Mir375 (microRNA 375) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mir375 (microRNA 375) Rattus norvegicus
Analyze
Symbol: Mir375
Name: microRNA 375
RGD ID: 2325360
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Orthologous to human MIR375 (microRNA 375); INTERACTS WITH 2,5-hexanedione; aflatoxin B1; amphetamine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-375; rno-mir-375
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,906,582 - 83,906,656 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2976,457,911 - 76,457,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,457,911 - 76,457,985 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,902,918 - 84,902,992 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,031,868 - 90,031,942 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,418,026 - 88,418,100 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,161,716 - 82,161,790 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,161,716 - 82,161,790 (-)Ensemblrn6Rnor6.0
Rnor_5.0981,930,296 - 81,930,370 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera974,029,377 - 74,029,451 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling. Miao L, etal., Cancer Immunol Immunother. 2014 Jul;63(7):699-711. doi: 10.1007/s00262-014-1550-y. Epub 2014 Apr 10.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:17804764   PMID:18086561   PMID:20403161   PMID:22539037   PMID:22778717   PMID:23396279   PMID:24548484   PMID:24834976   PMID:25619565   PMID:26631961  
PMID:27371368   PMID:27521901   PMID:28254488   PMID:28356269   PMID:29187583   PMID:29322249   PMID:30618075   PMID:32196570   PMID:32644005   PMID:33107061   PMID:33128129   PMID:34036397  
PMID:34280452   PMID:34845965   PMID:39438882  


Genomics

Comparative Map Data
Mir375
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,906,582 - 83,906,656 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2976,457,911 - 76,457,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,457,911 - 76,457,985 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,902,918 - 84,902,992 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,031,868 - 90,031,942 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,418,026 - 88,418,100 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,161,716 - 82,161,790 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,161,716 - 82,161,790 (-)Ensemblrn6Rnor6.0
Rnor_5.0981,930,296 - 81,930,370 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera974,029,377 - 74,029,451 (-)NCBICelera
Cytogenetic Map9q33NCBI
MIR375
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,001,645 - 219,001,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,001,645 - 219,001,708 (-)Ensemblhg38GRCh38
GRCh372219,866,367 - 219,866,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,574,610 - 219,574,673 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2213,636,080 - 213,636,143 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,720,395 - 211,720,458 (-)NCBIHuRef
CHM1_12219,873,820 - 219,873,883 (-)NCBICHM1_1
T2T-CHM13v2.02219,490,020 - 219,490,083 (-)NCBIT2T-CHM13v2.0
Mir375
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,939,817 - 74,939,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,939,817 - 74,939,880 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,900,658 - 74,900,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,900,658 - 74,900,721 (-)Ensemblmm10GRCm38
MGSCv37174,947,232 - 74,947,295 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera175,455,688 - 75,455,751 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
MIR375
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,568,052 - 25,568,121 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,568,052 - 25,568,127 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,388,246 - 26,388,315 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,583,487 - 25,583,556 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,583,487 - 25,583,562 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,488,066 - 25,488,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,423,157 - 25,423,226 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,443,921 - 25,443,990 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Pdk1rno-miR-375-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18591395

Predicted Targets
Summary Value
Count of predictions:6750
Count of gene targets:4551
Count of transcripts:4805
Interacting mature miRNAs:rno-miR-375-3p, rno-miR-375-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
7 13 21 15 3 3 18 8 5 14 12

Sequence


Ensembl Acc Id: ENSRNOT00000053578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,457,911 - 76,457,985 (-)Ensembl
Rnor_6.0 Ensembl982,161,716 - 82,161,790 (-)Ensembl
RefSeq Acc Id: NR_032271
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,906,582 - 83,906,656 (-)NCBI
mRatBN7.2976,457,911 - 76,457,985 (-)NCBI
Rnor_6.0982,161,716 - 82,161,790 (-)NCBI
Rnor_5.0981,930,296 - 81,930,370 (-)NCBI
Celera974,029,377 - 74,029,451 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325360 AgrOrtholog
BioCyc Gene G2FUF-27108 BioCyc
Ensembl Genes ENSRNOG00000035455 Ensembl
miRBase MI0006140 ENTREZGENE
NCBI Gene 100314263 ENTREZGENE
PhenoGen Mir375 PhenoGen
RatGTEx ENSRNOG00000035455 RatGTEx
RNAcentral URS00000ED600 RNACentral
  URS000075CCDA RNACentral
  URS000075DEE4 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir375  microRNA 375  Mir375  microRNA mir-375  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir375  microRNA mir-375      Symbol and Name status set to provisional 70820 PROVISIONAL