Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) - Rat Genome Database

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Gene: Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) Mus musculus
Analyze
Symbol: Pfkfb1
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
RGD ID: 11083
MGI Page MGI
Description: Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in negative regulation of glycolytic process through fructose-6-phosphate. Predicted to be part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Predicted to be active in cytosol. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFK-2/FBPase-2 gene A; PFK/FBPase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,370,441 - 149,426,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,371,225 - 149,426,874 (+)EnsemblGRCm39 Ensembl
GRCm38X150,587,445 - 150,643,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,588,229 - 150,643,878 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,024,464 - 147,078,403 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X145,930,637 - 145,984,576 (+)NCBIMGSCv36mm8
CeleraX133,769,155 - 133,816,855 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-fructofuranose 2,6-bisphosphate  (EXP)
beta-hexachlorocyclohexane  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
cantharidin  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
clofibric acid  (ISO)
cyclosporin A  (EXP,ISO)
D-glucopyranose 6-phosphate  (EXP)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
flavonoids  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
furan  (ISO)
gentamycin  (ISO)
glyceraldehyde 3-phosphate  (EXP)
Heptachlor epoxide  (EXP)
indole-3-methanol  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
metacetamol  (EXP)
metformin  (EXP,ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Batra RS, etal., FEBS Lett 1996 Sep 16;393(2-3):167-73.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Effect of starvation on gene expression of regulatory enzymes of glycolysis/gluconeogenesis in genetically obese (fa/fa) Zucker rats. Perez JX, etal., Int J Obes Relat Metab Disord. 1998 Jul;22(7):667-72.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
Additional References at PubMed
PMID:1339450   PMID:2856848   PMID:6265919   PMID:9202079   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12230553   PMID:12477932   PMID:14681479   PMID:15331593  
PMID:16141072   PMID:16141073   PMID:16155866   PMID:18799693   PMID:21074528   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:27597886   PMID:27626380   PMID:38355793  


Genomics

Comparative Map Data
Pfkfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,370,441 - 149,426,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,371,225 - 149,426,874 (+)EnsemblGRCm39 Ensembl
GRCm38X150,587,445 - 150,643,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,588,229 - 150,643,878 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,024,464 - 147,078,403 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X145,930,637 - 145,984,576 (+)NCBIMGSCv36mm8
CeleraX133,769,155 - 133,816,855 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
PFKFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,932,961 - 54,998,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,932,961 - 54,998,534 (-)EnsemblGRCh38hg38GRCh38
GRCh37X54,959,394 - 55,025,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,976,315 - 55,037,236 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X54,842,610 - 54,903,532NCBI
CeleraX58,794,738 - 58,855,654 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,011,285 - 52,075,912 (-)NCBIHuRef
CHM1_1X54,949,616 - 55,015,006 (-)NCBICHM1_1
T2T-CHM13v2.0X54,226,089 - 54,293,383 (-)NCBIT2T-CHM13v2.0
Pfkfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X22,936,038 - 22,989,691 (+)NCBIGRCr8
mRatBN7.2X19,508,522 - 19,562,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,508,546 - 19,562,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX16,945,153 - 16,997,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X23,126,385 - 23,178,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,023,399 - 20,075,389 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X23,092,143 - 23,145,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,092,159 - 23,144,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X39,838,471 - 39,886,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X39,891,912 - 39,939,574 (+)NCBI
CeleraX19,781,360 - 19,833,302 (+)NCBICelera
Cytogenetic MapXq12NCBI
Pfkfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554752,279,390 - 2,342,750 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554752,279,390 - 2,343,881 (-)NCBIChiLan1.0ChiLan1.0
PFKFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,327,712 - 56,394,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,331,319 - 56,398,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,143,081 - 47,209,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X55,374,807 - 55,436,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX55,374,807 - 55,441,024 (-)Ensemblpanpan1.1panPan2
PFKFB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X46,617,522 - 46,691,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX46,613,847 - 46,691,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX37,952,977 - 38,026,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X46,906,002 - 46,979,845 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX46,906,011 - 46,980,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,415,757 - 46,489,624 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X46,882,333 - 46,956,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X46,824,607 - 46,898,459 (-)NCBIUU_Cfam_GSD_1.0
Pfkfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,409,064 - 39,466,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367511,753,627 - 1,806,294 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367511,753,627 - 1,806,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX47,765,154 - 47,859,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X47,771,751 - 47,859,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X53,701,871 - 53,795,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,015,810 - 51,077,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,016,318 - 51,071,977 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660864,991,650 - 5,055,662 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624910305,068 - 380,188 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624910303,697 - 380,491 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pfkfb1
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:712
Count of miRNA genes:424
Interacting mature miRNAs:474
Transcripts:ENSMUST00000080884, ENSMUST00000112713, ENSMUST00000124381, ENSMUST00000142848, ENSMUST00000150783, ENSMUST00000153221, ENSMUST00000154528
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301276Tswt_mtestis weight (mouse)Not determinedX138376411150789338Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse

Markers in Region
px-25h12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X150,638,540 - 150,638,639UniSTSGRCm38
MGSCv37X147,073,083 - 147,073,182UniSTSGRCm37
CeleraX133,774,376 - 133,774,475UniSTS
Cytogenetic MapXF2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001374170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK132629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX522768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000080884   ⟹   ENSMUSP00000079692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,372,917 - 149,426,874 (+)Ensembl
GRCm38.p6 EnsemblX150,589,921 - 150,643,878 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112713   ⟹   ENSMUSP00000108333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,377,474 - 149,426,874 (+)Ensembl
GRCm38.p6 EnsemblX150,594,478 - 150,643,878 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,371,252 - 149,395,928 (+)Ensembl
GRCm38.p6 EnsemblX150,588,256 - 150,612,932 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,396,930 - 149,407,702 (+)Ensembl
GRCm38.p6 EnsemblX150,613,934 - 150,624,706 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,377,606 - 149,426,853 (+)Ensembl
GRCm38.p6 EnsemblX150,594,610 - 150,643,857 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153221   ⟹   ENSMUSP00000115844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,371,225 - 149,408,179 (+)Ensembl
GRCm38.p6 EnsemblX150,588,229 - 150,625,183 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX149,408,337 - 149,424,973 (+)Ensembl
GRCm38.p6 EnsemblX150,625,341 - 150,641,977 (+)Ensembl
RefSeq Acc Id: NM_001374170   ⟹   NP_001361099
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,370,441 - 149,426,874 (+)NCBI
GRCm38X150,587,445 - 150,643,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374171   ⟹   NP_001361100
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,371,239 - 149,426,874 (+)NCBI
GRCm38X150,588,243 - 150,643,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374172   ⟹   NP_001361101
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,371,239 - 149,426,874 (+)NCBI
GRCm38X150,588,243 - 150,643,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374173   ⟹   NP_001361102
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,377,424 - 149,426,874 (+)NCBI
GRCm38X150,594,428 - 150,643,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374175   ⟹   NP_001361104
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,377,424 - 149,406,021 (+)NCBI
GRCm38X150,594,428 - 150,623,025 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411763   ⟹   NP_001398692
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,371,239 - 149,426,874 (+)NCBI
RefSeq Acc Id: NM_001411764   ⟹   NP_001398693
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,371,239 - 149,426,874 (+)NCBI
RefSeq Acc Id: NM_008824   ⟹   NP_032850
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,372,912 - 149,426,874 (+)NCBI
GRCm38X150,589,916 - 150,643,878 (+)NCBI
MGSCv37X147,024,464 - 147,078,403 (+)RGD
CeleraX133,769,137 - 133,816,855 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528756   ⟹   XP_006528819
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,377,247 - 149,419,016 (+)NCBI
GRCm38X150,594,254 - 150,636,020 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161849   ⟹   XP_036017742
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,377,255 - 149,426,874 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161850   ⟹   XP_036017743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X149,371,214 - 149,426,874 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032850   ⟸   NM_008824
- Peptide Label: isoform 2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528819   ⟸   XM_006528756
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001361099   ⟸   NM_001374170
- Peptide Label: isoform 2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001361101   ⟸   NM_001374172
- Peptide Label: isoform 2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001361100   ⟸   NM_001374171
- Peptide Label: isoform 2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001361102   ⟸   NM_001374173
- Peptide Label: isoform 1
- UniProtKB: P70266 (UniProtKB/Swiss-Prot),   A2AFN0 (UniProtKB/Swiss-Prot),   Q3V180 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001361104   ⟸   NM_001374175
- Peptide Label: isoform 3
- UniProtKB: A2AFM8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000108333   ⟸   ENSMUST00000112713
Ensembl Acc Id: ENSMUSP00000079692   ⟸   ENSMUST00000080884
Ensembl Acc Id: ENSMUSP00000115844   ⟸   ENSMUST00000153221
RefSeq Acc Id: XP_036017743   ⟸   XM_036161850
- Peptide Label: isoform X2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036017742   ⟸   XM_036161849
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001398692   ⟸   NM_001411763
- Peptide Label: isoform 2
- UniProtKB: A2AFM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398693   ⟸   NM_001411764
- Peptide Label: isoform 4
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70266-F1-model_v2 AlphaFold P70266 1-471 view protein structure

Promoters
RGD ID:6846078
Promoter ID:MM_KWN:62303
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Brain
Transcripts:OTTMUST00000045940,   OTTMUST00000045941
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X147,022,564 - 147,023,064 (+)MPROMDB
RGD ID:6846082
Promoter ID:MM_KWN:62304
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:ENSMUST00000112720,   ENSMUST00000112725,   OTTMUST00000045909,   OTTMUST00000045937
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X147,024,121 - 147,024,621 (+)MPROMDB
RGD ID:6846077
Promoter ID:MM_KWN:62305
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   3T3L1_Day6,   Liver,   Lung
Transcripts:OTTMUST00000045938,   OTTMUST00000045939
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X147,028,101 - 147,028,882 (+)MPROMDB
RGD ID:13681606
Promoter ID:EPDNEW_M24952
Type:initiation region
Name:Pfkfb1_1
Description:Mus musculus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X150,589,941 - 150,590,001EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107816 AgrOrtholog
Ensembl Genes ENSMUSG00000025271 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000080884 ENTREZGENE
  ENSMUST00000080884.11 UniProtKB/Swiss-Prot
  ENSMUST00000112713 ENTREZGENE
  ENSMUST00000112713.3 UniProtKB/Swiss-Prot
  ENSMUST00000153221.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107816 ENTREZGENE
NCBI Gene 18639 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkfb1 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AFM8 ENTREZGENE, UniProtKB/TrEMBL
  A2AFM9 ENTREZGENE, UniProtKB/TrEMBL
  A2AFN0 ENTREZGENE
  F261_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V180 ENTREZGENE
UniProt Secondary A2AFN0 UniProtKB/Swiss-Prot
  Q3V180 UniProtKB/Swiss-Prot