Cdc25a (cell division cycle 25A) - Rat Genome Database

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Gene: Cdc25a (cell division cycle 25A) Rattus norvegicus
Analyze
Symbol: Cdc25a
Name: cell division cycle 25A
RGD ID: 621498
Description: Enables phosphoprotein phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Predicted to be active in cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division cycle 25 homolog A (S. cerevisiae); cell division cycle 25 homolog A (S. pombe); dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,742,824 - 118,761,190 (+)NCBIGRCr8
mRatBN7.28109,864,356 - 109,882,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,864,478 - 109,882,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,480,079 - 115,498,174 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,679,257 - 113,697,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,522,054 - 111,540,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Celera8109,154,287 - 109,172,351 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aniline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
diethyl maleate  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenhexamid  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
harmine  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (ISO)
isosilybin A  (ISO)
Lasiocarpine  (ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
n-propyl gallate  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pifithrin-?  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propylparaben  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
toosendanin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Aziz MH, etal., Cancer Res. 2008 Nov 1;68(21):9024-32.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Hulit J, etal., Cancer Res. 2006 Sep 1;66(17):8529-41.
5. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, etal., EMBO J 1994 Apr 1;13(7):1549-56.
6. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Lokeshwar VB, etal., Cancer Res. 2006 Dec 1;66(23):11219-27.
7. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Masyuk TV, etal., Gastroenterology. 2012 Mar;142(3):622-633.e4. doi: 10.1053/j.gastro.2011.11.036. Epub 2011 Dec 7.
8. Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients. Mehdipour P, etal., Cell Biol Int. 2009 Oct;33(10):1050-6. Epub 2009 Jun 23.
9. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. Mochizuki T, etal., J Biol Chem 1999 Jun 25;274(26):18659-66.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. Ray D, etal., Cancer Res. 2007 Feb 1;67(3):984-91.
13. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Ray D, etal., Cancer Res. 2007 Jul 15;67(14):6605-11.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes. Strazza M, etal., Neurochem Res. 2004 May;29(5):923-31.
17. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
18. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:11981756   PMID:14742443   PMID:18949056   PMID:19966869   PMID:20813185   PMID:21376736   PMID:22843495   PMID:22899714   PMID:24211536   PMID:39305937  


Genomics

Comparative Map Data
Cdc25a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,742,824 - 118,761,190 (+)NCBIGRCr8
mRatBN7.28109,864,356 - 109,882,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,864,478 - 109,882,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,480,079 - 115,498,174 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,679,257 - 113,697,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,522,054 - 111,540,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Celera8109,154,287 - 109,172,351 (+)NCBICelera
Cytogenetic Map8q32NCBI
CDC25A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,157,146 - 48,188,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,157,146 - 48,188,417 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,198,636 - 48,229,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,173,672 - 48,204,805 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,173,671 - 48,204,805NCBI
Celera348,147,668 - 48,178,797 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,253,008 - 48,284,141 (-)NCBIHuRef
CHM1_1348,150,488 - 48,181,619 (-)NCBICHM1_1
T2T-CHM13v2.0348,184,306 - 48,215,830 (-)NCBIT2T-CHM13v2.0
Cdc25a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,704,545 - 109,722,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,704,647 - 109,722,963 (+)EnsemblGRCm39 Ensembl
GRCm389109,875,518 - 109,893,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,875,579 - 109,893,895 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,778,083 - 109,796,394 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,733,366 - 109,751,296 (+)NCBIMGSCv36mm8
Celera9109,601,935 - 109,621,511 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.81NCBI
Cdc25a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,344,388 - 24,362,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,345,002 - 24,361,802 (+)NCBIChiLan1.0ChiLan1.0
CDC25A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,121,554 - 48,152,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,126,322 - 48,157,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,068,601 - 48,099,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,154,307 - 49,186,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,154,307 - 49,186,115 (-)Ensemblpanpan1.1panPan2
CDC25A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,823,683 - 40,849,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,823,459 - 40,847,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,741,248 - 40,764,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,309,415 - 41,334,896 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,309,419 - 41,334,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,549,928 - 40,573,619 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,951,503 - 40,974,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,231,962 - 41,255,400 (+)NCBIUU_Cfam_GSD_1.0
Cdc25a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,108,272 - 202,130,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365961,659,159 - 1,678,788 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365961,657,411 - 1,680,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21334,164,323 - 34,190,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,534,114 - 9,564,927 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,534,053 - 9,564,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,537,318 - 157,569,097 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,443,731 - 73,464,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473073,443,895 - 73,463,979 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdc25a
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:230
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000028141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH142287  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q32UniSTS
BF386976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,879,927 - 109,880,082 (+)MAPPERmRatBN7.2
Rnor_6.08117,968,743 - 117,968,897NCBIRnor6.0
Rnor_5.08117,321,265 - 117,321,419UniSTSRnor5.0
RGSC_v3.48114,253,197 - 114,253,351UniSTSRGSC3.4
Celera8109,169,597 - 109,169,751UniSTS
RH 3.4 Map81115.79UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028141   ⟹   ENSRNOP00000028141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,864,758 - 109,882,701 (+)Ensembl
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116348   ⟹   ENSRNOP00000082319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,864,478 - 109,881,103 (+)Ensembl
RefSeq Acc Id: NM_133571   ⟹   NP_598255
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,743,048 - 118,761,157 (+)NCBI
mRatBN7.28109,864,591 - 109,882,701 (+)NCBI
Rnor_6.08117,953,444 - 117,971,519 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
RGSC_v3.48114,237,704 - 114,255,971 (+)RGD
Celera8109,154,287 - 109,172,351 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243702   ⟹   XP_006243764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,742,829 - 118,761,190 (+)NCBI
mRatBN7.28109,864,356 - 109,882,734 (+)NCBI
Rnor_6.08117,953,223 - 117,971,552 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243703   ⟹   XP_006243765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,743,322 - 118,761,190 (+)NCBI
mRatBN7.28109,864,862 - 109,882,734 (+)NCBI
Rnor_6.08117,953,764 - 117,971,552 (+)NCBI
Rnor_5.08117,305,748 - 117,324,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264813   ⟹   XP_063120883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,742,824 - 118,759,479 (+)NCBI
RefSeq Acc Id: NP_598255   ⟸   NM_133571
- UniProtKB: P48965 (UniProtKB/Swiss-Prot),   G3V8T0 (UniProtKB/TrEMBL),   A6I3C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243764   ⟸   XM_006243702
- Peptide Label: isoform X1
- UniProtKB: P48965 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243765   ⟸   XM_006243703
- Peptide Label: isoform X2
- UniProtKB: P48965 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028141   ⟸   ENSRNOT00000028141
Ensembl Acc Id: ENSRNOP00000082319   ⟸   ENSRNOT00000116348
RefSeq Acc Id: XP_063120883   ⟸   XM_063264813
- Peptide Label: isoform X3
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48965-F1-model_v2 AlphaFold P48965 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621498 AgrOrtholog
BioCyc Gene G2FUF-29084 BioCyc
Ensembl Genes ENSRNOG00000020737 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028141.8 UniProtKB/TrEMBL
  ENSRNOT00000116348.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171102 UniProtKB/Swiss-Prot
NCBI Gene 171102 ENTREZGENE
PANTHER M-PHASE INDUCER PHOSPHATASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam M-inducer_phosp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdc25a PhenoGen
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020737 RatGTEx
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZUR1_RAT UniProtKB/TrEMBL
  A6I3C8_RAT UniProtKB/TrEMBL
  A6I3C9 ENTREZGENE, UniProtKB/TrEMBL
  G3V8T0 ENTREZGENE, UniProtKB/TrEMBL
  MPIP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc25a  cell division cycle 25A  Cdc25a  cell division cycle 25 homolog A (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-29 Bsnd  cell division cycle 25 homolog A (S. pombe)  Cdc25a  cell division cycle 25 homolog A (S. cerevisiae)  Name updated 1299863 APPROVED
2005-01-20 Cdc25a  cell division cycle 25 homolog A (S. cerevisiae)    cell division cycle 25A  Name updated 1299863 APPROVED
2002-08-07 Cdc25a  cell division cycle 25A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process immunodepletion inhibits cell cycle progression from G1 into the S phase 724653