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Gene: Scap (SREBF chaperone) Rattus norvegicus

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Symbol:

Scap

Name:

SREBF chaperone

RGD ID:

1309378

Description:

Predicted to enable sterol binding activity. Involved in response to vitamin B3. Part of protein-containing complex. Biomarker of end stage renal disease. Orthologous to human SCAP (SREBF chaperone); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC301024; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element-binding protein cleavage-activating protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCAP (SREBF chaperone)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Scap (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Scap (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCAP (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCAP (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Scap (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCAP (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCAP (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Scap (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Scap (SREBF chaperone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF628 (zinc finger protein 628)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Scap (SREBF chaperone)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SCAP (SREBF chaperone)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	scap (SREBF chaperone)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	SCAP	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	scap	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	119,184,366 - 119,239,086 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	119,184,438 - 119,239,075 (+)	Ensembl				GRCr8
mRatBN7.2	8	110,306,026 - 110,360,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	110,306,031 - 110,360,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	115,921,501 - 115,976,170 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	114,120,688 - 114,175,360 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,963,481 - 112,018,151 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	118,551,869 - 118,628,650 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	118,570,503 - 118,628,651 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	117,895,671 - 117,972,292 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	114,706,479 - 114,761,342 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	109,591,567 - 109,646,089 (+)	NCBI		Celera
RGSC_v3.1	8	114,725,918 - 114,780,799 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

end stage renal disease (IEP)

Experimental Diabetes Mellitus (IEP)

hepatocellular carcinoma (ISO)

Hypercholesterolemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(2E,4E)-hexa-2,4-dienoic acid (ISO)

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenic trichloride (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bezafibrate (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyproconazole (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

fenvalerate (EXP)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

fructose (ISO)

Ganoderic acid A (ISO)

gentamycin (EXP)

hydralazine (ISO)

lipopolysaccharide (EXP,ISO)

lovastatin (ISO)

menadione (ISO)

methidathion (ISO)

nicotinamide (IEP)

ozone (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rotenone (EXP)

simvastatin (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol metabolic process (IEA,ISO,ISS)

COPII-coated vesicle cargo loading (ISS)

immune response (ISO)

lipid metabolic process (IEA,ISO)

positive regulation of cholesterol biosynthetic process (IEA,ISO)

protein catabolic process (ISO)

regulation of cholesterol biosynthetic process (IBA,ISO)

regulation of fatty acid biosynthetic process (ISO)

regulation of fatty acid metabolic process (ISO)

regulation of transcription by RNA polymerase II (IEA,ISO)

response to hypoxia (ISO)

response to insulin (ISO)

response to vitamin B3 (IEP)

SREBP signaling pathway (IEA,ISO,ISS)

steroid metabolic process (IEA)

Cellular Component

cytoplasmic vesicle (IEA)

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

ER to Golgi transport vesicle membrane (IEA)

Golgi membrane (IEA,ISO,ISS)

protein-containing complex (IDA)

SREBP-SCAP complex (IBA,IEA,ISO)

Molecular Function

lipid binding (IEA)

protein binding (ISO)

protein-containing complex binding (IPI)

sterol binding (IEA,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

sterol regulatory element-binding protein signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.	Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
2.	Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.	Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.	Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
6.	Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia.	Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.	Yellaturu CR, etal., J Biol Chem. 2009 Mar 20;284(12):7518-32. Epub 2009 Jan 21.

Additional References at PubMed

PMID:11358865	PMID:11726962	PMID:12242332	PMID:12477932	PMID:16054043	PMID:17203467	PMID:17666524	PMID:22337502

Genomics

Comparative Map Data

Scap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	119,184,366 - 119,239,086 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	119,184,438 - 119,239,075 (+)	Ensembl				GRCr8
mRatBN7.2	8	110,306,026 - 110,360,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	110,306,031 - 110,360,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	115,921,501 - 115,976,170 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	114,120,688 - 114,175,360 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,963,481 - 112,018,151 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	118,551,869 - 118,628,650 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	118,570,503 - 118,628,651 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	117,895,671 - 117,972,292 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	114,706,479 - 114,761,342 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	109,591,567 - 109,646,089 (+)	NCBI		Celera
RGSC_v3.1	8	114,725,918 - 114,780,799 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

SCAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	47,413,681 - 47,477,127 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	47,413,681 - 47,477,126 (-)	Ensembl			hg38	GRCh38
GRCh37	3	47,455,171 - 47,517,431 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	47,430,188 - 47,492,449 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	3	47,393,823 - 47,458,772 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	47,498,135 - 47,563,088 (-)	NCBI		HuRef
CHM1_1	3	47,405,412 - 47,467,423 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	47,430,101 - 47,496,247 (-)	NCBI		T2T-CHM13v2.0

Scap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	110,162,356 - 110,214,017 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	110,162,356 - 110,214,018 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	110,333,288 - 110,384,949 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	110,333,288 - 110,384,950 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	110,235,797 - 110,287,450 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	110,178,523 - 110,230,113 (+)	NCBI		MGSCv36	mm8
Celera	9	110,062,305 - 110,113,905 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.91	NCBI

Scap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	24,813,534 - 24,869,480 (+)	Ensembl
ChiLan1.0	NW_004955420	24,813,683 - 24,869,602 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	47,370,784 - 47,435,759 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	47,375,552 - 47,441,673 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	47,314,535 - 47,379,455 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	48,414,012 - 48,446,721 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	48,414,012 - 48,479,845 (-)	Ensembl			panPan2	panpan1.1

SCAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	41,418,507 - 41,485,681 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	41,418,536 - 41,487,024 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	41,335,033 - 41,402,084 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	41,901,526 - 41,968,598 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	41,901,549 - 41,968,593 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	41,143,535 - 41,210,564 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	41,544,714 - 41,611,716 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	41,825,295 - 41,892,343 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Scap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	201,575,434 - 201,631,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	1,122,042 - 1,180,297 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	1,124,573 - 1,180,219 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	30,253,268 - 30,320,526 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	30,253,262 - 30,320,625 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	33,483,930 - 33,551,346 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	8,821,809 - 8,887,538 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	8,818,980 - 8,850,202 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	158,240,615 - 158,318,574 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	73,927,010 - 73,975,337 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	73,926,978 - 73,975,337 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Scap
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	100,917,024 - 100,971,073 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Scap
352 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	135
Count of miRNA genes:	113
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000028295
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

BE108733

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,329,343 - 110,329,549 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	118,597,322 - 118,597,527	NCBI	Rnor6.0
Rnor_5.0	8	117,940,964 - 117,941,169	UniSTS	Rnor5.0
RGSC_v3.4	8	114,730,016 - 114,730,221	UniSTS	RGSC3.4
Celera	8	109,614,754 - 109,614,959	UniSTS
RH 3.4 Map	8	1191.6	UniSTS
Cytogenetic Map	8	q32	UniSTS

UniSTS:236259

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,360,304 - 110,360,447 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	118,628,278 - 118,628,420	NCBI	Rnor6.0
Rnor_5.0	8	117,971,920 - 117,972,062	UniSTS	Rnor5.0
RGSC_v3.4	8	114,760,972 - 114,761,114	UniSTS	RGSC3.4
Celera	8	109,645,719 - 109,645,861	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC131852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028295 ⟹ ENSRNOP00000028295

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	119,184,438 - 119,239,075 (+)	Ensembl
mRatBN7.2 Ensembl	8	110,306,031 - 110,360,666 (+)	Ensembl
Rnor_6.0 Ensembl	8	118,570,503 - 118,628,639 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090238 ⟹ ENSRNOP00000072003

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	118,570,569 - 118,628,651 (+)	Ensembl

RefSeq Acc Id:

NM_001100966 ⟹ NP_001094436

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	119,184,438 - 119,239,086 (+)	NCBI
mRatBN7.2	8	110,306,026 - 110,360,677 (+)	NCBI
Rnor_6.0	8	118,570,503 - 118,628,648 (+)	NCBI
Rnor_5.0	8	117,895,671 - 117,972,292 (+)	NCBI
RGSC_v3.4	8	114,706,479 - 114,761,342 (+)	RGD
Celera	8	109,591,567 - 109,646,089 (+)	RGD

Sequence:

show sequence

GGCGGGGAGCTGCGCGGGCGCCGGGCGGCCGGGAGGGAGAGGGCGGGCTCGAAACACCGGATCG
CGGGCCAGGAGCGCGCAGGCCGCTCTCCGCCGCTCCGTCGCCGCCGCCCGGGAGCTGCCTCGCC
GCCACAGGCACCTCTCCCGTGGTTGGAGGAAACGAGGCATTCTAGAAGGGGATAGCAGGTACCT
GCAGATGATGTGCATTGTCATTGGTATCCAGCATCTTCCAGGCTGATCCATGGTCACTTTCCGG
GATGGCAACAAGGTGACTTAGCTGAGGATGACCCTGACTGAAAGGCTTCGTGAGAAGATATCTC
AGGCGTTCTACAACCATGGGCTGCTCTGCGCATCCTACCCCATTCCCATCATCCTCTTCACAGG
ACTCTGCATCCTAGCCTGCTGCTACCCGCTGCTGAAGCTTCCCTTGCCTGGAACGGGACCCGTG
GAATTCTCCACGCCTGTGAAGGGTTACTCGCCCCCGCCTGCGGACTCTGACCACAAACAAGGAG
AGCCCAGTGAGCAGCCAGAGTGGTATGTGGGTGCCCCCGTGGCATACATCCAGCAGATATTCGT
GAAGTCATCAGTGTCTCCCTGGCACAGAAACCTTCTGGCAGTAGATGTGTTCCGGTCACCTCTG
TCCCGAGCATTCCAACTGGTGGAAGAGATCCGGAACCATGTGCTGAGAGACAGCTCAGGGACCA
AGAGCCTGGAGGAAGTTTGCCTGCAGGTGACAGACCTGCTGCCAGGCCTCAGGAAACTCCGGAG
CCTACTTCCCGAACATGGCTGCCTGCTGCTGTCACCTGGGAACTTCTGGCAGAATGACTGGGAA
AGATTCCATGCTGACCCTGACATCATTGGAACCATCCATCAGCATGAGCCTAAAACCCTACAGA
CATCAGCCACACTCAAAGACTTGCTGTTCGGTGTTCCTGGGAAGTACAGTGGGGTCAGCCTCTA
CACGAGGAAGAGGATGGTCTCATACACCATCACCCTGGTCTTCCAGCGCTACCATGCCAAGTTT
CTGAGCAGCCTCCGTGCCCGGCTCATGCTTCTGCACCCCAGCCCCAACTGCAGCCTCCGAGCAG
AGAACCTGGTGCATGTGCACTTCAAAGAGGAGATTGGCATTGCCGAGCTCATCCCCCTCGTGAC
CACCTACATCATCCTGTTTGCCTACATCTACTTCTCCACACGCAAGATCGACATGGTCAAGTCC
AAGTGGGGCCTCGCCCTGGCAGCCGTGGTCACAGTGCTTAGCTCGCTGCTCATGTCTGTGGGGC
TCTGCACTCTCTTCGGCCTGACGCCCACACTCAATGGCGGCGAGATTTTCCCATATCTGGTGGT
GGTTATTGGGCTAGAGAATGTGTTGGTGCTCACCAAGTCAGTGGTATCAACTCCAGTGGACCTT
GAGGTGAAGCTTCGAATTGCACAAGGCTTAAGCAGTGAGAGCTGGTCCATCATGAAGAACGTAG
CAACTGAACTGGGCATCATCCTCATTGGCTACTTCACCCTTGTGCCTGCCATCCAAGAGTTCTG
CCTCTTTGCTGTGGTGGGCCTGGTGTCTGACTTCTTCCTCCAGATGCTGTTCTTCACCACCGTG
CTGTCCATCGACATTCGCCGGATGGAGCTAGCAGACCTGAACAAGCGGCTGCCCCCTGAGTCCT
GCCTGCCCTCAGCCAAGCCTGTGGGGAGGCCAGCCCGATATGAGAGACAGCTAGCTGTACGGCC
GTCCACACCACACACCATCACATTGCAACCATCTTCCTTCCGAAACCTGCGGCTTCCCAAAAGG
CTGCGTGTCATCTACTTCCTGGCCCGCACTCGCCTGGCACAGCGCCTCATCATGGCTGGTACAG
TTGTCTGGATTGGCATCCTGGTATATACAGACCCGGCAGGGCTGCGCACCTACCTCGCTGCCCA
GGTGACAGAACAGAGCCCACTGGGTGAGGGTTCCCTGGGGCCCATGCCTGTGCCTAGTGGAGTG
CTGCCTGCCAGCCACCCGGACCCTGCCTTCTCCATCTTCCCACCTGATGCTCCTAAACTGCCAG
AGAACCAGACGTTGCCAGGTGAGCTGCCTGAGCATGCCGTTCCAGCAGAGGGCGTCCAGGACAG
CCGAGCCCCAGAGGTGACTTGGGGGCCCGAGGATGAGGAGCTGTGGAGGAAATTGTCCTTCCGC
CACTGGCCCACACTCTTCAACTACTATAATATCACACTGGCCAAAAGGTACATCAGCCTGCTGC
CTGTCATCCCTGTCACACTACACCTGAATCCACGGGAGGCTCTGGAGGGGCGACACCCTCAGGA
TGGCCGCACTGCCTGGGCCCCACCAGAGCCTTTGCCTGCTGGCCTGTGGGAGACCGGACCTAAG
GGGCCAGGTGGAACACAGACCCATGGCGACATTACCTTGTACAAGGTGGCTGCACTTGGCCTGG
CAGCGGGCATTGTCCTAGTGCTGCTGCTGCTCTGCCTCTACCGGGTGCTCTGCCCGCGAAACTA
CGGGCAGCCGGGTGGTGGTGCGGGCAGGCGGAGGCGCGGAGAGCTGCCTTGCGATGACTATGGC
TACGCACCGCCTGAGACGGAGATAGTGCCGCTGGTGCTGCGAGGGCACCTCATGGACATCGAGT
GTCTGGCTAGCGATGGGATGCTCCTGGTGAGCTGCTGCCTGGCTGGCCAAGTCTGCGTGTGGGA
TGCACAGACCGGGGACTGCCTCACTCGCATCCCGCGCCCTGGGCCACGCCGGGACAGCTGCGGA
GGCGGAGCTTTTGAAGCTCAGGAGAACTGGGAAAGACTGTCTGATGGGGGCAAAGCTAGCCCGG
AAGAGCCTGGCGACAGCCCTCCGCTGCGACGCCGCCCTCGAGGGCCTCCACCGCCTTCCCTCTT
TGGGGACCAGCCAGACCTCACCTGCTTAATCGACACCAACTTCTCAGTGCAGCTGCCCCCAGAG
CCCACTCAGCCCGAGCCTCGGCACCGGGCGGGCTGTGGCCGCTCTAGAGACTCTGGTTACGACT
TCAGCCGTCTGGTGCAGCGTGTGTACCAAGAGGAAGGCCTGGCTGCTGTGCACATGTCGGCCCT
GCGCCCACCCTCCCCGGGACCTCCCCTGCCCCAGGCCTCTCAAGAAGAGGGGACTGCTCCCGAG
AAGGGCTCCCCCCCTCTGGCCTGGGCCCCCAGCACAGCCGGTTCCATCTGGAGCTTAGAGTTGC
AAGGCAGTCTCATCGTGGTTGGGCGAAGCAGCGGCCGGCTGGAGGTGTGGGATGCCATTGAGGG
CGTGCTCTGCTGCAGCAATGAGGAGATCTCCTCAGGCATCACAGCCCTTGTCTTCTTAGACAGG
AGGATTGTAGCTGCTCGGCTCAACGGTTCCCTCGATTTCTTTTCCTTGGAGACCCACACTTCCC
TCAGCCCCCTGCAGTTCAGAGGGACCCCAGGGAGAGGCAGTTCTCCTTCCTCGCCTGTGTACAG
CAGCAGCAACACTGTGGCCTGTCACCTGACCCACACAGTCCCCTGTGCACACCAGAAACCCATC
ACAGCCCTGAGAGCAGCAGCGGGGCGCCTGGTGACAGGGAGCCAAGACCATACTCTGAGAGTCT
TCCGACTGGAGGATTCGTGTTGCCTCTTTACCCTGCAGGGCCACTCGGGGGCAATCACAACTGT
GTACATTGATCAGACCATGGTATTGGCCAGTGGAGGACAAGATGGAGCCATCTGCCTGTGGGAT
GTACTAACAGGCAGCCGGGTCAGCCATACATTTGCTCACCGTGGAGATGTCACCTCCCTCACCT
GTACCACTTCCTGTGTTATCAGTAGTGGCCTGGATGACTTCATCAACATCTGGGACCGAAGCAC
AGGCATCAAGCTGTACTCCATTCAGCAGGACCTGGGCTGTGGTGCAAGCTTGGGTGTCATCTCT
GATAACCTTCTGGTGACCGGCGGCCAGGGATGTGTCTCCTTTTGGGACCTAAACTATGGGGACC
TGTTACAGACAGTCTACTTGGGAAAGAACAGTGAAGCCCAGCCTGCCCGGCAGATTTTGGTGCT
GGACAATGCTGCCATTGTCTGCAACTTTGGCAGTGAGCTCAGCCTAGTGTATGTGCCCTCTGTG
CTGGAGAAACTGGACTGAAGGCAGGTCAACTGCACTATGCCTTTCCCCCATCCCAAGGTGGGGC
ACTGGGGATTGCAACTCTTTGGACCTAGACTGGAGGCAATAGGTAGGCATCTTTGCAGCTGACT
CAGAACTGTTGTCTCCTGACTGTAATAATAAACTTTTTTTTAAAAACCCAAAAAAAAAAGAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017595597 ⟹ XP_017451086

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	119,207,261 - 119,239,086 (+)	NCBI
mRatBN7.2	8	110,328,855 - 110,360,677 (+)	NCBI
Rnor_6.0	8	118,596,889 - 118,628,650 (+)	NCBI

Sequence:

show sequence

TACAACCATGGGCTGCTCTGCGCATCCTACCCCATTCCCATCATCCTCTTCACAGGACTCTGCA
TCCTAGCCTGCTGTATGTGGGTGCCCCCGTGGCATACATCCAGCAGATATTCGTGAAGTCATCA
GTGTCTCCCTGGCACAGAAACCTTCTGGCAGTAGATGTGTTCCGGTCACCTCTGTCCCGAGCAT
TCCAACTGGTGGAAGAGATCCGGAACCATGTGCTGAGAGACAGCTCAGGGACCAAGAGCCTGGA
GGAAGTTTGCCTGCAGGTGACAGACCTGCTGCCAGGCCTCAGGAAACTCCGGAGCCTACTTCCC
GAACATGGCTGCCTGCTGCTGTCACCTGGGAACTTCTGGCAGAATGACTGGGAAAGATTCCATG
CTGACCCTGACATCATTGGAACCATCCATCAGCATGAGCCTAAAACCCTACAGACATCAGCCAC
ACTCAAAGACTTGCTGTTCGGTGTTCCTGGGAAGTACAGTGGGGTCAGCCTCTACACGAGGAAG
AGGATGGTCTCATACACCATCACCCTGGTCTTCCAGCGCTACCATGCCAAGTTTCTGAGCAGCC
TCCGTGCCCGGCTCATGCTTCTGCACCCCAGCCCCAACTGCAGCCTCCGAGCAGAGAACCTGGT
GCATGTGCACTTCAAAGAGGAGATTGGCATTGCCGAGCTCATCCCCCTCGTGACCACCTACATC
ATCCTGTTTGCCTACATCTACTTCTCCACACGCAAGATCGACATGGTCAAGTCCAAGTGGGGCC
TCGCCCTGGCAGCCGTGGTCACAGTGCTTAGCTCGCTGCTCATGTCTGTGGGGCTCTGCACTCT
CTTCGGCCTGACGCCCACACTCAATGGCGGCGAGATTTTCCCATATCTGGTGGTGGTTATTGGG
CTAGAGAATGTGTTGGTGCTCACCAAGTCAGTGGTATCAACTCCAGTGGACCTTGAGGTGAAGC
TTCGAATTGCACAAGGCTTAAGCAGTGAGAGCTGGTCCATCATGAAGAACGTAGCAACTGAACT
GGGCATCATCCTCATTGGCTACTTCACCCTTGTGCCTGCCATCCAAGAGTTCTGCCTCTTTGCT
GTGGTGGGCCTGGTGTCTGACTTCTTCCTCCAGATGCTGTTCTTCACCACCGTGCTGTCCATCG
ACATTCGCCGGATGGAGCTAGCAGACCTGAACAAGCGGCTGCCCCCTGAGTCCTGCCTGCCCTC
AGCCAAGCCTGTGGGGAGGCCAGCCCGATATGAGAGACAGCTAGCTGTACGGCCGTCCACACCA
CACACCATCACATTGCAACCATCTTCCTTCCGAAACCTGCGGCTTCCCAAAAGGCTGCGTGTCA
TCTACTTCCTGGCCCGCACTCGCCTGGCACAGCGCCTCATCATGGCTGGTACAGTTGTCTGGAT
TGGCATCCTGGTATATACAGACCCGGCAGGGCTGCGCACCTACCTCGCTGCCCAGGTGACAGAA
CAGAGCCCACTGGGTGAGGGTTCCCTGGGGCCCATGCCTGTGCCTAGTGGAGTGCTGCCTGCCA
GCCACCCGGACCCTGCCTTCTCCATCTTCCCACCTGATGCTCCTAAACTGCCAGAGAACCAGAC
GTTGCCAGGTGAGCTGCCTGAGCATGCCGTTCCAGCAGAGGGCGTCCAGGACAGCCGAGCCCCA
GAGGTGACTTGGGGGCCCGAGGATGAGGAGCTGTGGAGGAAATTGTCCTTCCGCCACTGGCCCA
CACTCTTCAACTACTATAATATCACACTGGCCAAAAGGTACATCAGCCTGCTGCCTGTCATCCC
TGTCACACTACACCTGAATCCACGGGAGGCTCTGGAGGGGCGACACCCTCAGGATGGCCGCACT
GCCTGGGCCCCACCAGAGCCTTTGCCTGCTGGCCTGTGGGAGACCGGACCTAAGGGGCCAGGTG
GAACACAGACCCATGGCGACATTACCTTGTACAAGGTGGCTGCACTTGGCCTGGCAGCGGGCAT
TGTCCTAGTGCTGCTGCTGCTCTGCCTCTACCGGGTGCTCTGCCCGCGAAACTACGGGCAGCCG
GGTGGTGGTGCGGGCAGGCGGAGGCGCGGAGAGCTGCCTTGCGATGACTATGGCTACGCACCGC
CTGAGACGGAGATAGTGCCGCTGGTGCTGCGAGGGCACCTCATGGACATCGAGTGTCTGGCTAG
CGATGGGATGCTCCTGGTGAGCTGCTGCCTGGCTGGCCAAGTCTGCGTGTGGGATGCACAGACC
GGGGACTGCCTCACTCGCATCCCGCGCCCTGGGCCACGCCGGGACAGCTGCGGAGGCGGAGCTT
TTGAAGCTCAGGAGAACTGGGAAAGACTGTCTGATGGGGGCAAAGCTAGCCCGGAAGAGCCTGG
CGACAGCCCTCCGCTGCGACGCCGCCCTCGAGGGCCTCCACCGCCTTCCCTCTTTGGGGACCAG
CCAGACCTCACCTGCTTAATCGACACCAACTTCTCAGTGCAGCTGCCCCCAGAGCCCACTCAGC
CCGAGCCTCGGCACCGGGCGGGCTGTGGCCGCTCTAGAGACTCTGGTTACGACTTCAGCCGTCT
GGTGCAGCGTGTGTACCAAGAGGAAGGCCTGGCTGCTGTGCACATGTCGGCCCTGCGCCCACCC
TCCCCGGGACCTCCCCTGCCCCAGGCCTCTCAAGAAGAGGGGACTGCTCCCGAGAAGGGCTCCC
CCCCTCTGGCCTGGGCCCCCAGCACAGCCGGTTCCATCTGGAGCTTAGAGTTGCAAGGCAGTCT
CATCGTGGTTGGGCGAAGCAGCGGCCGGCTGGAGGTGTGGGATGCCATTGAGGGCGTGCTCTGC
TGCAGCAATGAGGAGATCTCCTCAGGCATCACAGCCCTTGTCTTCTTAGACAGGAGGATTGTAG
CTGCTCGGCTCAACGGTTCCCTCGATTTCTTTTCCTTGGAGACCCACACTTCCCTCAGCCCCCT
GCAGTTCAGAGGGACCCCAGGGAGAGGCAGTTCTCCTTCCTCGCCTGTGTACAGCAGCAGCAAC
ACTGTGGCCTGTCACCTGACCCACACAGTCCCCTGTGCACACCAGAAACCCATCACAGCCCTGA
GAGCAGCAGCGGGGCGCCTGGTGACAGGGAGCCAAGACCATACTCTGAGAGTCTTCCGACTGGA
GGATTCGTGTTGCCTCTTTACCCTGCAGGGCCACTCGGGGGCAATCACAACTGTGTACATTGAT
CAGACCATGGTATTGGCCAGTGGAGGACAAGATGGAGCCATCTGCCTGTGGGATGTACTAACAG
GCAGCCGGGTCAGCCATACATTTGCTCACCGTGGAGATGTCACCTCCCTCACCTGTACCACTTC
CTGTGTTATCAGTAGTGGCCTGGATGACTTCATCAACATCTGGGACCGAAGCACAGGCATCAAG
CTGTACTCCATTCAGCAGGACCTGGGCTGTGGTGCAAGCTTGGGTGTCATCTCTGATAACCTTC
TGGTGACCGGCGGCCAGGGATGTGTCTCCTTTTGGGACCTAAACTATGGGGACCTGTTACAGAC
AGTCTACTTGGGAAAGAACAGTGAAGCCCAGCCTGCCCGGCAGATTTTGGTGCTGGACAATGCT
GCCATTGTCTGCAACTTTGGCAGTGAGCTCAGCCTAGTGTATGTGCCCTCTGTGCTGGAGAAAC
TGGACTGAAGGCAGGTCAACTGCACTATGCCTTTCCCCCATCCCAAGGTGGGGCACTGGGGATT
GCAACTCTTTGGACCTAGACTGGAGGCAATAGGTAGGCATCTTTGCAGCTGACTCAGAACTGTT
GTCTCCTGACTGTAATAATAAACTTTTTTTTAAAAAACCACA

hide sequence

RefSeq Acc Id:

XM_039081248 ⟹ XP_038937176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	119,184,442 - 119,239,086 (+)	NCBI
mRatBN7.2	8	110,306,032 - 110,360,677 (+)	NCBI

RefSeq Acc Id:

XM_063265270 ⟹ XP_063121340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	119,184,442 - 119,239,086 (+)	NCBI

RefSeq Acc Id:

XM_063265271 ⟹ XP_063121341

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	119,184,366 - 119,239,086 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094436	(Get FASTA)	NCBI Sequence Viewer
	XP_017451086	(Get FASTA)	NCBI Sequence Viewer
	XP_038937176	(Get FASTA)	NCBI Sequence Viewer
	XP_063121340	(Get FASTA)	NCBI Sequence Viewer
	XP_063121341	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A2RRU4	(Get FASTA)	NCBI Sequence Viewer
	AAI31853	(Get FASTA)	NCBI Sequence Viewer
	EDL77086	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028295
	ENSRNOP00000028295.5

RefSeq Acc Id:

NP_001094436 ⟸ NM_001100966

- UniProtKB:

A2RRU4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGY
SPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEE
IRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDII
GTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLM
LLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAV
VTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQG
LSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRME
LADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLAR
TRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPA
FSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYY
NITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHG
DITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIV
PLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQEN
WERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHR
AGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWA
PSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNG
SLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGR
LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSH
TFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQ
GCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD

hide sequence

RefSeq Acc Id:

XP_017451086 ⟸ XM_017595597

- Peptide Label:

isoform X2

- Sequence:

show sequence

MVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYII
LFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGL
ENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAV
VGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPH
TITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQ
SPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPE
VTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTA
WAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPG
GGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTG
DCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQP
DLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPS
PGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCC
SNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNT
VACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQ
TMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKL
YSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAA
IVCNFGSELSLVYVPSVLEKLD

hide sequence

Ensembl Acc Id:

ENSRNOP00000072003 ⟸ ENSRNOT00000090238

Ensembl Acc Id:

ENSRNOP00000028295 ⟸ ENSRNOT00000028295

RefSeq Acc Id:	XP_038937176 ⟸ XM_039081248
- Peptide Label:	isoform X1
- UniProtKB:	A2RRU4 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063121341 ⟸ XM_063265271
- Peptide Label:	isoform X1
- UniProtKB:	A2RRU4 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063121340 ⟸ XM_063265270
- Peptide Label:	isoform X1
- UniProtKB:	A2RRU4 (UniProtKB/Swiss-Prot)

Protein Domains

SSD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2RRU4-F1-model_v2	AlphaFold	A2RRU4	1-1276	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696329

Promoter ID:

EPDNEW_R6854

Type:

initiation region

Name:

Scap_1

Description:

SREBF chaperone

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	118,570,553 - 118,570,613	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309378	AgrOrtholog
BioCyc Gene	G2FUF-29075	BioCyc
Ensembl Genes	ENSRNOG00000020853	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000028295	ENTREZGENE
	ENSRNOT00000028295.8	UniProtKB/Swiss-Prot
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7189794	IMAGE-MGC_LOAD
InterPro	Beta-prop_SCAP	UniProtKB/Swiss-Prot
	HMGCR/SNAP/NPC1-like_SSD	UniProtKB/Swiss-Prot
	SCAP	UniProtKB/Swiss-Prot
	SCAP_N	UniProtKB/Swiss-Prot
	SSD	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_CS	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:301024	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156813	IMAGE-MGC_LOAD
NCBI Gene	301024	ENTREZGENE
PANTHER	PTHR46378	UniProtKB/Swiss-Prot
	STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN	UniProtKB/Swiss-Prot
Pfam	Beta-prop_SCAP	UniProtKB/Swiss-Prot
	SCAP_N	UniProtKB/Swiss-Prot
	Sterol-sensing	UniProtKB/Swiss-Prot
PhenoGen	Scap	PhenoGen
PROSITE	SSD	UniProtKB/Swiss-Prot
	WD_REPEATS_1	UniProtKB/Swiss-Prot
	WD_REPEATS_2	UniProtKB/Swiss-Prot
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020853	RatGTEx
SMART	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	Multidrug efflux transporter AcrB transmembrane domain	UniProtKB/Swiss-Prot
	SSF50978	UniProtKB/Swiss-Prot
UniProt	A2RRU4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Scap	SREBF chaperone	Scap_predicted	SREBP cleavage activating protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Scap_predicted	SREBP cleavage activating protein (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations