Tsc22d1 (TSC22 domain family, member 1) - Rat Genome Database

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Gene: Tsc22d1 (TSC22 domain family, member 1) Rattus norvegicus
Analyze
Symbol: Tsc22d1
Name: TSC22 domain family, member 1
RGD ID: 3850
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion; nucleus; and plasma membrane. Orthologous to human TSC22D1 (TSC22 domain family member 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100912462; LOC498545; MGC156831; regulatory protein TSC-22; similar to transforming growth factor beta 1 induced transcript 4 isoform 1; TGFB-stimulated clone 22 homolog; Tgfb1i4; transforming growth factor beta 1 induced transcript 4; Transforming growth factor beta stimulated clone 22; transforming growth factor beta-1-induced transcript 4 protein; TS22A; TSC-22; TSC22 domain family protein 1; uncharacterized LOC100912462
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81558,159,612 - 58,260,244 (+)NCBIGRCr8
mRatBN7.21551,750,489 - 51,850,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,749,510 - 51,850,958 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1555,889,187 - 55,989,358 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01557,007,507 - 57,107,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,826,931 - 53,926,796 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,554,358 - 58,658,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,554,374 - 58,658,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01562,249,572 - 62,348,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41557,404,929 - 57,502,817 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11557,515,360 - 57,518,594 (+)NCBI
Celera1551,368,663 - 51,469,040 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A5  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
losartan  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
oxazepam  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vincristine  (ISO)
zearalenone  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
membrane  (IEA)
mitochondrion  (ISO)
nucleus  (IEA,ISO)
plasma membrane  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Hamil KG and Hall SH, Endocrinology 1994 Mar;134(3):1205-12.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. Ohta S, etal., Eur J Biochem. 1996 Dec 15;242(3):460-6.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:15489334   PMID:19745830   PMID:21791611   PMID:22871113   PMID:30053369  


Genomics

Comparative Map Data
Tsc22d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81558,159,612 - 58,260,244 (+)NCBIGRCr8
mRatBN7.21551,750,489 - 51,850,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,749,510 - 51,850,958 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1555,889,187 - 55,989,358 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01557,007,507 - 57,107,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,826,931 - 53,926,796 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,554,358 - 58,658,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,554,374 - 58,658,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01562,249,572 - 62,348,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41557,404,929 - 57,502,817 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11557,515,360 - 57,518,594 (+)NCBI
Celera1551,368,663 - 51,469,040 (+)NCBICelera
Cytogenetic Map15q11NCBI
TSC22D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381344,432,143 - 44,577,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1344,432,143 - 44,577,147 (-)EnsemblGRCh38hg38GRCh38
GRCh371345,006,279 - 45,150,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361343,905,658 - 44,048,701 (-)NCBINCBI36Build 36hg18NCBI36
Celera1326,063,743 - 26,206,780 (-)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1325,807,840 - 25,952,293 (-)NCBIHuRef
CHM1_11344,973,738 - 45,118,257 (-)NCBICHM1_1
T2T-CHM13v2.01343,651,902 - 43,797,110 (-)NCBIT2T-CHM13v2.0
Tsc22d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391476,652,401 - 76,745,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1476,652,401 - 76,745,205 (+)EnsemblGRCm39 Ensembl
GRCm381476,414,961 - 76,507,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1476,414,961 - 76,507,765 (+)EnsemblGRCm38mm10GRCm38
MGSCv371476,815,628 - 76,907,573 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361475,149,976 - 75,241,916 (+)NCBIMGSCv36mm8
Celera1473,915,823 - 74,008,437 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.44NCBI
Tsc22d1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555182,321,226 - 2,450,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555182,322,566 - 2,451,519 (-)NCBIChiLan1.0ChiLan1.0
TSC22D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21443,932,792 - 44,078,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11335,012,499 - 35,157,957 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01325,597,530 - 25,743,522 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13198,324,581 - 198,469,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3198,325,494 - 198,469,869 (+)Ensemblpanpan1.1panPan2
TSC22D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1226,375,585 - 6,506,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl226,375,577 - 6,505,672 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,365,529 - 6,496,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0226,493,917 - 6,624,793 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl226,494,019 - 6,624,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1226,276,217 - 6,407,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,338,136 - 6,468,818 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0226,345,130 - 6,475,898 (+)NCBIUU_Cfam_GSD_1.0
Tsc22d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945154,776,673 - 154,890,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936791694,954 - 811,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936791697,244 - 811,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSC22D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,518,795 - 22,634,407 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,518,792 - 22,634,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21122,821,681 - 22,853,358 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSC22D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1322,529,552 - 22,673,495 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605721,449,369 - 21,593,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsc22d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474810,420,659 - 10,592,135 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474810,420,584 - 10,589,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tsc22d1
579 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:948
Count of miRNA genes:239
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000001360, ENSRNOT00000058206
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat

Markers in Region
D15Rat18  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1551,406,647 - 51,406,792UniSTS
RH 3.4 Map15465.6RGD
RH 3.4 Map15465.6UniSTS
SHRSP x BN Map1534.6299UniSTS
SHRSP x BN Map1534.6299RGD
FHH x ACI Map1547.39RGD
Cytogenetic Map15q11UniSTS
Egr5-rs  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,850,447 - 51,850,638 (+)MAPPERmRatBN7.2
Rnor_6.01558,657,646 - 58,657,836NCBIRnor6.0
Rnor_5.01562,348,091 - 62,348,281UniSTSRnor5.0
RGSC_v3.41557,502,307 - 57,502,497UniSTSRGSC3.4
Celera1551,468,530 - 51,468,720UniSTS
Cytogenetic Map15q11UniSTS
RH132445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,850,615 - 51,850,827 (+)MAPPERmRatBN7.2
mRatBN7.23122,796,314 - 122,796,526 (+)MAPPERmRatBN7.2
Rnor_6.03128,444,710 - 128,444,921NCBIRnor6.0
Rnor_6.01558,657,814 - 58,658,025NCBIRnor6.0
Rnor_5.01562,348,259 - 62,348,470UniSTSRnor5.0
Rnor_5.03134,933,486 - 134,933,697UniSTSRnor5.0
RGSC_v3.43123,548,723 - 123,548,934UniSTSRGSC3.4
RGSC_v3.41557,502,475 - 57,502,686UniSTSRGSC3.4
Celera1551,468,698 - 51,468,909UniSTS
Celera3121,538,315 - 121,538,526UniSTS
Cytogenetic Map15q11UniSTS
RH132755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,776,100 - 51,776,301 (+)MAPPERmRatBN7.2
Rnor_6.01558,580,041 - 58,580,241NCBIRnor6.0
Rnor_5.01562,275,255 - 62,275,455UniSTSRnor5.0
RGSC_v3.41557,430,540 - 57,430,740UniSTSRGSC3.4
Celera1551,394,275 - 51,394,475UniSTS
RH 3.4 Map15464.31UniSTS
Cytogenetic Map15q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_360080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_360081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC059146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG372788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB771530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001360   ⟹   ENSRNOP00000001360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,847,734 - 51,850,953 (+)Ensembl
Rnor_6.0 Ensembl1558,654,913 - 58,658,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000058206   ⟹   ENSRNOP00000055007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,750,489 - 51,850,958 (+)Ensembl
Rnor_6.0 Ensembl1558,554,374 - 58,658,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107638   ⟹   ENSRNOP00000082152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,796,135 - 51,850,953 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109894   ⟹   ENSRNOP00000080511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,832,613 - 51,850,953 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110180   ⟹   ENSRNOP00000091237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,750,826 - 51,850,958 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110281   ⟹   ENSRNOP00000085587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,749,510 - 51,775,414 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119698   ⟹   ENSRNOP00000087730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,847,688 - 51,849,235 (+)Ensembl
RefSeq Acc Id: NM_001109912   ⟹   NP_001103382
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,778 - 58,260,244 (+)NCBI
mRatBN7.21551,750,489 - 51,850,958 (+)NCBI
Rnor_6.01558,554,429 - 58,658,156 (+)NCBI
Rnor_5.01562,249,572 - 62,348,601 (+)NCBI
RGSC_v3.41557,404,929 - 57,502,817 (+)RGD
Celera1551,368,663 - 51,469,040 (+)RGD
Sequence:
RefSeq Acc Id: NM_013043   ⟹   NP_037175
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,257,001 - 58,260,244 (+)NCBI
mRatBN7.21551,847,715 - 51,850,958 (+)NCBI
Rnor_6.01558,654,913 - 58,658,156 (+)NCBI
Rnor_5.01562,249,572 - 62,348,601 (+)NCBI
RGSC_v3.41557,404,929 - 57,502,817 (+)RGD
Celera1551,465,797 - 51,469,040 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252340   ⟹   XP_006252402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,185,806 (+)NCBI
mRatBN7.21551,750,731 - 51,776,517 (+)NCBI
Rnor_6.01558,554,425 - 58,589,694 (+)NCBI
Rnor_5.01562,249,572 - 62,348,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093593   ⟹   XP_038949521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,230,209 - 58,260,242 (+)NCBI
mRatBN7.21551,820,924 - 51,850,958 (+)NCBI
RefSeq Acc Id: XM_063274557   ⟹   XP_063130627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,260,242 (+)NCBI
RefSeq Acc Id: XM_063274558   ⟹   XP_063130628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,612 - 58,260,242 (+)NCBI
RefSeq Acc Id: XM_063274559   ⟹   XP_063130629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,260,242 (+)NCBI
RefSeq Acc Id: XR_005493779
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,185,806 (+)NCBI
mRatBN7.21551,750,731 - 51,776,517 (+)NCBI
RefSeq Acc Id: XR_010057848
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,185,806 (+)NCBI
RefSeq Acc Id: XR_360080
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,185,806 (+)NCBI
mRatBN7.21551,750,731 - 51,776,517 (+)NCBI
Rnor_6.01558,554,425 - 58,589,694 (+)NCBI
Rnor_5.01562,249,572 - 62,348,601 (+)NCBI
Sequence:
RefSeq Acc Id: XR_360081
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,159,619 - 58,185,806 (+)NCBI
mRatBN7.21551,750,731 - 51,776,517 (+)NCBI
Rnor_6.01558,554,425 - 58,589,694 (+)NCBI
Rnor_5.01562,249,572 - 62,348,601 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001103382   ⟸   NM_001109912
- Peptide Label: isoform 1
- UniProtKB: P62501 (UniProtKB/Swiss-Prot),   D3Z8M8 (UniProtKB/Swiss-Prot),   A0JPR0 (UniProtKB/Swiss-Prot),   A0A8I6AF76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037175   ⟸   NM_013043
- Peptide Label: isoform 2
- UniProtKB: A6HTV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252402   ⟸   XM_006252340
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A468 (UniProtKB/TrEMBL),   A0A8I6AF76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055007   ⟸   ENSRNOT00000058206
Ensembl Acc Id: ENSRNOP00000001360   ⟸   ENSRNOT00000001360
RefSeq Acc Id: XP_038949521   ⟸   XM_039093593
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000082152   ⟸   ENSRNOT00000107638
Ensembl Acc Id: ENSRNOP00000091237   ⟸   ENSRNOT00000110180
Ensembl Acc Id: ENSRNOP00000085587   ⟸   ENSRNOT00000110281
Ensembl Acc Id: ENSRNOP00000087730   ⟸   ENSRNOT00000119698
Ensembl Acc Id: ENSRNOP00000080511   ⟸   ENSRNOT00000109894
RefSeq Acc Id: XP_063130628   ⟸   XM_063274558
- Peptide Label: isoform X1
- UniProtKB: P62501 (UniProtKB/Swiss-Prot),   D3Z8M8 (UniProtKB/Swiss-Prot),   A0JPR0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130627   ⟸   XM_063274557
- Peptide Label: isoform X1
- UniProtKB: P62501 (UniProtKB/Swiss-Prot),   D3Z8M8 (UniProtKB/Swiss-Prot),   A0JPR0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130629   ⟸   XM_063274559
- Peptide Label: isoform X1
- UniProtKB: P62501 (UniProtKB/Swiss-Prot),   D3Z8M8 (UniProtKB/Swiss-Prot),   A0JPR0 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62501-F1-model_v2 AlphaFold P62501 1-143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699839
Promoter ID:EPDNEW_R10362
Type:multiple initiation site
Name:Tsc22d1_1
Description:TSC22 domain family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01558,654,907 - 58,654,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3850 AgrOrtholog
BioCyc Gene G2FUF-13057 BioCyc
Ensembl Genes ENSRNOG00000001030 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001360.4 UniProtKB/Swiss-Prot
  ENSRNOT00000058206.5 UniProtKB/Swiss-Prot
  ENSRNOT00000107638.1 UniProtKB/TrEMBL
  ENSRNOT00000109894.1 UniProtKB/TrEMBL
  ENSRNOT00000110180.1 UniProtKB/TrEMBL
  ENSRNOT00000110281.1 UniProtKB/TrEMBL
  ENSRNOT00000119698.1 UniProtKB/TrEMBL
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TSC-22_Dip_Bun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSC22/BUN_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:498545 UniProtKB/Swiss-Prot
NCBI Gene Tsc22d1 ENTREZGENE
PANTHER TSC22 UniProtKB/TrEMBL
  TSC22 DOMAIN FAMILY PROTEIN 1 UniProtKB/Swiss-Prot
  TSC22 DOMAIN FAMILY PROTEIN 1 UniProtKB/Swiss-Prot
  TSC22 DOMAIN FAMILY PROTEIN 1 UniProtKB/TrEMBL
  TSC22 DOMAIN FAMILY PROTEIN 1 UniProtKB/TrEMBL
  TSC22 DOMAIN FAMILY PROTEIN 1 UniProtKB/TrEMBL
Pfam TSC22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tsc22d1 PhenoGen
PROSITE TSC22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001030 RatGTEx
Superfamily-SCOP Delta-sleep-inducing peptide immunoreactive peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204146
UniProt A0A8I5ZPR9_RAT UniProtKB/TrEMBL
  A0A8I5ZUE9_RAT UniProtKB/TrEMBL
  A0A8I6A468 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4Q2_RAT UniProtKB/TrEMBL
  A0A8I6AF76 ENTREZGENE, UniProtKB/TrEMBL
  A0JPR0 ENTREZGENE
  A6HTV1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8M8 ENTREZGENE
  P62501 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPR0 UniProtKB/Swiss-Prot
  D3Z8M8 UniProtKB/Swiss-Prot
  Q00992 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Tsc22d1  TSC22 domain family, member 1  LOC100912462  uncharacterized LOC100912462  Data merged from RGD:6487133 737654 PROVISIONAL
2012-07-05 LOC100912462  uncharacterized LOC100912462      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-10-11 Tsc22d1  TSC22 domain family, member 1  Tgfb1i4  transforming growth factor beta 1 induced transcript 4  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-10-11 Tgfb1i4  transforming growth factor beta 1 induced transcript 4  LOC498545  similar to transforming growth factor beta 1 induced transcript 4 isoform 1  Data merged from RGD:1590792 737654 APPROVED
2006-11-20 LOC498545  similar to transforming growth factor beta 1 induced transcript 4 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tgfb1i4  Transforming growth factor beta stimulated clone 22      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a leucine zipper region 634428