Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2343
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3
Acc ID: CHEBI:3385
Term: carbachol
Definition: An ammonium salt that has formula C6H15N2O2.Cl.
Chemical ID: MESH:D002217
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm3multiple interactionsEXP 6480464CTD[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to CarbacholPMID:15105209
Chrm3affects bindingISOCHRM3 (Homo sapiens)6480464CTDCHRM3 protein binds to CarbacholPMID:9224827
Chrm3affects response to substanceISOChrm3 (Mus musculus)6480464CTDCHRM3 protein affects the susceptibility to CarbacholPMID:14724830
Chrm3increases activityISOCHRM3 (Homo sapiens)6480464CTDCarbachol results in increased activity of CHRM3 proteinPMID:20708676
Chrm3increases response to substanceISOChrm3 (Mus musculus)6480464CTDCHRM3 protein results in increased susceptibility to CarbacholPMID:19407017
Chrm3multiple interactionsISOCHRM3 (Homo sapiens)6480464CTDAtropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; Carbachol binds to and results in increased activity of CHRM3 protein; Carbachol binds to and results in increased activity of CHRM3 protein mutant form; Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]; Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]PMID:20466821 PMID:20708676 PMID:9224827
Go Back to source page   Continue to Ontology report