Tyro3 (TYRO3 protein tyrosine kinase) - Rat Genome Database

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Gene: Tyro3 (TYRO3 protein tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Tyro3
Name: TYRO3 protein tyrosine kinase
RGD ID: 3923
Description: Enables phosphatidylinositol 3-kinase binding activity. Involved in protein phosphorylation. Located in endoplasmic reticulum membrane and nuclear envelope. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase); INTERACTS WITH 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Brt; Bruton agammaglobulinemia tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase SKY
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,231,468 - 127,254,806 (+)NCBIGRCr8
mRatBN7.23106,777,686 - 106,797,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,777,635 - 106,797,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,453,352 - 110,472,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,048,900 - 119,067,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,709,292 - 116,728,321 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,597,102 - 111,616,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,597,102 - 111,616,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,145,366 - 118,165,796 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,309,671 - 106,328,607 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13106,206,098 - 106,225,035 (+)NCBI
Celera3105,690,533 - 105,707,759 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
ADP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
hydrogen peroxide  (ISO)
maneb  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (EXP)
progesterone  (EXP)
rac-lactic acid  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic cell clearance  (IEA,ISO,ISS)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell adhesion  (IEA)
cell migration  (IBA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
establishment of localization in cell  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
forebrain cell migration  (IEA,ISO,ISS)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lymphocyte activation  (ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
natural killer cell differentiation  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO,ISS)
negative regulation of innate immune response  (IEA,ISO,ISS)
negative regulation of lymphocyte activation  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO,ISS)
negative regulation of toll-like receptor signaling pathway  (IEA,ISO,ISS)
nervous system development  (IBA)
neuron apoptotic process  (IEA,ISO)
neuron cellular homeostasis  (IEA,ISO,ISS)
neuron migration  (IEA,ISO)
neuropeptide signaling pathway  (IEA,ISO)
ovulation cycle  (IEA,ISO,ISS)
phagocytosis  (IBA)
platelet activation  (ISO,ISS)
platelet aggregation  (IBA,IEA,ISO,ISS)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO,ISS)
positive regulation of viral life cycle  (IEA,ISO)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (IDA)
secretion by cell  (IEA,ISO,ISS)
spermatogenesis  (IEA,ISO,ISS)
substrate adhesion-dependent cell spreading  (IEA,ISO,ISS)
symbiont entry into host cell  (IEA)
vagina development  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. Gould WR, etal., J Thromb Haemost. 2005 Apr;3(4):733-41. Epub 2005 Feb 23.
4. A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress. Kajii Y, etal., Biol Cell. 1996;88(1-2):45-54.
5. Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. Lan Z, etal., Blood. 2000 Jan 15;95(2):633-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Molecular cloning and in situ localization in the brain of rat sky receptor tyrosine kinase. Ohashi K, etal., J Biochem (Tokyo) 1995 Jun;117(6):1267-75.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7511603   PMID:7537495   PMID:9331176   PMID:10227296   PMID:11452127   PMID:15650770   PMID:16751775   PMID:17442946   PMID:17980494   PMID:18083102   PMID:18159085   PMID:18393392  
PMID:18787040   PMID:19027714   PMID:20546121   PMID:21084607   PMID:21270900   PMID:22119469   PMID:22606290   PMID:33450132  


Genomics

Comparative Map Data
Tyro3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,231,468 - 127,254,806 (+)NCBIGRCr8
mRatBN7.23106,777,686 - 106,797,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,777,635 - 106,797,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,453,352 - 110,472,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,048,900 - 119,067,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,709,292 - 116,728,321 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,597,102 - 111,616,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,597,102 - 111,616,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,145,366 - 118,165,796 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,309,671 - 106,328,607 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13106,206,098 - 106,225,035 (+)NCBI
Celera3105,690,533 - 105,707,759 (+)NCBICelera
Cytogenetic Map3q35NCBI
TYRO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381541,559,212 - 41,583,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1541,557,675 - 41,583,589 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,851,410 - 41,875,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,638,524 - 39,658,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 341539,638,523 - 39,658,818NCBI
Celera1518,619,191 - 18,639,503 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,699,536 - 18,719,735 (+)NCBIHuRef
CHM1_11541,969,757 - 41,990,068 (+)NCBICHM1_1
T2T-CHM13v2.01539,365,361 - 39,389,764 (+)NCBIT2T-CHM13v2.0
Tyro3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,628,123 - 119,648,585 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,628,214 - 119,648,585 (+)EnsemblGRCm39 Ensembl
GRCm382119,797,740 - 119,818,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,797,733 - 119,818,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,625,250 - 119,643,840 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,490,955 - 119,509,545 (+)NCBIMGSCv36mm8
Celera2120,956,991 - 120,973,578 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Tyro3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554168,359,207 - 8,377,692 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554168,361,722 - 8,377,629 (+)NCBIChiLan1.0ChiLan1.0
TYRO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,800,411 - 30,820,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,951,644 - 34,976,218 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01520,499,789 - 20,520,152 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,739,509 - 38,760,288 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,739,509 - 38,760,288 (+)Ensemblpanpan1.1panPan2
TYRO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,571,230 - 8,602,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,571,475 - 8,598,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,630,043 - 8,657,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,705,504 - 8,732,865 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,705,752 - 8,732,961 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,626,748 - 8,654,350 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,745,727 - 8,761,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,865,937 - 8,893,363 (+)NCBIUU_Cfam_GSD_1.0
Tyro3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864087,044,633 - 87,062,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,893,078 - 4,910,859 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,893,185 - 4,910,779 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYRO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1129,811,544 - 129,829,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11129,811,540 - 129,829,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21144,883,363 - 144,900,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYRO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12641,429,667 - 41,449,130 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2641,429,556 - 41,449,175 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604899,532,509 - 99,554,583 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyro3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,710,821 - 8,728,072 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,711,487 - 8,729,025 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tyro3
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:222
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000007656
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
Tyro3  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.43106,327,758 - 106,327,964UniSTSRGSC3.4
Celera3105,706,911 - 105,707,117UniSTS
Celera3105,707,001 - 105,707,156UniSTS
D15S1348  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,796,193 - 106,796,430 (+)MAPPERmRatBN7.2
Rnor_6.03111,615,194 - 111,615,430NCBIRnor6.0
Rnor_5.03118,164,839 - 118,165,075UniSTSRnor5.0
RGSC_v3.43106,327,658 - 106,327,894UniSTSRGSC3.4
Celera3105,706,811 - 105,707,047UniSTS
Cytogenetic Map3q36.1UniSTS
Tyro3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03118,165,029 - 118,165,184UniSTSRnor5.0
Celera3105,707,001 - 105,707,156UniSTS
Cytogenetic Map3q36.1UniSTS
Tyro3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03118,164,939 - 118,165,145UniSTSRnor5.0
RGSC_v3.43106,327,758 - 106,327,964UniSTSRGSC3.4
Celera3105,706,911 - 105,707,117UniSTS
Cytogenetic Map3q36.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000081462   ⟹   ENSRNOP00000069466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,777,635 - 106,797,142 (+)Ensembl
Rnor_6.0 Ensembl3111,597,102 - 111,616,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112329   ⟹   ENSRNOP00000088930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,778,493 - 106,797,142 (+)Ensembl
RefSeq Acc Id: NM_017092   ⟹   NP_058788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,231,903 - 127,250,943 (+)NCBI
mRatBN7.23106,778,102 - 106,797,142 (+)NCBI
Rnor_6.03111,597,102 - 111,616,142 (+)NCBI
Rnor_5.03118,145,366 - 118,165,796 (+)NCBI
RGSC_v3.43106,309,671 - 106,328,607 (+)RGD
Celera3105,690,533 - 105,707,759 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104341   ⟹   XP_038960269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,231,468 - 127,254,806 (+)NCBI
mRatBN7.23106,777,686 - 106,797,154 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058788 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960269 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA07119 (Get FASTA)   NCBI Sequence Viewer  
  EDL79928 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069466.2
  ENSRNOP00000088930.1
GenBank Protein P55146 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058788   ⟸   NM_017092
- Peptide Label: precursor
- UniProtKB: P55146 (UniProtKB/Swiss-Prot),   A0A8I6ABP1 (UniProtKB/TrEMBL),   A6HPH7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069466   ⟸   ENSRNOT00000081462
RefSeq Acc Id: XP_038960269   ⟸   XM_039104341
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABP1 (UniProtKB/TrEMBL),   A6HPH7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088930   ⟸   ENSRNOT00000112329
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55146-F1-model_v2 AlphaFold P55146 1-880 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692337
Promoter ID:EPDNEW_R2860
Type:initiation region
Name:Tyro3_1
Description:TYRO3 protein tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,597,080 - 111,597,140EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3923 AgrOrtholog
BioCyc Gene G2FUF-48189 BioCyc
Ensembl Genes ENSRNOG00000058586 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081462.2 UniProtKB/TrEMBL
  ENSRNOT00000112329.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25232 UniProtKB/Swiss-Prot
NCBI Gene 25232 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR TYRO3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tyro3 PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058586 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205180
UniProt A0A8I6ABP1 ENTREZGENE, UniProtKB/TrEMBL
  A6HPH7 ENTREZGENE, UniProtKB/TrEMBL
  F1M7U7_RAT UniProtKB/TrEMBL
  P55146 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tyro3  TYRO3 protein tyrosine kinase  Tyro3  TYRO3 protein tyrosine kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tyro3  TYRO3 protein tyrosine kinase 3    Bruton agammaglobulinemia tyrosine kinase  Name updated 629478 APPROVED
2002-06-10 Tyro3  Bruton agammaglobulinemia tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains extracellular domain consists of two immunoglobulin (Ig)-like and two fibronectin type III (FN III) motifs 729988