RGD Reference Report - Insulin inhibits glucocorticoid-induced stimulation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene transcription. - Rat Genome Database

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Insulin inhibits glucocorticoid-induced stimulation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene transcription.

Authors: Lemaigre, FP  Lause, P  Rousseau, GG 
Citation: Lemaigre FP, etal., FEBS Lett. 1994 Mar 7;340(3):221-5.
RGD ID: 2302680
Pubmed: PMID:8131849   (View Abstract at PubMed)

6-Phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase (FBPase-2) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. Transcription of the mRNA encoding rat liver PFK-2/FBPase-2 is stimulated by insulin and by glucocorticoids in rat hepatoma cells. We show here that insulin can also prevent and reverse this glucocorticoid effect. The inhibitory effect of insulin is independent of extracellular glucose and does not require ongoing protein synthesis. We conclude that insulin exerts opposite effects on PFK-2/FBPase-2 gene transcription depending on the hormonal context.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pfkfb1Ratresponse to glucocorticoid  IEP  RGD 
Pfkfb1Ratresponse to insulin  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pfkfb1  (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1)


Additional Information