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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrimidinecarboxylic acid
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Accession:CHEBI:78574 term browser browse the term
Definition:Any pyrimidine that bears one or more carboxylic acid substituents.
Synonyms:related_synonym: pyrimidinecarboxylic acids


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dihydroorotic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
increases oxidation
increases metabolic processing		 ISO
EXP		 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; azastene inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; HR 325 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; toltrazuril inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]		 CTD PMID:9776318 PMID:9802339 PMID:11248707 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
orotic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:25601987 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression EXP Orotic Acid results in decreased expression of CYP2C6 protein CTD PMID:25786523 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A1 mRNA CTD PMID:15670589 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A2 mRNA CTD PMID:15670589 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165 		JBrowse link
G Edn1 endothelin 1 increases expression EXP Orotic Acid results in increased expression of EDN1 protein CTD PMID:25601987 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [INS protein results in increased abundance of Nitric Oxide]; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:25601987 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Orotic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:25601987 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:25601987 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in decreased expression of PPARA protein CTD PMID:15670589 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein] CTD PMID:25601987 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions		 ISO Orotic Acid results in increased phosphorylation of RPS6KB1 protein
Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:22863860 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases phosphorylation
multiple interactions		 ISO Orotic Acid results in decreased phosphorylation of RPTOR protein
Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein]; Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein]		 CTD PMID:22863860 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in decreased expression of RXRA protein CTD PMID:15670589 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases export		 ISO
EXP		 4-Aminobenzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; [Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; gamma-Aminobutyric Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Niacin promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Orotic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; phenylpyruvic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Salicylic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]
4-Aminobenzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; [Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Niacin promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Orotic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; phenylacetic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Salicylic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]		 CTD PMID:22981274 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein]; Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] CTD PMID:22863860 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        donor 18883
          Bronsted acid 18763
            oxoacid 18736
              carbon oxoacid 18612
                carboxylic acid 18609
                  pyrimidinecarboxylic acid 17
                    (6R)-6-(4-bromophenyl)-3-(2-furanylmethyl)-4-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid methyl ester 0
                    2,4-dioxo-1H-pyrimidine-5-carboxylic acid [2-(2-bromoanilino)-2-oxoethyl] ester 0
                    2-(3,5-dimethyl-1-pyrazolyl)-4-(4-hydroxyanilino)-5-pyrimidinecarboxylic acid ethyl ester 0
                    2-(3,5-dimethyl-1-pyrazolyl)-4-(4-morpholinyl)-5-pyrimidinecarboxylic acid ethyl ester 0
                    2-(5-methyl-3-oxo-1H-pyrazol-2-yl)-6-oxo-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                    2-(butylthio)-4-oxo-1H-pyrimidine-6-carboxylic acid 0
                    4,6-dimethyl-N-(1-phenylethylideneamino)-2-pyrimidinecarboxamide 0
                    4-(2,5-dimethylphenyl)-6-[[(4-methylphenyl)methylamino]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                    4-(2-furanyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                    4-(3,4-dihydroxyphenyl)-6-[(4-fluoro-3-methylphenyl)sulfonylmethyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                    4-(cyclohexylamino)-2-(3,5-dimethyl-1-pyrazolyl)-5-pyrimidinecarboxylic acid ethyl ester 0
                    4-[5-(3-chloro-2-methylphenyl)-2-furanyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                    4-[5-(3-chlorophenyl)-2-furanyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester 0
                    4-amino-2-(butylthio)-5-pyrimidinecarboxylic acid ethyl ester 0
                    4-amino-2-[(4-amino-6-anilino-1,3,5-triazin-2-yl)methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                    4-amino-2-[[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                    4-amino-2-[[4-amino-6-(4-methylanilino)-1,3,5-triazin-2-yl]methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                    4-amino-2-sulfanylpyrimidine-5-carboxylic acid 0
                    5-propyl-2-pyridinecarboxylic acid 0
                    6-(2-chlorophenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid 2-methylpropyl ester 0
                    9,10-dehydrofusaric acid methyl ester 0
                    Alloxanoic acid 0
                    CJ-14,877 0
                    CJ-14,897 0
                    Caripyrin 0
                    Choline orotate 0
                    Dehydrofusaric acid 0
                    Fusaric acid methyl ester 0
                    Fusaricate H 0
                    Fusaricate I 0
                    Fusaricate J 0
                    Fusaricate K 0
                    LSM-20446 0
                    N-[(4-fluorophenyl)methylideneamino]-3-methyl-2,4-dioxo-1H-pyrimidine-6-carboxamide 0
                    N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide 0
                    Penicolinate A 0
                    Penicolinate B 0
                    Penicolinate C 0
                    Penicolinate D 0
                    Penicolinate E 0
                    Phenopicolinic acid 0
                    Vertilecanin A 0
                    Vertilecanin A Methy ester 0
                    pyrimidinedicarboxylic acid + 0
                    pyrimidinemonocarboxylic acid + 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    diazines 13204
                                      pyrimidines 13070
                                        pyrimidinecarboxylic acid 17
                                          (6R)-6-(4-bromophenyl)-3-(2-furanylmethyl)-4-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid methyl ester 0
                                          2,4-dioxo-1H-pyrimidine-5-carboxylic acid [2-(2-bromoanilino)-2-oxoethyl] ester 0
                                          2-(3,5-dimethyl-1-pyrazolyl)-4-(4-hydroxyanilino)-5-pyrimidinecarboxylic acid ethyl ester 0
                                          2-(3,5-dimethyl-1-pyrazolyl)-4-(4-morpholinyl)-5-pyrimidinecarboxylic acid ethyl ester 0
                                          2-(5-methyl-3-oxo-1H-pyrazol-2-yl)-6-oxo-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                                          2-(butylthio)-4-oxo-1H-pyrimidine-6-carboxylic acid 0
                                          4,6-dimethyl-N-(1-phenylethylideneamino)-2-pyrimidinecarboxamide 0
                                          4-(2,5-dimethylphenyl)-6-[[(4-methylphenyl)methylamino]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                                          4-(2-furanyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                                          4-(3,4-dihydroxyphenyl)-6-[(4-fluoro-3-methylphenyl)sulfonylmethyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                                          4-(cyclohexylamino)-2-(3,5-dimethyl-1-pyrazolyl)-5-pyrimidinecarboxylic acid ethyl ester 0
                                          4-[5-(3-chloro-2-methylphenyl)-2-furanyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester 0
                                          4-[5-(3-chlorophenyl)-2-furanyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester 0
                                          4-amino-2-(butylthio)-5-pyrimidinecarboxylic acid ethyl ester 0
                                          4-amino-2-[(4-amino-6-anilino-1,3,5-triazin-2-yl)methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                                          4-amino-2-[[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                                          4-amino-2-[[4-amino-6-(4-methylanilino)-1,3,5-triazin-2-yl]methylthio]-5-pyrimidinecarboxylic acid ethyl ester 0
                                          4-amino-2-sulfanylpyrimidine-5-carboxylic acid 0
                                          5-propyl-2-pyridinecarboxylic acid 0
                                          6-(2-chlorophenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid 2-methylpropyl ester 0
                                          9,10-dehydrofusaric acid methyl ester 0
                                          Alloxanoic acid 0
                                          CJ-14,877 0
                                          CJ-14,897 0
                                          Caripyrin 0
                                          Choline orotate 0
                                          Dehydrofusaric acid 0
                                          Fusaric acid methyl ester 0
                                          Fusaricate H 0
                                          Fusaricate I 0
                                          Fusaricate J 0
                                          Fusaricate K 0
                                          LSM-20446 0
                                          N-[(4-fluorophenyl)methylideneamino]-3-methyl-2,4-dioxo-1H-pyrimidine-6-carboxamide 0
                                          N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide 0
                                          Penicolinate A 0
                                          Penicolinate B 0
                                          Penicolinate C 0
                                          Penicolinate D 0
                                          Penicolinate E 0
                                          Phenopicolinic acid 0
                                          Vertilecanin A 0
                                          Vertilecanin A Methy ester 0
                                          pyrimidinedicarboxylic acid + 0
                                          pyrimidinemonocarboxylic acid + 17
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