Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) - Rat Genome Database

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Gene: Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) Chinchilla lanigera
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Symbol: Pfkfb1
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
RGD ID: 8829237
Description: ENCODES a protein that exhibits 6-phosphofructo-2-kinase activity (ortholog); ATP binding (ortholog); fructose-2,6-bisphosphate 2-phosphatase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); carbohydrate phosphorylation (ortholog); fructose 2,6-bisphosphate metabolic process (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; gluconeogenesis pathway; ASSOCIATED WITH autistic disorder (ortholog); Cornelia de Lange syndrome 2 (ortholog); hyperinsulinism (ortholog); FOUND IN 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,342,750 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pfkfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,342,750 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBIChiLan1.0ChiLan1.0
PFKFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,932,961 - 54,998,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,932,961 - 54,998,534 (-)EnsemblGRCh38hg38GRCh38
GRCh37X54,959,394 - 55,025,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,976,315 - 55,037,236 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X54,842,610 - 54,903,532NCBI
CeleraX58,794,738 - 58,855,654 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,011,285 - 52,075,912 (-)NCBIHuRef
CHM1_1X54,949,616 - 55,015,006 (-)NCBICHM1_1
T2T-CHM13v2.0X54,226,089 - 54,293,383 (-)NCBIT2T-CHM13v2.0
Pfkfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,370,441 - 149,426,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,371,225 - 149,426,874 (+)EnsemblGRCm39 Ensembl
GRCm38X150,587,445 - 150,643,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,588,229 - 150,643,878 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,024,464 - 147,078,403 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X145,930,637 - 145,984,576 (+)NCBIMGSCv36mm8
CeleraX133,769,155 - 133,816,855 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Pfkfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X22,936,038 - 22,989,691 (+)NCBIGRCr8
mRatBN7.2X19,508,522 - 19,562,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,508,546 - 19,562,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX16,945,153 - 16,997,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X23,126,385 - 23,178,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,023,399 - 20,075,389 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,092,143 - 23,145,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X39,838,471 - 39,886,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X39,891,912 - 39,939,574 (+)NCBI
CeleraX19,781,360 - 19,833,302 (+)NCBICelera
Cytogenetic MapXq12NCBI
PFKFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,327,712 - 56,394,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,331,319 - 56,398,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,143,081 - 47,209,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X55,374,807 - 55,436,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX55,374,807 - 55,441,024 (-)Ensemblpanpan1.1panPan2
PFKFB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X46,617,522 - 46,691,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX46,613,847 - 46,691,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX37,952,977 - 38,026,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X46,906,002 - 46,979,845 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX46,906,011 - 46,980,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,415,757 - 46,489,624 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X46,882,333 - 46,956,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X46,824,607 - 46,898,459 (-)NCBIUU_Cfam_GSD_1.0
Pfkfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,409,064 - 39,466,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367511,753,627 - 1,806,294 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367511,753,627 - 1,806,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX47,765,154 - 47,859,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X47,771,751 - 47,859,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X53,701,871 - 53,795,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,015,810 - 51,077,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,016,318 - 51,071,977 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660864,991,650 - 5,055,662 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624910305,068 - 380,188 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624910303,697 - 380,491 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Ensembl Acc Id: ENSCLAT00000013513   ⟹   ENSCLAP00000013361
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,342,750 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000013514   ⟹   ENSCLAP00000013362
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,338,233 (-)Ensembl
RefSeq Acc Id: XM_005401535   ⟹   XP_005401592
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005401536   ⟹   XP_005401593
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554752,279,390 - 2,337,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013502854   ⟹   XP_013358308
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013502855   ⟹   XP_013358309
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554752,279,390 - 2,342,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013502856   ⟹   XP_013358310
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005401592   ⟸   XM_005401535
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VDQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005401593   ⟸   XM_005401536
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358310   ⟸   XM_013502856
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VDQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358308   ⟸   XM_013502854
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VDQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358309   ⟸   XM_013502855
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VDQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000013361   ⟸   ENSCLAT00000013513
Ensembl Acc Id: ENSCLAP00000013362   ⟸   ENSCLAT00000013514
Protein Domains
6-phosphofructo-2-kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013513 ENTREZGENE
  ENSCLAT00000013513.1 UniProtKB/TrEMBL
  ENSCLAT00000013514 ENTREZGENE
  ENSCLAT00000013514.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/TrEMBL
NCBI Gene Pfkfb1 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 1 UniProtKB/TrEMBL
  PTHR10606 UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/TrEMBL
PIRSF 6PFK_2-Ptase UniProtKB/TrEMBL
PRINTS 6PFRUCTKNASE UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/TrEMBL
SMART PGAM UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF53254 UniProtKB/TrEMBL
UniProt A0A8C2VDQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VFV0 ENTREZGENE, UniProtKB/TrEMBL