Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B)

Gene: Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) Rattus norvegicus

Analyze

Symbol:

Ppm1b

Name:

protein phosphatase, Mg2+/Mn2+ dependent, 1B

RGD ID:

3374

Description:

Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of defense response to virus; negative regulation of interferon-beta production; and regulation of signal transduction. Predicted to be located in membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PP2C-beta; Pp2c2; protein phosphatase 1B; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C isoform beta; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Ppm1b (protein phosphatase 1B, magnesium dependent, beta isoform)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZC2HC1B (zinc finger C2HC-type containing 1B)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ppm1b (protein phosphatase 1B, magnesium dependent, beta isoform)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppm1bb (protein phosphatase, Mg2+/Mn2+ dependent, 1Bb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	ppm1ba (protein phosphatase, Mg2+/Mn2+ dependent, 1Ba)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PTC4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Saccharomyces cerevisiae (baker's yeast):	PTC2	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PTC3	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alph	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ppm-1.A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6036	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ppm1b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	15,399,559 - 15,460,301 (-)	NCBI		GRCr8
mRatBN7.2	6	9,646,695 - 9,707,471 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	9,655,765 - 9,707,974 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	9,935,440 - 9,996,111 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	10,244,815 - 10,305,488 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	9,766,465 - 9,827,173 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	8,219,385 - 8,280,127 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	8,218,696 - 8,280,124 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	8,151,741 - 8,212,739 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	8,319,544 - 8,373,795 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	8,319,543 - 8,373,795 (+)	NCBI
Celera	6	9,370,886 - 9,431,637 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypotonia-cystinuria syndrome (ISO)

Lynch syndrome (ISO)

Myocardial Ischemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

acetazolamide (ISO)

aconitine (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

calcidiol (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

clozapine (EXP)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glafenine (EXP)

haloperidol (EXP)

indometacin (ISO)

iron dichloride (ISO)

isotretinoin (ISO)

ivermectin (ISO)

methapyrilene (EXP,ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

methylseleninic acid (ISO)

N-nitrosodiethylamine (EXP)

nicotine (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

piroxicam (ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenomethionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

tributylstannane (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (EXP)

zinc sulfate (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO,ISS)

negative regulation of defense response to virus (IEA,ISO,ISS)

negative regulation of interferon-beta production (IEA,ISO,ISS)

negative regulation of non-canonical NF-kappaB signal transduction (IEA,ISO,ISS)

positive regulation of canonical Wnt signaling pathway (IBA)

Cellular Component

cytosol (IBA,IEA,ISO,ISS)

membrane (IEA,ISO,ISS)

nucleolus (IEA,ISO)

nucleus (IBA)

Molecular Function

magnesium ion binding (IEA)

manganese ion binding (IEA)

myosin phosphatase activity (IEA)

protein binding (ISO)

protein serine/threonine phosphatase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules.	Kato S, etal., FEBS Lett 1996 Nov 4;396(2-3):293-7.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	The mouse protein phosphatase 2Cbeta (Ppm1b) gene maps to the distal part of mouse chromosome 17.	Watanabe T, etal., Genomics 1996 Apr 1;33(1):147-9.

Additional References at PubMed

PMID:1312947	PMID:7532404	PMID:8889548	PMID:12477932	PMID:18930133	PMID:20801214	PMID:22750291	PMID:23088624	PMID:35352799

Genomics

Comparative Map Data

Ppm1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	15,399,559 - 15,460,301 (-)	NCBI		GRCr8
mRatBN7.2	6	9,646,695 - 9,707,471 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	9,655,765 - 9,707,974 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	9,935,440 - 9,996,111 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	10,244,815 - 10,305,488 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	9,766,465 - 9,827,173 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	8,219,385 - 8,280,127 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	8,218,696 - 8,280,124 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	8,151,741 - 8,212,739 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	8,319,544 - 8,373,795 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	8,319,543 - 8,373,795 (+)	NCBI
Celera	6	9,370,886 - 9,431,637 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

PPM1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	44,168,875 - 44,246,928 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	44,167,969 - 44,244,384 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	44,396,014 - 44,461,785 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	44,249,504 - 44,315,246 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	44,307,666 - 44,370,261	NCBI
Celera	2	44,234,958 - 44,300,689 (+)	NCBI		Celera
Cytogenetic Map	2	p21	NCBI
HuRef	2	44,132,461 - 44,198,020 (+)	NCBI		HuRef
CHM1_1	2	44,325,419 - 44,391,185 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	44,174,224 - 44,253,771 (+)	NCBI		T2T-CHM13v2.0

Ppm1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	85,264,169 - 85,331,420 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	85,264,169 - 85,331,419 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	84,956,741 - 85,023,992 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	84,956,741 - 85,023,991 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	85,356,081 - 85,423,332 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	84,866,341 - 84,925,447 (+)	NCBI		MGSCv36	mm8
Celera	17	89,319,953 - 89,386,219 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	55.13	NCBI

Ppm1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	11,276,525 - 11,352,095 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	11,276,525 - 11,338,586 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPM1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	82,182,330 - 82,253,280 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	82,186,287 - 82,257,250 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	44,254,168 - 44,325,132 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	45,230,001 - 45,262,587 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	45,230,001 - 45,262,587 (+)	Ensembl	panpan1.1		panPan2

PPM1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	46,590,110 - 46,680,792 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	46,590,079 - 46,665,866 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	46,450,255 - 46,538,849 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	47,467,776 - 47,557,210 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	47,468,700 - 47,547,566 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	47,175,538 - 47,264,123 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	47,466,410 - 47,555,184 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	47,649,226 - 47,737,813 (+)	NCBI		UU_Cfam_GSD_1.0

Ppm1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	36,292,532 - 36,376,368 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	7,722,396 - 7,805,036 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	7,732,724 - 7,804,964 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPM1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	96,221,873 - 96,317,247 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	96,237,660 - 96,317,278 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	102,392,133 - 102,472,029 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPM1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	63,003,885 - 63,093,584 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	63,016,553 - 63,093,592 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	48,789,555 - 48,865,251 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppm1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	25,656,755 - 25,723,236 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	25,657,084 - 25,738,913 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppm1b
380 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	143
Count of miRNA genes:	115
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000040509, ENSRNOT00000048656
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	5074497	19988050	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat

Markers in Region

BE112607

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	9,706,372 - 9,706,532 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	8,220,324 - 8,220,483	NCBI	Rnor6.0
Rnor_5.0	6	8,152,936 - 8,153,095	UniSTS	Rnor5.0
RGSC_v3.4	6	8,319,625 - 8,319,784	UniSTS	RGSC3.4
Celera	6	9,430,539 - 9,430,698	UniSTS
Cytogenetic Map	6	q12	UniSTS

RH141215

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	9,653,748 - 9,653,953 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	8,272,867 - 8,273,071	NCBI	Rnor6.0
Rnor_5.0	6	8,205,479 - 8,205,683	UniSTS	Rnor5.0
RGSC_v3.4	6	8,373,116 - 8,373,320	UniSTS	RGSC3.4
Celera	6	9,377,939 - 9,378,143	UniSTS
Cytogenetic Map	6	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001270620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_033096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ271834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ271837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ780970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV110469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV777419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM042005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM075941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM104054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM108050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM141620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FN800175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S90449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000040509 ⟹ ENSRNOP00000041472

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	8,219,385 - 8,280,124 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000048656 ⟹ ENSRNOP00000048342

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	8,220,228 - 8,273,549 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079279 ⟹ ENSRNOP00000074301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	9,655,765 - 9,707,974 (-)	Ensembl
Rnor_6.0 Ensembl	6	8,220,228 - 8,271,054 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083470 ⟹ ENSRNOP00000074150

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	9,665,052 - 9,677,022 (-)	Ensembl
Rnor_6.0 Ensembl	6	8,218,696 - 8,270,293 (+)	Ensembl

RefSeq Acc Id:

NM_001270619 ⟹ NP_001257548

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	15,408,631 - 15,459,460 (-)	NCBI
mRatBN7.2	6	9,655,765 - 9,706,628 (-)	NCBI
Rnor_6.0	6	8,220,228 - 8,271,055 (+)	NCBI
Rnor_5.0	6	8,151,741 - 8,212,739 (+)	NCBI
Celera	6	9,379,955 - 9,430,794 (-)	NCBI

Sequence:

show sequence

AAGGAGCGGAGCGGCCGCTGCTCAATGGCGGAAAAGCCGCTGGTACTCTGACCGCCTGGTCCCC
CCTGGCAGTTGCGGGGGAGTTTCCTGCCGGCGCGGCTGGAGTCTCTGTTTCTCTGTGTCCGGTG
GCTGGAAGATGCTCCAGAGAGATCAGGCTGCGGCGGAGGAGGTGGCGGCGGCCGAGTCGGCAGC
GGCGCTGGGTTGGAGAGAAGGCGGCGGCGGCGGCGTGAGGGGCCGGACGGTGTAAACAGCTCGG
GCGGCGGCGGTGGCCGAGCCCCCGAGGGCGAAGCGGCGGCGGAGGCGGTGTCGCGTCTCGGGAG
AAAGCCGGGGGCCGCGGGCGGCTGTGCGGCGGGCAAGCCCGCGAGACCTTGCCTTCCACCTTCG
CCCCAGATTCGTTACTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAGCACAATGC
TCACGGTGCAGGGAACGGTCTGCGTTACGGTCTGAGCAGTATGCAAGGATGGAGAGTAGAAATG
GAAGACGCACACACTGCTGTTGTGGGAATTCCTCACGGCTTGGAGGACTGGTCGTTTTTTGCAG
TCTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGTTCAACACATCTATTAGAACACAT
CACTACCAATGAAGACTTTAGGGCAGCTGACAAATCAGGCTTTGCTCTTGAGCCGTCAGTGGAA
AATGTTAAGACTGGTATCCGAACTGGCTTTTTGAAAATTGATGAATATATGCGTAACTTTTCAG
ACCTGAGGAACGGGATGGACAGGAGCGGCTCTACCGCAGTGGGCGTGATGATTTCACCGACACA
CATCTACTTTATCAACTGCGGTGACTCGAGAGCTGTTCTGTGTAGGAATGGACAAGTCTGCTTT
TCTACCCAGGATCACAAACCTTGTAATCCAATGGAAAAGGAGCGCATCCAAAATGCAGGAGGCA
GTGTAATGATACAGCGTGTGAATGGGTCGTTAGCAGTGTCTCGTGCTCTGGGGGACTATGATTA
CAAGTGTGTTGATGGCAAGGGCCCCACAGAGCAGCTTGTTTCTCCAGAGCCTGAGGTTTATGAG
ATTCTAAGAGCAGAAGAGGATGAATTTGTCGTCCTGGCTTGTGATGGGATCTGGGATGTGATGA
GCAATGAGGAGCTCTGTGAGTTTGTTAACTCTAGGCTTGAGGTGTCAGACGACCTGGAGAATGT
GTGCAATTGGGTAGTGGACACTTGTTTACATAAGGGAAGTCGAGATAACATGAGTATTGTGTTA
GTTTGCTTTGCAAATGCCCCCAAGGTCTCAGATGAAGCCGTGAAAAGAGATTTAGAGTTGGACA
AGCACTTGGAATCACGGGTGGAAGAAATCATGCAGAAGTCTGGAGAGGAAGGAATGCCTGATCT
TGCCCATGTGATGCGCATTTTGTCTGCAGAAAATATCCCAAATTTACCTCCCGGGGGAGGCCTC
GCTGGCAAGCGCAATGTTATTGAAGCTGTTTATAGTAGACTTAATCCAAACAAAGACAATGATG
GGGCCTCCGAGGAAGCAGAGGAAAGTGGATCACAGGGGAAATTGGTGGAAGCTCTCAGGCAAAT
GAGAGTTAACCATAGGGGCAACTACCGACAACTGCTGGAGGAGATGCTGACTAGTTACAGGCTA
GCTAAAGTAGAGGGAGAAGAGAGCCCGGCTGGCCCAGCTGCTGCAACTGCTTCTTCGAACAGTG
ATGCTGGAAACCCAGTGGCAGTGCAGGAGAGACACACTGAAAGTGGTCCTGCTGAATTAGACAG
CCCTAAATGAAGATGCAGGGACAAAGACGAGTGCTGAAACAATATGACCTTTTTGGGGTAATAT
TTTTGTGATCTTGATTTGACAGTTTTTACTTAGGAAGTATACTGTGTGCATTTATATAACCATT
TTGTTATTTGAATCTTGGAAAACTAGTTTTCTTATATTCCTATAGCCTTGTTTTTTCTAAAGGC
CTTTAAATACACCTTTATGATAGTTTAAGATTGACTATTTATAGTAACTTTGATTTAATGAAGT
TTTATGTCATTTCACCTTGTATCCCAGAAAATAGGTTGTCATTATTAATTTCAGTAGCTTAATT
CTTACTAGCTAGGATATAGATTACTGATTGGAAAGACAGCTGTACACTGTGGAAAGAACTGTTA
CTGTAGAATTGACACTGCTTATTTTATATCAAACCCGCCATAGTTAGCTTTGTAATACCTGTGT
GTTCACTTGCTATTTTAGTTCTTTAAAGAATGGCTAGAGCTGGCCCATAACTTTTCTTTCAGAG
TTGATAATCTGTGTTTTTAATTGTTTCTATTTTACATTTCTGTAGCCTTACTTTTAGAATTTAT
TGAGATATTGGATGTGTGGTTACTTTTCCTTTCTCTGTATTCTTTATGAAAAATTTTTAAAGAA
CTATGTACTTTTCATATAGCTTTCATATGTATATTCTGTATAGCCTACTATACACTTAAAAATG
TATGTCAACCGCGTGTTTAGAATGAAATGATCAGTGTTTAAGTCCAAATAAAGCATGTGATGTG
GAATCATCTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001270620 ⟹ NP_001257549

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	15,399,559 - 15,460,301 (-)	NCBI
mRatBN7.2	6	9,646,695 - 9,707,471 (-)	NCBI
Rnor_6.0	6	8,219,385 - 8,280,124 (+)	NCBI
Rnor_5.0	6	8,151,741 - 8,212,739 (+)	NCBI
Celera	6	9,370,886 - 9,431,637 (-)	NCBI

Sequence:

show sequence

GGCTGAAGCAAAACAACGCCTTCTCTCCAGGCCCTTTCTCCAACCTCTCTGTACTCTCCCTTCA
CAGCTCTAAGTCAAAGAGAGGCGTCCATCTCTTCCAATGAGGGTCTAGGGACACTTTTCTGGCC
AATCAGGAGCTGGATCTCTCCACTCTGGGTGGGACAAATTTCCACCTATAAGTGGACTGCCCGT
TGGTTTCTTTATGGTGTTCGTTTTCCTCGAGGCATAGAGGTCAGAACTGCAGGGTCTTCAGATT
CGGGGCTTGGCCGCCTCCGAAGACTAGCCAATCCCTTTTAGGATACTTTTGCGTGTTCATTTAA
AAAAAGCCGAAGTGACGGACTTGGAAATTGGTTCAGTGAAGGACAAGCAGGGGAAGCCAATCAT
CGGAGGGCCAGGCCTCCATTTGGACCAATCAGAAAAGGAAATCGGTCTCCAAGGGGGGCGTAAT
TTGACTGACAGAGGACTCTACCTATGGCTACTAGGGTGGGCAGGCCGGTGACGTCGGGAGTTAG
TGCAAGGCGGAGGTGGGGCTGAATAAAGTAAATGTTGCGGGGGAGTTTCCTGCCGGCGCGGCTG
GAGTCTCTGTTTCTCTGTGTCCGGTGGCTGGAAGATGCTCCAGAGAGATCAGGCTGCGGCGGAG
GAGGTGGCGGCGGCCGAGTCGGCAGCGGCGCTGGGTTGGAGAGAAGGCGGCGGCGGCGGCGTGA
GGGGCCGGACGGTGTAAACAGCTCGGGCGGCGGCGGTGGCCGAGCCCCCGAGGGCGAAGCGGCG
GCGGAGGCGGTGTCGCGTCTCGGGAGAAAGCCGGGGGCCGCGGGCGGCTGTGCGGCGGGCAAGC
CCGCGAGACCTTGCCTTCCACCTTCGCCCCAGATTCGTTACTAAACATGGGTGCATTTTTGGAT
AAACCCAAAACTGAAAAGCACAATGCTCACGGTGCAGGGAACGGTCTGCGTTACGGTCTGAGCA
GTATGCAAGGATGGAGAGTAGAAATGGAAGACGCACACACTGCTGTTGTGGGAATTCCTCACGG
CTTGGAGGACTGGTCGTTTTTTGCAGTCTATGATGGTCATGCTGGATCCCGAGTGGCAAATTAC
TGTTCAACACATCTATTAGAACACATCACTACCAATGAAGACTTTAGGGCAGCTGACAAATCAG
GCTTTGCTCTTGAGCCGTCAGTGGAAAATGTTAAGACTGGTATCCGAACTGGCTTTTTGAAAAT
TGATGAATATATGCGTAACTTTTCAGACCTGAGGAACGGGATGGACAGGAGCGGCTCTACCGCA
GTGGGCGTGATGATTTCACCGACACACATCTACTTTATCAACTGCGGTGACTCGAGAGCTGTTC
TGTGTAGGAATGGACAAGTCTGCTTTTCTACCCAGGATCACAAACCTTGTAATCCAATGGAAAA
GGAGCGCATCCAAAATGCAGGAGGCAGTGTAATGATACAGCGTGTGAATGGGTCGTTAGCAGTG
TCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCCACAGAGCAGCTTG
TTTCTCCAGAGCCTGAGGTTTATGAGATTCTAAGAGCAGAAGAGGATGAATTTGTCGTCCTGGC
TTGTGATGGGATCTGGGATGTGATGAGCAATGAGGAGCTCTGTGAGTTTGTTAACTCTAGGCTT
GAGGTGTCAGACGACCTGGAGAATGTGTGCAATTGGGTAGTGGACACTTGTTTACATAAGGGAA
GTCGAGATAACATGAGTATTGTGTTAGTTTGCTTTGCAAATGCCCCCAAGGTCTCAGATGAAGC
CGTGAAAAGAGATTTAGAGTTGGACAAGCACTTGGAATCACGGGTGGAAGAAATCATGCAGAAG
TCTGGAGAGGAAGGAATGCCTGATCTTGCCCATGTGATGCGCATTTTGTCTGCAGAAAATATCC
CAAATTTACCTCCCGGGGGAGGCCTCGCTGGCAAGCGCAATGTTATTGAAGCTGTTTATAGTAG
ACTTAATCCAAACAAAGACAATGATGGGTTTTACCAACCTTCAATTCCATACAGTGACAATGTT
TTCCTATTATGAATGGCAGACTTGAGCACGTCTATTTGTAAAGCCAGCTGAGAACTCTGGTGAC
ACAGCAGAGGCTGATCAACCTACCAAGAGCCCGGAAGTACAAAGAAGAACAAAAGTTTTGTTTT
GTTTTTGTAAACTCGAAAGAAAAAAAACAAGTCCAGCATTACGTCAGTGCGGTATCTGTTCCGC
TGTGAGCGGTAACCTTCTAGCCCATCAGCGAAGGAGGAGGAGAGCTCCCACCTTGCCTTACAAA
CCTTGCTTTTCCATGTTCATGCAATAAACACGTTTGGCTTCTTGAAAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

NM_033096 ⟹ NP_149087

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	15,406,137 - 15,459,460 (-)	NCBI
mRatBN7.2	6	9,653,271 - 9,706,628 (-)	NCBI
Rnor_6.0	6	8,220,228 - 8,273,549 (+)	NCBI
Rnor_5.0	6	8,151,741 - 8,212,739 (+)	NCBI
RGSC_v3.4	6	8,319,544 - 8,373,795 (+)	RGD
Celera	6	9,377,461 - 9,430,794 (-)	NCBI

Sequence:

show sequence

AAGGAGCGGAGCGGCCGCTGCTCAATGGCGGAAAAGCCGCTGGTACTCTGACCGCCTGGTCCCC
CCTGGCAGTTGCGGGGGAGTTTCCTGCCGGCGCGGCTGGAGTCTCTGTTTCTCTGTGTCCGGTG
GCTGGAAGATGCTCCAGAGAGATCAGGCTGCGGCGGAGGAGGTGGCGGCGGCCGAGTCGGCAGC
GGCGCTGGGTTGGAGAGAAGGCGGCGGCGGCGGCGTGAGGGGCCGGACGGTGTAAACAGCTCGG
GCGGCGGCGGTGGCCGAGCCCCCGAGGGCGAAGCGGCGGCGGAGGCGGTGTCGCGTCTCGGGAG
AAAGCCGGGGGCCGCGGGCGGCTGTGCGGCGGGCAAGCCCGCGAGACCTTGCCTTCCACCTTCG
CCCCAGATTCGTTACTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAGCACAATGC
TCACGGTGCAGGGAACGGTCTGCGTTACGGTCTGAGCAGTATGCAAGGATGGAGAGTAGAAATG
GAAGACGCACACACTGCTGTTGTGGGAATTCCTCACGGCTTGGAGGACTGGTCGTTTTTTGCAG
TCTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGTTCAACACATCTATTAGAACACAT
CACTACCAATGAAGACTTTAGGGCAGCTGACAAATCAGGCTTTGCTCTTGAGCCGTCAGTGGAA
AATGTTAAGACTGGTATCCGAACTGGCTTTTTGAAAATTGATGAATATATGCGTAACTTTTCAG
ACCTGAGGAACGGGATGGACAGGAGCGGCTCTACCGCAGTGGGCGTGATGATTTCACCGACACA
CATCTACTTTATCAACTGCGGTGACTCGAGAGCTGTTCTGTGTAGGAATGGACAAGTCTGCTTT
TCTACCCAGGATCACAAACCTTGTAATCCAATGGAAAAGGAGCGCATCCAAAATGCAGGAGGCA
GTGTAATGATACAGCGTGTGAATGGGTCGTTAGCAGTGTCTCGTGCTCTGGGGGACTATGATTA
CAAGTGTGTTGATGGCAAGGGCCCCACAGAGCAGCTTGTTTCTCCAGAGCCTGAGGTTTATGAG
ATTCTAAGAGCAGAAGAGGATGAATTTGTCGTCCTGGCTTGTGATGGGATCTGGGATGTGATGA
GCAATGAGGAGCTCTGTGAGTTTGTTAACTCTAGGCTTGAGGTGTCAGACGACCTGGAGAATGT
GTGCAATTGGGTAGTGGACACTTGTTTACATAAGGGAAGTCGAGATAACATGAGTATTGTGTTA
GTTTGCTTTGCAAATGCCCCCAAGGTCTCAGATGAAGCCGTGAAAAGAGATTTAGAGTTGGACA
AGCACTTGGAATCACGGGTGGAAGAAATCATGCAGAAGTCTGGAGAGGAAGGAATGCCTGATCT
TGCCCATGTGATGCGCATTTTGTCTGCAGAAAATATCCCAAATTTACCTCCCGGGGGAGGCCTC
GCTGGCAAGCGCAATGTTATTGAAGCTGTTTATAGTAGACTTAATCCAAACAAAGACAATGATG
GGGGCGCTGGCGATCTAGAAGACTCATTGGTAGCCTTATAACCTTCTAAATGCTTTTGATTCTG
AAAATTGGGGGAAAACTTTTAATCATATTTTCTTCAATACAAGGGGAACTATTCTTGTGAATTC
CCACTGTTTTGTGGTATGAGCAGAAGCCATTAGCATTTCCCACCATTTGCTCATGTTTGTACTT
CCCAGTAATCGCCACTCTTAGCACTGCCTGGACTCAACAGTATTCTCGCCAGCCTCAGGCCTCT
GCTTACAACTGTATTGAATTTTTGGCCCTAGAAAAACAAAATGACCCTACAAATCAACAAGTGT
GCCTGAGGTGCATGGGAATATAGTTAGCTATACTCTGAAGATACGTTAAGGGTTTGTTTGTTTG
TTTGTTTTTTAAAAGCAAAACAAAACAACAACATAGAAGCATGTAAGAGTAAAGGATTGCAAGA
GAAGTTCAGTTTTTCAGTTTACTAAGTTGGAAGCCTTTCGTTAGTTCTGTGGCTTGGAATTTCA
TTTGAGCAATATACTATAGGATATGTATTTATTATTAATTGTTATTTAATTTTTTTCCAATTTA
CTTGTATTACCAAATTGGGTTCTCCAATAATGTAACATTGCCTTGCTTCAAGATCCATTGTTTG
GCAATAATATAAACCCTTAAAGATTTCCGCATGTGTCTGCTACATCGTTCAGATCTTACTAGAA
GATCTTTTGAAACCAAGTGAGTTAATTTAAGGCTATTTATAATTTGCTTTGTCATCTTACTGGC
TTCGCATTATTTTAATTGATGAGATTTACCTTTATAATGTAAATTGTAATCTTCTTGTTTTACA
TGTGGATTTCTATAGTTTTAATTTTTTCAGCTTTTAAGATACAAGTTTTATGTAATTTGGTATA
ATTTTTAACTGTTTATGTTATTTTAAAAGCTCAGAATATCACATCAAAATACTATAAATACATT
TTAAAGTATCTATTTTAGATCTAAGGAAATACAGAGATATTTTCATGGGTTCAGTAACCTTTCA
TTTTATAACATTGGGCACGGTACAGAGTGGCTGTCACATCGGTACTTAAATTATTTAGTTCTAT
TTTTACAATAACTTTAAATTTTTTAAGTTTTGCATGTATTGAATTTAGTGCTGAACATGAAGAG
TAAACTATTTACCAAAAAGAAGTTCCTGGAGTTTGGAGAAGTAACGAATGTATCCATCTGTACA
TGATTTACATGTTGTGGATGCTTTGTAAACATTTCCCCATGTTTTAATTGTGTTTCAGCAGGTT
GTAATTGCCTCTGTGTGTAGCTGAACATGAGTCATTATCTGGTCCTGTATGAAATGGAATGTAT
GGTATTTTCTGTATCATTTTCCTGAGGCTGTGTTTGGGGAGCCACACATTCGAATACAGTTTTC
CTGATCACTTGATTTCTTGTGCACCTGATTTTTGCTCTCAAAGGAATTACTGCCACAATATATT
TTATTTATTCTTTAGATTTTAGCCTTGTCAGTTGAAGTGCTTCACATGATGGTGTTAAAAACTA
CTTGTCCCTTTACTGGGGGTTTGGGGGTTGTTAAAAGATGGGGAGGAAGAATGCAAATGGGTCA
TTGTTAACCTGTCCCCACTGATCCCACCTGTACTCATAGTCCCTTCCAGGATGGTATTCTGATG
TTTCCTACAATACGGTGACCATAGGCAACTTGTTACCTGAATAAAGGATCGATTTTAAACAGCC
TGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001257548	(Get FASTA)	NCBI Sequence Viewer
	NP_001257549	(Get FASTA)	NCBI Sequence Viewer
	NP_149087	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB21898	(Get FASTA)	NCBI Sequence Viewer
	AAH61986	(Get FASTA)	NCBI Sequence Viewer
	AAH81762	(Get FASTA)	NCBI Sequence Viewer
	CAC28066	(Get FASTA)	NCBI Sequence Viewer
	CAC28067	(Get FASTA)	NCBI Sequence Viewer
	EDM02680	(Get FASTA)	NCBI Sequence Viewer
	EDM02681	(Get FASTA)	NCBI Sequence Viewer
	EDM02682	(Get FASTA)	NCBI Sequence Viewer
	EDM02683	(Get FASTA)	NCBI Sequence Viewer
	EDM02684	(Get FASTA)	NCBI Sequence Viewer
	EDM02685	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074150.2
	ENSRNOP00000074301.2
	ENSRNOP00055031648
	ENSRNOP00060005528
	ENSRNOP00065009212
GenBank Protein	P35815	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_149087 ⟸ NM_033096
- Peptide Label:	isoform 1
- UniProtKB:	Q546R0 (UniProtKB/Swiss-Prot), Q64046 (UniProtKB/Swiss-Prot), P35815 (UniProtKB/Swiss-Prot), A6H9H9 (UniProtKB/TrEMBL), A6H9H5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAG SRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENVKTGIRTGFLKIDEYMRNFSDLRNGMD RSGSTAVGVMISPTHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPMEKERIQNAGGSVMIQRV NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCE FVNSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFANAPKVSDEAVKRDLELDKHLESRV EEIMQKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPNKDNDGGAGDLE DSLVAL hide sequence

RefSeq Acc Id:	NP_001257549 ⟸ NM_001270620
- Peptide Label:	isoform 3
- UniProtKB:	Q642F2 (UniProtKB/TrEMBL), D3ZLY2 (UniProtKB/TrEMBL), A6H9H8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAG SRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENVKTGIRTGFLKIDEYMRNFSDLRNGMD RSGSTAVGVMISPTHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPMEKERIQNAGGSVMIQRV NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCE FVNSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFANAPKVSDEAVKRDLELDKHLESRV EEIMQKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPNKDNDGFYQPSI PYSDNVFLL hide sequence

RefSeq Acc Id:	NP_001257548 ⟸ NM_001270619
- Peptide Label:	isoform 2
- UniProtKB:	Q99ND8 (UniProtKB/TrEMBL), A6H9I0 (UniProtKB/TrEMBL), A0A0G2K7Q5 (UniProtKB/TrEMBL), Q6P6W5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAG SRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENVKTGIRTGFLKIDEYMRNFSDLRNGMD RSGSTAVGVMISPTHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPMEKERIQNAGGSVMIQRV NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCE FVNSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFANAPKVSDEAVKRDLELDKHLESRV EEIMQKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPNKDNDGASEEAE ESGSQGKLVEALRQMRVNHRGNYRQLLEEMLTSYRLAKVEGEESPAGPAAATASSNSDAGNPVA VQERHTESGPAELDSPK hide sequence

RefSeq Acc Id:

ENSRNOP00000074301 ⟸ ENSRNOT00000079279

RefSeq Acc Id:

ENSRNOP00000048342 ⟸ ENSRNOT00000048656

RefSeq Acc Id:

ENSRNOP00000074150 ⟸ ENSRNOT00000083470

RefSeq Acc Id:

ENSRNOP00000041472 ⟸ ENSRNOT00000040509

Protein Domains

PPM-type phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P35815-F1-model_v2	AlphaFold	P35815	1-390	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694378

Promoter ID:

EPDNEW_R4903

Type:

multiple initiation site

Name:

Ppm1b_1

Description:

protein phosphatase, Mg2+/Mn2+ dependent, 1B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	8,220,226 - 8,220,286	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3374	AgrOrtholog
BioCyc Gene	G2FUF-38652	BioCyc
Ensembl Genes	ENSRNOG00000030667	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055022700	UniProtKB/Swiss-Prot
	ENSRNOG00060004300	UniProtKB/Swiss-Prot
	ENSRNOG00065007932	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000079279.2	UniProtKB/TrEMBL
	ENSRNOT00000083470.2	UniProtKB/TrEMBL
	ENSRNOT00055038977	UniProtKB/Swiss-Prot
	ENSRNOT00060007288	UniProtKB/Swiss-Prot
	ENSRNOT00065012514	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.10.430	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599216	IMAGE-MGC_LOAD
	IMAGE:7113731	IMAGE-MGC_LOAD
InterPro	PP2C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PP2C_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PP2C_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PP2C_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPM-type_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPM-type_phosphatase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24667	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72371	IMAGE-MGC_LOAD
	MGC:93319	IMAGE-MGC_LOAD
NCBI Gene	24667	ENTREZGENE
PANTHER	PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN PHOSPHATASE 1B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PP2C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PP2C_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ppm1b	PhenoGen
PROSITE	PPM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPM_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000030667	RatGTEx
	ENSRNOG00055022700	RatGTEx
	ENSRNOG00060004300	RatGTEx
	ENSRNOG00065007932	RatGTEx
SMART	PP2Cc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF81601	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81606	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K7C6_RAT	UniProtKB/TrEMBL
	A0A0G2K7Q5	ENTREZGENE, UniProtKB/TrEMBL
	A6H9H5	ENTREZGENE, UniProtKB/TrEMBL
	A6H9H8	ENTREZGENE, UniProtKB/TrEMBL
	A6H9H9	ENTREZGENE, UniProtKB/TrEMBL
	A6H9I0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZLY2	ENTREZGENE
	P35815	ENTREZGENE, UniProtKB/Swiss-Prot
	Q546R0	ENTREZGENE
	Q64046	ENTREZGENE
	Q642F2	ENTREZGENE, UniProtKB/TrEMBL
	Q6P6W5	ENTREZGENE, UniProtKB/TrEMBL
	Q99ND8	ENTREZGENE
UniProt Secondary	D3ZLY2	UniProtKB/TrEMBL
	Q546R0	UniProtKB/Swiss-Prot
	Q64046	UniProtKB/Swiss-Prot
	Q99ND8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-03	Ppm1b	protein phosphatase, Mg2+/Mn2+ dependent, 1B	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ppm1b	Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)