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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gabapentin
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Accession:CHEBI:42797 term browser browse the term
Definition:A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Synonyms:exact_synonym: [1-(aminomethyl)cyclohexyl]acetic acid
 related_synonym: 1-(Aminomethyl)cyclohexaneacetic acid;   Formula=C9H17NO2;   InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12);   InChIKey=UGJMXCAKCUNAIE-UHFFFAOYSA-N;   Neurontin;   SMILES=NCC1(CCCCC1)CC(O)=O;   gabapentina;   gabapentine;   gabapentinum
 alt_id: CHEBI:5237
 xref: Beilstein:2359739;   CAS:60142-96-3;   DrugBank:DB00996;   Drug_Central:1264;   HMDB:HMDB0005015;   KEGG:D00332;   LINCS:LSM-5716
 xref_mesh: MESH:C040029
 xref: PDBeChem:GBN;   PMID:22048285;   PMID:22144034;   PMID:22240839;   PMID:22240859;   PMID:22279347;   PMID:22296650;   PMID:22345405;   PMID:22352861;   PMID:22419014;   PMID:22422817;   PMID:22464746;   PMID:22467888;   PMID:22556282;   PMID:22575516;   PMID:22612015;   PMID:22865488;   PMID:22888801;   PMID:22934077;   PMID:22946876;   PMID:23018586;   PMID:23053645;   Patent:EP1140793;   Patent:US2008103334;   Patent:US2008269326;   Patent:US2009043126;   Patent:US2009292138;   Patent:US2012046272;   Patent:WO2005037784;   Patent:WO2008060572;   Patent:WO2010023694;   Reaxys:2359739;   VSDB:2975;   Wikipedia:Gabapentin


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gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase decreases activity ISO gabapentin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP gabapentin results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO gabapentin results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A decreases activity
multiple interactions		 ISO gabapentin results in decreased activity of CACNA1A protein
gabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]		 CTD PMID:12770949 PMID:12817894 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,624,489 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B decreases activity ISO gabapentin results in decreased activity of CACNA1B protein CTD PMID:12770949 NCBI chr 9:137,877,782...138,124,619
Ensembl chr 9:137,877,782...138,124,624 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D multiple interactions ISO CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding
multiple interactions		 ISO gabapentin binds to CACNA2D1 protein
CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]
[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride; [gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]		 CTD PMID:16380257 PMID:17442347 PMID:17881535 PMID:19796812 PMID:20340177 More... NCBI chr 7:81,946,444...82,443,956
Ensembl chr 7:81,946,444...82,443,956 		JBrowse link
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 affects activity
affects binding		 ISO
EXP		 CACNA2D2 protein affects the activity of gabapentin
gabapentin binds to CACNA2D2 protein		 CTD PMID:11687876 PMID:14660671 NCBI chr 3:50,362,613...50,504,244
Ensembl chr 3:50,362,613...50,504,244 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 multiple interactions ISO CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr12:48,814,480...48,828,941
Ensembl chr12:48,813,794...48,828,941 		JBrowse link
G CP ceruloplasmin decreases expression ISO gabapentin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression ISO gabapentin results in decreased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression ISO gabapentin results in decreased expression of CYP2E1 mRNA CTD PMID:17381134 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO gabapentin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO Gabapentin inhibits the reaction [monobutyl phthalate results in increased expression of DLG4 protein] CTD PMID:35278568 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836 		JBrowse link
G F10 coagulation factor X decreases expression ISO gabapentin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Gabapentin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions EXP CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions EXP CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr 9:98,288,109...98,708,935
Ensembl chr 9:98,288,109...98,708,935 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Gabapentin results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 decreases expression ISO gabapentin results in decreased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression ISO gabapentin results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO gabapentin results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 decreases expression ISO gabapentin results in decreased expression of HSP90AA1 mRNA CTD PMID:17381134 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G IGF1 insulin like growth factor 1 increases expression ISO gabapentin results in increased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP gabapentin results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KYAT1 kynurenine aminotransferase 1 decreases activity ISO gabapentin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G LPO lactoperoxidase decreases expression EXP Gabapentin results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases expression EXP Gabapentin results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NCL nucleolin increases expression ISO gabapentin results in increased expression of NCL mRNA CTD PMID:17381134 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641 		JBrowse link
G NOS2 nitric oxide synthase 2 increases expression ISO gabapentin results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO gabapentin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PNOC prepronociceptin decreases expression ISO gabapentin results in decreased expression of PNOC mRNA CTD PMID:18281898 NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355 		JBrowse link
G PON1 paraoxonase 1 decreases activity EXP gabapentin results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 decreases expression EXP Gabapentin results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases expression
decreases expression		 ISO gabapentin results in increased expression of SLC22A7 mRNA
gabapentin results in decreased expression of SLC22A7 mRNA		 CTD PMID:17381134 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 decreases expression EXP Gabapentin results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 increases import EXP SLC7A5 protein results in increased import of gabapentin CTD PMID:27818298 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507 		JBrowse link
G ST13 ST13 Hsp70 interacting protein increases expression ISO gabapentin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO gabapentin results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SYN1 synapsin I multiple interactions ISO Gabapentin inhibits the reaction [monobutyl phthalate results in increased expression of SYN1 protein] CTD PMID:35278568 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857 		JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions ISO gabapentin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TKT transketolase increases expression ISO gabapentin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO gabapentin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression ISO gabapentin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO gabapentin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        xenobiotic 20362
          gabapentin 45
            gabapentin enacarbil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbon oxoacid 22761
                                    carboxylic acid 22741
                                      monocarboxylic acid 21745
                                        fatty acid 19090
                                          short-chain fatty acid 17994
                                            fatty acid 4:0 8284
                                              butyric acid 6785
                                                gamma-aminobutyric acid 160
                                                  gabapentin 45
                                                    gabapentin enacarbil 0
paths to the root