CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: idarubicin
Accession: CHEBI:42068
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Definition: An anthracycline antibiotic that has formula 497.49392.
Synonyms: related_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7S-cis)-; Formula=C26H27NO9; InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1; InChIKey=XDXDZDZNSLXDNA-TZNDIEGXSA-N; SMILES=C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O
alt_id: CHEBI:35758; CHEBI:42066
xref: Beilstein:3641270; CAS:58957-92-9; DrugBank:DB01177; Drug_Central:1414; LINCS:LSM-5769
xref_mesh: MESH:D015255
xref: Wikipedia:Idarubicin
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
Idarubicin binds to and affects the folding of ABCC1 protein
CTD
PMID:11278000
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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App
amyloid beta precursor protein
increases response to substance
ISO
APP gene mutant form results in increased susceptibility to Idarubicin
CTD
PMID:25926793
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ar
androgen receptor
increases activity
ISO
Idarubicin results in increased activity of AR protein
CTD
PMID:25257666
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atrx
ATRX, chromatin remodeler
decreases expression multiple interactions
ISO
Idarubicin results in decreased expression of ATRX mRNA [Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA]
CTD
PMID:28973540
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
Idarubicin results in increased expression of BAX mRNA; Idarubicin results in increased expression of BAX protein Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein]
CTD
PMID:28973540
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
multiple interactions increases activity
ISO
Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein]
CTD
PMID:17965967 PMID:18438337
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA]
CTD
PMID:28973540
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Esr1
estrogen receptor 1
decreases activity increases activity
ISO
Idarubicin results in decreased activity of ESR1 protein Idarubicin results in increased activity of ESR1 protein
CTD
PMID:25257666
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Exo1
exonuclease 1
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein] Idarubicin results in decreased expression of EXO1 mRNA; Idarubicin results in decreased expression of EXO1 protein
CTD
PMID:28973540
NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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Fen1
flap structure-specific endonuclease 1
multiple interactions
ISO
[Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA
CTD
PMID:28973540
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions increases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA]
CTD
PMID:28973540
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gadd45g
growth arrest and DNA-damage-inducible, gamma
multiple interactions increases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA]
CTD
PMID:28973540
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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Gsr
glutathione-disulfide reductase
multiple interactions
ISO
Idarubicin promotes the reaction [Glutaral results in decreased activity of GSR protein]
CTD
PMID:19490936
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmox1
heme oxygenase 1
increases expression
ISO
Idarubicin results in increased expression of HMOX1
CTD
PMID:26260164
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Idarubicin results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Npm1
nucleophosmin 1
multiple interactions
ISO
NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin]
CTD
PMID:20172040
NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
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Nppb
natriuretic peptide B
increases expression
ISO
Idarubicin results in increased expression of NPPB protein
CTD
PMID:16151589
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions decreases activity increases activity
ISO
Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] Idarubicin results in decreased activity of NR1H4 protein Idarubicin results in increased activity of NR1H4 protein
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Ogg1
8-oxoguanine DNA glycosylase
decreases expression multiple interactions
ISO
Idarubicin results in decreased expression of OGG1 mRNA; Idarubicin results in decreased expression of OGG1 protein Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]
CTD
PMID:28973540
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Parp1
poly (ADP-ribose) polymerase 1
increases expression multiple interactions
ISO
Idarubicin results in increased expression of PARP1 mRNA; Idarubicin results in increased expression of PARP1 protein Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein]
CTD
PMID:28973540
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ppard
peroxisome proliferator-activated receptor delta
decreases activity
ISO
Idarubicin results in decreased activity of PPARD protein
CTD
PMID:25257666
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
decreases activity
ISO
Idarubicin results in decreased activity of PPARG protein
CTD
PMID:25257666
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression multiple interactions
ISO
Idarubicin results in increased expression of PPP1R15A mRNA; Idarubicin results in increased expression of PPP1R15A protein Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein]
CTD
PMID:28973540
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Pttg1
PTTG1 regulator of sister chromatid separation, securin
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein]
CTD
PMID:28973540
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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Rad17
RAD17 checkpoint clamp loader component
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA]
CTD
PMID:28973540
NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
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Rad51
RAD51 recombinase
multiple interactions
ISO
[Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA
CTD
PMID:28973540
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rad9a
RAD9 checkpoint clamp component A
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA]
CTD
PMID:28973540
NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
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Terf1
telomeric repeat binding factor 1
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA]
CTD
PMID:28973540
NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
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Topbp1
DNA topoisomerase II binding protein 1
decreases expression multiple interactions
ISO
Idarubicin results in decreased expression of TOPBP1 mRNA Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
CTD
PMID:28973540
NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA]
CTD
PMID:28973540
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ung
uracil-DNA glycosylase
decreases expression multiple interactions
ISO
Idarubicin results in decreased expression of UNG mRNA Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA]
CTD
PMID:28973540
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Vdr
vitamin D receptor
decreases activity
ISO
Idarubicin results in decreased activity of VDR protein
CTD
PMID:25257666
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Xiap
X-linked inhibitor of apoptosis
multiple interactions
ISO
[Idarubicin co-treated with triptolide] affects the expression of XIAP protein
CTD
PMID:18922616
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
multiple interactions
ISO
[Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA
CTD
PMID:28973540
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Xrcc1
X-ray repair cross complementing 1
multiple interactions decreases expression
ISO
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein] Idarubicin results in decreased expression of XRCC1 mRNA; Idarubicin results in decreased expression of XRCC1 protein
CTD
PMID:28973540
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Xrcc6
X-ray repair cross complementing 6
multiple interactions
ISO
[Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA
CTD
PMID:28973540
NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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