Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase) - Rat Genome Database

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Gene: Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase) Rattus norvegicus
Analyze
Symbol: Ogt
Name: O-linked N-acetylglucosamine (GlcNAc) transferase
RGD ID: 62060
Description: Enables several functions, including identical protein binding activity; peptide binding activity; and protein O-acetylglucosaminyltransferase activity. Involved in several processes, including positive regulation of biosynthetic process; regulation of protein localization; and regulation of protein phosphorylation. Located in euchromatin; neuronal cell body; and zymogen granule. Part of protein N-acetylglucosaminyltransferase complex. Is active in several cellular components, including cerebellar granule cell to Purkinje cell synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase); PARTICIPATES IN DNA modification pathway; hexosamine biosynthetic pathway; O-linked glycan biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: O linked N-acetylglucosamine transferase; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,811,317 - 70,856,123 (+)NCBIGRCr8
mRatBN7.2X66,771,278 - 66,816,148 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,771,349 - 66,816,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,254,707 - 68,299,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,754,901 - 71,799,700 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,316,012 - 69,360,811 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,540,870 - 71,585,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,528,988 - 71,585,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,721,369 - 89,766,218 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,794,801 - 89,838,207 (+)NCBI
CeleraX67,126,677 - 67,171,365 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hemin  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paracetamol sulfate  (ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO,ISS)
cellular response to glucose stimulus  (IEA,IMP,ISO,ISS)
cellular response to insulin stimulus  (IEP)
cellular response to lipopolysaccharide  (IMP)
cellular response to toxic substance  (IEP)
chromatin organization  (IEA)
circadian regulation of gene expression  (IEA,ISO,ISS)
forebrain development  (IEP)
glucosamine metabolic process  (IDA,IMP)
hemopoiesis  (IEA,ISO)
intracellular distribution of mitochondria  (IMP)
mitophagy  (IEA,ISO)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of non-canonical inflammasome complex assembly  (IEA,ISO,ISS)
negative regulation of peptidyl-serine phosphorylation  (IMP)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein targeting to membrane  (IMP)
negative regulation of protein ubiquitination  (IEA,ISO,ISS)
positive regulation of cell size  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of lipid biosynthetic process  (IEA,ISO)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of proteolysis  (IEA,ISO,ISS)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of TORC1 signaling  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription from RNA polymerase II promoter by glucose  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
protein O-linked glycosylation  (IBA,IDA,IEA,IMP,ISO)
protein processing  (IEA,ISO,ISS)
regulation of gluconeogenesis  (IEA,ISO,ISS)
regulation of glycolytic process  (IEA,ISO,ISS)
regulation of insulin receptor signaling pathway  (IEA,ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
regulation of Rac protein signal transduction  (IEA,ISO)
regulation of synapse assembly  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to insulin  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex. Akimoto Y, etal., Brain Res. 2003 Mar 21;966(2):194-205. doi: 10.1016/s0006-8993(02)04158-6.
2. Localization of the O-linked N-acetylglucosamine transferase in rat pancreas. Akimoto Y, etal., Diabetes. 1999 Dec;48(12):2407-13.
3. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
4. Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status. Chen J, etal., FEBS Lett. 2015 Aug 19;589(18):2347-58. doi: 10.1016/j.febslet.2015.07.030. Epub 2015 Jul 29.
5. Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Copeland RJ, etal., Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. Epub 2008 Apr 29.
6. Role of O-linked beta-N-acetylglucosamine modification in the subcellular distribution of alpha4 phosphoprotein and Sp1 in rat lymphoma cells. Dauphinee SM, etal., J Cell Biochem. 2005 Oct 15;96(3):579-88.
7. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
8. O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2. Ding F, etal., Amino Acids. 2013 Aug;45(2):339-49. doi: 10.1007/s00726-013-1504-2. Epub 2013 May 12.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. O-linked beta-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells. Goldberg H, etal., Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26. doi: 10.1152/ajpendo.00108.2011. Epub 2011 Jun 28.
12. Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase. Haltiwanger RS, etal., J Biol Chem. 1992 May 5;267(13):9005-13.
13. O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress. Ho SR, etal., FEBS Lett. 2010 Jan 4;584(1):49-54. doi: 10.1016/j.febslet.2009.11.059. Epub .
14. O-GlcNAcylation of cofilin promotes breast cancer cell invasion. Huang X, etal., J Biol Chem. 2013 Dec 20;288(51):36418-25. doi: 10.1074/jbc.M113.495713. Epub 2013 Nov 8.
15. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. Iyer SP, etal., J Biol Chem 2003 Feb 14;278(7):5399-409.
16. Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase. Konrad RJ, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):207-12.
17. Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats. Kreppel LK and Hart GW, J Biol Chem. 1999 Nov 5;274(45):32015-22.
18. Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. Kreppel LK, etal., J Biol Chem 1997 Apr 4;272(14):9308-15.
19. O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway. Lima VV, etal., Cardiovasc Res. 2011 Feb 15;89(3):614-22. doi: 10.1093/cvr/cvq338. Epub 2010 Oct 26.
20. Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. Liu Y, etal., PLoS One. 2012;7(8):e43724. doi: 10.1371/journal.pone.0043724. Epub 2012 Aug 22.
21. Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure. Lunde IG, etal., Physiol Genomics. 2012 Feb 1;44(2):162-72. doi: 10.1152/physiolgenomics.00016.2011. Epub 2011 Nov 29.
22. Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1. Majumdar G, etal., Diabetes. 2004 Dec;53(12):3184-92.
23. Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain. Marz P, etal., J Biol Chem. 2006 Jul 21;281(29):20263-70. Epub 2006 May 18.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition. Ngoh GA, etal., J Mol Cell Cardiol. 2008 Aug;45(2):313-25. doi: 10.1016/j.yjmcc.2008.04.009. Epub 2008 May 2.
27. Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. Ohashi N, etal., Diabetes. 2017 Sep;66(9):2351-2362. doi: 10.2337/db16-1427. Epub 2017 Jun 21.
28. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Pekkurnaz G, etal., Cell. 2014 Jul 3;158(1):54-68. doi: 10.1016/j.cell.2014.06.007.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Yang X, etal., Cell. 2002 Jul 12;110(1):69-80.
34. Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling. Zou L, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H515-23. doi: 10.1152/ajpheart.01025.2008. Epub 2008 Dec 19.
Additional References at PubMed
PMID:8889548   PMID:11700029   PMID:12060780   PMID:12724313   PMID:12911634   PMID:12947022   PMID:14675536   PMID:15247246   PMID:17208994   PMID:17670746   PMID:18029144   PMID:18288188  
PMID:20018852   PMID:20506529   PMID:20824293   PMID:21240259   PMID:21285374   PMID:21700703   PMID:22871113   PMID:22923583   PMID:23222540   PMID:23352454   PMID:23353889   PMID:23395176  
PMID:23777819   PMID:24474760   PMID:25416863   PMID:26678539   PMID:27527864   PMID:28584052   PMID:30053369   PMID:30699359  


Genomics

Comparative Map Data
Ogt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,811,317 - 70,856,123 (+)NCBIGRCr8
mRatBN7.2X66,771,278 - 66,816,148 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,771,349 - 66,816,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,254,707 - 68,299,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,754,901 - 71,799,700 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,316,012 - 69,360,811 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,540,870 - 71,585,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,528,988 - 71,585,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,721,369 - 89,766,218 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,794,801 - 89,838,207 (+)NCBI
CeleraX67,126,677 - 67,171,365 (+)NCBICelera
Cytogenetic MapXq22NCBI
OGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,533,104 - 71,575,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,533,087 - 71,575,892 (+)EnsemblGRCh38hg38GRCh38
GRCh37X70,752,954 - 70,795,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,669,658 - 70,712,465 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X70,535,953 - 70,578,761NCBI
CeleraX71,105,953 - 71,148,788 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,568,037 - 64,610,949 (+)NCBIHuRef
CHM1_1X70,645,269 - 70,688,159 (+)NCBICHM1_1
T2T-CHM13v2.0X69,966,355 - 70,009,143 (+)NCBIT2T-CHM13v2.0
Ogt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,683,617 - 100,727,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,683,666 - 100,727,957 (+)EnsemblGRCm39 Ensembl
GRCm38X101,640,011 - 101,684,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,640,060 - 101,684,351 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,835,403 - 98,879,690 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,842,783 - 97,887,068 (+)NCBIMGSCv36mm8
CeleraX88,557,707 - 88,602,477 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.45NCBI
Ogt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,062,076 - 11,114,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,062,258 - 11,112,252 (+)NCBIChiLan1.0ChiLan1.0
OGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X71,207,676 - 71,250,405 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X71,211,279 - 71,254,011 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,798,219 - 60,840,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,852,687 - 70,894,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,852,687 - 70,894,921 (+)Ensemblpanpan1.1panPan2
OGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,821,227 - 55,857,597 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,821,234 - 55,855,502 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,648,032 - 46,684,418 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,790,423 - 56,826,854 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,790,237 - 56,826,844 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,757,798 - 54,794,161 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X56,089,784 - 56,126,154 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X56,017,174 - 56,053,590 (+)NCBIUU_Cfam_GSD_1.0
Ogt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,337,214 - 46,375,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493676299,293 - 137,874 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493676299,335 - 137,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,521,098 - 57,558,515 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,521,091 - 57,558,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,962,783 - 65,000,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,351,047 - 61,393,541 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,351,054 - 61,394,305 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660653,211,654 - 3,252,407 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ogt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,863,337 - 1,910,177 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,863,110 - 1,912,299 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ogt
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:271
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000004692
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
SHGC-16181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,784,990 - 66,785,134 (+)MAPPERmRatBN7.2
Rnor_6.0X71,554,488 - 71,554,631NCBIRnor6.0
Rnor_5.0X72,403,823 - 72,403,966UniSTSRnor5.0
RGSC_v3.4X89,735,070 - 89,735,213UniSTSRGSC3.4
CeleraX67,140,233 - 67,140,376UniSTS
Cytogenetic MapXq31UniSTS
RH141352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,806,246 - 66,806,449 (+)MAPPERmRatBN7.2
Rnor_6.0X71,575,803 - 71,576,005NCBIRnor6.0
Rnor_5.0X72,425,138 - 72,425,340UniSTSRnor5.0
RGSC_v3.4X89,756,321 - 89,756,523UniSTSRGSC3.4
CeleraX67,161,468 - 67,161,670UniSTS
Cytogenetic MapXq31UniSTS
RH135882  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,814,765 - 66,814,896 (+)MAPPERmRatBN7.2
Rnor_6.0X71,584,524 - 71,584,654NCBIRnor6.0
Rnor_5.0X72,433,859 - 72,433,989UniSTSRnor5.0
RGSC_v3.4X89,764,836 - 89,764,966UniSTSRGSC3.4
CeleraX67,169,983 - 67,170,113UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004692   ⟹   ENSRNOP00000004692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,771,349 - 66,816,146 (+)Ensembl
Rnor_6.0 EnsemblX71,540,895 - 71,585,908 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075963   ⟹   ENSRNOP00000068306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,528,988 - 71,552,338 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082967   ⟹   ENSRNOP00000072791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,771,379 - 66,816,111 (+)Ensembl
Rnor_6.0 EnsemblX71,540,929 - 71,585,908 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100805   ⟹   ENSRNOP00000086509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,773,795 - 66,816,146 (+)Ensembl
RefSeq Acc Id: NM_001398715   ⟹   NP_001385644
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,811,366 - 70,856,123 (+)NCBI
mRatBN7.2X66,771,382 - 66,816,148 (+)NCBI
RefSeq Acc Id: NM_017107   ⟹   NP_058803
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,811,335 - 70,856,123 (+)NCBI
mRatBN7.2X66,771,351 - 66,816,148 (+)NCBI
Rnor_6.0X71,540,918 - 71,585,906 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
RGSC_v3.4X89,721,369 - 89,766,218 (+)RGD
CeleraX67,126,677 - 67,171,365 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257057   ⟹   XP_006257119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,811,317 - 70,856,123 (+)NCBI
mRatBN7.2X66,771,278 - 66,814,087 (+)NCBI
Rnor_6.0X71,540,870 - 71,583,977 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058803   ⟸   NM_017107
- Peptide Label: isoform 1
- UniProtKB: P56558 (UniProtKB/Swiss-Prot),   G3V6F4 (UniProtKB/TrEMBL),   A6IQC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257119   ⟸   XM_006257057
- Peptide Label: isoform X1
- UniProtKB: P56558 (UniProtKB/Swiss-Prot),   A0A0G2K3V4 (UniProtKB/TrEMBL),   A6IQC5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072791   ⟸   ENSRNOT00000082967
Ensembl Acc Id: ENSRNOP00000068306   ⟸   ENSRNOT00000075963
Ensembl Acc Id: ENSRNOP00000004692   ⟸   ENSRNOT00000004692
Ensembl Acc Id: ENSRNOP00000086509   ⟸   ENSRNOT00000100805
RefSeq Acc Id: NP_001385644   ⟸   NM_001398715
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K3V4 (UniProtKB/TrEMBL),   A6IQC5 (UniProtKB/TrEMBL)
Protein Domains
O-GlcNAc transferase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56558-F1-model_v2 AlphaFold P56558 1-1036 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701881
Promoter ID:EPDNEW_R12403
Type:initiation region
Name:Ogt_1
Description:O-linked N-acetylglucosamine transferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,540,951 - 71,541,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62060 AgrOrtholog
BioCyc Gene G2FUF-2092 BioCyc
Ensembl Genes ENSRNOG00000003359 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004692.8 UniProtKB/TrEMBL
  ENSRNOT00000082967.2 UniProtKB/TrEMBL
  ENSRNOT00000100805.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.720.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro OGT/SEC/SPY_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26295 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26295 ENTREZGENE
PANTHER PTHR44366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ogt PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003359 RatGTEx
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3V4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5Z2_RAT UniProtKB/TrEMBL
  A6IQC5 ENTREZGENE, UniProtKB/TrEMBL
  A6IQC7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6F4 ENTREZGENE, UniProtKB/TrEMBL
  OGT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase  Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)    O linked N-acetylglucosamine transferase   Name updated 1299863 APPROVED
2002-06-10 Ogt  O linked N-acetylglucosamine transferase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol and nucleus 61681
gene_domains contains repeats of the tetratricopeptide repeat motif 61681