Hao2 (hydroxyacid oxidase 2) - Rat Genome Database

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Gene: Hao2 (hydroxyacid oxidase 2) Rattus norvegicus
Analyze
Symbol: Hao2
Name: hydroxyacid oxidase 2
RGD ID: 70972
Description: Enables (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Involved in mandelate metabolic process. Located in peroxisome. Orthologous to human HAO2 (hydroxyacid oxidase 2); PARTICIPATES IN glyoxylate and dicarboxylate metabolic pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (S)-2-hydroxy-acid oxidase, peroxisomal; 2-Hydroxyacid oxidase 2; Hao3; HAOX2; hydroxyacid oxidase (glycolate oxidase) 3; hydroxyacid oxidase 2 (long chain); hydroxyacid oxidase 3 (medium-chain); LCHAO; long chain alpha-hydroxy acid oxidase; long-chain L-2-hydroxy acid oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp73 Niddm62
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,888,848 - 188,921,567 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,889,212 - 188,913,133 (-)EnsemblGRCr8
mRatBN7.22186,200,137 - 186,232,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,200,504 - 186,224,425 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,857,178 - 193,881,103 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,652,271 - 191,676,187 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,489,732 - 186,513,657 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,785,492 - 200,808,868 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,778,122 - 200,808,857 (+)Ensemblrn6Rnor6.0
Rnor_5.02220,246,117 - 220,278,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,532,833 - 193,557,229 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,682,304 - 178,706,224 (-)NCBICelera
RGSC_v3.12193,495,586 - 193,519,983 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
AB-Fubinaca  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bromobenzene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dibromoacetic acid  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
isotretinoin  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
profenofos  (EXP)
propiconazole  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
triadimefon  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
peroxisomal matrix  (IBA,IEA,ISO)
peroxisome  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and nucleotide sequence of cDNA encoding rat kidney long-chain L-2-hydroxy acid oxidase. Expression of the catalytically active recombinant protein as a chimaera. Belmouden A, etal., Eur J Biochem 1993 May 15;214(1):17-25.
2. Crystal structure analysis of recombinant rat kidney long chain hydroxy acid oxidase. Cunane LM, etal., Biochemistry. 2005 Feb 8;44(5):1521-31.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
6. Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Lee SJ, etal., Hypertens Res 2003 Jan;26(1):75-87.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1939137   PMID:3061453   PMID:10777549   PMID:15489334   PMID:18614015   PMID:20178365   PMID:23376485   PMID:26658681  


Genomics

Comparative Map Data
Hao2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,888,848 - 188,921,567 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,889,212 - 188,913,133 (-)EnsemblGRCr8
mRatBN7.22186,200,137 - 186,232,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,200,504 - 186,224,425 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,857,178 - 193,881,103 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,652,271 - 191,676,187 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,489,732 - 186,513,657 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,785,492 - 200,808,868 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,778,122 - 200,808,857 (+)Ensemblrn6Rnor6.0
Rnor_5.02220,246,117 - 220,278,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,532,833 - 193,557,229 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,682,304 - 178,706,224 (-)NCBICelera
RGSC_v3.12193,495,586 - 193,519,983 (-)NCBI
Cytogenetic Map2q34NCBI
HAO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,368,785 - 119,394,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,368,727 - 119,394,258 (+)Ensemblhg38GRCh38
GRCh371119,911,408 - 119,936,753 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,712,925 - 119,738,274 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341119,623,443 - 119,648,793NCBI
Celera1118,142,224 - 118,167,573 (+)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,769,864 - 117,795,303 (+)NCBIHuRef
CHM1_11120,026,956 - 120,052,305 (+)NCBICHM1_1
T2T-CHM13v2.01119,375,119 - 119,407,329 (+)NCBIT2T-CHM13v2.0
Hao2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,781,835 - 98,802,692 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,781,837 - 98,800,555 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38398,874,519 - 98,895,376 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,874,521 - 98,893,239 (-)Ensemblmm10GRCm38
MGSCv37398,678,442 - 98,697,153 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36399,003,638 - 99,022,274 (-)NCBIMGSCv36mm8
Celera3100,210,261 - 100,228,985 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.9NCBI
Hao2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543522,380,388 - 22,404,052 (+)Ensembl
ChiLan1.0NW_00495543522,380,395 - 22,404,426 (+)NCBIChiLan1.0ChiLan1.0
HAO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,985,096 - 112,010,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,588,950 - 111,614,331 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,160,326 - 83,185,688 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,157,570 - 118,182,957 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,157,037 - 118,182,957 (-)EnsemblpanPan2panpan1.1
HAO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,505,463 - 56,529,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,505,506 - 56,528,954 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1756,154,387 - 56,178,251 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01757,378,470 - 57,402,319 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,378,390 - 57,401,965 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,414,332 - 56,438,197 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,446,707 - 56,470,576 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,036,690 - 57,060,535 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hao2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505810,309,168 - 10,329,798 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366274,159,214 - 4,179,806 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366274,167,501 - 4,179,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,588,861 - 101,732,304 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14101,588,510 - 101,787,818 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,579,140 - 111,777,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,376,096 - 14,408,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,374,543 - 14,407,992 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603817,036,701 - 17,062,595 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hao2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477214,981,666 - 15,023,173 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477214,981,777 - 15,022,699 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hao2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1358,678,837 - 58,704,499 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hao2
384 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000046942
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH130402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,200,443 - 186,200,659 (-)MAPPERmRatBN7.2
Rnor_6.02200,808,346 - 200,808,561NCBIRnor6.0
Rnor_5.02220,277,948 - 220,278,163UniSTSRnor5.0
RGSC_v3.42193,532,773 - 193,532,988UniSTSRGSC3.4
Celera2178,682,244 - 178,682,459UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS
RH130963  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,200,637 - 186,200,837 (-)MAPPERmRatBN7.2
Rnor_6.02200,808,168 - 200,808,367NCBIRnor6.0
Rnor_5.02220,277,770 - 220,277,969UniSTSRnor5.0
RGSC_v3.42193,532,967 - 193,533,166UniSTSRGSC3.4
Celera2178,682,438 - 178,682,637UniSTS
RH 3.4 Map21259.0UniSTS
Cytogenetic Map2q34UniSTS
RH140192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,200,301 - 186,200,497 (-)MAPPERmRatBN7.2
Rnor_6.02200,808,508 - 200,808,703NCBIRnor6.0
Rnor_5.02220,278,110 - 220,278,305UniSTSRnor5.0
RGSC_v3.42193,532,631 - 193,532,826UniSTSRGSC3.4
Celera2178,682,102 - 178,682,297UniSTS
RH 3.4 Map21259.6UniSTS
Cytogenetic Map2q34UniSTS
AI232087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,200,359 - 186,200,472 (-)MAPPERmRatBN7.2
Rnor_6.02200,808,533 - 200,808,645NCBIRnor6.0
Rnor_5.02220,278,135 - 220,278,247UniSTSRnor5.0
RGSC_v3.42193,532,689 - 193,532,801UniSTSRGSC3.4
Celera2178,682,160 - 178,682,272UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 9 20 58 87 81 59 29 59 4 256 66 40 116 63 22 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000046942   ⟹   ENSRNOP00000040223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,889,212 - 188,913,133 (-)Ensembl
mRatBN7.2 Ensembl2186,200,504 - 186,224,425 (-)Ensembl
Rnor_6.0 Ensembl2200,785,507 - 200,808,501 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091444   ⟹   ENSRNOP00000071695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,889,212 - 188,905,051 (-)Ensembl
mRatBN7.2 Ensembl2186,200,504 - 186,216,343 (-)Ensembl
Rnor_6.0 Ensembl2200,793,571 - 200,808,501 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091845   ⟹   ENSRNOP00000074018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,200,504 - 186,217,055 (-)Ensembl
Rnor_6.0 Ensembl2200,778,122 - 200,808,857 (+)Ensembl
RefSeq Acc Id: NM_032082   ⟹   NP_114471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,889,212 - 188,913,133 (-)NCBI
mRatBN7.22186,200,504 - 186,224,425 (-)NCBI
Rnor_6.02200,785,507 - 200,808,501 (+)NCBI
Rnor_5.02220,246,117 - 220,278,112 (+)NCBI
RGSC_v3.42193,532,833 - 193,557,229 (-)RGD
Celera2178,682,304 - 178,706,224 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233022   ⟹   XP_006233084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,913,196 (-)NCBI
mRatBN7.22186,200,137 - 186,224,481 (-)NCBI
Rnor_6.02200,785,492 - 200,808,868 (+)NCBI
Rnor_5.02220,246,117 - 220,278,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233024   ⟹   XP_006233086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,913,196 (-)NCBI
mRatBN7.22186,200,137 - 186,224,481 (-)NCBI
Rnor_6.02200,785,492 - 200,808,868 (+)NCBI
Rnor_5.02220,246,117 - 220,278,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233025   ⟹   XP_006233087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,913,196 (-)NCBI
mRatBN7.22186,200,137 - 186,224,481 (-)NCBI
Rnor_6.02200,785,492 - 200,808,868 (+)NCBI
Rnor_5.02220,246,117 - 220,278,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103263   ⟹   XP_038959191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,921,553 (-)NCBI
mRatBN7.22186,200,137 - 186,232,997 (-)NCBI
RefSeq Acc Id: XM_063282643   ⟹   XP_063138713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,913,196 (-)NCBI
RefSeq Acc Id: XM_063282644   ⟹   XP_063138714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,888,848 - 188,921,567 (-)NCBI
RefSeq Acc Id: NP_114471   ⟸   NM_032082
- UniProtKB: Q07523 (UniProtKB/Swiss-Prot),   A6K3E3 (UniProtKB/TrEMBL),   A0A0G2K713 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233084   ⟸   XM_006233022
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UQG3 (UniProtKB/TrEMBL),   A0A0G2K713 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233086   ⟸   XM_006233024
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K713 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233087   ⟸   XM_006233025
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K713 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071695   ⟸   ENSRNOT00000091444
Ensembl Acc Id: ENSRNOP00000040223   ⟸   ENSRNOT00000046942
Ensembl Acc Id: ENSRNOP00000074018   ⟸   ENSRNOT00000091845
RefSeq Acc Id: XP_038959191   ⟸   XM_039103263
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K713 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138714   ⟸   XM_063282644
- Peptide Label: isoform X5
- UniProtKB: Q07523 (UniProtKB/Swiss-Prot),   A0A0G2K713 (UniProtKB/TrEMBL),   A6K3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138713   ⟸   XM_063282643
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K713 (UniProtKB/TrEMBL)
Protein Domains
FMN hydroxy acid dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07523-F1-model_v2 AlphaFold Q07523 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691603
Promoter ID:EPDNEW_R2128
Type:multiple initiation site
Name:Hao2_1
Description:hydroxyacid oxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02200,785,525 - 200,785,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70972 AgrOrtholog
BioCyc Gene G2FUF-51904 BioCyc
Ensembl Genes ENSRNOG00000019470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046942 ENTREZGENE
  ENSRNOT00000046942.3 UniProtKB/Swiss-Prot
  ENSRNOT00000091444 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132928 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  Alpha-hydoxy_acid_DH_FMN UniProtKB/Swiss-Prot
  FMN-dep_DH UniProtKB/Swiss-Prot
  FMN_HAD UniProtKB/Swiss-Prot
  FMN_hydac_DH_AS UniProtKB/Swiss-Prot
KEGG Report rno:84029 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93324 IMAGE-MGC_LOAD
NCBI Gene 84029 ENTREZGENE
PANTHER 2-HYDROXYACID OXIDASE 2 UniProtKB/Swiss-Prot
  S -2-HYDROXY-ACID OXIDASE-RELATED UniProtKB/Swiss-Prot
Pfam FMN_dh UniProtKB/Swiss-Prot
PhenoGen Hao2 PhenoGen
PIRSF Al-hdrx_acd_dh UniProtKB/Swiss-Prot
PROSITE FMN_HYDROXY_ACID_DH_1 UniProtKB/Swiss-Prot
  FMN_HYDROXY_ACID_DH_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019470 RatGTEx
Superfamily-SCOP FMN-linked oxidoreductases UniProtKB/Swiss-Prot
UniProt A0A0G2K713 ENTREZGENE
  A0A8L2UQG3 ENTREZGENE, UniProtKB/TrEMBL
  A6K3E3 ENTREZGENE, UniProtKB/TrEMBL
  HAOX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Hao2  hydroxyacid oxidase 2  Hao2  hydroxyacid oxidase 2 (long chain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hao2  hydroxyacid oxidase 2 (long chain)  Hao3  hydroxyacid oxidase (glycolate oxidase) 3  Symbol and Name updated 1299863 APPROVED
2002-07-09 Hao3  hydroxyacid oxidase (glycolate oxidase) 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease high expression associated with lower blood pressure in a SS/Jr.WKY congenic strain, compared to the SS/Jr 631320
gene_expression expressed in kidney 631320
gene_function oxidizes L-2 hydroxy acids into keto acids; FMN-dependent 631320
gene_protein 1648-bp cDNA codes for 352 aa protein 70759