Rgs8 (regulator of G-protein signaling 8) - Rat Genome Database

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Gene: Rgs8 (regulator of G-protein signaling 8) Rattus norvegicus
Analyze
Symbol: Rgs8
Name: regulator of G-protein signaling 8
RGD ID: 3571
Description: Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and response to amphetamine. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body membrane. Orthologous to human RGS8 (regulator of G protein signaling 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105444
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,355,078 - 68,399,412 (+)NCBIGRCr8
mRatBN7.21365,804,703 - 65,848,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,804,797 - 65,846,807 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,417,809 - 68,450,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,707,795 - 69,740,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,960,758 - 66,993,076 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,086,654 - 71,141,820 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,086,745 - 71,141,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,051,812 - 76,105,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,735,814 - 68,766,956 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11368,749,893 - 68,781,036 (+)NCBI
Celera1365,717,445 - 65,747,668 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
2. RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell. Itoh M, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):223-8.
3. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum. Saitoh O, etal., Cerebellum. 2003;2(2):154-60.
9. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents. Saitoh O, etal., J Biol Chem 1999 Apr 2;274(14):9899-904.
10. RGS8 accelerates G-protein-mediated modulation of K+ currents. Saitoh O, etal., Nature 1997 Dec 4;390(6659):525-9.
11. Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Saitoh O, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):10138-43.
12. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:13679049   PMID:15489334   PMID:18434541  


Genomics

Comparative Map Data
Rgs8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,355,078 - 68,399,412 (+)NCBIGRCr8
mRatBN7.21365,804,703 - 65,848,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,804,797 - 65,846,807 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,417,809 - 68,450,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,707,795 - 69,740,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,960,758 - 66,993,076 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,086,654 - 71,141,820 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,086,745 - 71,141,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,051,812 - 76,105,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,735,814 - 68,766,956 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11368,749,893 - 68,781,036 (+)NCBI
Celera1365,717,445 - 65,747,668 (+)NCBICelera
Cytogenetic Map13q21NCBI
RGS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,641,818 - 182,752,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,641,816 - 182,684,587 (-)EnsemblGRCh38hg38GRCh38
GRCh371182,610,953 - 182,721,511 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,882,415 - 180,908,690 (-)NCBINCBI36Build 36hg18NCBI36
Build 341179,347,448 - 179,373,706NCBI
Celera1155,727,019 - 155,753,291 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,852,220 - 153,878,494 (-)NCBIHuRef
CHM1_11184,039,323 - 184,065,602 (-)NCBICHM1_1
T2T-CHM13v2.01182,001,318 - 182,111,553 (-)NCBIT2T-CHM13v2.0
Rgs8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,528,612 - 153,573,415 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,528,771 - 153,576,069 (+)EnsemblGRCm39 Ensembl
GRCm381153,652,959 - 153,697,669 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,653,025 - 153,700,323 (+)EnsemblGRCm38mm10GRCm38
MGSCv371155,500,167 - 155,544,795 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,415,255 - 155,459,883 (+)NCBIMGSCv36mm8
Celera1156,084,491 - 156,129,267 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.41NCBI
Rgs8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,482,810 - 21,523,674 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,482,810 - 21,523,518 (-)NCBIChiLan1.0ChiLan1.0
RGS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2167,044,870 - 67,087,649 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,728,350 - 66,771,131 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,160,368 - 158,268,521 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,811,997 - 161,847,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,813,540 - 161,855,027 (-)Ensemblpanpan1.1panPan2
RGS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,053,946 - 16,081,661 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,053,946 - 16,080,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha715,639,499 - 15,667,210 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0715,782,579 - 15,810,267 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,782,585 - 15,823,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,694,205 - 15,721,875 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,802,473 - 15,830,139 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0715,932,004 - 15,959,681 (-)NCBIUU_Cfam_GSD_1.0
Rgs8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,230,610 - 89,268,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364817,077,330 - 7,110,747 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364817,077,345 - 7,115,350 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9123,955,241 - 124,047,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19123,937,721 - 124,053,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29136,138,527 - 136,261,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,683,978 - 46,724,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,683,783 - 46,726,543 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,901,830 - 47,944,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481411,177,025 - 11,208,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481411,176,559 - 11,208,684 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs8
421 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:503
Count of miRNA genes:261
Interacting mature miRNAs:338
Transcripts:ENSRNOT00000003239
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat

Markers in Region
D13Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,846,377 - 65,846,580 (+)MAPPERmRatBN7.2
Rnor_6.01371,139,243 - 71,139,445NCBIRnor6.0
Rnor_5.01376,104,495 - 76,104,697UniSTSRnor5.0
RGSC_v3.41368,766,526 - 68,766,728UniSTSRGSC3.4
Celera1365,747,238 - 65,747,440UniSTS
Cytogenetic Map13q21UniSTS
BF387596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,844,759 - 65,844,956 (+)MAPPERmRatBN7.2
Rnor_6.01371,137,625 - 71,137,821NCBIRnor6.0
Rnor_5.01376,102,877 - 76,103,073UniSTSRnor5.0
RGSC_v3.41368,764,908 - 68,765,104UniSTSRGSC3.4
Celera1365,745,620 - 65,745,816UniSTS
RH 3.4 Map13340.1UniSTS
Cytogenetic Map13q21UniSTS
BF415829  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,825,175 - 65,825,270 (+)MAPPERmRatBN7.2
Rnor_6.01371,116,207 - 71,116,301NCBIRnor6.0
Rnor_5.01376,081,459 - 76,081,553UniSTSRnor5.0
RGSC_v3.41368,744,556 - 68,744,650UniSTSRGSC3.4
Celera1365,726,175 - 65,726,269UniSTS
RH 3.4 Map13339.9UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 36 112 63 62 32 25 32 5 163 79 93 35 60 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003239   ⟹   ENSRNOP00000003239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,816,434 - 65,846,807 (+)Ensembl
Rnor_6.0 Ensembl1371,107,465 - 71,139,672 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083366   ⟹   ENSRNOP00000073985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,804,797 - 65,846,807 (+)Ensembl
Rnor_6.0 Ensembl1371,086,745 - 71,141,075 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088329   ⟹   ENSRNOP00000074194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1371,110,064 - 71,137,018 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118774   ⟹   ENSRNOP00000090756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,820,459 - 65,846,807 (+)Ensembl
RefSeq Acc Id: NM_019344   ⟹   NP_062217
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,366,898 - 68,399,412 (+)NCBI
mRatBN7.21365,816,434 - 65,848,955 (+)NCBI
Rnor_6.01371,107,465 - 71,139,673 (+)NCBI
Rnor_5.01376,051,812 - 76,105,170 (+)NCBI
RGSC_v3.41368,735,814 - 68,766,956 (+)RGD
Celera1365,717,445 - 65,747,668 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250015   ⟹   XP_006250077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,355,078 - 68,399,412 (+)NCBI
mRatBN7.21365,804,703 - 65,848,953 (+)NCBI
Rnor_6.01371,086,654 - 71,141,820 (+)NCBI
Rnor_5.01376,051,812 - 76,105,170 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250016   ⟹   XP_006250078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,367,227 - 68,399,412 (+)NCBI
mRatBN7.21365,816,764 - 65,848,953 (+)NCBI
Rnor_6.01371,107,707 - 71,141,820 (+)NCBI
Rnor_5.01376,051,812 - 76,105,170 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091033   ⟹   XP_038946961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,355,398 - 68,399,412 (+)NCBI
mRatBN7.21365,804,930 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091035   ⟹   XP_038946963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,355,350 - 68,399,412 (+)NCBI
mRatBN7.21365,804,893 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091036   ⟹   XP_038946964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,366,742 - 68,399,412 (+)NCBI
mRatBN7.21365,816,261 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091037   ⟹   XP_038946965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,366,497 - 68,399,412 (+)NCBI
mRatBN7.21365,816,036 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091039   ⟹   XP_038946967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,366,716 - 68,399,412 (+)NCBI
mRatBN7.21365,816,241 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091040   ⟹   XP_038946968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,355,342 - 68,399,412 (+)NCBI
mRatBN7.21365,804,886 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091041   ⟹   XP_038946969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,367,227 - 68,399,412 (+)NCBI
mRatBN7.21365,816,705 - 65,848,953 (+)NCBI
RefSeq Acc Id: XM_039091042   ⟹   XP_038946970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,366,716 - 68,399,412 (+)NCBI
mRatBN7.21365,816,643 - 65,848,953 (+)NCBI
RefSeq Acc Id: NP_062217   ⟸   NM_019344
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250077   ⟸   XM_006250015
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250078   ⟸   XM_006250016
- Peptide Label: isoform X2
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073985   ⟸   ENSRNOT00000083366
Ensembl Acc Id: ENSRNOP00000003239   ⟸   ENSRNOT00000003239
Ensembl Acc Id: ENSRNOP00000074194   ⟸   ENSRNOT00000088329
RefSeq Acc Id: XP_038946968   ⟸   XM_039091040
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946963   ⟸   XM_039091035
- Peptide Label: isoform X2
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946961   ⟸   XM_039091033
- Peptide Label: isoform X2
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946965   ⟸   XM_039091037
- Peptide Label: isoform X2
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946967   ⟸   XM_039091039
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946964   ⟸   XM_039091036
- Peptide Label: isoform X2
- UniProtKB: P49804 (UniProtKB/Swiss-Prot),   A6ICV3 (UniProtKB/TrEMBL),   A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946970   ⟸   XM_039091042
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946969   ⟸   XM_039091041
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP34 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090756   ⟸   ENSRNOT00000118774
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49804-F1-model_v2 AlphaFold P49804 1-180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3571 AgrOrtholog
BioCyc Gene G2FUF-17878 BioCyc
Ensembl Genes ENSRNOG00000002369 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018466 UniProtKB/Swiss-Prot
  ENSRNOG00060014310 UniProtKB/Swiss-Prot
  ENSRNOG00065024937 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003239.7 UniProtKB/Swiss-Prot
  ENSRNOT00000083366.2 UniProtKB/TrEMBL
  ENSRNOT00000118774.1 UniProtKB/TrEMBL
  ENSRNOT00055031381 UniProtKB/Swiss-Prot
  ENSRNOT00060024492 UniProtKB/Swiss-Prot
  ENSRNOT00065042874 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317138 IMAGE-MGC_LOAD
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_RGS8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54297 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105444 IMAGE-MGC_LOAD
NCBI Gene 54297 ENTREZGENE
PANTHER PTHR10845:SF147 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs8 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002369 RatGTEx
  ENSRNOG00055018466 RatGTEx
  ENSRNOG00060014310 RatGTEx
  ENSRNOG00065024937 RatGTEx
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207322
UniProt A0A0G2K6Y1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP34 ENTREZGENE, UniProtKB/TrEMBL
  A6ICV3 ENTREZGENE, UniProtKB/TrEMBL
  P49804 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs8  regulator of G-protein signaling 8      Name updated 70584 APPROVED