GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdc25a | increases expression | ISO | CDC25A (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of CDC25A mRNA; Estradiol results in increased expression of CDC25A protein | PMID:24481588 PMID:24758408 PMID:28880708 PMID:31614463 PMID:9705214 | Cdc25a | multiple interactions | ISO | CDC25A (Homo sapiens) | 6480464 | CTD | [Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK2 protein; [Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK4 protein; sodium arsenite inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA] | PMID:24758408 PMID:28880708 PMID:9705214 | |
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