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Gene: Bcl2l10 (Bcl2-like 10) Rattus norvegicus

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Symbol:

Bcl2l10

Name:

Bcl2-like 10

RGD ID:

621015

Description:

Predicted to enable several functions, including calcium ion binding activity; caspase binding activity; and identical protein binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in several cellular components, including mitochondria-associated endoplasmic reticulum membrane contact site; mitochondrion; and spindle. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in multiple myeloma; myelodysplastic syndrome; and stomach carcinoma. Orthologous to human BCL2L10 (BCL2 like 10); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; ammonium chloride; arsenous acid.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

anti-apoptotic protein Boo; apoptosis regulator Bcl-B; bcl-2-like protein 10; BCL2 like 10; bcl2-L-10; BCL2-like 10 (apoptosis facilitator)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCL2L10 (BCL2 like 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Bcl2l10 (Bcl2-like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BCL2L10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bcl2l10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCL2L10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BCL2L10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bcl2l10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Bcl2l10 (BCL2 like 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Bcl2l10 (Bcl2-like 10)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BCL2L10 (BCL2 like 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bcl2l10 (BCL2 like 10)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	bcl2l10	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bcl2l10	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	84,987,833 - 84,993,878 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	84,987,833 - 84,993,872 (+)	Ensembl				GRCr8
mRatBN7.2	8	76,107,326 - 76,113,373 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	76,107,326 - 76,113,367 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	81,615,059 - 81,621,142 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	79,879,784 - 79,885,827 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	77,714,395 - 77,720,476 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	82,288,705 - 82,294,750 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	82,288,705 - 82,294,744 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	81,891,899 - 81,897,944 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	80,172,804 - 80,178,851 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	75,896,757 - 75,902,804 (+)	NCBI		Celera
RGSC_v3.1	8	80,191,857 - 80,197,905 (+)	NCBI
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast carcinoma (ISO)

multiple myeloma (ISO)

myelodysplastic syndrome (ISO)

stomach carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1,3,5-trinitro-1,3,5-triazinane (EXP)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

3,3'-diindolylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Brevetoxin B (ISO)

bufalin (ISO)

Bufotalin (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

diarsenic trioxide (EXP)

diazinon (EXP)

dibutyl phthalate (ISO)

dieldrin (EXP)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

flutamide (ISO)

folic acid (ISO)

furosemide (EXP)

iodoacetic acid (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (ISO)

monoethyl phthalate (ISO)

Myrtucommulone A (ISO)

nickel dichloride (EXP)

nicotine (ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

paraquat (ISO)

pentanal (ISO)

perfluorooctanoic acid (ISO)

potassium chloride (ISO)

propanal (ISO)

pyrazinecarboxamide (EXP)

rotenone (ISO)

silicon dioxide (ISO)

vinclozolin (EXP)

VX nerve agent (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA,ISO,ISS)

extrinsic apoptotic signaling pathway in absence of ligand (IBA)

intrinsic apoptotic signaling pathway in response to DNA damage (IBA)

microtubule organizing center organization (ISO,ISS)

negative regulation of apoptotic process (ISO)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (ISO)

negative regulation of intrinsic apoptotic signaling pathway (ISO)

oligodendrocyte differentiation (IEP)

positive regulation of apoptotic process (IBA,ISO)

regulation of apoptotic process (IEA)

release of cytochrome c from mitochondria (IBA)

transmembrane transport (IEA)

Cellular Component

cytosol (ISO)

endoplasmic reticulum (IEA,ISO)

membrane (ISO)

mitochondria-associated endoplasmic reticulum membrane contact site (ISO,ISS)

mitochondrial outer membrane (IBA)

mitochondrion (IEA,ISO,ISS)

nuclear membrane (IEA)

spindle (IEA,ISO,ISS)

Molecular Function

calcium ion binding (ISO,ISS)

caspase binding (ISO)

channel activity (IBA)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

intrinsic apoptotic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid neoplasms and de novo myelodysplastic syndromes.	Fabiani E, etal., Leuk Lymphoma. 2014 Jul;55(7):1538-43. doi: 10.3109/10428194.2013.845885. Epub 2013 Nov 1.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.	Hamouda MA, etal., J Exp Med. 2016 Aug 22;213(9):1705-22. doi: 10.1084/jem.20150983. Epub 2016 Jul 25.
4.	Bcl-2-related protein family gene expression during oligodendroglial differentiation.	Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Apoptosis - associated genes and their role in predicting responses to neoadjuvant breast cancer treatment.	Tvrdík D, etal., Med Sci Monit. 2012 Jan;18(1):BR60-67.
11.	Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-azacytidine.	Voso MT, etal., Leukemia. 2011 Dec;25(12):1910-3. doi: 10.1038/leu.2011.170. Epub 2011 Jul 15.
12.	BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells.	Xu JD, etal., J Pathol. 2011 Feb;223(3):400-9. doi: 10.1002/path.2811. Epub 2010 Nov 22.

Additional References at PubMed

PMID:9829980	PMID:9878060	PMID:11278245	PMID:19255499	PMID:22905226

Genomics

Comparative Map Data

Bcl2l10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	84,987,833 - 84,993,878 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	84,987,833 - 84,993,872 (+)	Ensembl				GRCr8
mRatBN7.2	8	76,107,326 - 76,113,373 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	76,107,326 - 76,113,367 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	81,615,059 - 81,621,142 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	79,879,784 - 79,885,827 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	77,714,395 - 77,720,476 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	82,288,705 - 82,294,750 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	82,288,705 - 82,294,744 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	81,891,899 - 81,897,944 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	80,172,804 - 80,178,851 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	75,896,757 - 75,902,804 (+)	NCBI		Celera
RGSC_v3.1	8	80,191,857 - 80,197,905 (+)	NCBI
Cytogenetic Map	8	q24	NCBI

BCL2L10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	52,109,263 - 52,112,775 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	52,109,263 - 52,112,775 (-)	Ensembl			hg38	GRCh38
GRCh37	15	52,401,460 - 52,404,972 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	50,189,114 - 50,192,264 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	50,189,113 - 50,192,264	NCBI
Celera	15	29,296,261 - 29,299,399 (-)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	29,232,794 - 29,235,957 (-)	NCBI		HuRef
CHM1_1	15	52,520,130 - 52,523,278 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	49,917,909 - 49,921,421 (-)	NCBI		T2T-CHM13v2.0

Bcl2l10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	75,255,040 - 75,258,922 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	75,255,040 - 75,258,931 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	75,347,758 - 75,351,640 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	75,347,758 - 75,351,649 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	75,195,565 - 75,199,447 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	75,133,695 - 75,137,549 (+)	NCBI		MGSCv36	mm8
Celera	9	72,507,133 - 72,511,009 (+)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	42.3	NCBI

BCL2L10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	41,344,811 - 41,356,450 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	45,525,286 - 45,531,038 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	31,049,509 - 31,057,273 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	49,376,576 - 49,380,109 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	49,376,576 - 49,380,109 (-)	Ensembl			panPan2	panpan1.1

Bcl2l10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	96,095,024 - 96,098,766 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936471	13,943,600 - 13,946,085 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCL2L10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	119,594,004 - 119,607,709 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	132,686,957 - 132,697,574 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCL2L10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	31,274,015 - 31,277,377 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	31,274,119 - 31,276,937 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	109,950,516 - 109,953,967 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bcl2l10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624731	8,399,936 - 8,403,904 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bcl2l10
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	69,638,180 - 69,642,874 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bcl2l10
47 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	273
Count of miRNA genes:	165
Interacting mature miRNAs:	185
Transcripts:	ENSRNOT00000012409
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	6	49	118	37	33	9	32	9	4	166	99	102	42	49	24	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY029163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012409 ⟹ ENSRNOP00000012409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	84,987,833 - 84,993,872 (+)	Ensembl
mRatBN7.2 Ensembl	8	76,107,326 - 76,113,367 (+)	Ensembl
Rnor_6.0 Ensembl	8	82,288,705 - 82,294,744 (+)	Ensembl

RefSeq Acc Id:

NM_053733 ⟹ NP_446185

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	84,987,833 - 84,993,878 (+)	NCBI
mRatBN7.2	8	76,107,326 - 76,113,373 (+)	NCBI
Rnor_6.0	8	82,288,705 - 82,294,750 (+)	NCBI
Rnor_5.0	8	81,891,899 - 81,897,944 (+)	NCBI
RGSC_v3.4	8	80,172,804 - 80,178,851 (+)	RGD
Celera	8	75,896,757 - 75,902,804 (+)	RGD

Sequence:

show sequence

GAGGCCAAAAGATGGGTGACCCGCTGCAGGATCGCACTAGACGGCTGCTGACTGACTACATATT
GTTCTGCGCACGGGCGCCGAACACCCCTGAGCCACTGCCCACGTCTGTTGAGGCGGCCTTGCTG
CGCTCTGTGACTAGTCAGATCCAACAGGAGCACCAGGATCTTTTCAACTCCTTCCGCGACTACC
AGGGCAACCGCCTGGAGCTGGTGACACAGATGGCGGATGAGTTGCTCTCCAATGACCAAGAGTT
CAACTGGGGCCGCCTGGTGATGCTCCTGGCCTTCGTGGGGACGCTAATGAACCAAGACAGGACT
GTTAAGCGGAGGAGGGATCAAAGAAACCGTCTCCTACTGGAGCGAGACTGCTATCTCATAGTGA
GCTTGCTGTACAATCGACTCACAGGACGGCATCGCTCCTGGCTGGAGGCTCACGGTGGCTGGGA
TGGCTTTTGCCAATTCTTCAAGAACCCCTTACCACCCGGCTTCTGGAGAAGATTGCTGATCCGG
GCTATTCTGTCCTGTTTCTTTGCAACGGCCATCTTTTATATCTGGAAATGTTTATAAGTTTTAA
ATTTTTAAATCGATCTTACCTGCCTAACTGCGGGCCCTCTAAGGGACAATTCTGGGTAGTTGGA
TAAGAACTGAGGAAATCCTCCTGCCTAGAGACATTTCTACCTGCATGCTACACGGAGTTCCGGG
TTTGGGATGGGCCTAAGTAGCTCTTTGCTAAGTGGGGAGATGGTCTATATCACTCCAAAGAACT
TCAGAAAAACGCTGCACCCACTCACTAGATGTGTTGTTGTCTGCATTTGGCTGCAGGCACAGCA
GAGCCACTCCCATCTGTTGCAGGGTTCTCAGCTGCTGTTAAGTAGCCAGGGGCAGGGCAGGGGG
TCCTAAACCCCAGAGCCCAGAGCCCGGAGCAATGAAGAATGCAATAGGAAACCTGAAGGAATCC
TTTGAAACCTAAATCCTTCCATGCCTCATTCCCAGGGCTTCTGAATTTATAATGCTCCCCTTAA
TACAGTTTTAAGTAACTTCGAATTCTTAATAAATGTATACATTTAAAAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_446185	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK31792	(Get FASTA)	NCBI Sequence Viewer
	EDL77801	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012409
	ENSRNOP00000012409.3
GenBank Protein	Q99M66	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446185 ⟸ NM_053733
- UniProtKB:	Q99M66 (UniProtKB/Swiss-Prot), A6I1C6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGDPLQDRTRRLLTDYILFCARAPNTPEPLPTSVEAALLRSVTSQIQQEHQDLFNSFRDYQGNR LELVTQMADELLSNDQEFNWGRLVMLLAFVGTLMNQDRTVKRRRDQRNRLLLERDCYLIVSLLY NRLTGRHRSWLEAHGGWDGFCQFFKNPLPPGFWRRLLIRAILSCFFATAIFYIWKCL hide sequence

Ensembl Acc Id:

ENSRNOP00000012409 ⟸ ENSRNOT00000012409

Protein Domains

Bcl-2 Bcl-2 homology region 1-3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99M66-F1-model_v2	AlphaFold	Q99M66	1-185	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621015	AgrOrtholog
BioCyc Gene	G2FUF-29821	BioCyc
Ensembl Genes	ENSRNOG00000009308	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012409	ENTREZGENE
	ENSRNOT00000012409.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.437.10	UniProtKB/Swiss-Prot
InterPro	Bcl-2_BH1-3	UniProtKB/Swiss-Prot
	Bcl2-like	UniProtKB/Swiss-Prot
	Bcl2_BH2_motif_CS	UniProtKB/Swiss-Prot
	Blc2-like_sf	UniProtKB/Swiss-Prot
	Blc2_fam	UniProtKB/Swiss-Prot
KEGG Report	rno:114552	UniProtKB/Swiss-Prot
NCBI Gene	114552	ENTREZGENE
PANTHER	BCL-2-LIKE PROTEIN 10	UniProtKB/Swiss-Prot
	PTHR11256	UniProtKB/Swiss-Prot
Pfam	Bcl-2	UniProtKB/Swiss-Prot
PhenoGen	Bcl2l10	PhenoGen
PROSITE	BCL2_FAMILY	UniProtKB/Swiss-Prot
	BH2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009308	RatGTEx
SMART	BCL	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56854	UniProtKB/Swiss-Prot
UniProt	A6I1C6	ENTREZGENE, UniProtKB/TrEMBL
	B2L10_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-05	Bcl2l10	Bcl2-like 10	Bcl2l10	BCL2 like 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-20	Bcl2l10	BCL2 like 10	Bcl2l10	BCL2-like 10 (apoptosis facilitator)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Bcl2l10	BCL2-like 10 (apoptosis facilitator)	Bcl2l10	Bcl2-like 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Bcl2l10	Bcl2-like 10		BCL2-like 10 (apoptosis facilitator)	Name updated	1299863	APPROVED
2002-08-07	Bcl2l10	BCL2-like 10 (apoptosis facilitator)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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