RGD Reference Report - O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress. - Rat Genome Database

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O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress.

Authors: Ho, SR  Wang, K  Whisenhunt, TR  Huang, P  Zhu, X  Kudlow, JE  Paterson, AJ 
Citation: Ho SR, etal., FEBS Lett. 2010 Jan 4;584(1):49-54. doi: 10.1016/j.febslet.2009.11.059. Epub .
RGD ID: 8554219
Pubmed: PMID:19932102   (View Abstract at PubMed)
PMCID: PMC2802345   (View Article at PubMed Central)
DOI: DOI:10.1016/j.febslet.2009.11.059   (Journal Full-text)

The FOXO4 transcription factor plays an important role in cell survival in response to oxidative stress. The regulation of FOXO4 is orchestrated by post-translational modifications including phosphorylation, acetylation, and ubiquitination. Here, we demonstrate that O-GlcNAcylation also contributes to the FOXO4-dependent oxidative stress response. We show that hydrogen peroxide treatment of HEK293 cells increases FOXO4 association with OGT, the enzyme that adds O-GlcNAc to proteins, causing FOXO4 O-GlcNAcylation and enhanced transcriptional activity under acute oxidative stress. O-GlcNAcylation is known to be protective for cells under stress conditions, including oxidative stress. Our data provide a mechanism of FOXO4 anti-oxidative protection through O-GlcNAcylation.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:Q9WVH38554219PMID:19932102IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Ogt  (O-linked N-acetylglucosamine (GlcNAc) transferase)


Additional Information