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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbachol
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Accession:CHEBI:3385 term browser browse the term
Definition:An ammonium salt that has formula C6H15N2O2.Cl.
Synonyms:exact_synonym: 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride
 related_synonym: (2-Carbamoyloxyethyl)trimethylammonium chloride;   (2-Hydroxyethyl)trimethyl ammonium chloride carbamate;   (2-Hydroxyethyl)trimethylammonium chloride carbamate;   2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride;   2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride;   Carbachol chloride;   Choline carbamate chloride;   Choline chlorine carbamate;   Formula=C6H15ClN2O2;   Formula=C6H15N2O2.Cl;   InChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H;   InChIKey=AIXAANGOTKPUOY-UHFFFAOYSA-N;   Karbachol;   Karbamoylcholin chlorid;   SMILES=[Cl-].C[N+](C)(C)CCOC(N)=O;   carbacholum;   carbacol
 alt_id: CHEBI:41364
 xref: Beilstein:3917459;   CAS:51-83-2;   DrugBank:DB00411;   KEGG:D00524
 xref_mesh: MESH:D002217
 xref: Patent:DE539329;   Patent:US1894162;   Wikipedia:Carbachol


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carbachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
multiple interactions
increases hydrolysis		 ISO Carbachol binds to ACHE protein
Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Carbachol results in increased metabolism of and results in increased secretion of ACHE protein
ACHE protein results in increased hydrolysis of Carbachol		 CTD PMID:18602908 PMID:20493829 PMID:23047022 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Carbachol CTD PMID:12869393 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp5 aquaporin 5 affects localization ISO Carbachol affects the localization of AQP5 protein CTD PMID:19443731 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]; Nicardipine inhibits the reaction [Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]] CTD PMID:12646291 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein] CTD PMID:10758335 PMID:19200344 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Carbachol results in increased expression of BCL2 protein
Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]		 CTD PMID:10758335 PMID:17708838 PMID:19200344 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO
EXP		 Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein]
Carbachol results in decreased expression of CASP3 protein		 CTD PMID:17708838 PMID:19200344 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression		 ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases activity
multiple interactions
affects binding		 ISO Carbachol results in increased activity of CHRM1 protein
[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein; brucine promotes the reaction [Carbachol binds to CHRM1 protein]
CHRM1 protein binds to Carbachol
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Gadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Lanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]		 CTD PMID:8683117 PMID:9224827 PMID:11527950 PMID:18316702 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding		 ISO eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein]
CHRM2 protein binds to Carbachol
Carbachol binds to and results in increased activity of CHRM2 protein; Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]		 CTD PMID:9224827 PMID:11181912 PMID:19002953 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases activity
affects binding
affects response to substance
increases response to substance		 ISO
EXP		 Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; Carbachol binds to and results in increased activity of CHRM3 protein; Carbachol binds to and results in increased activity of CHRM3 protein mutant form; Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]; Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]
CHRM3 protein binds to Carbachol
CHRM3 protein affects the susceptibility to Carbachol
CHRM3 protein results in increased susceptibility to Carbachol
[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol		 CTD PMID:9224827 PMID:14724830 PMID:15105209 PMID:19407017 PMID:20466821 More... NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding		 ISO brucine promotes the reaction [Carbachol binds to CHRM4 protein]
CHRM4 protein binds to Carbachol		 CTD PMID:9224827 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP carbachol affects binding competes with [Epibatidine binds to Chrna2 protein] RGD PMID:15016836 RGD:2303194 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding
multiple interactions		 EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein]
Carbachol affects binding [Epibatidine binds to Chrna3 protein]		 CTD
RGD		 PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding		 ISO
EXP		 Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
carbachol affects binding to Chrna4 protein; carbachol competes with [Epibatidine binds to Chrna4 protein]		 CTD
RGD		 PMID:14645658 PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
affects activity		 ISO
EXP		 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]; Carbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]
Carbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]		 CTD PMID:10216184 PMID:19448648 PMID:21703337 PMID:29248576 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding		 ISO
EXP		 Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
carbachol affects binding to Chrnb2 protein; carbachol competes with [Epibatidine binds to Chrnb2 protein]		 CTD
RGD		 PMID:14645658 PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects phosphorylation EXP Carbachol affects the phosphorylation of CREB1 protein CTD PMID:21295078 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases phosphorylation ISO carbachol decreases phosphorylation of EEF2 protein in colon cancer cells RGD PMID:31227218 RGD:153298919 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein CTD PMID:8683117 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression
multiple interactions		 EXP Carbachol results in increased expression of FGF1 protein
KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]		 CTD PMID:15264218 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP
ISO		 Carbachol results in increased expression of FOS protein
Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]		 CTD PMID:10404113 PMID:10758335 PMID:11074189 PMID:16023590 PMID:21295078 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gcg glucagon increases secretion
multiple interactions		 ISO Carbachol results in increased secretion of GCG protein
NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]		 CTD PMID:3329090 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance EXP GNA11 results in increased susceptibility to Carbachol CTD PMID:8014894 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821 		JBrowse link
G Hdc histidine decarboxylase affects response to substance ISO HDC protein affects the susceptibility to Carbachol CTD PMID:12893847 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Il10 interleukin 10 affects expression ISO Carbachol affects the expression of IL10 mRNA CTD PMID:15698499 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta affects expression
increases expression		 EXP Carbachol affects the expression of IL1B protein
Carbachol results in increased expression of IL1B protein		 CTD PMID:16023590 PMID:21121909 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 increases expression ISO Carbachol results in increased expression of IL4 mRNA CTD PMID:15698499 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Ins1 insulin 1 multiple interactions
increases secretion		 ISO
EXP		 [Carbachol co-treated with Glucose] results in increased secretion of INS1 protein
Sirolimus inhibits the reaction [Carbachol results in increased secretion of INS1 protein]		 CTD PMID:14578291 PMID:30761839 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects response to substance ISO KCNH2 protein mutant form affects the susceptibility to Carbachol CTD PMID:29574456 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Lyz2 lysozyme 2 affects secretion ISO Carbachol affects the secretion of LYZ protein CTD PMID:15234967 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
decreases phosphorylation		 EXP
ISO		 Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Carbachol results in increased activity of MAPK1 protein
Carbachol results in decreased phosphorylation of MAPK1 protein		 CTD PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases activity		 EXP
ISO		 Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Carbachol results in decreased phosphorylation of MAPK3 protein
Carbachol results in increased activity of MAPK3 protein		 CTD PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Carbachol results in increased phosphorylation of MYL9 protein CTD PMID:17272850 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase affects response to substance EXP MYLK protein affects the susceptibility to Carbachol CTD PMID:17272850 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein] CTD PMID:3329090 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity		 ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein
Carbachol results in increased activity of PRKCZ protein		 CTD PMID:15255942 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression EXP Carbachol affects the expression of PTGS2 protein CTD PMID:16023590 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein; Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sct secretin decreases activity EXP SCT protein results in decreased activity of Carbachol CTD PMID:10198350 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases activity ISO Carbachol results in increased activity of SLC9A1 protein CTD PMID:12842825 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Carbachol results in increased phosphorylation of and results in increased activity of SRC protein; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression
multiple interactions
decreases expression
increases activity		 EXP
ISO		 Carbachol results in increased expression of TNF protein
Carbachol affects the expression of TNF protein
TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]; TNF protein inhibits the reaction [Carbachol results in increased abundance of phosphatidylbutanol]
Carbachol results in decreased expression of TNF mRNA
TNF results in increased activity of Carbachol		 CTD PMID:11245595 PMID:15086448 PMID:15698499 PMID:16023590 PMID:21121909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases activity ISO Carbachol results in increased activity of TRPC1 protein CTD PMID:19289841 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 increases activity ISO Carbachol results in increased activity of TRPC2 protein CTD PMID:19289841 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions
increases activity		 ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Carbachol results in increased activity of TRPC3 protein] CTD PMID:19289841 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 multiple interactions
increases activity
increases response to substance		 ISO TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]; TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]
Carbachol results in increased activity of TRPC4 protein
TRPC4 protein results in increased susceptibility to Carbachol		 CTD PMID:11830588 PMID:19289841 PMID:29658714 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:107,946,163...108,230,991
Ensembl chr  X:107,939,131...108,230,991 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity		 ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein] CTD PMID:17603544 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          analgesic 14719
            non-narcotic analgesic 13886
              carbachol 56
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  ammonium 8298
                                    ammonium ion derivative 8293
                                      ammonium compound 5184
                                        ammonium salt 4908
                                          carbachol 56
paths to the root