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Gene: Nek2 (NIMA-related kinase 2) Rattus norvegicus

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Symbol:

Nek2

Name:

NIMA-related kinase 2

RGD ID:

619792

Description:

Predicted to enable protein kinase activity and protein phosphatase binding activity. Predicted to be involved in centrosome separation; protein autophosphorylation; and regulation of cell cycle process. Predicted to act upstream of or within several processes, including blastocyst development; mitotic spindle assembly; and positive regulation of telomere maintenance. Predicted to be located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and midbody. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; serine/threonine-protein kinase Nek2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEK2 (NIMA related kinase 2)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nek2 (NIMA (never in mitosis gene a)-related expressed kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nek2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEK2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEK2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nek2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEK2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEK2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nek2 (NIMA related kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NEK2 (NIMA related kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nek2 (NIMA (never in mitosis gene a)-related expressed kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nek2 (NIMA-related kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KIN3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Nek2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nek2	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)

Related Pseudogenes:

Nek2l1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,936,809 - 105,950,054 (+)	NCBI		GRCr8
mRatBN7.2	13	103,405,818 - 103,419,063 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,405,819 - 103,419,051 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,925,762 - 105,939,011 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	107,309,612 - 107,322,857 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,524,711 - 104,537,957 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,511,546 - 110,524,750 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,511,668 - 110,522,769 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	115,071,708 - 115,084,946 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,895,671 - 107,908,904 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	108,084,908 - 108,096,196 (+)	NCBI
Celera	13	102,845,789 - 102,858,739 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

fundus dystrophy (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

lung non-small cell carcinoma (ISO)

Neoplasm Invasiveness (ISO)

parathyroid carcinoma (ISO)

retinitis pigmentosa 67 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2-palmitoylglycerol (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

azathioprine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bicalutamide (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

capsaicin (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cryptolepine (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

deguelin (ISO)

diallyl trisulfide (ISO)

diazinon (EXP)

dichloroacetic acid (ISO)

dicrotophos (ISO)

digitonin (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

etoposide (ISO)

fenpyroximate (ISO)

fructose (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

geraniol (ISO)

glucose (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

iron dichloride (ISO)

leflunomide (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

lucanthone (ISO)

MeIQx (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylparaben (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

nitrofen (EXP)

oxaliplatin (ISO)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

PhIP (ISO)

phorbol 13-acetate 12-myristate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP,ISO)

progesterone (ISO)

propanal (ISO)

pyrimidifen (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sirolimus (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tebufenpyrad (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thifluzamide (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

Tributyltin oxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst development (ISO)

centrosome separation (ISO)

chromosome segregation (IBA,ISO)

mitotic sister chromatid segregation (ISO)

mitotic spindle assembly (ISO)

negative regulation of centriole-centriole cohesion (ISO)

positive regulation of telomere maintenance (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

regulation of attachment of spindle microtubules to kinetochore (ISO)

regulation of mitotic centrosome separation (ISO)

Cellular Component

centrosome (IBA,ISO)

condensed nuclear chromosome (ISO)

cytoplasm (IBA)

kinetochore (ISO)

midbody (ISO)

nucleoplasm (ISO)

nucleus (IBA)

protein-containing complex (ISO)

spindle pole (ISO)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein kinase activity (ISO)

protein phosphatase binding (ISO)

protein serine/threonine kinase activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle.	Ha Kim Y, etal., Biochem Biophys Res Commun 2002 Jan 18;290(2):730-6.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10880350	PMID:14668482	PMID:14697346	PMID:14978040	PMID:15479717	PMID:17621308	PMID:17626005	PMID:18086858	PMID:18297113	PMID:19117032	PMID:21076410	PMID:21399614
PMID:21531765	PMID:24554434	PMID:26220856

Genomics

Comparative Map Data

Nek2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,936,809 - 105,950,054 (+)	NCBI		GRCr8
mRatBN7.2	13	103,405,818 - 103,419,063 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,405,819 - 103,419,051 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,925,762 - 105,939,011 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	107,309,612 - 107,322,857 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,524,711 - 104,537,957 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,511,546 - 110,524,750 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,511,668 - 110,522,769 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	115,071,708 - 115,084,946 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,895,671 - 107,908,904 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	108,084,908 - 108,096,196 (+)	NCBI
Celera	13	102,845,789 - 102,858,739 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

NEK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	211,658,256 - 211,675,621 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	211,658,657 - 211,675,630 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	211,831,598 - 211,848,963 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	209,902,745 - 209,915,590 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	208,224,516 - 208,237,362	NCBI
Celera	1	185,063,198 - 185,076,042 (-)	NCBI		Celera
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	182,509,044 - 182,526,419 (-)	NCBI		HuRef
CHM1_1	1	213,104,002 - 213,121,393 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	210,904,362 - 210,921,749 (-)	NCBI		T2T-CHM13v2.0

Nek2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,553,622 - 191,565,161 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	191,553,556 - 191,565,162 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,821,449 - 191,833,049 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,821,444 - 191,833,050 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,645,352 - 193,656,928 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	193,522,177 - 193,533,657 (+)	NCBI		MGSCv36	mm8
Celera	1	198,772,491 - 198,784,119 (+)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.94	NCBI

Nek2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,553,819 - 5,566,361 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,553,661 - 5,563,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

NEK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	37,726,246 - 37,744,856 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	37,690,783 - 37,709,409 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	187,225,947 - 187,243,605 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	192,088,393 - 192,105,737 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,092,885 - 192,105,737 (-)	Ensembl	panpan1.1		panPan2

NEK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,039,617 - 10,052,511 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,040,187 - 10,052,512 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	9,617,334 - 9,630,223 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	9,745,394 - 9,758,577 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	9,745,398 - 9,758,560 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	9,668,208 - 9,681,172 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	9,770,376 - 9,783,529 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	9,894,933 - 9,908,005 (-)	NCBI		UU_Cfam_GSD_1.0

Nek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	64,442,747 - 64,455,130 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	1,682,984 - 1,695,414 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	1,683,027 - 1,695,410 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	131,547,069 - 131,561,095 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	131,547,044 - 131,560,527 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,585,644 - 144,599,144 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,816,929 - 17,847,348 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	17,829,546 - 17,842,463 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	18,353,967 - 18,371,748 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nek2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,334,681 - 17,352,259 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,334,782 - 17,351,609 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nek2
86 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Markers in Region

UniSTS:465399

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	13,946,926 - 13,947,427 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	15,941,209 - 15,941,709	NCBI	Rnor6.0
Rnor_5.0	8	16,016,439 - 16,016,939	UniSTS	Rnor5.0
RGSC_v3.4	8	14,245,570 - 14,246,070	UniSTS	RGSC3.4
Celera	8	15,406,473 - 15,406,973	UniSTS
Cytogenetic Map	8	q12	UniSTS
Cytogenetic Map	13	q27	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	6	31	33	29	17	6	17	6	57	24	19	10	19	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF352021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV771094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006235 ⟹ ENSRNOP00000006235

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,405,819 - 103,419,051 (+)	Ensembl
Rnor_6.0 Ensembl	13	110,511,668 - 110,522,769 (+)	Ensembl

RefSeq Acc Id:

NM_053691 ⟹ NP_446143

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,936,809 - 105,950,054 (+)	NCBI
mRatBN7.2	13	103,405,818 - 103,419,063 (+)	NCBI
Rnor_6.0	13	110,511,546 - 110,524,750 (+)	NCBI
Rnor_5.0	13	115,071,708 - 115,084,946 (+)	NCBI
RGSC_v3.4	13	107,895,671 - 107,908,904 (+)	RGD
Celera	13	102,845,789 - 102,858,739 (+)	RGD

Sequence:

show sequence

CGGCCGGTTGCTCCGCTCCGACAAGCAGACTAGGGTCCCCGGGGTCGGCGCTGTTGGCGTGCGG
CGGGCGAGCCTGGACTCCGAGCGGCGCGGTAGTGTGGTTGCCGGGGTGGCCGCTCGTCATGCCG
TCCCGGGTGGAGGACTACGAGGTGCTGCACAGCATCGGCACCGGCTCCTACGGCCGCTGTCAGA
AGATTCGGAGGAAGAGCGACGGCAAGATCCTGGTGTGGAAAGAACTTGACTATGGCTCCATGAC
AGAGGTGGAGAAACAAATGCTTGTGTCTGAAGTGAACTTGCTTCGTGAGCTGAAACATCCAAAC
ATCGTCCGTTACTACGATCGTATTATCGACAGAACCAACACAACCCTATACATTGTCATGGAGT
ACTGTGAGGGCGGGGACCTGGCTAGTGTCATTACAAAGGGGACCAAGGATAGACAATACTTAGA
GGAAGAGTTTGTCCTTCGAGTGATGACTCAGTTGACACTGGCCCTGAAAGAGTGTCACAGAAGG
AGCGATGGTGGCCACACTGTACTTCACCGGGACCTAAAGCCAGCCAATGTCTTCCTGGACAGCA
AGCACAATGTCAAGCTTGGGGACTTTGGGCTAGCTAGAATATTGAATCACGACACAAGTTTTGC
AAAGACGTTTGTTGGCACACCCTATTACATGTCTCCTGAGCAAATAAGCCGCTTGTCTTACAAT
GAGAAGTCGGACATCTGGTCGCTGGGCTGCCTGCTGTATGAGCTGTGTGCACTAATGCCTCCAT
TTACAGCTTTCAACCAGAAAGAGTTAGCGGGGAAAATCAGGGAAGGGAGGTTCCGGCGCATCCC
CTACCGCTACTCTGATGGCTTGAATGACCTCATCACTCGGATGCTGAATTTAAAGGACTACCAT
CGACCTTCAGTGGAGGAAATTCTGGAGAGCCCTTTGATAGCAGACTTGGTTGCAGAAGAGCAAA
GGAGAAATCTGGAGAGGAGGGGACGGCGCTCAGGCGAGCCTTCGAAGCTGCAGGACTCCAGCCC
TGTGCTGAGTGAGCTCAAGTTGAAGGAAAGGCAGCTGCAGGATCGAGAGCGAGCACTGAGAGCT
CGGGAGGACAGCCTGGAGCAGAAAGAACGTGAACTTTGTATTCGAGAGAGACTTGCCGAGGACA
AACTGGCCAGAGCCGAGAGTCTGCTGAAGAACTACAGCCTGCTGAAGGAGCACAGGCTCCTGTG
TCTGGCTGGCGGCTCAGAACTTGATCTCCCATCTTCAGCACTGAAGAAGAAGGTTCATTTCCAT
GGGGAGAGCAAAGAGAACACCGCAAGGAGTGAGAATTCCGAGAGCCAGCTCGCCAAGTCCAAGT
GCAGGGACCTGAAGAAGAGGCTTCATGCTGCCCAGCTGCGTGCTCAAGCCCTGTCTGATATTGA
GAAGAACTACCAGCTAAAGAGCAGGCAGATCCTGGGCATGCGTTAGGCCAGCAAGGCATGGAGC
CGGGTCAGCACTGGTGCTGACAACGCACGAGAGATTGGACTCAGCTGCTGTAGTGTGTGTGTGT
GGTGAGCATGGCCCTGGGATTGTTTGTGGTCTCCGAGATGGACATGTCCTCTTCCTAATCCCCC
TGTGTAGAAAGCATGCTGTCTTTGCTGAGTGCTTGGGCTTTTGATCCTGTGTGCGATTACTACT
TGAAATATGAGATGGGACACTATAGATACCATAGATCTTAGGAGAAACAATGTTAGGGAAAGAA
CATTTAACCTGGAGGAGTTGGAGAGGTTTGCTCAACTGAGAGATGCGGCCTTCATGGCAGTTTG
CAGGTGAGGCTTCAGCAGGTATGTGATCTTGCTGCTAACGGAATAGGGCAGGGCCCACAGGGTT
CCGTCCATGTCAGAGGTGCGGTGAGCTTATCAGTGTGTGATGCTACAGGGAGAGACCCAGCCTC
TGGCCTGAGCCTGAGGAGAAGCCACTCACCAGCATTCCAGTTCCAAGATGCTCCTGGTGCTAGT
TAAAATGCAGATTAGACTTGGGAGGGAAGAACAAGGGCTGAAGCCTTTACTCACCTTGGGGAAA
CTCGTTCTAGCACAGCACCCAGTGAGACTGACAAGGCTTGCACTAGAGACAGGCTGCTGGGAGC
CCTGAGAGCTTCCTCCCCACTGTGTGCATGGCCTGTCCCCTTCTGTCTGTATCTGACCTCAATG
TCAGTTGATAACATTATTAAGTGCTGTCTGTGCCCTCAAGTATGAGCTGAATGGTCGGAAATGC
CACAGAGTCTATATATTTTAAATCACACATGTGGTCCCCAAACATTGAATGTTGGAGAACTGTC
TTCAGAAAGTTGGTCTATTTAAGGCTACTGGGGAAAAGGGCGGGTCTCCTTTGCTATCTGTCCA
CAGCCCCTTTGCTTCAGCAAAGAACAGTGTGCATGCATGCAGTCTGTGTTTGAGAGCCATGCGA
GCCTTCACCTCTGTGAGGGCCAGATGGCTGTTTGTCTACAGTTTCCTGAAGGCCTCAGCAGAAA
GGGATTCCTTTTTCCTAGTAAGTGCTGCTGGCTGAGAGGAGGTCAGAAGTATTTTAATGCCATC
TGTTTCATGGCTAAACACGCAGACTCCTTGCATTTTAAAATTCTGTGTCCTTTACTTTTTGGAG
CTATACTAGCTTGCTTGGGTGTGTAACTTGCCAGAGTTGACTTTTCTAGTGCTTTATGTAAACT
CTGCTGTTGGCACTTGCAGCTGAAGCAGCTGAAAGAGGGGCTGCTCACTGTTGCAGCACTGGGA
TCCCTGGCAGCTGCAGCGGCAATGCTTAAGGAGCTTTTGCAACTTTGACTTCAGTAGCAGCTTG
GGATGATAAAATATGGTGAGTGTCTTGTCTGCTGTGGAGGGCCTGACAATCTGCCAGGTGGGAA
GTCTTGTTAGAAACCAGAAACTCAGTGTGGTGGTTATCCCACCTTTTCTTTCTTTCTCCTTTGG
TCTATAATGATATTGACATAGCTATTCAGAGTAAAATCTATGTATACAAAAAAATTCTAAGTAT
GAGGTTTTAAATGTTCTTGAACTTCAGAAAAACTTGATTGGATACAATTGTTTATAATTAACAA
GTCATCTTATTTATAAATTTTCCAATATAATATAAATCTATTTTGTGGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446143	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK71134	(Get FASTA)	NCBI Sequence Viewer
	EDL95009	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006235.3

RefSeq Acc Id:

NP_446143 ⟸ NM_053691

- UniProtKB:

A6JH03 (UniProtKB/TrEMBL), G3V6L2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPSRVEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKH
PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKDRQYLEEEFVLRVMTQLTLALKECH
RRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQISRLS
YNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKD
YHRPSVEEILESPLIADLVAEEQRRNLERRGRRSGEPSKLQDSSPVLSELKLKERQLQDRERAL
RAREDSLEQKERELCIRERLAEDKLARAESLLKNYSLLKEHRLLCLAGGSELDLPSSALKKKVH
FHGESKENTARSENSESQLAKSKCRDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR

hide sequence

Ensembl Acc Id:

ENSRNOP00000006235 ⟸ ENSRNOT00000006235

Protein Domains

Protein kinase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699121

Promoter ID:

EPDNEW_R9646

Type:

initiation region

Name:

Nek2_1

Description:

NIMA-related kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	110,511,568 - 110,511,628	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619792	AgrOrtholog
BioCyc Gene	G2FUF-16824	BioCyc
Ensembl Genes	ENSRNOG00000004487	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006235.6	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	NEK_Ser/Thr_kinase_NIMA	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:114482	UniProtKB/TrEMBL
NCBI Gene	114482	ENTREZGENE
PANTHER	CAMK FAMILY PROTEIN KINASE	UniProtKB/TrEMBL
	NIMA-RELATED KINASE 2	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Nek2	PhenoGen
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004487	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A6JH03	ENTREZGENE, UniProtKB/TrEMBL
	G3V6L2	ENTREZGENE, UniProtKB/TrEMBL
	Q91XQ1_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-21	Nek2	NIMA-related kinase 2	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2		NIMA (never in mitosis gene a)-related kinase 2	Name updated	1299863	APPROVED
2002-08-07	Nek2	NIMA (never in mitosis gene a)-related kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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