Akap4 (A-kinase anchoring protein 4)

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Gene: Akap4 (A-kinase anchoring protein 4) Rattus norvegicus

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Symbol:

Akap4

Name:

A-kinase anchoring protein 4

RGD ID:

620828

Description:

Predicted to enable protein kinase A binding activity. Predicted to be involved in flagellated sperm motility and protein localization. Predicted to act upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; establishment of protein localization; and sperm flagellum assembly. Predicted to be located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Orthologous to human AKAP4 (A-kinase anchoring protein 4); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; perfluorododecanoic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

75 kDa fibrous sheath protein; A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4; AKAP-4; major sperm fibrous sheath protein; PRKA4; protein kinase A-anchoring protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKAP4 (A-kinase anchoring protein 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Akap4 (A kinase anchor protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Akap4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AKAP4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AKAP4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Akap4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AKAP4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AKAP4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Akap4 (A-kinase anchoring protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AKAP4 (A-kinase anchoring protein 4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Akap4 (A kinase anchor protein 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	18,107,256 - 18,117,549 (-)	NCBI		GRCr8
mRatBN7.2	X	15,435,391 - 15,445,684 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	15,435,410 - 15,445,684 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	20,251,578 - 20,261,972 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	19,821,331 - 19,831,725 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,086,288 - 16,096,682 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	16,296,027 - 16,306,078 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	16,296,735 - 16,306,078 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	17,081,382 - 17,091,111 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	27,515,009 - 27,524,606 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	27,568,477 - 27,578,075 (-)	NCBI
Celera	X	15,510,282 - 15,520,669 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

congenital disorder of glycosylation type IIm (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

male infertility (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

Stocco Dos Santos type X-linked intellectual disability (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Thrombocytopenia 1 (ISO)

Wiskott-Aldrich syndrome (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

folic acid (ISO)

formaldehyde (ISO)

mono(2-ethylhexyl) phthalate (ISO)

perfluorododecanoic acid (EXP)

sodium fluoride (ISO)

T-2 toxin (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell surface receptor protein serine/threonine kinase signaling pathway (IEA,ISO)

establishment of localization in cell (IEA,ISO)

establishment of protein localization (IEA,ISO)

flagellated sperm motility (ISO,ISS)

protein localization (IBA,ISO)

sperm flagellum assembly (IEA,ISO)

Cellular Component

cilium (ISO)

cytoplasm (IBA)

motile cilium (IEA,ISO,ISS)

perinuclear region of cytoplasm (IEA,ISO)

sperm end piece (IEA,ISO)

sperm fibrous sheath (IBA,IEA,ISO)

sperm flagellum (ISO)

sperm head-tail coupling apparatus (IEA,ISO)

sperm midpiece (IEA,ISO)

sperm principal piece (IBA,IEA,ISO)

Z disc (IEA,ISO)

Molecular Function

protein binding (ISO)

protein kinase A binding (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

protein kinase A (PKA) signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A-kinase anchoring proteins: from protein complexes to physiology and disease.	Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.	Miki K, etal., Dev Biol 2002 Aug 15;248(2):331-42.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Localized effects of cAMP mediated by distinct routes of protein kinase A.	Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.

Additional References at PubMed

PMID:8088444	PMID:9822690	PMID:9852104	PMID:12606363	PMID:15385410	PMID:16687649	PMID:17923693	PMID:21630459	PMID:21715716	PMID:30137358	PMID:30745215

Genomics

Comparative Map Data

Akap4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	18,107,256 - 18,117,549 (-)	NCBI		GRCr8
mRatBN7.2	X	15,435,391 - 15,445,684 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	15,435,410 - 15,445,684 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	20,251,578 - 20,261,972 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	19,821,331 - 19,831,725 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,086,288 - 16,096,682 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	16,296,027 - 16,306,078 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	16,296,735 - 16,306,078 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	17,081,382 - 17,091,111 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	27,515,009 - 27,524,606 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	27,568,477 - 27,578,075 (-)	NCBI
Celera	X	15,510,282 - 15,520,669 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

AKAP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	50,190,777 - 50,201,007 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	50,190,777 - 50,201,007 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	49,955,420 - 49,965,658 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	49,842,151 - 49,852,404 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	49,658,457 - 49,668,040	NCBI
Celera	X	54,024,511 - 54,034,765 (-)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	47,427,699 - 47,437,860 (-)	NCBI		HuRef
CHM1_1	X	50,035,048 - 50,045,361 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	49,508,429 - 49,518,665 (-)	NCBI		T2T-CHM13v2.0

Akap4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	6,933,754 - 6,944,848 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	6,933,758 - 6,944,848 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	7,067,515 - 7,078,609 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	7,067,519 - 7,078,609 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	6,644,645 - 6,655,735 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	6,224,469 - 6,235,378 (+)	NCBI		MGSCv36	mm8
MGSCv36	X	3,237,368 - 3,248,069 (+)	NCBI		MGSCv36	mm8
Celera	X	4,385,111 - 4,395,986 (-)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	3.17	NCBI

Akap4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955543	1,357,997 - 1,367,897 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955543	1,358,086 - 1,367,838 (+)	NCBI	ChiLan1.0	ChiLan1.0

AKAP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	51,609,197 - 51,621,892 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	51,612,573 - 51,625,268 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	42,396,399 - 42,406,725 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	50,109,391 - 50,119,651 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	50,109,367 - 50,119,658 (-)	Ensembl	panpan1.1		panPan2

AKAP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	42,935,831 - 42,946,248 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	42,935,815 - 42,946,149 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	17,313,189 - 17,323,613 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	43,074,974 - 43,085,399 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	43,074,994 - 43,085,299 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	43,060,826 - 43,071,242 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	43,048,110 - 43,058,530 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	43,143,002 - 43,153,434 (-)	NCBI		UU_Cfam_GSD_1.0

Akap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	35,452,021 - 35,462,091 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936721	1,692,623 - 1,702,348 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936721	1,692,623 - 1,700,256 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKAP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	43,885,394 - 43,895,981 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	43,885,584 - 43,895,142 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	48,812,671 - 48,822,999 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKAP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	47,046,209 - 47,056,961 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	47,046,240 - 47,056,319 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666086	628,681 - 638,923 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Akap4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624893	1,759,045 - 1,767,918 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624893	1,759,148 - 1,767,831 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Akap4
32 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Markers in Region

U10341

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	15,435,405 - 15,435,507 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	16,296,042 - 16,296,143	NCBI	Rnor6.0
Rnor_5.0	X	17,081,397 - 17,081,498	UniSTS	Rnor5.0
Celera	X	15,510,297 - 15,510,398	UniSTS
Cytogenetic Map	X	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											7
Medium
Low	1	1	6		1		2	2	3		1	1	2
Below cutoff		16	13	9	7	9	3	5	4	5	16	3	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001431627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_024402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF008114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003939 ⟹ ENSRNOP00000003939

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	15,435,410 - 15,445,684 (-)	Ensembl
Rnor_6.0 Ensembl	X	16,296,735 - 16,306,078 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102856 ⟹ ENSRNOP00000088271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	15,435,410 - 15,442,370 (-)	Ensembl

RefSeq Acc Id:

NM_024402 ⟹ NP_077378

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,107,256 - 18,117,549 (-)	NCBI
mRatBN7.2	X	15,435,391 - 15,445,684 (-)	NCBI
Rnor_6.0	X	16,296,027 - 16,306,078 (-)	NCBI
Rnor_5.0	X	17,081,382 - 17,091,111 (-)	NCBI
RGSC_v3.4	X	27,515,009 - 27,524,606 (-)	RGD
Celera	X	15,510,282 - 15,520,669 (-)	RGD

Sequence:

show sequence

AGAGTCATCGCAGCATCCAAATTCTCCAAAAAAAATACCATCCCAAGGTCCCAAATGATTGCTT
ACTGTGGCACTACAAAGATGTCTGATGACATTGACTGGTTACACAGCCGCAGAGGCGTGTGCAA
GGTAGATCTTTACAGCCCAGAAGGACAACAAGATCAGGACCGAAAAGTGATATGCTTTGTGGAT
GTGTCCACCTTGAATGTGGAAGATGATTCCAAGGGTGCTGCTGGTCCCAGGTCAGACGGCGAAT
TAAACCTGGAGAATCTGGAAGAAAAAGAGATTATCGTGATCAAGGACACAGAAAAACAAGACCA
GCCTAAGACGGAGGGATCTGTATGCCTTTTCAAACAAGCTCCCTCTGACCCCATAAGTGTCCTC
AACTGGCTCCTCAATGATCTCCAGAAGTACGCCTTGGGTTTCCAACATGCATTAAGTCCCTCAG
CCTCTAGCTGTAAACATAAAGTAGGAGACCTAGAGGGTGATTATCACAAAATTCCCTCAGAGAA
CTGCTACAGTGTGTATGCTGATCAAGTAAACTTAGATTATTTGAACAAAGGACCTCAAAACCTT
CGCCTAGAAATGGCGGCATCCAAAAATACCAACAATAACCAAAGTCCCTCAAATCCTGCAACTA
AATCTCCTAGCAATCAGAGGTCAGTTGCCACTCCTGATGGAGAATGTTCGATGGACGACCTCTC
CTACTATGTCAACCGATTGTCATCTCTAGTAATCCAAATGGCCCGTAAGGAAATCAAGGACAAA
TTGGAAGGTGGAAACAAATGCCTCCATCATTCCATGTATACATCAGGAGAAAAGGGGAAAACCA
GCCCCCGGAGTGCTGTCAGCAAAATTGCTTCTGAGATGGCCCATGAAGCTGTTGAACTGACCTC
ATCAGAAATGCGTGGCAATGGAGAAGAAGGCAGGGATGGCCGGAAAACCTTTTTGTATAGTGAG
TTATCTAATAAGAACAAGTGTGGAGAGAAGCAGCAGATGTGCCCAAAAGACAGCAAAGAATTTG
CAGATTCCATCAGCAAGGGGCTTATGGTTTATGCAAATCAGGTAGCATCTGACATGATGGTCTC
TGTTATGAAAACCTTGAAAGTGCACAGCTGTGGGAAGCCAATTCCAGCTTGTGTGGTCCTGAAG
AGGGTACTATTAAAGCACACCAAGGAAATTGTATCTGATCTGATTGACTCATGCATGAAGAACT
TGCATAATATAACAGGAGTCCTGATGACAGACTCAGACTTCGTTTCTGCTGTCAAGAGGAATCT
TTTCAATCATGGTAAACAAAATGCAGCAGACATCATGGAGGCCATGCTAAAGCGTCTGGTCAGT
GCTCTTCTTGGTGAGAAGAAGGAGACTAAATCTCAAAGTTTGGCATATGCAACCTTAAAAGCTG
GAACTCATGACCCGAAATGCAAGAATCAGAGCCTTGAGTTCTCAGCTATGAAAGCTGAAATGAA
AGGAAAGGACAAAGGCAAAACTAAAGGAGATCCATGCTGTAAATCACTGACAAGTGCTGAGAGA
GTCAGCGAACATATCCTCAAAGAGAGCCTTACTATGTGGAACAACCAGAAGCAAGGAACCCAAG
GCAGGGTGCCTAACAAAGTATGCCCTAGTAAAGATGAAAAGAGAGAGAAGATCAGTCCTTCCAC
AGACTCACTGGCCAAGGATCTAATTGTCTCTGCCCTTATGCTCATTCAATACCATCTGACCCAA
CAAGCGAAGGGCAAAGATCCATGTGAAGAGGAGTGCCCTGGTTCCTCCATGGGCTATATGTCGC
AAAGTGCACAATATGAAAAGAGTGGAGGTGGCCAAAGTTCTAAATCACTTTCAATGAAGCATTT
TGAATCTCGTGGAGCTCCTGGACCATCTACATGTGCGAAGGAAAATCAACTTGAGTCCCAGAAG
ATGGATATGTCAAACATGGTTCTGTCCCTGATTCAGAAACTTCTGAGTGAGAGCCCTTTCAGCT
GTGATGAACTATCTGAAAGTGAGAATAAGCGTTGTTGTGATTCTCGATCAAAGCAAGCAGCTCC
CGTGGCCAAGAGACCTGAAGATCAAAGCCAAGACAGCACAGAAATGGACTTCATCAGCGGGATG
AAGCAAATGAACCGGCAGTTTATAGACCAACTAGTAGAATCGGTGATGAAACTGTGCCTGATCA
TGGCTAAGTACAGCAACAATGGAGCAGCACTAGCTGAGCTAGAAGAGCAAGCAGCCCTAGCAAG
CAATGGCCCCAGATGTGGCCGTGAGGCTGTGATGTCACAAAGTTATCTGGAAACTCCTGGCCCT
GAAGTTATCGTCAACAATCAGTGCTCTACAAGCAACTTGCAGAAGCAGCTGCAGGCTGTCCTGC
AATGGATTGCAGCGTCTCAGTTTAATGTGCCCATGCTCTACTTCATGGGAGATGATGATGGACA
ACTAGAGAAGCTCCCTGAAGTTTCAGCTAAGGCAGCAGAGAAAGGTTACAGTGTAGGAGATCTT
CTTCAGGAGGTCATGAAGTTTGCCAAAGAACGACAACTGGATGAAGCCGTGGGCAACATGGCTA
GAAAGCAACTGCTGGACTGGCTTCTCGCTAACCTGTAAGCTGAGAATTCCTCTGACTCCCTCCA
TCCATCCTCTCCCCGGCAGCAATTCCACCCAGCTGGAGCCACCCTCACCATCAGGCTGGTAAAC
TGCACAATTGTGATCACATTTACCAATACATCTGAGCAGTTGAACTGTGAAAATACGGGGTGCC
CTCCTGGGCAACATGAATAAAAAAAATTCAAAAA

hide sequence

RefSeq Acc Id:

XM_039100088 ⟹ XP_038956016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,107,256 - 18,116,943 (-)	NCBI
mRatBN7.2	X	15,435,400 - 15,445,044 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001418556	(Get FASTA)	NCBI Sequence Viewer
	NP_077378	(Get FASTA)	NCBI Sequence Viewer
	XP_038956016	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB62877	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003939.7
	ENSRNOP00000088271.1
GenBank Protein	O35774	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_077378 ⟸ NM_024402

- Sequence:

show sequence

MIAYCGTTKMSDDIDWLHSRRGVCKVDLYSPEGQQDQDRKVICFVDVSTLNVEDDSKGAAGPRS
DGELNLENLEEKEIIVIKDTEKQDQPKTEGSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHAL
SPSASSCKHKVGDLEGDYHKIPSENCYSVYADQVNLDYLNKGPQNLRLEMAASKNTNNNQSPSN
PATKSPSNQRSVATPDGECSMDDLSYYVNRLSSLVIQMARKEIKDKLEGGNKCLHHSMYTSGEK
GKTSPRSAVSKIASEMAHEAVELTSSEMRGNGEEGRDGRKTFLYSELSNKNKCGEKQQMCPKDS
KEFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRVLLKHTKEIVSDLIDSC
MKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGEKKETKSQSLAYAT
LKAGTHDPKCKNQSLEFSAMKAEMKGKDKGKTKGDPCCKSLTSAERVSEHILKESLTMWNNQKQ
GTQGRVPNKVCPSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGSSMG
YMSQSAQYEKSGGGQSSKSLSMKHFESRGAPGPSTCAKENQLESQKMDMSNMVLSLIQKLLSES
PFSCDELSESENKRCCDSRSKQAAPVAKRPEDQSQDSTEMDFISGMKQMNRQFIDQLVESVMKL
CLIMAKYSNNGAALAELEEQAALASNGPRCGREAVMSQSYLETPGPEVIVNNQCSTSNLQKQLQ
AVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVG
NMARKQLLDWLLANL

hide sequence

Ensembl Acc Id:

ENSRNOP00000003939 ⟸ ENSRNOT00000003939

RefSeq Acc Id:	XP_038956016 ⟸ XM_039100088
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A7I7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088271 ⟸ ENSRNOT00000102856

Protein Domains

A-kinase anchor 110kDa C-terminal RII binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35774-F1-model_v2	AlphaFold	O35774	1-847	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701752

Promoter ID:

EPDNEW_R12276

Type:

initiation region

Name:

Akap4_1

Description:

A-kinase anchoring protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	16,306,132 - 16,306,192	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620828	AgrOrtholog
BioCyc Gene	G2FUF-2876	BioCyc
Ensembl Genes	ENSRNOG00000002921	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003939.7	UniProtKB/TrEMBL
	ENSRNOT00000102856.1	UniProtKB/TrEMBL
InterPro	AKAP_110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AKAP_110_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RII_binding_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPHK1-interactor_AKAP_110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:79254	UniProtKB/Swiss-Prot
NCBI Gene	79254	ENTREZGENE
PANTHER	A-KINASE ANCHOR PROTEIN 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10226	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AKAP_110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RII_binding_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Akap4	PhenoGen
RatGTEx	ENSRNOG00000002921	RatGTEx
SMART	AKAP_110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A7I7	ENTREZGENE, UniProtKB/TrEMBL
	A6KPB5_RAT	UniProtKB/TrEMBL
	AKAP4_RAT	UniProtKB/Swiss-Prot
	F1LMR8_RAT	UniProtKB/TrEMBL
	O35774	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Akap4	A-kinase anchoring protein 4	Akap4	A kinase (PRKA) anchor protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-25	Akap4	A kinase (PRKA) anchor protein 4	Akap4	A-kinase anchor protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Akap4	A-kinase anchor protein 4		75 kDa fibrous sheath protein	Name updated	1299863	APPROVED
2002-08-07	Akap4	75 kDa fibrous sheath protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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