Bhlhe40 (basic helix-loop-helix family, member e40) - Rat Genome Database

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Gene: Bhlhe40 (basic helix-loop-helix family, member e40) Rattus norvegicus
Analyze
Symbol: Bhlhe40
Name: basic helix-loop-helix family, member e40
RGD ID: 68439
Description: Predicted to enable several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein dimerization activity. Involved in several processes, including circadian rhythm; negative regulation of transcription by RNA polymerase II; and regulation of neuronal synaptic plasticity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human BHLHE40 (basic helix-loop-helix family member e40); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basic helix-loop-helix domain containing, class B2; Bhlhb2; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; Dec1; enhancer-of split and hairy-related protein 2; enhancer-of-split and hairy-related protein 2; SHARP-2; Sharp2; stimulated by retinoic acid 14; Stra13; Stra14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,174,450 - 143,180,150 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4143,174,048 - 143,180,783 (+)EnsemblGRCr8
mRatBN7.24141,618,453 - 141,624,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4147,040,502 - 147,046,182 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,821,233 - 142,826,913 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,465,221 - 141,470,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)Ensemblrn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4130,269,971 - 130,275,671 (+)NCBICelera
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Cytogenetic Map4q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
ferric oxide  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
Heptachlor epoxide  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naled  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
Pf-06840003  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
PX-866  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear body  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
10. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells. Yamada K, etal., Biol Reprod 2004 Jan;70(1):76-82. Epub 2003 Sep 3.
Additional References at PubMed
PMID:12297495   PMID:12624110   PMID:12796501   PMID:14672706   PMID:14725860   PMID:15038852   PMID:15147242   PMID:15193144   PMID:15560782   PMID:15733865   PMID:17487425   PMID:18411297  
PMID:18602890   PMID:19029909   PMID:19786558   PMID:20205554   PMID:21430201   PMID:26590300   PMID:26820676   PMID:27792527   PMID:28797635   PMID:29952285   PMID:30012868   PMID:35659652  
PMID:36881362  


Genomics

Comparative Map Data
Bhlhe40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,174,450 - 143,180,150 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4143,174,048 - 143,180,783 (+)EnsemblGRCr8
mRatBN7.24141,618,453 - 141,624,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4147,040,502 - 147,046,182 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,821,233 - 142,826,913 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,465,221 - 141,470,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)Ensemblrn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4130,269,971 - 130,275,671 (+)NCBICelera
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Cytogenetic Map4q41NCBI
BHLHE40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3834,979,437 - 4,985,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl34,978,715 - 4,985,323 (+)Ensemblhg38GRCh38
GRCh3735,021,122 - 5,027,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,996,208 - 5,001,861 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3434,996,207 - 5,001,861NCBI
Celera34,959,047 - 4,964,811 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef34,954,421 - 4,960,188 (+)NCBIHuRef
CHM1_134,971,113 - 4,976,884 (+)NCBICHM1_1
T2T-CHM13v2.034,970,406 - 4,979,102 (+)NCBIT2T-CHM13v2.0
Bhlhe40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,637,590 - 108,643,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,637,590 - 108,643,886 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386108,660,629 - 108,666,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,660,629 - 108,666,925 (+)Ensemblmm10GRCm38
MGSCv376108,610,623 - 108,616,919 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366108,626,406 - 108,632,702 (+)NCBIMGSCv36mm8
Celera6110,461,756 - 110,468,060 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.85NCBI
Bhlhe40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,463,018 - 8,468,877 (-)Ensembl
ChiLan1.0NW_0049554218,463,337 - 8,468,877 (-)NCBIChiLan1.0ChiLan1.0
BHLHE40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v224,985,872 - 4,991,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan134,990,663 - 4,996,646 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v034,927,487 - 4,933,215 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,028,217 - 5,033,968 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,028,515 - 5,032,470 (+)EnsemblpanPan2panpan1.1
BHLHE40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,641,872 - 12,647,519 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,642,702 - 12,647,525 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2012,616,237 - 12,621,884 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02012,685,779 - 12,691,425 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,685,620 - 12,691,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,390,474 - 12,396,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,731,885 - 12,737,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,718,100 - 12,723,747 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bhlhe40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,360,673 - 11,365,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365774,315,977 - 4,322,032 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365774,316,099 - 4,321,193 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHLHE40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,526,116 - 61,533,674 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11361,526,121 - 61,533,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,830,821 - 67,836,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BHLHE40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,049,673 - 41,055,365 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,049,712 - 41,055,360 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041125,612,281 - 125,617,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,413,365 - 15,420,123 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477315,413,400 - 15,418,220 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bhlhe40
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1638,132,293 - 38,138,492 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bhlhe40
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:88
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000009563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
D4Wox44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,623,426 - 141,623,565 (+)MAPPERmRatBN7.2
Rnor_6.04140,708,592 - 140,708,730NCBIRnor6.0
Rnor_5.04205,175,102 - 205,175,240UniSTSRnor5.0
RGSC_v3.44144,144,459 - 144,144,597UniSTSRGSC3.4
Celera4130,274,944 - 130,275,082UniSTS
Cytogenetic Map4q41UniSTS
RH139327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,621,578 - 141,621,825 (+)MAPPERmRatBN7.2
Rnor_6.04140,706,744 - 140,706,990NCBIRnor6.0
Rnor_5.04205,173,254 - 205,173,500UniSTSRnor5.0
RGSC_v3.44144,142,611 - 144,142,857UniSTSRGSC3.4
Celera4130,273,096 - 130,273,342UniSTS
RH 3.4 Map8866.1UniSTS
Cytogenetic Map4q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009563   ⟹   ENSRNOP00000009564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4143,174,048 - 143,180,783 (+)Ensembl
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)Ensembl
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)Ensembl
RefSeq Acc Id: NM_053328   ⟹   NP_445780
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84143,174,450 - 143,180,150 (+)NCBI
mRatBN7.24141,618,453 - 141,624,154 (+)NCBI
Rnor_6.04140,703,619 - 140,709,319 (+)NCBI
Rnor_5.04205,170,129 - 205,175,829 (+)NCBI
RGSC_v3.44144,139,486 - 144,145,186 (+)RGD
Celera4130,269,971 - 130,275,671 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445780 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63587 (Get FASTA)   NCBI Sequence Viewer  
  BAD01588 (Get FASTA)   NCBI Sequence Viewer  
  EDL91480 (Get FASTA)   NCBI Sequence Viewer  
  O35780 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445780   ⟸   NM_053328
- UniProtKB: O35780 (UniProtKB/Swiss-Prot),   F7FCF3 (UniProtKB/TrEMBL),   Q76JQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009564   ⟸   ENSRNOT00000009563
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35780-F1-model_v2 AlphaFold O35780 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693283
Promoter ID:EPDNEW_R3808
Type:initiation region
Name:Bhlhe40_1
Description:basic helix-loop-helix family, member e40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04140,703,686 - 140,703,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68439 AgrOrtholog
BioCyc Gene G2FUF-43448 BioCyc
Ensembl Genes ENSRNOG00000007152 Ensembl
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  6.10.250.980 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES_HEY UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report rno:79431 UniProtKB/Swiss-Prot
NCBI Gene Bhlhe40 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot
Pfam Hairy_orange UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Bhlhe40 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007152 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot
  SSF47459 UniProtKB/Swiss-Prot
TIGR TC233060
UniProt BHE40_RAT UniProtKB/Swiss-Prot
  F7FCF3 ENTREZGENE, UniProtKB/TrEMBL
  O35780 ENTREZGENE
  Q76JQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-19 Bhlhe40  basic helix-loop-helix family, member e40  Bhlhb2  basic helix-loop-helix domain containing, class B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bhlhb2  basic helix-loop-helix domain containing, class B2       Name updated 70584 APPROVED
2002-02-27 Bhlhb2  basic helix-loop-helix domain containing, class B2      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the suprachiasmic nucleus of the hypothalamus (SCN) in a circadian fashion 625726
gene_expression expression in neurons of the cerebral cortex is induced by kainic acid 68312
gene_process expression may be associated with neuronal stimulation 728119
gene_product member of a family of neuronal bHLH proteins 728119