Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) - Rat Genome Database

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Gene: Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) Rattus norvegicus
Analyze
Symbol: Pfkfb1
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
RGD ID: 3307
Description: Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including carbohydrate phosphorylation; positive regulation of glycolytic process through fructose-6-phosphate; and response to glucagon. Located in cytosol. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-PF2-K/Fru-2,6-P2ase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (liver and muscle); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 1; 6-Phosphofructo-2-kinase/fructose-26-bisphosphatase 1 (liver and muscle); 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; PFK/FBPase 1; PFK2/FBPase2; Pfkfb01; PFRX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X22,936,038 - 22,989,691 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX22,937,494 - 22,989,704 (+)EnsemblGRCr8
mRatBN7.2X19,508,522 - 19,562,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,508,546 - 19,562,182 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX16,945,153 - 16,997,192 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X23,126,385 - 23,178,425 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,023,399 - 20,075,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,092,143 - 23,145,923 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)Ensemblrn6Rnor6.0
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X39,838,471 - 39,886,071 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX19,781,360 - 19,833,302 (+)NCBICelera
RGSC_v3.1X39,891,912 - 39,939,574 (+)NCBI
Cytogenetic MapXq12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-D-fructofuranose 2,6-bisphosphate  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
clofibric acid  (EXP)
cyclosporin A  (ISO)
D-glucopyranose 6-phosphate  (ISO)
dibenz[a,h]anthracene  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
furan  (EXP)
gentamycin  (EXP)
glyceraldehyde 3-phosphate  (ISO)
Heptachlor epoxide  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (EXP)
Lasiocarpine  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. Baltrusch S, etal., Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.
2. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. Baltrusch S, etal., J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.
3. Differential regulation of the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and pyruvate kinase by cyclic adenosine 3',5'-monophosphate in fetal and adult hepatocytes. Casado M, etal., J Cell Physiol. 1995 Dec;165(3):630-8.
4. Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism. Choi IY, etal., Eur J Biochem. 2002 Sep;269(18):4418-26.
5. Isolation of a cDNA clone for rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase. Colosia AD, etal., Biochem Biophys Res Commun 1987 Mar 30;143(3):1092-8.
6. Molecular forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase expressed in rat skeletal muscle. Crepin KM, etal., J Biol Chem 1992 Oct 25;267(30):21698-704.
7. Rat muscle 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Study of the kinase domain by site-directed mutagenesis. Crepin KM, etal., J Biol Chem 1993 Jul 15;268(20):15277-84.
8. Complete nucleotide sequence coding for rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase derived from a cDNA clone. Darville MI, etal., FEBS Lett 1987 Nov 30;224(2):317-21.
9. Characterization of an enhancer upstream from the muscle-type promoter of a gene encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Darville MI, etal., Nucleic Acids Res 1992 Jul 25;20(14):3575-83.
10. 5' flanking sequence and structure of a gene encoding rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Darville MI, etal., Proc Natl Acad Sci U S A 1989 Sep;86(17):6543-7.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Properties of phospho- and dephospho- forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis. Kurland IJ, etal., J Biol Chem. 1992 Mar 5;267(7):4416-23.
15. Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation. Langer S, etal., FEBS Lett. 2012 May 21;586(10):1419-25. doi: 10.1016/j.febslet.2012.03.066.
16. Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases. Lee YH, etal., Biochemistry. 1996 May 14;35(19):6010-9.
17. Insulin inhibits glucocorticoid-induced stimulation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene transcription. Lemaigre FP, etal., FEBS Lett. 1994 Mar 7;340(3):221-5.
18. Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Massa L, etal., Diabetes. 2004 Apr;53(4):1020-9.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Okar DA, etal., Adv Enzyme Regul. 2004;44:123-54. doi: 10.1016/j.advenzreg.2003.11.006.
21. Effect of starvation on gene expression of regulatory enzymes of glycolysis/gluconeogenesis in genetically obese (fa/fa) Zucker rats. Perez JX, etal., Int J Obes Relat Metab Disord. 1998 Jul;22(7):667-72.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Study of the roles of Arg-104 and Arg-225 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by site-directed mutagenesis. Rider MH, etal., Biochem J. 1995 Jul 1;309 ( Pt 1):341-6.
27. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
28. Transcriptional and posttranscriptional regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase during liver regeneration. Rosa JL, etal., Proc Natl Acad Sci U S A. 1992 May 1;89(9):3746-50.
29. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:2539378   PMID:2547611   PMID:2557623   PMID:2557826   PMID:2826464   PMID:2837207   PMID:2848802   PMID:3040762   PMID:6281762   PMID:9253407   PMID:9464277   PMID:10095107  
PMID:12379646   PMID:14623077   PMID:15896703   PMID:23291237   PMID:25416956   PMID:28706006  


Genomics

Comparative Map Data
Pfkfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X22,936,038 - 22,989,691 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX22,937,494 - 22,989,704 (+)EnsemblGRCr8
mRatBN7.2X19,508,522 - 19,562,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,508,546 - 19,562,182 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX16,945,153 - 16,997,192 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X23,126,385 - 23,178,425 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,023,399 - 20,075,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,092,143 - 23,145,923 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)Ensemblrn6Rnor6.0
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X39,838,471 - 39,886,071 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX19,781,360 - 19,833,302 (+)NCBICelera
RGSC_v3.1X39,891,912 - 39,939,574 (+)NCBI
Cytogenetic MapXq12NCBI
PFKFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,932,961 - 54,998,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,931,434 - 54,998,534 (-)Ensemblhg38GRCh38
GRCh37X54,959,394 - 55,025,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,976,315 - 55,037,236 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X54,842,610 - 54,903,532NCBI
CeleraX58,794,738 - 58,855,654 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,011,285 - 52,075,912 (-)NCBIHuRef
CHM1_1X54,949,616 - 55,015,006 (-)NCBICHM1_1
T2T-CHM13v2.0X54,226,089 - 54,293,383 (-)NCBIT2T-CHM13v2.0
Pfkfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,370,441 - 149,426,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,371,225 - 149,426,874 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X150,587,445 - 150,643,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,588,229 - 150,643,878 (+)Ensemblmm10GRCm38
MGSCv37X147,024,464 - 147,078,403 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X145,930,637 - 145,984,576 (+)NCBIMGSCv36mm8
CeleraX133,769,155 - 133,816,855 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Pfkfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,342,750 (-)Ensembl
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBIChiLan1.0ChiLan1.0
PFKFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,327,712 - 56,394,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,331,319 - 56,398,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,143,081 - 47,209,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X55,374,807 - 55,436,887 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX55,374,807 - 55,441,024 (-)EnsemblpanPan2panpan1.1
PFKFB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X46,617,522 - 46,691,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX46,613,847 - 46,691,038 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX37,952,977 - 38,026,831 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X46,906,002 - 46,979,845 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX46,906,011 - 46,980,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,415,757 - 46,489,624 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X46,882,333 - 46,956,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X46,824,607 - 46,898,459 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfkfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,409,064 - 39,466,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367511,753,627 - 1,806,294 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367511,753,627 - 1,806,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX47,765,154 - 47,859,061 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X47,771,751 - 47,859,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X53,701,871 - 53,795,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,015,810 - 51,077,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,016,318 - 51,071,977 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660864,991,650 - 5,055,662 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624910305,068 - 380,188 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624910303,697 - 380,491 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pfkfb1
257 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:129
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000000178, ENSRNOT00000033656
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
DXMgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X22,938,477 - 22,938,615 (+)Marker Load Pipeline
mRatBN7.2X19,510,953 - 19,511,091 (-)MAPPERmRatBN7.2
mRatBN7.2X19,510,953 - 19,511,180 (-)MAPPERmRatBN7.2
Rnor_6.0X23,143,400 - 23,143,537NCBIRnor6.0
Rnor_6.0X23,143,255 - 23,143,537NCBIRnor6.0
Rnor_5.0X23,563,507 - 23,563,644UniSTSRnor5.0
Rnor_5.0X23,563,362 - 23,563,644UniSTSRnor5.0
RGSC_v3.4X39,834,773 - 39,834,910UniSTSRGSC3.4
RGSC_v3.4X39,834,772 - 39,834,910RGDRGSC3.4
CeleraX19,782,147 - 19,782,284UniSTS
RGSC_v3.1X39,888,241 - 39,888,379RGD
RH 2.0 Map21174.0RGD
Cytogenetic MapXq22-q31UniSTS
DXArb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,510,770 - 19,511,180 (-)MAPPERmRatBN7.2
mRatBN7.2X19,510,770 - 19,511,071 (-)MAPPERmRatBN7.2
Rnor_6.0X23,143,420 - 23,143,720NCBIRnor6.0
Rnor_6.0X23,143,275 - 23,143,720NCBIRnor6.0
Rnor_5.0X23,563,382 - 23,563,827UniSTSRnor5.0
Rnor_5.0X23,563,527 - 23,563,827UniSTSRnor5.0
RGSC_v3.4X39,834,590 - 39,834,890UniSTSRGSC3.4
CeleraX19,781,964 - 19,782,264UniSTS
RGSC_v3.1X39,888,058 - 39,888,359RGD
Cytogenetic MapXq22-q31UniSTS
DXWox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X22,938,479 - 22,938,614 (+)Marker Load Pipeline
mRatBN7.2X19,510,955 - 19,511,090 (-)MAPPERmRatBN7.2
mRatBN7.2X19,510,955 - 19,511,180 (-)MAPPERmRatBN7.2
Rnor_6.0X23,143,401 - 23,143,535NCBIRnor6.0
Rnor_6.0X23,143,256 - 23,143,535NCBIRnor6.0
Rnor_5.0X23,563,508 - 23,563,642UniSTSRnor5.0
Rnor_5.0X23,563,363 - 23,563,642UniSTSRnor5.0
RGSC_v3.4X39,834,775 - 39,834,909UniSTSRGSC3.4
RGSC_v3.4X39,834,774 - 39,834,909RGDRGSC3.4
CeleraX19,782,149 - 19,782,283UniSTS
RGSC_v3.1X39,888,243 - 39,888,378RGD
RH 3.4 MapX209.72RGD
RH 3.4 MapX209.72UniSTS
RH 2.0 Map21201.6RGD
Cytogenetic MapXq22-q31UniSTS
Cytogenetic MapXq21UniSTS
RH130115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,561,912 - 19,562,097 (-)MAPPERmRatBN7.2
Rnor_6.0X23,092,210 - 23,092,394NCBIRnor6.0
Rnor_5.0X23,512,733 - 23,512,917UniSTSRnor5.0
RGSC_v3.4X39,885,836 - 39,886,020UniSTSRGSC3.4
CeleraX19,833,067 - 19,833,251UniSTS
Cytogenetic MapXq22-q31UniSTS
RH94813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,561,977 - 19,562,161 (-)MAPPERmRatBN7.2
Rnor_6.0X23,092,146 - 23,092,329NCBIRnor6.0
Rnor_5.0X23,512,669 - 23,512,852UniSTSRnor5.0
RGSC_v3.4X39,885,901 - 39,886,084UniSTSRGSC3.4
CeleraX19,833,132 - 19,833,315UniSTS
Cytogenetic MapXq22-q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 161 91 90 59 85 59 6 334 181 11 140 70 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001435552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001435553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY707861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ422136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000178   ⟹   ENSRNOP00000000178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX22,937,494 - 22,989,687 (+)Ensembl
mRatBN7.2 EnsemblX19,508,546 - 19,562,155 (+)Ensembl
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000033656   ⟹   ENSRNOP00000035212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX22,942,149 - 22,989,704 (+)Ensembl
mRatBN7.2 EnsemblX19,514,626 - 19,562,182 (+)Ensembl
Rnor_6.0 EnsemblX23,092,159 - 23,139,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081239   ⟹   ENSRNOP00000071567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX22,937,691 - 22,989,670 (+)Ensembl
mRatBN7.2 EnsemblX19,510,167 - 19,562,148 (+)Ensembl
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102413   ⟹   ENSRNOP00000093099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX22,964,794 - 22,989,704 (+)Ensembl
mRatBN7.2 EnsemblX19,537,270 - 19,562,182 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000174108   ⟹   ENSRNOP00000105342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX22,941,617 - 22,989,684 (+)Ensembl
RefSeq Acc Id: NM_001271063   ⟹   NP_001257992
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,937,691 - 22,989,670 (+)NCBI
mRatBN7.2X19,510,167 - 19,562,148 (+)NCBI
Rnor_6.0X23,092,159 - 23,144,324 (-)NCBI
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBI
CeleraX19,781,360 - 19,833,302 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271064   ⟹   NP_001257993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,937,691 - 22,989,670 (+)NCBI
mRatBN7.2X19,510,167 - 19,562,148 (+)NCBI
Rnor_6.0X23,092,159 - 23,144,324 (-)NCBI
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBI
CeleraX19,781,360 - 19,833,302 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012621   ⟹   NP_036753
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,942,176 - 22,989,670 (+)NCBI
mRatBN7.2X19,514,653 - 19,562,148 (+)NCBI
Rnor_6.0X23,092,159 - 23,139,694 (-)NCBI
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBI
RGSC_v3.4X39,838,471 - 39,886,071 (+)RGD
CeleraX19,785,844 - 19,833,302 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256790   ⟹   XP_006256852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,938,089 - 22,989,691 (+)NCBI
mRatBN7.2X19,512,616 - 19,562,165 (+)NCBI
Rnor_6.0X23,092,143 - 23,143,304 (-)NCBI
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256791   ⟹   XP_006256853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,945,313 - 22,989,691 (+)NCBI
mRatBN7.2X19,517,775 - 19,562,165 (+)NCBI
Rnor_6.0X23,092,143 - 23,139,419 (-)NCBI
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773123   ⟹   XP_008771345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,936,079 - 22,989,691 (+)NCBI
mRatBN7.2X19,508,551 - 19,562,165 (+)NCBI
Rnor_6.0X23,092,149 - 23,145,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773124   ⟹   XP_008771346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,936,038 - 22,989,691 (+)NCBI
mRatBN7.2X19,508,522 - 19,562,165 (+)NCBI
Rnor_6.0X23,092,149 - 23,145,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099481   ⟹   XP_038955409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,938,075 - 22,981,413 (+)NCBI
mRatBN7.2X19,512,606 - 19,553,895 (+)NCBI
RefSeq Acc Id: XM_039099483   ⟹   XP_038955411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X22,938,055 - 22,974,379 (+)NCBI
mRatBN7.2X19,512,590 - 19,546,855 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257992 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257993 (Get FASTA)   NCBI Sequence Viewer  
  NP_001422481 (Get FASTA)   NCBI Sequence Viewer  
  NP_001422482 (Get FASTA)   NCBI Sequence Viewer  
  NP_036753 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256852 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256853 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771345 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771346 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955409 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955411 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02888 (Get FASTA)   NCBI Sequence Viewer  
  AAA02889 (Get FASTA)   NCBI Sequence Viewer  
  AAA40624 (Get FASTA)   NCBI Sequence Viewer  
  AAA58780 (Get FASTA)   NCBI Sequence Viewer  
  AAA79008 (Get FASTA)   NCBI Sequence Viewer  
  AAU88257 (Get FASTA)   NCBI Sequence Viewer  
  ACV65519 (Get FASTA)   NCBI Sequence Viewer  
  CAA33606 (Get FASTA)   NCBI Sequence Viewer  
  CAA33607 (Get FASTA)   NCBI Sequence Viewer  
  CAA68694 (Get FASTA)   NCBI Sequence Viewer  
  EDL86339 (Get FASTA)   NCBI Sequence Viewer  
  EDL86340 (Get FASTA)   NCBI Sequence Viewer  
  EDL86341 (Get FASTA)   NCBI Sequence Viewer  
  EDL86342 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000178
  ENSRNOP00000035212
  ENSRNOP00000035212.1
  ENSRNOP00000071567
  ENSRNOP00000105342
GenBank Protein P07953 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036753   ⟸   NM_012621
- Peptide Label: isoform 1
- UniProtKB: P16119 (UniProtKB/Swiss-Prot),   P07953 (UniProtKB/Swiss-Prot),   A6KL80 (UniProtKB/TrEMBL),   C9DRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257992   ⟸   NM_001271063
- Peptide Label: isoform 2
- UniProtKB: A0A0H2UH89 (UniProtKB/TrEMBL),   A6KL78 (UniProtKB/TrEMBL),   C9DRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257993   ⟸   NM_001271064
- Peptide Label: isoform 3
- UniProtKB: A0A0G2K0S8 (UniProtKB/TrEMBL),   C9DRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256852   ⟸   XM_006256790
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256853   ⟸   XM_006256791
- Peptide Label: isoform X3
- UniProtKB: C9DRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771346   ⟸   XM_008773124
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771345   ⟸   XM_008773123
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UH89 (UniProtKB/TrEMBL),   A6KL78 (UniProtKB/TrEMBL),   C9DRP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035212   ⟸   ENSRNOT00000033656
Ensembl Acc Id: ENSRNOP00000000178   ⟸   ENSRNOT00000000178
Ensembl Acc Id: ENSRNOP00000071567   ⟸   ENSRNOT00000081239
RefSeq Acc Id: XP_038955411   ⟸   XM_039099483
- Peptide Label: isoform X5
- UniProtKB: Q5Y297 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955409   ⟸   XM_039099481
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000093099   ⟸   ENSRNOT00000102413
Ensembl Acc Id: ENSRNOP00000105342   ⟸   ENSRNOT00000174108
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07953-F1-model_v2 AlphaFold P07953 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701775
Promoter ID:EPDNEW_R12299
Type:initiation region
Name:Pfkfb1_1
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X23,139,771 - 23,139,831EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3307 AgrOrtholog
BioCyc Gene G2FUF-2810 BioCyc
BioCyc Pathway PWY66-423 [fructose 2,6-bisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY66-423 BioCyc
Ensembl Genes ENSRNOG00000000165 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000178 ENTREZGENE
  ENSRNOT00000033656 ENTREZGENE
  ENSRNOT00000033656.3 UniProtKB/Swiss-Prot
  ENSRNOT00000081239 ENTREZGENE
  ENSRNOT00000174108 ENTREZGENE
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot
  6Phosfructo_kin UniProtKB/Swiss-Prot
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24638 UniProtKB/Swiss-Prot
NCBI Gene 24638 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 1 UniProtKB/Swiss-Prot
  PTHR10606 UniProtKB/Swiss-Prot
Pfam 6PF2K UniProtKB/Swiss-Prot
  His_Phos_1 UniProtKB/Swiss-Prot
PhenoGen Pfkfb1 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot
PROSITE PG_MUTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000165 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF53254 UniProtKB/Swiss-Prot
UniProt A0A0G2K0S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UH89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF58_RAT UniProtKB/TrEMBL
  A6KL78 ENTREZGENE, UniProtKB/TrEMBL
  A6KL80 ENTREZGENE, UniProtKB/TrEMBL
  A6KL81_RAT UniProtKB/TrEMBL
  C9DRP4 ENTREZGENE, UniProtKB/TrEMBL
  F261_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P16119 ENTREZGENE
  Q5Y297 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P16119 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Pfkfb1  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1   Name updated 629478 APPROVED
2002-06-10 Pfkfb1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation cAMP-dependent protein kinase mediates activity of liver isozyme, but not of muscle isozyme 729562
gene_transcript encodes two isozymes by alternative splicing from two promoters 729562