Rab8b (RAB8B, member RAS oncogene family) - Rat Genome Database

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Gene: Rab8b (RAB8B, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab8b
Name: RAB8B, member RAS oncogene family
RGD ID: 628764
Description: Enables TPR domain binding activity. Involved in cell-substrate junction organization; positive regulation of cell projection organization; and positive regulation of corticotropin secretion. Located in cell tip and perinuclear region of cytoplasm. Is active in presynapse. Orthologous to human RAB8B (RAB8B, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTPase Rab8b; ras-related protein Rab-8B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,340,106 - 76,417,638 (-)NCBIGRCr8
mRatBN7.2867,458,921 - 67,536,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,458,923 - 67,536,384 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,992,995 - 73,067,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0871,265,830 - 71,340,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0869,100,711 - 69,178,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0872,641,680 - 72,714,646 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,638,003 - 72,714,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,975,899 - 77,047,482 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,156,502 - 71,231,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1871,175,555 - 71,250,861 (-)NCBI
Celera874,168,077 - 74,238,512 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethylbenzene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
o-xylene  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3. Armstrong J, etal., J Cell Sci. 1996 Jun;109 ( Pt 6):1265-74.
2. Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells. Chen S, etal., J Biol Chem 2001 Apr 20;276(16):13209-16. Epub 2001 Jan 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Heidrych P, etal., Hum Mol Genet. 2008 Dec 1;17(23):3814-21. doi: 10.1093/hmg/ddn279. Epub 2008 Sep 4.
6. Rab8B GTPase and junction dynamics in the testis. Lau AS and Mruk DD, Endocrinology. 2003 Apr;144(4):1549-63.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
12. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:12477932   PMID:17646400   PMID:18346465   PMID:18614015   PMID:19056867   PMID:19717423   PMID:20458337   PMID:20937701   PMID:21255211   PMID:22871113  


Genomics

Comparative Map Data
Rab8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,340,106 - 76,417,638 (-)NCBIGRCr8
mRatBN7.2867,458,921 - 67,536,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,458,923 - 67,536,384 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,992,995 - 73,067,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0871,265,830 - 71,340,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0869,100,711 - 69,178,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0872,641,680 - 72,714,646 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,638,003 - 72,714,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,975,899 - 77,047,482 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,156,502 - 71,231,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1871,175,555 - 71,250,861 (-)NCBI
Celera874,168,077 - 74,238,512 (+)NCBICelera
Cytogenetic Map8q24NCBI
RAB8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,189,606 - 63,267,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,189,560 - 63,267,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371563,481,805 - 63,559,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,268,781 - 61,347,028 (+)NCBINCBI36Build 36hg18NCBI36
Build 341561,268,785 - 61,343,422NCBI
Celera1540,361,335 - 40,438,724 (+)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1540,304,775 - 40,382,999 (+)NCBIHuRef
CHM1_11563,600,874 - 63,679,075 (+)NCBICHM1_1
T2T-CHM13v2.01560,994,386 - 61,072,552 (+)NCBIT2T-CHM13v2.0
Rab8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,750,891 - 66,826,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,750,946 - 66,826,969 (-)EnsemblGRCm39 Ensembl
GRCm38966,843,609 - 66,919,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,843,664 - 66,919,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv37966,691,471 - 66,767,512 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36966,642,808 - 66,718,831 (-)NCBIMGSCv36mm8
Celera964,077,884 - 64,154,033 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map936.17NCBI
Rab8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545012,026,784 - 12,095,422 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545012,026,784 - 12,095,332 (-)NCBIChiLan1.0ChiLan1.0
RAB8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21652,438,265 - 52,516,306 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11556,614,260 - 56,692,351 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,136,776 - 42,214,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11560,432,749 - 60,510,547 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,432,749 - 60,510,547 (+)Ensemblpanpan1.1panPan2
RAB8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,784,298 - 27,845,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,784,387 - 27,842,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3027,703,275 - 27,764,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03027,955,859 - 28,017,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3027,955,891 - 28,017,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13027,893,427 - 27,955,069 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03027,955,252 - 28,016,926 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,198,967 - 28,260,665 (+)NCBIUU_Cfam_GSD_1.0
Rab8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640105,920,372 - 105,983,602 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647123,768,415 - 23,834,129 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647123,768,460 - 23,832,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,772,851 - 108,840,227 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11108,772,851 - 108,840,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,998,446 - 120,063,398 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,275,555 - 20,354,298 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2620,275,258 - 20,354,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048121,045,683 - 121,125,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247819,251,212 - 9,325,642 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247819,253,039 - 9,324,873 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab8b
361 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:239
Count of miRNA genes:153
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000024286
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat

Markers in Region
D8Rat179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,507,778 - 67,507,950 (+)MAPPERmRatBN7.2
Rnor_6.0872,683,617 - 72,683,788NCBIRnor6.0
Rnor_5.0877,017,836 - 77,018,007UniSTSRnor5.0
RGSC_v3.4871,201,291 - 71,201,463RGDRGSC3.4
RGSC_v3.4871,201,292 - 71,201,463UniSTSRGSC3.4
RGSC_v3.1871,220,301 - 71,220,644RGD
Celera874,195,846 - 74,196,017UniSTS
SHRSP x BN Map845.61UniSTS
SHRSP x BN Map845.61RGD
Cytogenetic Map8q24UniSTS
D8Rat211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,480,448 - 67,480,652 (+)MAPPERmRatBN7.2
Rnor_6.0872,659,195 - 72,659,396NCBIRnor6.0
Rnor_5.0876,993,414 - 76,993,615UniSTSRnor5.0
RGSC_v3.4871,174,974 - 71,175,178RGDRGSC3.4
RGSC_v3.4871,174,975 - 71,175,178UniSTSRGSC3.4
RGSC_v3.1871,193,728 - 71,194,344RGD
Celera874,220,793 - 74,220,996UniSTS
SHRSP x BN Map844.83UniSTS
SHRSP x BN Map844.83RGD
Cytogenetic Map8q24UniSTS
RH139304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,532,522 - 67,532,666 (+)MAPPERmRatBN7.2
Rnor_6.0872,710,768 - 72,710,911NCBIRnor6.0
Rnor_5.0877,043,604 - 77,043,747UniSTSRnor5.0
RGSC_v3.4871,227,929 - 71,228,072UniSTSRGSC3.4
Celera874,171,812 - 74,171,955UniSTS
RH 3.4 Map8849.3UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024286   ⟹   ENSRNOP00000024287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl867,458,923 - 67,536,384 (-)Ensembl
Rnor_6.0 Ensembl872,638,003 - 72,714,664 (-)Ensembl
RefSeq Acc Id: NM_153317   ⟹   NP_695229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,340,106 - 76,417,548 (-)NCBI
mRatBN7.2867,458,921 - 67,536,371 (-)NCBI
Rnor_6.0872,641,680 - 72,714,646 (-)NCBI
Rnor_5.0876,975,899 - 77,047,482 (-)NCBI
RGSC_v3.4871,156,502 - 71,231,807 (-)RGD
Celera874,168,077 - 74,238,512 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080932   ⟹   XP_038936860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,350,768 - 76,417,638 (-)NCBI
mRatBN7.2867,469,588 - 67,536,466 (-)NCBI
RefSeq Acc Id: XM_039080935   ⟹   XP_038936863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,340,108 - 76,417,358 (-)NCBI
mRatBN7.2867,458,921 - 67,536,156 (-)NCBI
RefSeq Acc Id: NP_695229   ⟸   NM_153317
- UniProtKB: P70550 (UniProtKB/Swiss-Prot),   B0BMV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024287   ⟸   ENSRNOT00000024286
RefSeq Acc Id: XP_038936863   ⟸   XM_039080935
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936860   ⟸   XM_039080932
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70550-F1-model_v2 AlphaFold P70550 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696091
Promoter ID:EPDNEW_R6616
Type:initiation region
Name:Rab8b_1
Description:RAB8B, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0872,714,615 - 72,714,675EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628764 AgrOrtholog
BioCyc Gene G2FUF-30008 BioCyc
Ensembl Genes ENSRNOG00000018009 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055026262 UniProtKB/Swiss-Prot
  ENSRNOG00060021628 UniProtKB/Swiss-Prot
  ENSRNOG00065006849 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024286.5 UniProtKB/Swiss-Prot
  ENSRNOT00055045303 UniProtKB/Swiss-Prot
  ENSRNOT00060037465 UniProtKB/Swiss-Prot
  ENSRNOT00065010670 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9091689 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266688 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187328 IMAGE-MGC_LOAD
NCBI Gene 266688 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-8B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab8b PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018009 RatGTEx
  ENSRNOG00055026262 RatGTEx
  ENSRNOG00060021628 RatGTEx
  ENSRNOG00065006849 RatGTEx
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KF00_RAT UniProtKB/TrEMBL
  B0BMV5 ENTREZGENE, UniProtKB/TrEMBL
  P70550 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab8b  RAB8B, member RAS oncogene family    GTPase Rab8b  Name updated 1299863 APPROVED
2003-02-27 Rab8b  GTPase Rab8b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression induces cAMP induced adrenocorticotropic hormone (ACTH) secretion 737646
gene_physical_interaction binds TPR-containing Rab8b interacting protein TRIP8b 737646