CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: triazolobenzodiazepine
Accession: CHEBI:35501
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Definition: Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a triazole.
Synonyms: related_synonym: triazolobenzodiazepines
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Crh
corticotropin releasing hormone
multiple interactions
EXP
adinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin]
CTD
PMID:1480515
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases methylation multiple interactions
ISO
CYP2C19 protein results in decreased methylation of adinazolam Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]
CTD
PMID:9600717
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases methylation multiple interactions
ISO
CYP3A4 protein results in decreased methylation of adinazolam Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]
CTD
PMID:9600717
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Htr2a
5-hydroxytryptamine receptor 2A
decreases expression
EXP
adinazolam results in decreased expression of HTR2A protein
CTD
PMID:1664741
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects chemical synthesis
ISO
CYP3A4 protein affects the chemical synthesis of alpha-hydroxyalprazolam
CTD
PMID:12196913
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
affects chemical synthesis
EXP
CYP3A23-3A1 protein affects the chemical synthesis of alpha-hydroxyalprazolam
CTD
PMID:12196913
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Capn1
calpain 1
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein]
CTD
PMID:19490937
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3
caspase 3
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein
CTD
PMID:19490937
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ctsb
cathepsin B
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
CTD
PMID:19490937
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions affects metabolic processing
ISO
CYP3A4 protein binds to and affects the metabolism of Alprazolam CYP3A4 protein affects the metabolism of Alprazolam
CTD
PMID:12196913 PMID:15856409 PMID:16042670
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
affects metabolic processing
EXP
CYP3A23-3A1 protein affects the metabolism of Alprazolam
CTD
PMID:12196913
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases hydroxylation
ISO
CYP3A5 protein results in increased hydroxylation of Alprazolam
CTD
PMID:15903124
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Il2
interleukin 2
decreases expression
ISO
Alprazolam results in decreased expression of IL2 protein
CTD
PMID:1624223
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Lhb
luteinizing hormone subunit beta
increases secretion
ISO
Alprazolam results in increased secretion of LHB protein
CTD
PMID:7883836
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein
CTD
PMID:19490937
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Plcb1
phospholipase C beta 1
decreases expression
EXP
Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein
CTD
PMID:12527476
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Ppia
peptidylprolyl isomerase A
increases hydroxylation
ISO
PPIA protein results in increased hydroxylation of Alprazolam
CTD
PMID:15806426
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Akr1c1
aldo-keto reductase family 1, member C1
decreases activity
ISO
Estazolam results in decreased activity of AKR1C1 protein
CTD
PMID:11995921
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases activity
ISO
Estazolam results in decreased activity of AKR1C2 protein
CTD
PMID:11995921
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
Estazolam results in decreased activity of AKR1C3 protein
CTD
PMID:11995921
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases hydroxylation
ISO
CYP3A4 protein results in increased hydroxylation of Estazolam
CTD
PMID:16012077
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Arc
activity-regulated cytoskeleton-associated protein
decreases expression
ISO
Triazolam results in decreased expression of ARC mRNA
CTD
PMID:27489535
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Bdnf
brain-derived neurotrophic factor
multiple interactions
ISO
[Triazolam co-treated with zolpidem] results in decreased expression of BDNF protein
CTD
PMID:24367698
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions affects metabolic processing
ISO
[Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam]; Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CYP3A4 protein affects the metabolism of Triazolam
CTD
PMID:10952769 PMID:15286053 PMID:15863898 PMID:16042670 PMID:19299527 PMID:22447115 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Triazolam results in decreased expression of FOS mRNA
CTD
PMID:27489535
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gria1
glutamate ionotropic receptor AMPA type subunit 1
decreases expression
ISO
Triazolam results in decreased expression of GRIA1 protein
CTD
PMID:27489535
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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Gria4
glutamate ionotropic receptor AMPA type subunit 4
decreases expression
ISO
Triazolam results in decreased expression of GRIA4 protein
CTD
PMID:27489535
NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
ISO
Triazolam results in decreased expression of NR4A1 mRNA
CTD
PMID:27489535
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Triazolam inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Triazolam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:21561794
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Triazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
G
Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
Triazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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