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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of TRH mRNA | CTD | PMID:10443546 PMID:15781040 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of TRH mRNA | CTD | PMID:15781040 PMID:10443546 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | Estradiol promotes the reaction [TRH protein results in increased secretion of TSHB protein] | CTD | PMID:16570238 | 5-azacytidine | decreases expression | ISO | RGD:69154 | 6480464 | Azacitidine results in decreased expression of TRH mRNA | CTD | PMID:19194470 | adinazolam | multiple interactions | EXP | | 6480464 | adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | all-trans-retinoic acid | decreases expression | ISO | RGD:11452 | 6480464 | Tretinoin results in decreased expression of TRH mRNA | CTD | PMID:16788091 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of TRH mRNA | CTD | PMID:20488242 | alprazolam | multiple interactions | EXP | | 6480464 | Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | amitriptyline | multiple interactions | ISO | RGD:69154 | 6480464 | Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] | CTD | PMID:6455462 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of TRH mRNA | CTD | PMID:16483693 | carbon dioxide | increases response to substance | ISO | RGD:69154 | 6480464 | TRH protein results in increased susceptibility to Carbon Dioxide | CTD | PMID:8957205 | chlordiazepoxide | multiple interactions | EXP | | 6480464 | Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | copper atom | decreases secretion | ISO | RGD:11452 | 6480464 | Copper deficiency results in decreased secretion of TRH protein modified form | CTD | PMID:19815072 | copper(0) | decreases secretion | ISO | RGD:11452 | 6480464 | Copper deficiency results in decreased secretion of TRH protein modified form | CTD | PMID:19815072 | dexamethasone | multiple interactions | EXP | | 6480464 | Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] | CTD | PMID:9681491 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of TRH protein | CTD | PMID:9681491 | diazepam | multiple interactions | EXP | | 6480464 | Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | disodium selenite | decreases expression | ISO | RGD:69154 | 6480464 | Sodium Selenite results in decreased expression of TRH mRNA | CTD | PMID:18175754 | disulfiram | multiple interactions | EXP | | 6480464 | Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] | CTD | PMID:9681491 | disulfiram | increases expression | EXP | | 6480464 | Disulfiram results in increased expression of TRH mRNA alternative form | CTD | PMID:9681491 | disulfiram | decreases expression | EXP | | 6480464 | Disulfiram results in decreased expression of TRH protein | CTD | PMID:9681491 | erythrosine sodium | multiple interactions | EXP | | 6480464 | Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] | CTD | PMID:2160137 | estazolam | multiple interactions | EXP | | 6480464 | Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | fonofos | increases methylation | ISO | RGD:69154 | 6480464 | Fonofos results in increased methylation of TRH promoter | CTD | PMID:22847954 | kainic acid | decreases expression | EXP | | 6480464 | Kainic Acid results in decreased expression of TRH mRNA | CTD | PMID:10443546 | kainic acid | increases expression | EXP | | 6480464 | Kainic Acid results in increased expression of TRH mRNA | CTD | PMID:10443546 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of TRH mRNA | CTD | PMID:20080153 | L-ascorbic acid | decreases expression | ISO | RGD:11452 | 6480464 | Ascorbic Acid results in decreased expression of TRH mRNA | CTD | PMID:15305145 | morphine | increases expression | ISO | RGD:11452 | 6480464 | Morphine results in increased expression of TRH mRNA | CTD | PMID:21178816 | parathion | increases methylation | ISO | RGD:69154 | 6480464 | Parathion results in increased methylation of TRH promoter | CTD | PMID:22847954 | streptozocin | decreases expression | EXP | | 6480464 | Streptozocin results in decreased expression of TRH mRNA | CTD | PMID:16118471 | streptozocin | multiple interactions | EXP | | 6480464 | TRH protein inhibits the reaction [Streptozocin inhibits the reaction [Blood Glucose results in increased secretion of INS1 protein]] | CTD | PMID:16118471 | terbufos | increases methylation | ISO | RGD:69154 | 6480464 | terbufos results in increased methylation of TRH promoter | CTD | PMID:22847954 | triazolam | multiple interactions | EXP | | 6480464 | Triazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] | CTD | PMID:2845442 | valproic acid | decreases expression | ISO | RGD:11452 | 6480464 | Valproic Acid results in decreased expression of TRH mRNA | CTD | PMID:21427059 | verapamil | multiple interactions | ISO | RGD:69154 | 6480464 | Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]; more ... | CTD | PMID:7851873 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
References - curated| 1. |
Alexander K, etal., Cell Mol Neurobiol. 2005 Jun;25(3-4):681-95. |
| 2. |
Angel Vargas M, etal., Eur J Endocrinol 2002 Sep;147(3):363-9. |
| 3. |
Ao Y, etal., Endocrinology. 2006 Dec;147(12):6004-10. Epub 2006 Sep 7. |
| 4. |
Bacova Z, etal., Gen Physiol Biophys. 2005 Jun;24(2):181-97. |
| 5. |
Ciosek J J Physiol Pharmacol 2002 Sep;53(3):423-37. |
| 6. |
de Gortari P, etal., Regul Pept. 2005 Apr 15;127(1-3):141-50. |
| 7. |
Deng PY, etal., J Physiol. 2006 Dec 1;577(Pt 2):497-511. Epub 2006 Sep 21. |
| 8. |
Espinosa VP, etal., Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E175-86. Epub 2006 Aug 22. |
| 9. |
Fiedler J, etal., J Neuroendocrinol. 2006 May;18(5):367-76. |
| 10. |
Garcia SI, etal., Hypertension 2002 Feb;39(2 Pt 2):491-5. |
| 11. |
GOA data from the GO Consortium |
| 12. |
Gotoh K, etal., J Neurochem. 2007 Nov;103(3):1102-10. Epub 2007 Aug 30. |
| 13. |
Hou TD and Du JZ, Neuro Endocrinol Lett. 2005 Feb;26(1):43-9. |
| 14. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 15. |
Landa MS, etal., Am J Physiol Endocrinol Metab. 2007 Jan 16;. |
| 16. |
Lechan RM, etal., Science 1986 Jan 10;231(4734):159-61. |
| 17. |
Lee SL, etal., Ann N Y Acad Sci 1989;553:14-28. |
| 18. |
Lee SL, etal., J Biol Chem 1988 Nov 15;263(32):16604-9. |
| 19. |
MGD data from the GO Consortium |
| 20. |
Morel G, etal., Neuroendocrinology. 1985 Oct;41(4):312-20. |
| 21. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 22. |
Nie Y, etal., Brain Res. 2005 Aug 23;1054(1):45-54. |
| 23. |
Pekary AE, etal., Neurochem Int. 2006 Feb;48(3):208-17. Epub 2005 Nov 15. |
| 24. |
RGD automated data pipeline |
| 25. |
RGD automated import pipeline for gene-chemical interactions |
| 26. |
RGD Automated Pipelines |
| 27. |
Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35 |
References - uncurated| PubMed | 12456804 |
| 12477932 | |
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| 17726229 | |
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| 18191132 | |
| 18427988 | |
| 18467436 | |
| 18474603 | |
| 18779326 | |
| 19302192 | |
| 19602869 | |
| 19617647 | |
| 20074584 | |
| 20136691 | |
| 21085660 | |
| 21135357 | |
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| 2119297 | |
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| 21569245 | |
| 22354782 | |
| 22719053 | |
| 22785235 | |
| 22884559 | |
| 22889935 | |
| 22911445 | |
| 22960404 | |
| 22981312 | |
| 22985455 | |
| 23063458 | |
| 23106615 | |
| 23297311 | |
| 23327999 | |
| 23333484 | |
| 23524276 | |
| 23537088 | |
| 23626844 |
RGD Disease Portals| Trh has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Trh (Rattus norvegicus) |
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| TRH (Homo sapiens) |
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| Trh (Mus musculus) |
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Position Markers| RH128079 |
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| X59387 |
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| RH142232 |
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| PMC304098P6 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013046 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06032355 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01031550 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC161830 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473957 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ100942 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ220299 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ221570 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ221573 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ221609 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222015 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222264 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222377 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222571 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ222984 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ223091 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228758 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228762 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229082 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ229292 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M12138 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M23631 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M23632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M23643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M27464 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M27465 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M36317 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013046 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037178 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037178 | (Get FASTA) |
| GenBank Protein | AAA42239 | (Get FASTA) |
| AAA42275 | (Get FASTA) | |
| AAA42276 | (Get FASTA) | |
| AAA65750 | (Get FASTA) | |
| AAI61830 | (Get FASTA) | |
| EDL91392 | (Get FASTA) | |
| P01150 | (Get FASTA) |
Promoters| RGD ID: | 6849976 | ||||||||||
| Promoter ID: | EP30077 | ||||||||||
| Type: | single initiation site | ||||||||||
| Name: | RN_THYL | ||||||||||
| Description: | Thyrotropin-releasing hormone | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Notes: | homology_group=Homology group 181; Mammalian thyrotropin-releaseing hormone | ||||||||||
| Experiment Methods: | Primer extension; Sequencing of a full-length cDNA; experiments performed with; closely related gene | ||||||||||
| Regulation: | hypothalamus( (repressed by or weakly expressed in) thyroxine), brain, testis | ||||||||||
| Position: |
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Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000011824 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000015944 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000015944 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25569 | ENTREZGENE |
| Germonline | ENSRNOG00000011824 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 5163 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:9091055 | IMAGE-MGC_LOAD |
| InterPro | TRH | UniProtKB/Swiss-Prot |
| IPI | IPI00210890 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25569 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:187310 | IMAGE-MGC_LOAD |
| PANTHER | PTHR17530 | UniProtKB/Swiss-Prot |
| Pfam | TRH | UniProtKB/Swiss-Prot |
| PIRSF | TRH | UniProtKB/Swiss-Prot |
| UniGene | Rn.22 | ENTREZGENE |
| UniProt | B1WBP2_RAT | UniProtKB/TrEMBL |
| TRH_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Trh | Tryrotropin releasing hormone | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_process | increases vasopressin storage in neurohypophysis, but decreases in hypothalamus | 634240 |
| More on Trh | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3903 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-07 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.