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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Erk5 MAPK signaling pathway
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Accession:PW:0000603 term browser browse the term
Definition:The Erk5 pathway, also known as the big MAP kinase, is activated by various stresses but not by inflammatory cytokines. In HeLa and PC12 cells, the pathway can be activated by growth factors.
Synonyms:related_synonym: Bmk1 MAPK signaling pathway;   ERK5 cascade;   Signalling to ERK5
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Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO
IMP 		RGD PMID:16376520 PMID:15631999 RGD:2298532, RGD:1582263 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 ISO RGD PMID:16376520 RGD:2298532 NCBI chr18:24,081,444...24,153,940
Ensembl chr18:24,081,444...24,147,323 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:91,519,976...91,588,651
Ensembl chr10:91,519,888...91,588,651 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO
IMP 		RGD PMID:16376520 PMID:11782488 RGD:2298532, RGD:2298794 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806 		JBrowse link
G Sh2d2a SH2 domain containing 2A ISO RGD PMID:16376520 RGD:2298532 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:175,609,874...175,616,685 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 4:154,800,590...154,926,147
Ensembl chr 4:154,800,590...154,926,147 		JBrowse link
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      mitogen activated protein kinase signaling pathway 299
        Erk5 MAPK signaling pathway 6
          altered Erk5 MAPK signaling pathway 2
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      kinase mediated signaling pathway 602
        serine/threonine-specific kinase mediated signaling pathway 476
          mitogen activated protein kinase signaling pathway 299
            Erk5 MAPK signaling pathway 6
              altered Erk5 MAPK signaling pathway 2
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