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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carfilzomib
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Accession:CHEBI:65347 term browser browse the term
Definition:A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma
Synonyms:exact_synonym: N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
 related_synonym: Formula=C40H57N5O7;   InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1;   InChIKey=BLMPQMFVWMYDKT-NZTKNTHTSA-N;   Kyprolis;   SMILES=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([C@@]1(OC1)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCC3=CC=CC=C3)=O)N4CCOCC4
 xref: CAS:868540-17-4;   Drug_Central:4483;   KEGG:D08880
 xref_mesh: MESH:C524865
 xref: PMID:19348473;   PMID:20937826;   PMID:21905015;   PMID:22235146;   PMID:22411899;   PMID:22507794;   PMID:22507799;   PMID:22555973;   PMID:22621161;   PMID:22645181;   PMID:22665938;   PMID:22726549;   PMID:22727391;   PMID:22734651;   PMID:22761464;   PMID:22763387;   Reaxys:12488950;   Wikipedia:Carfilzomib


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carfilzomib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24632418 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor multiple interactions ISO carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases response to substance ISO BRCA1 mutant form results in increased susceptibility to carfilzomib CTD PMID:25522274 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO carfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Bsg basigin (Ok blood group) multiple interactions
decreases expression		 ISO carfilzomib promotes the reaction [[Dronabinol co-treated with Cannabidiol] results in decreased expression of BSG mRNA]
carfilzomib results in decreased expression of BSG mRNA		 CTD PMID:27769052 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions		 ISO
EXP		 carfilzomib results in increased cleavage of CASP3 protein
carfilzomib results in increased activity of CASP3 protein
apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein]		 CTD PMID:27769052 PMID:27785949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP carfilzomib results in decreased activity of CAT protein CTD PMID:27785949 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ckm creatine kinase, M-type increases secretion
multiple interactions		 EXP
ISO		 carfilzomib results in increased secretion of CKM protein
apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein]
Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of CKM protein]		 CTD PMID:26899300 PMID:27785949 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression ISO carfilzomib results in decreased expression of COX8A mRNA CTD PMID:30818834 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions		 ISO carfilzomib results in decreased expression of CXCR4 mRNA
carfilzomib promotes the reaction [[Dronabinol co-treated with Cannabidiol] results in decreased expression of CXCR4 mRNA]		 CTD PMID:27769052 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; carfilzomib inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion
multiple interactions		 EXP carfilzomib results in increased secretion of GOT1 protein
apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein]		 CTD PMID:27785949 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:27900802 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases secretion		 EXP
ISO		 apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein]
Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of LDHA protein]		 CTD PMID:26899300 PMID:27785949 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions		 EXP carfilzomib results in increased expression of MAPK1 mRNA
apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA]		 CTD PMID:27785949 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions		 EXP carfilzomib results in increased expression of MAPK8 mRNA
apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA]		 CTD PMID:27785949 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] CTD PMID:24632418 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
decreases expression		 ISO Dexrazoxane inhibits the reaction [carfilzomib results in decreased expression of MYH6 mRNA] CTD PMID:26899300 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions		 ISO carfilzomib results in increased expression of MYH7 mRNA
Dexrazoxane inhibits the reaction [carfilzomib results in increased expression of MYH7 mRNA]		 CTD PMID:26899300 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO carfilzomib results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression		 EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA] CTD PMID:27900802 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II increases response to substance ISO PRKCSH gene mutant form results in increased susceptibility to carfilzomib CTD PMID:21685914 NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of PTGS2 mRNA] CTD PMID:27900802 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions		 EXP carfilzomib results in increased expression of RELA mRNA
apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA]		 CTD PMID:27785949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO carfilzomib results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of TIMP1 protein] CTD PMID:24632418 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of TNF protein] CTD PMID:27900802 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases activity
affects activity		 ISO carfilzomib results in increased activity of TP53 protein
carfilzomib affects the activity of TP53 protein		 CTD PMID:30818834 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO carfilzomib results in increased expression of ZFAND2A protein CTD PMID:31540997 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            antineoplastic agent 17749
              carfilzomib 34
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  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              peptide 11122
                                                oligopeptide 1339
                                                  tetrapeptide 65
                                                    carfilzomib 34
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