112108 PMID:26095818 PMID:27996348 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression		 ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein		 CTD PMID:23112108 PMID:26095818 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions		 ISO Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]		 CTD PMID:23112108 PMID:26095818 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein		 CTD PMID:26687534 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein] CTD PMID:27996348 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression		 ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A		 CTD PMID:26095818 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 PMID:27996348 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Furazolidone results in increased expression of HSPA5 protein
Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]		 CTD PMID:27996348 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Furazolidone results in increased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:27996348 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 PMID:27996348 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein		 CTD PMID:26687534 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
nitrofurantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nitrofurantoin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases export
affects abundance
multiple interactions
increases transport
affects response to substance
increases secretion		 ISO
EXP		 ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein results in increased export of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 affects the susceptibility to Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]		 CTD PMID:15709111 PMID:15722455 PMID:17093006 PMID:17785426 PMID:18799806 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Agt angiotensinogen decreases activity EXP Nitrofurantoin results in decreased activity of AGT protein CTD PMID:1313237 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein CTD PMID:11841787 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Cat catalase decreases activity ISO
EXP		 Nitrofurantoin results in decreased activity of CAT protein CTD PMID:1313237 PMID:9000262 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] CTD PMID:15748169 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] CTD PMID:34021431 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 EXP
ISO		 Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose		 CTD PMID:1313237 PMID:1901343 PMID:9000262 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity EXP Nitrofurantoin results in increased activity of HIF1A protein CTD PMID:11841787 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Nitrofurantoin results in increased expression of HMOX1 mRNA CTD PMID:7626009 PMID:11841787 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Nitrofurantoin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Nitrofurantoin results in increased expression of HSPA8 mRNA CTD PMID:7626009 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitrofurantoin results in increased expression of JUN mRNA CTD PMID:7626009 PMID:11841787 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Nitrofurantoin results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; Nitrofurantoin results in increased expression of and affects the localization of NFE2L2 protein; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein] CTD PMID:34021431 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases response to substance
affects reduction		 ISO NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin		 CTD PMID:9310146 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
multiple interactions
affects metabolic processing		 ISO
EXP		 POR protein results in increased metabolism of Nitrofurantoin
POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein]
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]		 CTD PMID:6802140 PMID:18206659 PMID:34021431 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] CTD PMID:15748169 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases activity
increases expression		 ISO
EXP		 Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA		 CTD PMID:11841787 PMID:15748169 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Nitrofurantoin results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
nitrofurazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA] CTD PMID:15945272 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP Nitrofurazone binds to GSK3B protein CTD PMID:18222664 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA] CTD PMID:15945272 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nitrofurazone results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Nitrofurazone inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA] CTD PMID:15945272 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Nitrofurazone results in decreased expression of LHB protein CTD PMID:11548123 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP Nitrofurazone results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions		 EXP Nitrofurazone results in increased expression of MYC mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]		 CTD PMID:15945272 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140 PMID:15488632 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prl prolactin decreases expression EXP Nitrofurazone results in decreased expression of PRL protein CTD PMID:11548123 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Tgfa transforming growth factor alpha increases expression
multiple interactions		 EXP Nitrofurazone results in increased expression of TGFA mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]		 CTD PMID:15945272 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA] CTD PMID:15945272 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO Nitrofurazone results in increased mutagenesis of TP53 gene CTD PMID:15488632 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          nitrofuran antibiotic 52
            (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide 0
            Nifurtimox 0
            furagin 0
            furazolidone 17
            nifursol 0
            nifurtoinol 0
            nitrofurantoin 24
            nitrofurazone 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organic heteromonocyclic compound 17804
                                    furans 8656
                                      nitrofuran antibiotic 52
                                        (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide 0
                                        Nifurtimox 0
                                        furagin 0
                                        furazolidone 17
                                        nifursol 0
                                        nifurtoinol 0
                                        nitrofurantoin 24
                                        nitrofurazone 16
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